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Dennis E. Discher

University Of Pennsylvania

$22,706,504
Attributed
$22,943,507
Total exposure
19
Grants
16
Lead (contact PI)

Attributed= this PI's even-split share of every grant they're on (the fair, additive number). Exposure = full size of all those grants.

Funding over time

peak $3.9M · FY200525
$5M$3.8M$2.5M$1.3M$0
'05
'06
'07
'08
'09
'10
'11
'12
'13
'14
'15
'16
'17
'18
'19
'20
'21
'22
'23
'24
'25

Funding mix

By agency

NIH$33,446,543 · 20

By mechanism

U54$15,983,719 · 5
R01$9,210,646 · 3
U01$4,251,467 · 1
R21$2,388,014 · 6
P01$1,201,120 · 2
S10$381,577 · 1

Top collaborators

Most similar at University Of Pennsylvania

Same institution · by research overlap

Others in their field

Top investigators on “Cells

Research focus

CellsMalignant NeoplasmsTumorMembraneSiteIn VitroMolecularLiverBaseMechanicsTissuesNuclearExhibitsProteinsCancer CellPeptidesSignal TransductionPhysicsMalignant Neoplasm Of LiverIn VivoLeadSciencePathway InteractionsShapes

Grant awards (80)

Live cell reporters of genetic changes in stiff vs soft surroundings - Causes & Consequences$625,343
U01 · FY2025 · CA · contact PI
Mechanics of Cells & Tissues impact Chromosome Instability & Phagocytic Interactions$405,782
P01 · FY2025 · CA · contact PI
2025 Physical Science of Cancer Gordon Research Conference and Gordon Research Seminar$25,000
R13 · FY2025 · CA · contact PI
Live cell reporters of genetic changes in stiff vs soft surroundings - Causes & Consequences$756,522
U01 · FY2024 · CA · contact PI
Mechanics of Cells & Tissues impact Chromosome Instability & Phagocytic Interactions$386,815
P01 · FY2024 · CA · contact PI
Stiff, solid microenvironments induce Chromosome loss and challenge Epigenetic therapies$116,406
U01 · FY2024 · CA · contact PI
Live cell reporters of genetic changes in stiff vs soft surroundings - Causes & Consequences$6,689
U01 · FY2024 · CA · contact PI
Live cell reporters of genetic changes in stiff vs soft surroundings - Causes & Consequences$778,993
U01 · FY2023 · CA · contact PI
Mechanics of Cells & Tissues impact Chromosome Instability & Phagocytic Interactions$408,523
P01 · FY2023 · CA · contact PI
Live cell reporters of genetic changes in stiff vs soft surroundings - Causes & Consequences$79,817
U01 · FY2023 · CA · contact PI
Live cell reporters of genetic changes in stiff vs soft surroundings - Causes & Consequences$904,567
U01 · FY2022 · CA · contact PI
Nanoscience of Self 2.0: blocking CD47 recognition by phagocytes in blood & solid tumor clearance$393,055
R01 · FY2022 · HL · contact PI
Live cell reporters of genetic changes in stiff vs soft surroundings - Causes & Consequences$66,580
U01 · FY2022 · CA · contact PI
Live cell reporters of genetic changes in stiff vs soft surroundings - Causes & Consequences$916,550
U01 · FY2021 · CA · contact PI
Nanoscience of Self 2.0: blocking CD47 recognition by phagocytes in blood & solid tumor clearance$393,055
R01 · FY2021 · HL · contact PI
Liver Cancer: pre-Malignant Stiffening, Membrane Transduction, & Nuclear Rheology$499,999
U54 · FY2020 · CA · contact PI
Nanoscience of Self 2.0: blocking CD47 recognition by phagocytes in blood & solid tumor clearance$393,055
R01 · FY2020 · HL · contact PI
Liver Cancer: pre-Malignant Stiffening, Membrane Transduction, & Nuclear Rheology$1,871,973
U54 · FY2019 · CA · contact PI
Nanoscience of Self 2.0: blocking CD47 recognition by phagocytes in blood & solid tumor clearance$393,055
R01 · FY2019 · HL · contact PI
Liver Cancer: pre-Malignant Stiffening, Membrane Transduction, & Nuclear Rheology: Administrative Core$343,905
U54 · FY2019 · CA · contact PI
Project 3: Nuclear Rheology & Stability in Cancer$300,465
U54 · FY2019 · CA · contact PI
PSOC@Penn Education and Outreach$127,373
U54 · FY2019 · CA · contact PI
Liver Cancer: pre-Malignant Stiffening, Membrane Transduction, & Nuclear Rheology$1,980,960
U54 · FY2018 · CA · contact PI
Liver Cancer: pre-Malignant Stiffening, Membrane Transduction, & Nuclear Rheology: Administrative Core$363,348
U54 · FY2018 · CA · contact PI
Project 1: Mechanisms of Stiffening in Liver Cancer$331,048
U54 · FY2018 · CA · contact PI
Project 3: Nuclear Rheology & Stability in Cancer$318,506
U54 · FY2018 · CA · contact PI
PSOC@Penn Education and Outreach$134,573
U54 · FY2018 · CA · contact PI
Liver Cancer: pre-Malignant Stiffening, Membrane Transduction, & Nuclear Rheology$2,076,805
U54 · FY2017 · CA · contact PI
Nanoscience of 'Self' - reductionist approaches to hCD47 inhibition of phagocytes$384,045
R01 · FY2017 · HL · contact PI
Liver Cancer: pre-Malignant Stiffening, Membrane Transduction, & Nuclear Rheology: Administrative Core$380,699
U54 · FY2017 · CA · contact PI
Project 1: Mechanisms of Stiffening in Liver Cancer$346,854
U54 · FY2017 · CA · contact PI
Project 3: Nuclear Rheology & Stability in Cancer$334,133
U54 · FY2017 · CA · contact PI
PSOC@Penn Education and Outreach$140,993
U54 · FY2017 · CA · contact PI
2017 Physical Science of Cancer Gordon Research Conference$5,000
R13 · FY2017 · CA · contact PI
Liver Cancer: pre-Malignant Stiffening, Membrane Transduction, & Nuclear Rheology$2,094,629
U54 · FY2016 · CA · contact PI
Liver Cancer: pre-Malignant Stiffening, Membrane Transduction, & Nuclear Rheology: Administrative Core$386,364
U54 · FY2016 · CA · contact PI
Nanoscience of 'Self' - reductionist approaches to hCD47 inhibition of phagocytes$384,045
R01 · FY2016 · HL · contact PI
Project 1: Mechanisms of Stiffening in Liver Cancer$352,015
U54 · FY2016 · CA · contact PI
Project 3: Nuclear Rheology & Stability in Cancer$339,195
U54 · FY2016 · CA · contact PI
Nuclear Mechanics varies with Tissue Mechanics & Regulates Cytoskeleton$192,762
R21 · FY2016 · HL · contact PI
PSOC@Penn Education and Outreach$143,098
U54 · FY2016 · CA · contact PI
Liver Cancer: pre-Malignant Stiffening, Membrane Transduction, & Nuclear Rheology$1,978,670
U54 · FY2015 · CA · contact PI
Nanoscience of 'Self' - reductionist approaches to hCD47 inhibition of phagocytes$378,284
R01 · FY2015 · HL · contact PI
Liver Cancer: pre-Malignant Stiffening, Membrane Transduction, & Nuclear Rheology: Administrative Core$360,278
U54 · FY2015 · CA · contact PI
Project 1: Mechanisms of Stiffening in Liver Cancer$328,252
U54 · FY2015 · CA · contact PI
Project 3: Nuclear Rheology & Stability in Cancer$316,148
U54 · FY2015 · CA · contact PI
Nuclear Mechanics varies with Tissue Mechanics & Regulates Cytoskeleton$233,340
R21 · FY2015 · HL · contact PI
PSOC@Penn Education and Outreach$133,436
U54 · FY2015 · CA · contact PI
Nanoscience of 'Self' - reductionist approaches to hCD47 inhibition of phagocytes$384,045
R01 · FY2014 · HL · contact PI
Avoiding clearance to maximize dose: Shape, Flexibility, and a "Marker of Self"$349,200
R01 · FY2014 · EB · contact PI
Avoiding clearance to maximize dose: Shape, Flexibility, and a "Marker of Self"$339,480
R01 · FY2013 · EB · contact PI
Avoiding clearance to maximize dose: Shape, Flexibility, and a "Marker of Self"$360,000
R01 · FY2012 · EB · contact PI
Cytoskeletal Pliability within Cells under Stress: RBCs and Marrow-derived SCs$301,763
R01 · FY2012 · HL · contact PI
Avoiding clearance to maximize dose: Shape, Flexibility, and a "Marker of Self"$346,500
R01 · FY2011 · EB · contact PI
Cytoskeletal Pliability within Cells under Stress: RBCs and Marrow-derived SCs$305,683
R01 · FY2011 · HL · contact PI
Understanding HIV escape using atomic force microscopy$214,341
R21 · FY2011 · AI
Cytoskeletal Pliability within Cells under Stress: RBCs and Marrow-derived SCs$305,396
R01 · FY2010 · HL · contact PI
Understanding HIV escape using atomic force microscopy$259,665
R21 · FY2010 · AI
Carrier Shape Matters: Filomicelles, Long-circulation, and the EPR effect$342,805
R01 · FY2009 · EB · contact PI
Cytoskeletal Pliability within Cells under Stress: RBCs and Marrow-derived SCs$305,676
R01 · FY2009 · HL · contact PI
Matrix-induced Myogenesis & Pharmaco-Screens of MSCs$164,333
R21 · FY2009 · AR · contact PI
Carrier Shape Matters: Filomicelles, Long-circulation, and the EPR effect$341,681
R01 · FY2008 · EB · contact PI
Cytoskeletal Pliability within Cells under Stress: RBCs and Marrow-derived SCs$330,947
R01 · FY2008 · HL · contact PI
Matrix-induced Myogenesis & Pharmaco-Screens of MSCs$199,391
R21 · FY2008 · AR · contact PI
AFM(T) + FLUORESCENCE MEASUREMENTS ON SINGLE MOLECULES$381,577
S10 · FY2007 · RR · contact PI
Carrier Shape Matters: Filomicelles, Long-circulation, and the EPR effect$347,541
R01 · FY2007 · EB · contact PI
SPECTRIN EXTENSIBILITY and CD47 CONNECTIONS & FUNCTION$263,002
R01 · FY2007 · HL · contact PI
Carrier Shape Matters: Filomicelles, Long-circulation, and the EPR effect$355,517
R01 · FY2006 · EB · contact PI
SPECTRIN EXTENSIBILITY and CD47 CONNECTIONS & FUNCTION$270,857
R01 · FY2006 · HL · contact PI
Myocytes sense substrate stiffness - New materials$186,191
R21 · FY2006 · EB · contact PI
SPECTRIN EXTENSIBILITY and CD47 CONNECTIONS &FUNCTION$277,375
R01 · FY2005 · HL
Myocytes sense substrate stiffness - New materials$229,180
R21 · FY2005 · EB
Worm-like Micelles for Targeted Delivery and Imaging$125,049
R21 · FY2005 · EB
SPECTRIN EXTENSIBILITY and CD47 CONNECTIONS &FUNCTION$262,750
R01 · FY2004 · HL
Worm-like Micelles for Targeted Delivery and Imaging$223,437
R21 · FY2004 · EB
CD47-Display on Nanomaterials$170,663
R21 · FY2004 · EB
CD47-Display on Nanomaterials$189,662
R21 · FY2003 · EB
RED CELL SPECTRIN AND ACTIN MICROSTRUCTURAL RESPONSES$240,895
R01 · FY2002 · HL
RED CELL SPECTRIN AND ACTIN MICROSTRUCTURAL RESPONSES$233,876
R01 · FY2001 · HL
RED CELL SPECTRIN AND ACTIN MICROSTRUCTURAL RESPONSES$227,063
R01 · FY2000 · HL