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24,576 grants matching “microbiome”
Molecular Biology of Oral Microbial Adhesins and Receptors
$1,060,527John O Cisar · National Institute Of Dental & Craniofacial Research · ZIA · FY2014 · DE
Prebiotics Intervention to Reduce Alzheimer's Disease Risk via Brain-Gut Axis in an APOE4 Mouse Model
$1,060,292Ai-Ling Lin · University Of Kentucky · RF1 · FY2019 · AG
Identification of novel MDR antimicrobials from human microbiome symbioses
$1,060,230Nasia Safdar · University Of Wisconsin-Madison · U19 · FY2022 · AI
Exploring roles of protein deamidation in oral inflammation
$1,059,247Pinghui Feng · University Of Southern California · R35 · FY2018 · DE
CHALLENGES TO ASTRONAUT HEALTH CAUSED BY SPACEFLIGHT-RELEVANT STRESSORS WILL IMPACT SIGNALING PATHWAYS BETWEEN SYSTEMS ULTIMATELY LEADING TO DEGENERATIVE CHANGES AS HOMEOSTASIS IS IMPAIRED. FOR EXAMPLE CHANGES IN THE MICROBIAL ENVIRONMENT CAN RESULT IN DRAMATIC CHANGES IN VARIOUS INTERNAL AND EXTERNAL MICROBIOMES. BOTH PSYCHOLOGICAL AND PHYSIOLOGICAL STRESS ACTIVATES THE SYMPATHETIC NERVOUS SYSTEM (SNS) AND INITIATES WIDE-RANGING PHYSIOLOGIC CHANGES. THESE CHANGES HAVE SERIOUS IMPLICATIONS ON IMMUNE FUNCTION AND THE ACTIVATION OF INFLAMMATORY PATHWAYS. WE PROPOSE TO USE CENTRIFUGATION TO CHARACTERIZE THE IMPACT OF CHRONIC CHANGES IN THE GRAVITATIONAL ENVIRONMENT ON CROSS-SYSTEM COMMUNICATION. .WE HYPOTHESIZE THAT HYPER-GRAVITY INDUCED CHANGES IN GUT MICROBIOME SNS FUNCTION AND INFLAMMATORY ACTIVITY LEAD TO A BREAKDOWN IN THE COMMUNICATION BETWEEN DISTINCT PHYSIOLOGICAL SYSTEMS (AS MEASURED BY CHANGES IN CARDIOPULMONARY CONTROL); AND THAT THESE RESPONSES DEPEND ON THE GRAVITATIONAL ENVIRONMENT. FURTHERMORE WE PROPOSE THAT THESE GRAVITY-DEPENDENT DEFICITS CAN BE COUNTERED BY A COMBINATION OF PREBIOTIC NUTRITIONAL SUPPLEMENTS THAT ARE KNOWN TO PREFERENTIALLY EXPAND STRESS PROTECTIVE BACTERIAL SPECIES..SPECIFIC AIMS .SPECIFIC AIM 1. CONFIRM THAT CENTRIFUGATION RESULTS IN DETECTABLE CHANGES IN GUT MICROBIOME AS WELL AS IN SYMPATHETIC AND INFLAMMATORY ACTIVITY INDICATIVE OF INCREASED HEALTH RISK. MICE WILL BE PLACED ON THE 8 FT DIAMETER CENTRIFUGE AT AMES RESEARCH CENTER AND EXPOSED TO 1.5 OR 2 G FOR 4 WEEKS. AFTER CENTRIFUGATION ADRENAL GLANDS BLOOD LIVER SPLEEN AND INTESTINES WILL BE COLLECTED AND ASSESSED FOR CHANGES IN SYMPATHETIC AND INFLAMMATORY ACTIVITY AS WELL AS FOR CHANGES IN MICROBIOME AS COMPARED TO MATCHED 1 G CONTROLS. .SPECIFIC AIM 2. CONFIRM THAT PROLONGED EXPOSURE TO HYPER-GRAVITY LEADS TO A BREAKDOWN IN COMMUNICATION BETWEEN DISTINCT PHYSIOLOGICAL SYSTEMS CAUSING DECREMENTS IN FUNCTION. THE SAME MICE USED IN AIM 1 WILL BE USED HERE. OUR MODEL FOCUSES ON BRAINSTEM CONTROL OF CARDIOPULMONARY FUNCTION DRIVEN PRIMARILY BY SYMPATHETIC/VAGAL INNERVATION. THE BRAINSTEM SPINAL CORD HEART AND LUNGS WILL BE COLLECTED. ANALYSIS WILL FOCUS SPECIFICALLY ON THE NUCLEUS TRACTUS SOLITARII (NTS) THE FIRST-ORDER INTEGRATIVE SITE FOR VAGAL AFFERENTS PROJECTING FROM THE GUT HEART AND LUNGS TO THE CENTRAL NERVOUS SYSTEM. THE NTS COORDINATES EFFERENT OUTPUT TO TARGETS THAT ARE CRITICAL FOR THE CONTROL OF BREATHING HEART/VASCULATURE AND GUT. IN VIVO AND IN VITRO ELECTROPHYSIOLOGY WILL BE USED TO QUANTIFY CHANGES IN SYMPATHETIC TONE AND CONFIRM THAT SYNAPTIC ACTIVITY WITHIN THE NTS IS ALTERED BY CHANGES IN MICROBIOME. IMMUNOHISTOCHEMISTRY AND RNASEQ WILL BE USED TO ASSESS CHANGES IN INFLAMMATION AND STRESS-RELATED MESSAGE ALLOWING US TO DETERMINE THE ROLE CYTOKINES AND DOWNSTREAM EFFECTORS PLAY IN MODULATING NTS NEURONAL ACTIVITY CORRELATED WITH CARDIORESPIRATORY CONTROL. .SPECIFIC AIM 3. DETERMINE THAT CENTRIFUGATION-INDUCED CHANGES IN HEALTH STATUS SIGNALING ARE LINKED TO CHANGES IN MICROBIOME. BASED ON OUR PREVIOUS FINDINGS WE HYPOTHESIZE THAT INGESTION OF A PREBIOTIC SUPPLEMENT BLEND [GALACTOOLIGOSACCHARIDES (GOS) + POLYDEXTROSE (PDX) + LACTOFERRIN + MILK FAT GLOBULE MEMBRANE PROTEIN (MFGMP)] WILL BOTH PREVENT GUT MICROBIAL DYSBIOSIS PRODUCED BY CENTRIFUGATION AND INCREASE SELECTIVE STRESS PROTECTIVE GUT BACTERIA (I.E. LACTOBACILLUS AND BIFIDOBACTERIA). PREBIOTIC-ENRICHED CHOW OR CALORICALLY MATCHED CHOW WILL BE AVAILABLE AD LIBITUM THROUGHOUT THE EXPERIMENT STARTING 1 WEEK PRIOR TO CENTRIFUGATION. MICE WILL BE PLACED ON THE 8 FT DIAMETER CENTRIFUGE AT AMES RESEARCH CENTER AND EXPOSED TO 2 G FOR 4 WEEKS. PARAMETERS DESCRIBED IN AIMS 1&2 WILL BE ASSESSED AS DESCRIBED. .
$1,058,979Loma Linda University · · FY2020 · National Aeronautics and Space Administration
Collaborative Protein Technology Resource - Nano-Scale Protein Analysis Section
$1,057,804Jinqiu Chen · Division Of Basic Sciences - Nci · ZIC · FY2020 · CA
Michigan Nutrition Obesity Research Center
$1,057,430Randy J. Seeley · University Of Michigan At Ann Arbor · P30 · FY2019 · DK
Kansas IDeA Network of Biomedical Research Excellence (K-INBRE)
$1,057,179Douglas E Wright · University Of Kansas Medical Center · P20 · FY2023 · GM
Investigation of role of microbiota in development, progression and therapy of cancers
$1,055,069Amiran Dzutsev · Division Of Basic Sciences - Nci · ZIA · FY2025 · CA
Determinants of inception of inflammation in inflammatory bowel diseases
$1,054,797Ashwin N Ananthakrishnan · Massachusetts General Hospital · R01 · FY2024 · DK
Multidisciplinary Training Program in Lung Disease
$1,054,715Robert Pickett Dickson · University Of Michigan At Ann Arbor · T32 · FY2021 · HL
Povidone Iodine Efficacy Study (PIES)
$1,054,167Dorota Teresa Kopycka-Kedzierawski · University Of Rochester · UH3 · FY2024 · DE
Mutographs differentiating the racial and temporal incidence of multiple myeloma
$1,054,153Gareth John Morgan · New York University School Of Medicine · R01 · FY2024 · CA
Food Allergy Outcomes Related to White and African American Racial Differences (FORWARD)
$1,054,023Ruchi S Gupta · Northwestern University At Chicago · R01 · FY2019 · AI
Liver Cancer Program
$1,051,369Anuradha Budhu · Division Of Basic Sciences - Nci · ZIA · FY2021 · CA
Project 4: Determining the ability of rapamycin to improve lifespan and healthspan in companion dogs
$1,050,844Matt Kaeberlein · University Of Washington · U19 · FY2020 · AG
Project 4: Determining the ability of rapamycin to improve lifespan and healthspan in companion dogs
$1,050,844Matt Kaeberlein · University Of Washington · U19 · FY2019 · AG
Determining the contribution of microbial-derived metabolites to protective immunity in obesity-driven cancer risk.
$1,050,313Liza Makowski Hayes · University Of Tennessee Health Sci Ctr · U01 · FY2022 · CA
Clinical Core
$1,050,259Douglas R Galasko · University Of California, San Diego · P30 · FY2021 · AG
A Novel Microbiome-Based Immune-Modulator that Potentiates Cancer Checkpoint Therapy
$1,049,717Gary Fanger · Rise Therapeutics, Llc · R44 · FY2022 · CA
NUMEROUS STUDIES HAVE REPORTED ANTIBIOTIC RESISTANCE IN MICROBIAL POPULATIONS ("RESISTOME") OF ANIMAL WASTE AND THEIR IMPACT ONTHE ENVIRONMENT. HOWEVER, LITTLE IS KNOWN CONCERNING THE IMPACT OF POULTRY LITTER ON ENVIRONMENTAL HEALTH. WE REPORTED THEIMMENSE ABUNDANCE OF ANTIBIOTIC RESISTANCE GENES IN THE LITTER MICROBIOME. WHILE POULTRY LITTER IS AN EXCELLENT NITROGEN SOURCE,ITS APPLICATION TO SOILS INTRODUCES A SIGNIFICANTLY LARGE ANTIBIOTIC RESISTANCE GENE LOAD TO THE SOIL MICROBIOME. OUR CENTRALHYPOTHESIS IS THAT MOBILE DNA FROM LITTER MAY SPREAD ANTIBIOTIC RESISTANCE GENES THROUGHOUT THE MICROBIAL COMMUNITY OF SOILSTHEREBY INCREASING THE CONTAMINATION OF CROPS MEANT FOR HUMAN CONSUMPTION. KILLING OR DISPLACING THE RESIDENT ANTIBIOTICRESISTANT POPULATION IN POULTRY LITTER COULD LIMIT ITS SPREAD TO OTHER MICROBIAL COMMUNITIES. TO IMPROVE SOIL MANAGEMENT PRACTICES,WE PROPOSE THE FOLLOWING OBJECTIVES. OBJECTIVE 1. QUANTIFY THE IMPACT OF POULTRY LITTER ON THE MICROBIAL SOIL CONSORTIUMAND "RESISTOME" OF CROP AND PASTURELANDS. ASSESS THE IMPACT OF SOIL AMENDMENTS ON SOIL CHEMISTRY, MICROBIAL DIVERSITY, ANDANTIBIOTIC RESISTANCE GENE ABUNDANCE IN CROP AND PASTURE LAND. OBJECTIVE 2. PROCESS POULTRY LITTER TO REDUCE THEENVIRONMENTAL SPREAD OF ANTIBIOTIC RESISTANCE GENES WHILE MAINTAINING ITS VITALITY AS A SOIL AMENDMENT. IDENTIFY ATREATMENT THAT REDUCES ANTIBIOTIC RESISTANCE GENE ABUNDANCE AND ANTIBIOTIC RESISTANCE TRANSFER. OBJECTIVE 3. DEVELOP BESTPRACTICES FOR POULTRY WASTE MANAGEMENT AND ITS APPLICATION TO SOILS FOR PRODUCING HEALTHY, SAFE AGRICULTURAL CROPS.DEVELOP EDUCATIONAL MATERIALS TO COMMUNICATE ENVIRONMENTAL AND PUBLIC HEALTH ISSUES ASSOCIATED WITH POULTRY LITTER AND BESTMANAGEMENT PRACTICES FOR HANDLING, PROCESSING, AND APPLYING POULTRY LITTER TO SOILS.
$1,049,296Virginia Polytechnic Institute & State University · · FY2020 · National Institute of Food and Agriculture
Molecular Characterization Trial of Irradiated Rectal Cancer
$1,048,656Encouse Golden · Weill Medical Coll Of Cornell Univ · U54 · FY2024 · CA
Determinants of inception of inflammation in inflammatory bowel diseases
$1,048,416Ashwin N Ananthakrishnan · Massachusetts General Hospital · R01 · FY2025 · DK
Sex Differences in Inflammation Across the Lifespan
$1,048,212Louise Deborah McCullough · University Of Texas Hlth Sci Ctr Houston · R35 · FY2023 · NS
Microbiome Core
$1,048,026David Neal Fredricks · University Of Washington · U19 · FY2018 · AI