Sort
85,873 grants matching “alzheimers”
Dissecting the Etiology of The Lewy Body Dementias
$2,383,188Steven M Finkbeiner · J. David Gladstone Institutes · RF1 · FY2022 · NS
Exploring Cognitive Aging Using Reference Ability Neural Networks
$2,382,905Yaakov Stern · Columbia University Health Sciences · R01 · FY2025 · AG
Colorado Adoption/Twin Study of Lifespan behavioral development & cognitive aging (CATSLife2)
$2,380,827Chandra A Reynolds · University Of California Riverside · R01 · FY2020 · AG
Identifying and Addressing Social Determinants of Health to Reduce the National Burden of and Inequities in Dementia
$2,380,546Daniel Kim · Northeastern University · RF1 · FY2023 · AG
Developing a NAMPT activator for Alzheimerâs disease
$2,380,457Beibei Chen · University Of Pittsburgh At Pittsburgh · U01 · FY2023 · AG
Type 2 Diabetes Mellitus and Vascular Contributions to Cognitive Impairment and Dementia (T2DM-VCID)
$2,380,018Deborah Allison Levine · University Of Michigan At Ann Arbor · RF1 · FY2024 · NS
Potassium Channels and Dendritic Function in Hippocampal Pyramidal Neurons
$2,380,000Dax A Hoffman · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2025 · HD
Evolution of Aging and Dementia in Female Primates
$2,379,667James G Herndon · Emory University · P01 · FY2009 · AG
ALZHEIMER'S DISEASE RESEARCH CENTER
$2,379,069Washington University · P50 · FY2000 · AG
Susceptibility and adverse health outcomes related to climate-sensitive events among older Medicare beneficiaries with Alzheimer and Dementia
$2,378,546Michelle L Bell · Yale University · RF1 · FY2023 · AG
OUR OVERALL OBJECTIVE IS TO DETERMINE THE SHORT- AND LONG-TERM RISKS OF RADIATION FROM THE SPACE ENVIRONMENT ON COGNITION MOTOR ABILITIES FATIGUE RESISTANCE ANXIETY AND CHANGES IN THE BRAIN AND CARDIOVASCULAR SYSTEM. OVER THE PAST 3 YEARS WE HAVE DETERMINED THAT LOW-DOSE 56FE (IRON) RADIATION HAS LONG-TERM SEX-SPECIFIC CONSEQUENCES ON COGNITION LOCOMOTION NEUROINFLAMMATION AND ALZHEIMERS DISEASE (AD) PATHOGENESIS WITH MALES BEING MORE VULNERABLE THAN FEMALES. ANALYSIS OF PROTON-IRRADIATED MICE IS UNDERWAY. OVER THE PAST YEAR WE HAVE DEVELOPED A COLLABORATION WITH DR. DORIS TAYLOR (TEXAS HEART INSTITUTE) CO-I ON THIS PROPOSAL BY SHARING THE HEART ONE KIDNEY AND BONE MARROW FROM EACH OF THE MICE IRRADIATED IN THREE OF OUR STUDIES. OVER THE NEXT 4 YEARS WE WILL EXTEND OUR RESEARCH BY COMPARING OUR EXISTING DATA FROM OUR CURRENT STUDIES ON THE LATE CENTRAL NERVOUS SYSTEM (CNS) AND CARDIOVASCULAR (CV) EFFECTS OF A SINGLE DOSE OF IRON RADIATION OR A SINGLE DOSE OF PROTONS WITH A SINGLE DOSE OF OXYGEN-16 OR MIXED BEAM GCR (PROTONS OXYGEN-16 AND IRON) IN MALE AND FEMALE AD-LIKE TRANSGENIC AND WILDTYPE MICE AND GAMMA IRRADIATED WILDTYPE MICE (AIM 1). IN ADDITION WE WILL EXAMINE THE SEX- AND APO E-SPECIFIC LATE CNS AND CV DOSE-SPECIFIC EFFECTS OF IRON RADIATION IN THE SAME AD-LIKE MOUSE MODEL MODIFIED BY TARGETED REPLACEMENT OF MURINE APO E WITH HUMAN APO E3 OR E4 TO DETERMINE IF HUMAN APOE4 A STRONG RISK FACTOR FOR AD AND CV DISEASE EXACERBATES THE EFFECTS OF RADIATION (AIM 2). THIS WORK WILL BE CONDUCTED IN COLLABORATION WITH INVESTIGATORS AT WASH U DUKE U AND NYU. WE WILL PERFORM LONGITUDINAL MAGNETIC RESONANCE IMAGING (MRI) ON THE BRAIN AND HEART IN A SUBSET OF MICE IN AIMS 1 AND 2 TO DETERMINE RADIATION-INDUCED CHANGES WITHIN INDIVIDUAL ANIMALS. IN ADDITION MICE WILL UNDERGO EXTENSIVE BEHAVIORAL TESTING AS WELL AS PATHOLOGICAL AND BIOCHEMICAL ANALYSIS OF BRAIN AND HEART. LASTLY WE WILL CONDUCT A STUDY TO TEST 2 NOVEL HUMAN 3D NEURAL ORGANOID MODELS OF ALZHEIMERS DISEASE DEVELOPED BY OUR COLLABORATORS AT MGH AND MIT (AIM 3) FOR ACUTE AND LATE CNS EFFECTS OF SPACE RADIATION ON NEURONAL HEALTH AMYLOID PLAQUES TAU PATHOLOGY AND EPIGENETICS AND TO INVESTIGATE THE POTENTIAL OF THESE MODELS FOR SCREENING MITIGATING TREATMENTS IN THE FUTURE. IN COLLABORATION WITH DR. TAYLOR WE WILL ALSO IRRADIATE UNDIFFERENTIATED INDUCED PLURIPOTENT STEM CELLS (IPSCS) FROM HUMAN MALES AND FEMALES TO DETERMINE WHETHER HIGHLY CHARGED HIGH ENERGY (HZE) PARTICLE IRRADIATION ALTERS THEIR ABILITY TO DIFFERENTIATE INTO CARDIOMYOCYTES MORPHOLOGY AND/OR MATURATION. IN SUMMARY WE PROPOSE TO TAKE OUR CURRENT STUDIES TO THE NEXT LOGICAL STEP IN AN EFFORT TO BETTER UNDERSTAND THE POTENTIAL RISKS OF GALACTIC COSMIC RADIATION (GCR) TO THE BRAIN AND CARDIOVASCULAR SYSTEM IN ORDER TO PREPARE ASTRONAUTS FOR LONG-TERM DEEP SPACE MISSION INCLUDING MISSIONS TO MARS.
$2,376,960Brigham & Womens Hospital Inc · · FY2020 · National Aeronautics and Space Administration
Einstein Aging Study
$2,376,760Richard B. Lipton · Albert Einstein College Of Medicine · P01 · FY2020 · AG
Developing a NAMPT activator for Alzheimerâs disease
$2,376,637Beibei Chen · University Of Pittsburgh At Pittsburgh · U01 · FY2024 · AG
Alzheimer's Disease Patient Registry (ADPR)
$2,376,521Eric B Larson · Kaiser Foundation Health Plan Of Washington · U01 · FY2010 · AG
National Social Life, Health and Aging Project: Baby Boom Cohort Wave 2
$2,376,133Linda J Waite · National Opinion Research Center · R01 · FY2021 · AG
CS6253 development for the treatment of apoE4 driven dementia includingAlzheimer's disease
$2,375,985Jan Johansson · Artery Therapeutics, Inc. · R44 · FY2020 · AG
Imaging Biomarker Core
$2,375,153Brian J Lopresti · University Of Pittsburgh At Pittsburgh · P01 · FY2023 · AG
Stathmin-2 and TDP-43 neurodegeneration in Alzheimerâs and multi-etiology dementias
$2,374,752Keith A Josephs · Mayo Clinic Rochester · RF1 · FY2021 · NS
Genetic and Environmental Risk Factors for Hemorrhagic Stroke â V
$2,374,719Daniel Woo · University Of Cincinnati · RF1 · FY2024 · NS
Personal Values in Dementia Experience, Caregiving, and Research
$2,374,537Winston Chiong · University Of California, San Francisco · RF1 · FY2024 · AG
EPIDEMIOLOGY OF DEMENTIA IN AN URBAN COMMUNITY
$2,374,020Columbia University Health Sciences · P01 · FY2002 · AG
Telehealth Use in Nursing Homes and the Quality of Care for Long-Stay Residents with Alzheimer's Disease and Related Dementias
$2,373,964Hye-Young Jung · Weill Medical Coll Of Cornell Univ · RF1 · FY2024 · AG
Interdisciplinary Research to Understand the Interplay of Diabetes, Cerebrovascular disease and Alzheimers disease
$2,373,535Jose A Luchsinger · Columbia University Health Sciences · RF1 · FY2017 · AG
Veterinary and Colony Management Core
$2,373,339Peter L Strick · University Of Pittsburgh At Pittsburgh · U19 · FY2023 · AG
Dynamic Brain Imaging of Speech in Primary Progressive Aphasia
$2,373,138Srikantan S Nagarajan · University Of California, San Francisco · RF1 · FY2023 · NS