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24,576 grants matching “microbiome”
The MetaCyc & BioCyc Pathway/Genome Databases
$1,005,713Peter D Karp · Sri International · R01 · FY2019 · GM
Fecal Microbiota Transplant for C. difficile Infection in Solid Organ Transplant Recipients
$1,005,421Nasia Safdar · University Of Wisconsin-Madison · U01 · FY2021 · AI
Inflammatory Bowel Disease Genetics Consortium Data Coordinating Center
$1,004,730Judy H Cho · Icahn School Of Medicine At Mount Sinai · U01 · FY2016 · DK
Determining the contribution of microbial-derived metabolites to protective immunity in obesity-driven cancer risk.
$1,003,836Liza Makowski Hayes · University Of Tennessee Health Sci Ctr · U01 · FY2024 · CA
The Center for High Content Functional Annotation of Natural Products
$1,003,696John B Macmillan · University Of California Santa Cruz · U41 · FY2020 · AT
Fecal Microbiota Transplant for C. difficile Infection in Solid Organ Transplant Recipients
$1,002,166Nasia Safdar · University Of Wisconsin-Madison · U01 · FY2019 · AI
A Novel Immunological-Directed Live Biotherapy Product for Treating Ulcerative Colitis
$1,001,952Gary Fanger · Rise Therapeutics, Llc · R44 · FY2023 · DK
Sequencing Technology Core
$1,001,799Donna Muzny · Baylor College Of Medicine · U19 · FY2019 · AI
Fecal Microbiota Transplant for C. difficile Infection in Solid Organ Transplant Recipients
$1,001,192Nasia Safdar · University Of Wisconsin-Madison · U01 · FY2020 · AI
Live microbial therapeutics: an enhanced treatment paradigm for classical homocystinuria
$1,000,496Joseph Moeller Schinaman · Petri Bio Llc · R44 · FY2024 · HD
California Partnership for Personalized Nutrition
$1,000,003Alexander D Borowsky · University Of California At Davis · UG1 · FY2022 · HD
NCS-FO: Developing engineering solutions to investigate microbiome-to-neuron communication
$1,000,000Reza Ghodssi · University Of Maryland, College Park · · FY2019 · ENG
SCH: An intraoral device for multimodal data integration and risk modification connects the oral microbiome to systemic health
$1,000,000Edward R Steager · University Of Pennsylvania · · FY2025 · CSE
Quorum Sensing Across Scales and Between Domains
$1,000,000Bonnie Bassler · Princeton University · · FY2025 · BIO
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** INFECTIOUS DISEASES AND HEAT STRESS, EXACERBATED BY CLIMATE CHANGE, ARE TWO SIGNIFICANT CHALLENGES FACING THE $34.68B US EGG INDUSTRY. HIGHLY PATHOGENIC AVIAN INFLUENZA (HPAI) OUTBREAKS IN THE U.S. IN 2014-2015 AND 2022 RESULTED IN LOSSES OF 57M AND 43M BIRDS, RESPECTIVELY. THE MANDATORY CONVERSION OF 66% HEN INVENTORY FROM CONVENTIONAL CAGED TO CAGE-FREE HOUSING BY 2026 WORSENS THE ABOVE CHALLENGES. ADVISED BY A BOARD OF EGG SUPPLY-CHAIN STAKEHOLDERS, THIS MULTIDISCIPLINARY TEAM, WITH EXPERTISE IN SCIENCE AND ENGINEERING TECHNOLOGIES FOR POULTRY HEALTH AND PERFORMANCE, AIMS TO DEVELOP HOLISTIC INTERVENTIONS TO ABATE DISEASES AND HEAT-STRESS IN CAGE-FREE EGG HOUSING. OUR OBJECTIVES ARE TO DEVELOP INTEGRATED RESEARCH, EXTENSION AND EDUCATION PROGRAMS TO: (1) ENGAGE STAKEHOLDERS TO ASSESS CHALLENGES AND NEEDS IN CAGE-FREE EGG PRODUCTION; (2) DEVELOP HOLISTIC INTERVENTIONS TO ENHANCE BIRD PERFORMANCE AND RESISTANCE TO DISEASES; (3) DEVELOP INNOVATIVE VENTILATION TO ABATE HEAT STRESS AND DISEASE TRANSMISSION; AND (4) EQUIP EGG FARMERS WITH THE KNOWLEDGE AND TOOLS DEVELOPED AND EMPOWER FUTURE WORKFORCE VIA MULTIDISCIPLINARY EDUCATION. THE PROJECT OUTCOMES INCLUDE (1) NEW KNOWLEDGE OF THE MICROBIOME IN CAGE-FREE HOUSING AND EFFECTIVE INTERVENTIONS TO IMPROVE HEN HEALTH, IMMUNITY, AND PERFORMANCE; (2) NEW VENTILATION TO ABATE HEAT STRESS AND DISEASE TRANSMISSION; (3) TRANSLATIONAL EXTENSION PROGRAMS TO ENABLE FARMERS TO PROTECT HEN HEALTH; AND (4) MULTIDISCIPLINARY CURRICULA FOR FUTURE WORKFORCE. THIS PROJECT ADDRESSES THE FIRST TWO PROGRAM AREA PRIORITIES OF THE USDA AFRI IDEAS GRANT PROGRAM: PRECISION ANIMAL MANAGEMENT AND ENVIRONMENTAL SYNERGIES OF ANIMAL PRODUCTION. IT WILL CONTRIBUTE TO HEALTHY AND SUSTAINABLE EGG PRODUCTION IN THE U.S.
$1,000,000Ohio State University, The · · FY2023 · National Institute of Food and Agriculture
R-5280, A Novel Modified Superior Resistant Starch Therapy for Type 1 Diabetes
$1,000,000Christian Furlan Freguia · Rise Therapeutics, Llc · R44 · FY2023 · DK
Stanford Tissue Mapping Center
$1,000,000Michael P Snyder · Stanford University · U54 · FY2019 · HG
2020 Waterman Award
$1,000,000Emily Balskus · Harvard University · · FY2020 · MPS
Acquisition of High Performance Data and Computing Infrastructure to Advance Biomedical Research
$1,000,000Thomas Furlani · State University Of New York At Buffalo · S10 · FY2019 · OD
NIDDK Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4)
$1,000,000Jeffrey P Krischer · University Of South Florida · UC4 · FY2020 · DK
MucoCept-CVN, a genetically enhanced vaginal Lactobacillus strain for the prevention of HIV acquisition in women: Finalization of formulation for the first-in-human clinical trial
$1,000,000Laurel A. Lagenaur · Osel, Inc. · R44 · FY2020 · AI
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** WEEDS ARE AMONG THE MAJOR FACTORS LIMITING YIELD IN ORGANIC VEGETABLE AND OTHER HORTICULTURAL CROP SYSTEMS AND THEIR MANAGEMENT IS PARTICULARLY CHALLENGING IN ORGANIC CROPS. THE LACK OF EFFECTIVE BIOLOGICAL WEED MANAGEMENT SOLUTIONS IS A MAJOR OBSTACLE TO THE ADOPTION OF ORGANIC FARMING PRACTICES AND REPRESENTS A KEY LIMITATION TO THE EXPANSION OF THE INDUSTRY DESPITE THE CONTINUOUS GROWTH OF THE U.S. ORGANIC MARKET.ANAEROBIC SOIL DISINFESTATION (ASD) IS EMERGING AS A BROAD-SPECTRUM BIOLOGICAL SOIL TREATMENT FOR THE MANAGEMENT OF SOILBORNE PESTS AND PATHOGENS, INCLUDING WEEDS. ANAEROBIC SOIL DISINFESTATION ALSO KNOWN AS BIOLOGICAL SOIL DISINFESTATION IS A MICROBIAL-DRIVEN PROCESS BASED ON THE USE OF ORGANIC AMENDMENTS.INTEGRATED A SERIES OF RESEARCH AND EXTENSION ACTIVITIES, THE PRIMARY GOAL OF THIS PROJECT IS TO INCREASE THE PROFITABILITY AND SUSTAINABILITY OF ORGANIC VEGETABLE AND OTHER SPECIALTY CROP PRODUCTION SYSTEMS AND TO FACILITATE THE TRANSITION FROM CONVENTIONAL TO ORGANIC PRODUCTION PRACTICES BY OPTIMIZING AND INTEGRATING THE USE OF ANAEROBIC SOIL DISINFESTATION AS A BIOLOGICAL WEED MANAGEMENT TACTIC IN SPECIALTY CROPS SYSTEMS, WHILE PROMOTING SOIL HEALTH.COORDINATED RESEARCH ACTIVITIES AND ON-FARM DEMONSTRATION TRIALS WILL BE CONDUCTED TO OPTIMIZE AND INTEGRATE ANAEROBIC SOIL DISINFESTATION INTO ORGANIC SPECIALTY CROP SYSTEMS AND EVALUATE THE EFFICACY OF ASD IN SUPPRESSING KEY WEED SPECIES IN FLORIDA AND PENNSYLVANIA, TWO STATES REPRESENTATIVE OF THE U.S. NORTHEAST AND SOUTHEAST REGIONS.BESIDES ASSESSING THE EFFICACY OF ANAEROBIC SOIL DISINFESTATION IN SUPPRESSING SPECIFIC WEEDS, THE PROJECT WILL ALLOW US TO INVESTIGATE THE IMPACT OF ASD ON THE SOIL-PLANT NUTRIENT DYNAMICS AND INVESTIGATE THE MECHANISM OF SUPPRESSION EXAMINING THE IMPACT OF THE TREATMENT ON THE SOIL MICROBIOME. TO ENSURE THE VIABILITY OF ASD WE WILL ASSESS ITS ECONOMIC SUSTAINABILITY AND WILL ASSESS ANY OBSTACLE TO THE ADOPTION OF THIS NEW BIOLOGICAL SOLUTION. THE RESEARCH-BASED KNOWLEDGE GENERATED THROUGH THE PROJECT ON ASD WILL BE DISSEMINATED VIA LOCAL, REGIONAL, AND NATIONAL LEVEL EXTENSION ACTIVITIES (ON-FARM DEMONSTRATIONS, FIELD DAYS, PRESENTATIONS AT GROWERS' MEETINGS, IN-SERVICE TRAINING, SEMINARS, WEBINARS), ALONG WITH THE PUBLICATION OF EDUCATIONAL MATERIAL (FACT-SHEETS, NEWSLETTERS, MAGAZINE, AND RESEARCH ARTICLES), CONTRIBUTING TO THE TRANSFER OF ASD PRINCIPALS AND PRACTICAL APPLICATION TO ORGANIC SPECIALTY CROP GROWERS AS A SUSTAINABLE WEED MANAGEMENT STRATEGY.
$1,000,000The Pennsylvania State University · · FY2024 · National Institute of Food and Agriculture
A novel, non-antibiotic, microbiome-directed agent to prevent post-surgical infection
$1,000,000Patrick Hennessey · Covira Surgical · R42 · FY2025 · AI
Improving diagnostic sensitivity for difficult-to-lyse microbial samples with nanodroplet technology
$1,000,000Sandeep Kasoji · Triangle Biotechnology, Inc. · R44 · FY2022 · AI
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** WITH THE GLOBAL POPULATION EXPECTED TO REACH 9.7 BILLION BY 2050, THE DEMAND FOR ANIMAL-BASED PROTEIN LIKE MEAT AND MILK IS INCREASING. THIS GROWTH POSES A CHALLENGE: HOW CAN FARMERS PRODUCE MORE FOOD WITHOUT HARMING THE ENVIRONMENT? LIVESTOCK, ESPECIALLY CATTLE, PRODUCE A SIGNIFICANT AMOUNT OF GREENHOUSE GASES (GHGS), MAINLY THROUGH METHANE EMISSIONS FROM THEIR DIGESTIVE SYSTEMS. THIS METHANE NOT ONLY CAN HARM THE PLANET BUT ALSO REPRESENTS A LOSS OF ABOUT 10% OF THE ENERGY COWS GET FROM THEIR FOOD. ADDITIONALLY, LIVESTOCK CAN POLLUTE WATER AND RELEASE OTHER HARMFUL GASES THROUGH MANURE MANAGEMENT. DESPITE EFFORTS, CURRENT STRATEGIES TO REDUCE THESE EMISSIONS HAVE SHOWN LIMITED SUCCESS WITHOUT AFFECTING THE ANIMALS' HEALTH AND PRODUCTIVITY. WE PROPOSE THAT A BETTER UNDERSTANDING OF THE MICROBES LIVING IN COWS' STOMACHS (RUMEN MICROBIOME) AND HOW THEY INTERACT WITH THE COWS' GENETICS AND DIET COULD BE THE KEY TO SOLVING THIS PROBLEM. OUR MAIN GOAL IS TO UNCOVER HOW THE RUMEN MICROBIOME AFFECTS METHANE PRODUCTION IN DAIRY COWS AND HOW DIET CHANGES CAN INFLUENCE THESE EMISSIONS. WE WILL FOCUS ON COWS WITH DIFFERENT GENETIC POTENTIALS FOR METHANE PRODUCTION TO INVESTIGATE IF DIET CAN MAKE A DIFFERENCE IN THEIR EMISSION LEVELS. WE ALSO AIM TO UNDERSTAND THE TRADE-OFFS INVOLVED IN REDUCING METHANE EMISSIONS AND THEIR IMPACT ON OTHER GREENHOUSE GASES PRODUCED FROM COW MANURE. FINALLY, WE WILL USE OUR FINDINGS TO DEVELOP EDUCATIONAL PROGRAMS AIMED AT PROMOTING ENVIRONMENTALLY FRIENDLY PRACTICES AMONG FARMERS AND THE BROADER COMMUNITY.BY THE END OF THIS RESEARCH, THE GOAL IS TO HAVE A CLEARER PICTURE OF HOW THE COW'S MICROBIOME INFLUENCES METHANE EMISSIONS. THIS KNOWLEDGE COULD LEAD TO THE DEVELOPMENT OF TARGETED FEEDING STRATEGIES AND BREEDING STRATEGIES THAT CONTRIBUTE TO LOWER METHANE EMISSIONS IN CATTLE, MAKING LIVESTOCK FARMING MORE SUSTAINABLE. WE ALSO ANTICIPATE THAT OUR FINDINGS WILL GUIDE THE DEVELOPMENT OF MORE EFFECTIVE WAYS TO MANAGE COW MANURE, REDUCING ITS ENVIRONMENTAL IMPACT. ULTIMATELY, THIS WORK WILL PROVIDE A FOUNDATION FOR FUTURE RESEARCH AND INNOVATION IN SUSTAINABLE LIVESTOCK PRODUCTION, GUIDING THE DEVELOPMENT OF MORE HOLISTIC AND EFFECTIVE APPROACHES TO REDUCE THE ENVIRONMENTAL IMPACT OF DAIRY FARMING.
$1,000,000University Of Wisconsin System · · FY2024 · National Institute of Food and Agriculture