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24,576 grants matching “microbiome”
R-5280, A Novel Modified Superior Resistant Starch Therapy for Type 1 Diabetes
$1,000,000Christian Furlan Freguia · Rise Therapeutics, Llc · R44 · FY2023 · DK
IND-enabling preclinical development of a system for the multipurpose prevention of HIV and unintended pregnancy
$999,998Thomas J. Smith · Auritec Pharmaceuticals, Inc. · R44 · FY2019 · AI
IND-enabling preclinical development of a system for the multipurpose prevention of HIV and unintended pregnancy
$999,998Thomas J. Smith · Auritec Pharmaceuticals, Inc. · R44 · FY2020 · AI
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE RISE IN ANTIBIOTIC RESISTANCE IS AN EMERGING GLOBAL PROBLEM AFFECTING HUMAN, ANIMAL, AND ENVIRONMENTAL HEALTH. THIS INCREASE MAY BE DUE, IN PART, TO THE INDUSTRIALIZATION OF LIVESTOCK PRODUCTION AND THE WIDESPREAD USE OF NON-THERAPEUTIC ANTIMICROBIAL GROWTH PROMOTANTS LEADING TO DECREASED EFFECTIVENESS OF CURRENT ANTIBIOTICS AGAINST HUMAN AND ANIMAL DISEASES. UNDERSTANDING THE ECOLOGY OF ANTIBIOTIC RESISTANCE GENE POOLS WITHIN LIVESTOCK PRODUCTION SYSTEMS AND ITS EFFECT ON MICROBIAL ECOLOGY WITHIN HOST SPECIES IS CRITICAL TO BETTER UNDERSTAND THE EMERGENCE AND SPREAD OF ANTIBIOTIC RESISTANCE FROM A ONE HEALTH PERSPECTIVE. THEREFORE, A CRITICAL GAP EXISTS IN UNDERSTANDING THE ECOLOGY, EMERGENCE, AND TRANSMISSION OF ANTIBIOTIC RESISTANCE IN THE PORK INDUSTRY, PRIMARILY DUE TO THE LACK OF INVESTIGATIONS FOCUSING ON PLASMIDS OR OTHER INTEGRATIVE AND COGNITIVE ELEMENTS, THE HOTSPOTS FOR ANTIMICROBIAL RESISTANCE (AMR) GENES THAT LEAD TO THE EMERGENCE OF AMR AMONG MICROBIAL POPULATIONS. THIS PROJECT, INVESTIGATES THE EFFECTS OF ANTIBIOTIC USE ON THE ECOLOGY OF THE MICROBIAL COMMUNITY, AMR GENE PREVALENCE, ENRICHMENT, AND TRANSMISSION BY EVALUATING THE MOBILE GENETIC ELEMENTS AND THE MICROBIOME IN THE SWINE PRODUCTION SYSTEM. ADDITIONALLY, THIS STUDY WILL DEVELOP NEW TOOLS TO IDENTIFY HOST-PLASMID ASSOCIATIONS AND HOST RANGE OF PLASMIDS TO PREDICT EMERGING AMR BACTERIA. ADDITIONALLY, THIS STUDY WILL EVALUATE AN ESSENTIAL OIL IDENTIFIED BY THIS TEAM FOR NURSERY PIGS AND DEVELOP SCIENCE-BASED INTERVENTION STRATEGIES TO REDUCE ANTIBIOTIC USE AND MITIGATE EMERGENCE OF AMR AND EFFECT CHANGE IN MANAGEMENT THROUGH OUTREACH. THIS WORK IS EXPECTED TO TRANSLATE TO THE DEVELOPMENT OF MANAGEMENT AND NUTRITIONAL STRATEGIES THAT REDUCE ANTIMICROBIAL USE AND ESTABLISH AN OUTREACH NETWORK THAT WILL IMPROVE THE CAPACITY NATIONWIDE TO ASSESS PRODUCER AND CONSUMER AMR-RELATED FOOD SAFETY NEEDS, AND TO DEVELOP, DELIVER AND EVALUATE OUTREACH PROGRAMS THAT WILL HELP PRODUCERS AND CONSUMERS TO ASSESS AND ADOPT PRACTICES THAT MITIGATE POTENTIAL RISKS FROM FOOD-BORNE AMR.
$999,981Board Of Regents Of The University Of Nebraska · · FY2023 · National Institute of Food and Agriculture
MRI: Development of a fully automated, 1,000-MicroChemostat microfluidic system for parallel, independent, long-duration, machine-guided experiments
$999,810John P Wikswo · Vanderbilt University · · FY2021 · BIO
CICI: RSARC: SECTOR: Building a Secure and Compliant Cyberinfrastructure for Translational Research
$999,651Yan Luo · University Of Massachusetts Lowell · · FY2017 · CSE
Collaborative Research: Updating iVirus - the CyVerse-powered analytical toolkit for viruses of microbes
$999,570Matthew Sullivan · Ohio State University, The · · FY2022 · BIO
Selection and preclinical development of a bacteria-targeting, non-antibiotic lead candidate to improve cancer chemotherapy outcomes
$999,480Ward Peterson · Symberix, Inc. · R44 · FY2020 · CA
An Inhaled Microbiome-Targeted Biotherapeutic for Treatment of COPD
$999,425Teodora Nicola · Alveolus Bio, Inc. · R44 · FY2024 · HL
CAREER: Scalable approaches for systems virology
$999,421Karthik Anantharaman · University Of Wisconsin-Madison · · FY2021 · BIO
Mali International Center for Excellence in Research: Parasitic Infectious Diseases and their Vectors
$999,237Carole Long · National Institute Of Allergy And Infectious Diseases · ZIA · FY2017 · AI
AWI-Gen Phase 2: Genomic and environmental risk factors for cardiometabolic disease in Africans
$999,112Michele Michele Ramsay · Wits Health Consortium (Pty), Ltd · U54 · FY2019 · HG
Role of the early life gut microbiome on immunoglobulin A and colonic immune development
$999,056Drew Joel Schwartz · Washington University · R56 · FY2025 · HD
Expanding the Market and Success Rates for Myeloablative Cancer Treatments Using PUL-042, an Innate Immune Stimulant
$998,771Brenton Scott · Pulmotect, Inc · R44 · FY2016 · HL
Expanding the Market and Success Rates for Myeloablative Cancer Treatments Using PUL-042, an Innate Immune Stimulant
$998,771Brenton Scott · Pulmotect, Inc · R44 · FY2017 · HL
2/3: The Chicago Cancer Health Equity Collaborative (ChicagoCHEC)
$998,721Christina Ciecierski · Northeastern Illinois University · U54 · FY2023 · CA
A Novel Probiotic for the Treatment of Sjogren's Syndrome
$998,658Gary Fanger · Rise Therapeutics, Llc · SB1 · FY2021 · DE
Multidimensional investigation of auditory dysfunction in Down syndrome
$998,372Joaquin M. Espinosa · University Of Colorado Denver · R01 · FY2025 · DC
Improving diagnostic sensitivity for difficult-to-lyse microbial samples with nanodroplet technology
$998,364Sandeep Kasoji · Triangle Biotechnology, Inc. · R44 · FY2023 · AI
Preventing outbreaks of foodborne pathogenic bacteria in edible sprouts via novel resistance-conferring seed treatments
$998,060Murli Manohar · Ascribe Bioscience Inc. · R44 · FY2022 · AI
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE EMERGENCE OF ANTIMICROBIAL RESISTANCE (AMR) HAS INCREASED THE PRESSURE TO FIND ALTERNATIVE MEANS TO ELIMINATE OR REDUCE THE USE OF MEDICALLY-IMPORTANT ANTIMICROBIALS, PARTICULARLY IN THE AGRICULTURAL INDUSTRY. BOVINE RESPIRATORY DISEASE COMPLEX IS ONE OF THE COSTLIEST ISSUES ASSOCIATED WITH FEEDLOT CATTLE AND IS FREQUENTLY COMBATTED THOUGH METAPHYLACTIC ADMINISTRATION OF ANTIMICROBIALS UPON FEEDLOT ARRIVAL. THEREFORE, RESEARCH IS NEEDED TO DETERMINE THE EMERGENCE, ECOLOGY, AND MICROBIOME OF AMR AND DEVELOP SCIENCE-BASED STRATEGIES TO REDUCE THE INCIDENCE OF AMR THROUGHOUT THE BEEF PRODUCTION CONTINUUM. THESE STUDIES WILL PURSE THE FOLLOWING OBJECTIVES 1) IDENTIFY A BEST MANAGEMENT PRACTICE FOR METAPHYLACTIC ANTIMICROBIAL USE IN HIGH-RISK CATTLE, 2) IMPLEMENT NOVEL SCIENCE-BASED INTERVENTION STRATEGY TO REDUCE THE SPREAD OF AMR IN THE BEEF CATTLE INDUSTRY, 3) DEVELOP SYSTEMS BASED APPROACHES TO IDENTIFY AMR RESERVOIRS BY EVALUATING THE HOST-MICROBIOME COMMUNITY DYNAMICS, AND 4) IMPROVE UNDERSTANDING AMONG CURRENT AND FUTURE VETERINARIANS AND NUTRITIONISTS OF POTENTIAL FOOD SAFETY RISKS ASSOCIATED WITH CARRIAGE OF AMR BY BEEF CATTLE AND MOTIVATE THEM TO ADVISE PRODUCERS OF BEST PRACTICES FOR ANTIMICROBIAL STEWARDSHIP. COMPLETION OF THIS RESEARCH WILL IDENTIFY CRITICAL CONTROL POINTS FOR CONTROLLING THE DEVELOPMENT OF AMR AND PROVIDE USABLE SCIENCE-BASED APPROACHES TO MITIGATE AMR IN BEEF PRODUCTION. THIS INFORMATION IS CRITICAL FOR SUSTAINABILITY IN THE BEEF FOOD SUPPLY AND JUDICIOUS USE OF ANTIMICROBIALS IN CATTLE PRODUCTION.
$997,829Texas Tech University System · · FY2020 · National Institute of Food and Agriculture
BREEDING RESILIENT, DISEASE-RESISTANT SWITCHGRASS CULTIVARS FOR MARGINAL LANDSJ. CARLSON, PH.D., PENN STATE UNIVERSITY (PRINCIPAL INVESTIGATOR)T. BELL, PH.D., PENN STATE UNIVERSITY (CO-INVESTIGATOR)M. HALL, PH.D., PENN STATE UNIVERSITY (CO-INVESTIGATOR)J. LASKY, PH.D., PENN STATE UNIVERSITY (CO-INVESTIGATOR)S. BONOS, PH.D., RUTGERS UNIVERSITY (CO-INVESTIGATOR)J. HANSEN, PH.D., CORNELL UNIVERSITY (CO-INVESTIGATOR)D. VIANDS, PH.D., CORNELL UNIVERSITY (CO-INVESTIGATOR)THE GOAL OF THIS PROJECT IS TO LEVERAGE PREVIOUS RESEARCH RESULTS TO ACCELERATE THE DEVELOPMENT OF SUPERIOR, DISEASE-RESISTANT, CLIMATE-RESILIENT SWITCHGRASS (PANICUM VIRGATUM L.) CULTIVARS FOR EXPANDING THE RANGE OF BIOMASS CULTIVATION IN THE NORTHEAST. SELECTIONS FROM PREVIOUS PROGENY TRIALS WILL BE AUGMENTED WITH NEW SELECTIONS FROM EVALUATIONS CONDUCTED IN A RANGE-WIDE ASSOCIATION MAPPING FAMILY. CANDIDATE GENES FOR DISEASE RESISTANCE AND GENOTYPE-BY-ENVIRONMENT INTERACTIONS RELEVANT TO THE HOLISTIC SWITCHGRASS SYSTEM AT MARGINAL GROWING SITES WILL BE IDENTIFIED FOR PRODUCTIVITY IMPROVEMENTS.SWITCHGRASS IS A FAST GROWING, PERENNIAL, WARM-SEASON GRASS, NATIVE TO MUCH OF NORTH AMERICA AND HAS GREAT POTENTIAL FOR DEVELOPMENT AS A BIOENERGY CROP. IN THE HUMID NORTHEAST, FUNGAL DISEASES ARE PREVALENT AND MAY REDUCE YIELD AND QUALITY OF CROPS. THIS PROJECT WILL FOCUS ON ANTHRACNOSE (CAUSED BY COLLETOTRICHUM NAVITAS) AND BIPOLARIS LEAF SPOT (CAUSED BY BIPOLARIS ORYZAE), FOR WHICH THE PIS HAVE CONDUCTED HERITABILITY STUDIES AND HAVE IDENTIFIED SEGREGATING VARIATION IN MAPPING POPULATIONS FOR THESE DISEASES. THIS RESEARCH WILL BE CRITICAL FOR FUTURE SUSTAINABLE UTILIZATION OF SWITCHGRASS IN WARM/HUMID ENVIRONMENTS IN THE NORTHEASTERN U.S. THAT ARE PRONE TO HEAVY DISEASE PRESSURE. THE RESOURCES DEVELOPED THROUGH THIS PROJECT WILL INCREASE THE EFFICIENCY OF SELECTION FOR SWITCHGRASS DISEASE RESISTANCE AND ULTIMATELY IMPROVE PLANT HEALTH, BIOMASS YIELD, AND LONG TERM BIOENERGY SUSTAINABILITY OF SWITCHGRASS ON MARGINAL LANDS.OUR OBJECTIVES ARE TO: 1) EXPAND THE BREEDING OF SUPERIOR, DISEASE-RESISTANT CULTIVARS FOR HIGH PRODUCTIVITY IN MARGINAL ENVIRONMENTS IN THE NORTHEAST; 2) DISCOVER GENES FOR RESISTANCE TO ANTHRACNOSE AND BIPOLARIS DISEASES AND FOR BIPMASS YIELD IN SWITCHGRASS; AND 3) IDENTIFY ASSOCIATIONS BETWEEN SOIL MICROBIAL COMMUNITIES, PLANT GENOTYPES, ENVIRONMENT FACTORS THAT EFFECT YIELD CHARACTERS AND DISEASE SUSCEPTIBILITY IN IN SWITCHGRASS.THIS PROJECT WILL LEVERAGE RESULTS AND MATERIALS FROM SEVERAL KEY RESEARCH PROGRAMS, INCLUDING TWO RECENT USDA CAP BIOENERGY PROJECTS. THIS INCLUDES SELECTIONS, CULTIVARS, POPULATIONS, PROGENY TRIALS, YIELD AND DISEASE SEVERITY DATA FOR SWITCHGRASS FROM THE NEWBIO PROJECT (THE NORTHEAST WOODY/WARM-SEASON BIOMASS CONSORTIUM FUNDED BY USDA-AFRI GRANT #2012-68005-19703). IN ADDITION, WE HAVE REPLICATED A PREVIOUSLY ESTABLISHED SWITCHGRASS ASSOCIATION PANEL (USDA-AFRI GRANT #2011-68005-30411) COMPOSED OF 528 GENOTYPES FROM ACROSS THE SPECIES' RANGE AT THREE SITES WITH CONTRASTING GROWING CONDITIONS NEAR CORNELL, RUTGERS AND PENN STATE UNIVERSITIES, INCLUDING A RECLAIMED SURFACE MINE. THIS PANEL WAS PREVIOUSLY GENOTYPED BY SEQUENCING, PROVIDING OVER A MILLION SINGLE NUCLEOTIDE POLYMORPHISMS FOR IDENTIFYING ASSOCIATIONS OF GENES WITH PHENOTYPIC VARIATION IN RESPONSE TO ANTHRACNOSE AND BIPOLARIS LEAFSPOT DISEASES, AS WELL AS GROWTH TRAITS, AND GENOTYPE-BY-ENVIRONMENT INTERACTIONS, INCLUDING SOIL MICROBIOME COMPOSITION. CANDIDATE GENES FOR DISEASE RESISTANCE WILL ALSO BE IDENTIFIED BY CONDUCTING DIFFERENTIAL GENE EXPRESSION ANALYSES AND MAPPING QUANTITATIVE TRAIT LOCI IN A POPULATION THAT SEGREGATES FOR ANTHRACNOSE-SUSCEPTIBILITY AND -RESISTANCE. METAGENOME SEQUENCING OF SOIL SAMPLES FROM THE ROOT ZONE OF PLANTS IN THE ASSOCIATION PANEL WILL BE USED TO REVEAL SPECIFIC INTERACTIONS OF MICROBES WITH SWITCHGRASS PLANTS BASED ON HOST PLANT GENOTYPE AND PLANTING SITE CONDITIONS.THE IMPACTS OF THIS PROJECT INCLUDE: A BETTER UNDERSTANDING OF DISEASE RESISTANCE MECHANISMS IN SWITCHGRASS, AND THE ROLE OF BOTH GENOTYPE AND ENVIRONMENTAL FACTORS ON DISEASE AND PLANT PRODUCTIVITY. NEW TOOLS FOR SELECTION FOR DISEASE RESISTANCE IN SWITCHGRASS BREEDING PROGRAMS WILL BE PROVIDED AS QTL MARKERS AND CANDIDATE GENES. AND NEW POPULATIONS, CULTIVARS AND GERMPLASM WILL BE PROVIDED TO ACCELERATE DEVELOPMENT AND DEPLOYMENT OF DISEASE RESISTANT AND HIGH-YIELDING SWITCHGRASS CULTIVARS FOR EXPANDING PERENNIAL BIOMASS CULTIVATION ON MARGINAL SITES SUCH AS ABANDONED FARM AND MIND LANDS.
$997,646The Pennsylvania State University · · FY2019 · National Institute of Food and Agriculture
Improving diagnostic sensitivity for difficult-to-lyse microbial samples with nanodroplet technology
$997,367Sandeep Kasoji · Triangle Biotechnology, Inc. · R44 · FY2024 · AI
Clinical Core
$997,140Douglas R Galasko · University Of California, San Diego · P30 · FY2023 · AG
Collaborative Research: Scaling from single-cell physiology to community stability in a natural gut microbiome
$996,521William B Ludington · Carnegie Institution Of Washington · · FY2021 · BIO