Sort
38,696 grants matching “als”
FURTHER DEVELOPMENT OF COLOVAC, A MULTI-ANTIGEN MULTI-PEPTIDE VACCINE, FOR COLON CANCER PREVENTION
$1,052,768Clinton Grubbs · University Of Alabama At Birmingham · N01 · FY2019 · CA
The role of DNA damage and repair at telomeres
$1,052,015Yie Liu · National Institute On Aging · ZIA · FY2015 · AG
The Miner Suite: State of the Art Bioinformatic Tools and Data Resources
$1,051,653John N Weinstein · Basic Sciences · Z01 · FY2007 · CA
THIS PROPOSAL SEEKS TO EXTEND LONG-TERM MICROWAVE MIDDLE ATMOSPHERIC MEASUREMENTS OF OZONE CHLORINE MONOXIDE AND WATER VAPOR WHICH HAVE BEEN SUPPORTED BY NASA AND HAVE BEEN PART OF THE NETWORK FOR ATMOSPHERIC COMPOSITION CHANGE (NDACC) SINCE THE EARLY 1990 S. THE MEASUREMENT DATABASE CONSISTS OF O3 AND H2O MEASUREMENTS FROM MAUNA LOA HAWAII AND LAUDER NEW ZEALAND; CLO MEASUREMENTS FROM MAUNA KEA HAWAII AND SCOTT BASE ANTARCTICA; AND H2O MEASUREMENTS FROM TABLE MOUNTAIN CALIFORNIA. ALL THREE OF THESE SPECIES PLAY AN IMPORTANT ROLE IN THE CLIMATE SYSTEM. OZONE MEASUREMENTS ARE ESSENTIAL TO MONITOR THE BEGINNING OF ITS RECOVERY AND CLO MEASUREMENTS ARE NEEDED TO INTERPRET THIS PROCESS. WATER VAPOR IS THE RESERVOIR OF ODD HYDROGEN IN THE MIDDLE ATMOSPHERE AND IS THEREFORE ALSO IMPORTANT TO OZONE CHEMISTRY. IT HAS ALSO BEEN SUGGESTED THAT VARIATIONS IN STRATOSPHERIC H2O HAVE HAD A SIGNIFICANT IMPACT ON DECADAL-SCALE GLOBAL SURFACE CLIMATE CHANGE. TO ILLUSTRATE THE SCIENTIFIC VALUE OF THESE MEASUREMENTS WE DISCUSS SEVERAL STUDIES CONDUCTED DURING THE 2013-2017 PROPOSAL CYCLE WHICH MAKE USE OF THESE LONG-TERM DATASETS. THESE INCLUDED LONG-TERM TREND STUDIES OF CLO OVER MAUNA KEA [CONNOR ET AL. 2013] STUDIES OF H2O OVER BOTH MAUNA LOA AND TABLE MOUNTAIN [NEDOLUHA ET AL. 2013A; NEDOLUHA ET AL. 2013B] A STUDY OF DIURNAL O3 VARIATIONS OVER MAUNA LOA [PARRISH ET AL. 2014] AND STUDIES OF THE EFFECTS OF CHANGING ATMOSPHERIC DYNAMICS ON O3 [NEDOLUHA ET AL. 2015A; NEDOLUHA ET AL. 2015B]. IN ADDITION A MANUSCRIPT RELATED TO LONG-TERM TRENDS IN CLO OVER SCOTT BASE HAS BEEN SUBMITTED [NEDOLUHA ET AL. 2016]. FINALLY THE DATA HAS AND IS BEING USED IN A NUMBER OF STUDIES LED BY OTHER AUTHORS. THE MOST IMPORTANT GOAL OF THIS WORK IS TO MAINTAIN STABLE MEASUREMENTS IN ORDER TO ENSURE THE ACCURATE DETECTION OF LONG-TERM CHANGE. IN ORDER TO ENSURE CONTINUED STABLE OPERATION INSTRUMENTS NEED TO BE UPDATED. THIS WILL MAKE IT POSSIBLE TO MAINTAIN THE INSTRUMENTS WITH CURRENTLY AVAILABLE TECHNOLOGY AND WILL REDUCE THE LONG-TERM MAINTENANCE REQUIREMENTS SO THAT WE CAN KEEP THEM OPERATING WITH A SINGLE FIELD ENGINEER AND SOME ON-SITE SUPPORT. THE H2O INSTRUMENTS UNDERWENT SIGNIFICANT UPDATES DURING THE 2009-2013 PROPOSAL CYCLE AND HAVE REQUIRED MINIMAL TECHNICAL ATTENTION DURING THE 2013-2017 PROPOSAL CYCLE. DURING THE 2013-2017 PROPOSAL CYCLE WE HAVE UNDERTAKEN MAJOR UPGRADES OF THE O3 INSTRUMENT AT MAUNA LOA AND A CLO INSTRUMENT WHICH BECAUSE OF ANTI-TELESCOPE PROTESTS HAD TO BE MOVED FROM MAUNA KEA TO MAUNA LOA. WHILE THE O3 INSTRUMENT HAS NOT YET UNDERGONE A FULL VALIDATION STUDY SEVERAL MONTHS OF RETRIEVALS AND COMPARISONS WITH AURA MLS SUGGEST THAT IT IS OPERATING SATISFACTORILY. THERE ARE SEVERAL MAJOR TECHNICAL TASKS WHICH WE PLAN TO ACCOMPLISH IN THE 2017-2021 TIMEFRAME. WE PLAN TO REPLACE THE CRYOGENICALLY OPERATING O3 RECEIVERS AT MAUNA LOA AND LAUDER WITH ROOM TEMPERATURE VERSIONS JUST AS HAS BEEN DONE FOR THE H2O SYSTEMS. WHILE THIS MAY RESULT IN SOME LOSS OF SIGNAL-TO-NOISE AND WILL RESULT IN AN INTERRUPTION OF MEASUREMENTS AT LAUDER ARE NOT IN GENERAL SIGNALTO- NOISE LIMITED AND IT WILL PUT THEM ON A MORE SUSTAINABLE LONG-TERM FOOTING. WE HAVE RETRIEVED CLO WITH THE NEW INSTRUMENT NOW ON MAUNA LOA AND THE INSTRUMENT APPEARS TO BE OPERATING VERY WELL BUT IT IS NOT YET CLEAR WHETHER CONDITIONS AT THIS SITE WHICH ARE SOMEWHAT POORER THAN ON MAUNA KEA WILL ALLOW US TO MAKE SUFFICIENT TRENDQUALITY CLO MEASUREMENTS. WE ARE CURRENTLY INVESTIGATING OPTIONS TO RETURN TO MAUNA KEA IN THE EVENT THAT CONDITIONS AT MAUNA LOA ARE FOUND TO BE NOT FULLY SATISFACTORY. THE CHALLENGE OF REPLACING THE AGING SCOTT BASE CLO INSTRUMENT IS THE MOST DAUNTING. AS A FIRST STEP TO THIS WE HAVE NEARLY FINISHED DEVELOPING A NEW CHLOE INSTRUMENT IN THE LAB AT NRL. THIS INSTRUMENT WILL FIRST BE DEPLOYED TO HAWAII AND AFTER COMPARISONS BETWEEN THE TWO CLO INSTRUMENTS IN HAWAII WE WILL MOVE ONE TO SCOTT BASE.
$1,051,461Bc Scientific Consulting Llc · · FY2020 · National Aeronautics and Space Administration
FANCONI ANEMIA:GENOTYPE-PHENOTYPE CORRELATIONS
$1,051,245Settara Chandrasekharappa · National Human Genome Research Institute · ZIA · FY2023 · HG
Single-neuron population dynamics in human speech motor cortex for a speech prosthesis
$1,050,840Jaimie M Henderson · Stanford University · U01 · FY2021 · DC
Structure and Function of Membrane Proteins
$1,050,283Miguel Holmgren · National Institute Of Neurological Disorders And Stroke · ZIA · FY2009 · NS
Phase III Trial of Minocycline in ALS:I-Clinical Center
$1,050,254Columbia University Health Sciences · R01 · FY2005 · NS
THE NEED FOR A MARINE BIODIVERSITY OBSERVATION NETWORK (MBON) WAS SUMMARIZED BY DUFFY ET AL (2013) WHO CONCLUDED THAT AN MBON SHOULD INTEGRATE BIOLOGICAL LEVELS FROM GENES TO HABITATS LINK BIODIVERSITY OBSERVATIONS TO ABIOTIC VARIABLES SITE PROJECTS TO INCORPORATE ENVIRONMENTAL FORCING AND BIOGEOGRAPHY AND MONITOR ADAPTIVELY TO ADDRESS EMERGING ISSUES. OUR DEMONSTRATION MBON PROJECT IN THE SANTA BARBARA CHANNEL NOW IN ITS FIFTH YEAR HAS ENDEAVORED TO MEET THESE GOALS. OUR MBON INCLUDES ALL LEVELS OF BIODIVERSITY AND HAS DEVELOPED NEW TOOLS TO EXPAND THE SCALES OF PRESENT OBSERVATION AND A DATA MANAGEMENT SYSTEM TO INTEGRATE DATA SOURCES. HERE WE PROPOSE TO MOVE TOWARD AN OPERATIONAL MODE AND EXPAND INTO A FULL REGIONAL MBON COVERING THE ENTIRE SOUTHERN CALIFORNIA BIGHT (SCB). SCB MBON HAS TWO BROAD OBJECTIVES DESCRIBED BELOW. 1. INTEGRATE BIODIVERSITY DATA TO ENABLE INFERENCES ABOUT REGIONAL BIODIVERSITY. SYNTHESIZING INFORMATION RELEVANT TO BIODIVERSITY REQUIRES INTEGRATING HIGHLY HETEROGENEOUS DATA COLLECTED AT WIDELY DIFFERENT TEMPORAL AND SPATIAL SCALES. WE WILL CONTINUE TO PRODUCE EXISTING MBON DATASETS WHILE ADDING NEW DATA TO EXPAND OUR GEOGRAPHICAL SCOPE. 2. DEVELOP ADVANCED METHODS IN OPTICAL AND ACOUSTIC IMAGING AND GENOMICS FOR MONITORING BIODIVERSITY TO FILL GAPS IN OUR KNOWLEDGE OF MARINE BIODIVERSITY USING TWO CLASSES OF METHODS: REMOTE SENSING OPTICAL AND ACOUSTIC IMAGERY FROM THE ECOSYSTEM SCALE DOWN TO THE SPECIES LEVEL AND MOLECULAR BIOLOGY FROM THE GENETIC SCALE UP THROUGH COMMUNITY LEVEL. THE APPROACH WE OUTLINE BELOW CONTINUES OUR EFFORT TO BUILD AN INTEGRATED MBON ADDING DATA ON ECOSYSTEM COMPONENTS (E.G. PHYTOPLANKTON BIODIVERSITY) AS STEPPING STONES. PRODUCTS WILL BE PRIORITIZED WITH INPUT FROM PARTNERS AND STAKEHOLDERS INCLUDING THE BUREAU OF OCEAN ENERGY MANAGEMENT NATIONAL PARK SERVICE NOAA S OFFICE OF NATIONAL MARINE SANCTUARIES AND NATIONAL MARINE FISHERIES SERVICE THE U.S. GEOLOGICAL SURVEY AND THE SOUTHERN CALIFORNIA COASTAL WATER RESOURCES PROGRAM.
$1,049,568University Of California, Santa Barbara · · FY2020 · National Aeronautics and Space Administration
The consequences of the unusual mutation responsible for the Repeat Expansion Diseases
$1,049,480Karen P. Usdin · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2025 · DK
MPD Clinical Consortium
$1,048,345Lewis Silverman · Icahn School Of Medicine At Mount Sinai · P01 · FY2011 · CA
Baptist Memorial Health Care/Mid South NCORP Consortium
$1,047,638Raymond U Osarogiagbon · Baptist Memorial Hospital - Tipton · UG1 · FY2025 · CA
RENNO ET AL. [2009A] PRESENTED PHYSICAL AND THERMODYNAMICAL EVIDENCE THAT LIQUID BRINES WERE OBSERVED AT THE PHOENIX LANDING SITE ON MARS ARCTIC. MOR
$1,047,443Regents Of The University Of Michigan · · FY2014 · National Aeronautics and Space Administration
NICOTINIC CHOLINERGIC SYSTEMS IN MUTANT MICE
$1,047,242Baylor College Of Medicine · P01 · FY2000 · DA
Post-transcriptional control of Proliferation, Stress Response & Carcinogenesis
$1,046,405Myriam Gorospe · National Institute On Aging · ZIA · FY2016 · AG
Mechanisms of axon guidance during development
$1,046,341Edward Giniger · National Institute Of Neurological Disorders And Stroke · Z01 · FY2008 · NS
Biology of T Cell Depletion
$1,045,977Crystal Mackall · Division Of Basic Sciences - Nci · ZIA · FY2009 · CA
Clinical Program in Pediatric Sarcomas
$1,045,977Crystal Mackall · Division Of Basic Sciences - Nci · ZIA · FY2009 · CA
Developing Immune Based Therapies
$1,045,977Crystal Mackall · Division Of Basic Sciences - Nci · ZIA · FY2009 · CA
THE LUNAR RECONNAISSANCE ORBITER (LRO) SPACECRAFT ONBOARD THE LUNAR ORBITER LASERALTIMETER (LOLA) IS A CRITICAL EXPERIMENT THAT IS PROVIDING A GLOBAL LUNAR GEODETIC NETWORKAND ALTIMETRY ROUGHNESS AND REFLECTIVITY MEASUREMENTS THAT ARE REVOLUTIONIZING THESE FIELDSAND ENHANCING THE CHARACTERIZATION OF THE LUNAR SURFACE IN A MANNER THAT IS ABSOLUTELYESSENTIAL FOR ENSURING SAFE AND SCIENTIFICALLY PRODUCTIVE LUNAR AND PLANETARY HUMAN ANDROBOTIC EXPLORATION IN THE COMING COMMERCIAL AND NASA PROGRAMS. ACQUISITION VERIFICATION VALIDATION DELIVERY OF DATA TO NASA ENGINEERS AND SCIENTISTS AND THEINTERNATIONAL SCIENTIFIC COMMUNITY AND DEMONSTRATION OF THE USEFULNESS OF THESE DATA INLOLA VALIDATION PROJECTS IS ESSENTIAL TO THE CURRENT AND FUTURE SUCCESS OF NASA.HERE WE OUTLINE A SERIES OF TASKS AND VALIDATION PROJECTS THAT ARE DESIGNED TO COMPLEMENTOTHER ACTIVITIES OF THE LUNAR ORBITER LASER ALTIMETER (LOLA) TEAM AND TO FULFILL THE GENERALREQUIREMENTS FOR PARTICIPATION AS A LUNAR ORBITER LASER ALTIMETER (LOLA) EXPERIMENT CO-INVESTIGATOR. WE OUTLINE THE THEMES AND TOPICS FOR LOLA DATA ACQUISITION DOCUMENTATION ANDVALIDATION AND DESCRIBE A SET OF EXPECTED ACCOMPLISHMENTS AND DELIVERABLES IN A MANNERSIMILAR TO PREVIOUS PARTICIPATION IN THIS AND SIMILAR EXPERIMENTS (E.G. SMITH ET AL. 1998 1999 2001 2010; KRESLAVSKY AND HEAD 1999 2000; ZUBER ET AL 1998 2000). A VALIDATION PROJECTIS DEFINED AS A SPECIFIC TASK THAT DEMONSTRATES TO THE ENGINEERING AND SCIENTIFIC COMMUNITY THEUSEFULNESS AND CAPABILITIES OF THE DATA AS APPLIED TO A PARTICULAR FUNDAMENTAL PROBLEM (E.G. PAST AND PRESENT LANDING SITE CHARACTERIZATION TECHNIQUES FOR APPLICATION TO THE MOON ASTEROIDS MARS; TOPOGRAPHIC CHARACTERIZATION OF LANDFORMS SUCH AS CRATERS TO ASSIST IN THEDESIGN OF FUTURE ALTIMETERS AND RELATED INSTRUMENTATION; SLOPE AND ROUGHNESS CHARACTERIZATIONFOR FUTURE LUNAR AND PLANETARY RESOURCE UTILIZATION; MECHANISMS FOR THE DOCUMENTATION ANDDETECTION OF VOLATILES IN PERMANENTLY SHADOWED AREAS) (E.G. FASSETT ET AL. 2011A B 2012A B;BAKER ET AL. 2011A B 2012; HEAD ET AL. 2010; HURWITZ ET AL. 2012 2013; JOZWIAK ET AL. 2012;KADISH ET AL 2011; VAUGHAN ET AL. 2013 KRESLAVSKY ET AL. 2012 2013; ZUBER ET AL. 2012).VALIDATION PROJECT DELIVERABLES TAKE THE FORM OF 1) PAPERS PUBLISHED IN THE SCIENTIFIC LITERATURE AND 2) DATA PLACED IN THE PLANETARY DATA SYSTEM AND ON INTERNET ARCHIVES(E.G. HTTP://WWW.PLANETARY.BROWN.EDU/HTML_PAGES/DATA.HTM). BELOW WE OUTLINE THESE SPECIFICTASKS DESCRIBE A SERIES OF VALIDATION PROJECTS AND PRESENT A WORK PLAN FOR THEIR TIMELYEXECUTION.
$1,045,000Brown University · · FY2020 · National Aeronautics and Space Administration
Comparative Genomic Studies on the Evolution of Morphological Complexity
$1,044,992Andreas Baxevanis · National Human Genome Research Institute · ZIA · FY2023 · HG
Eosinophils and Eosinophil Activation in the Pathogenesis of Human Disease
$1,044,758Amy Klion · National Institute Of Allergy And Infectious Diseases · ZIA · FY2014 · AI
NIEHS Statistical Consulting Service
$1,044,432Shyamal Peddada · National Institute Of Environmental Health Sciences · ZIA · FY2010 · ES
OXIDATIVE AND EXCITATORY TOXICITY IN NEURODEGENERATION
$1,044,304Massachusetts General Hospital · P01 · FY2000 · AG
Genetics Study of Nicotine Dependence in African Americans
$1,044,298Laura Jean Bierut · Washington University · R01 · FY2012 · DA