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24,827 grants matching “epilepsy”
Selective, epineural stimulation of peripheral nerves with interferential electrical fields
$638,718Stavros Zanos · Feinstein Institute For Medical Research · R01 · FY2025 · NS
Targeting Immune-Responsive Gene 1 (Irg1) and Itaconate for Cardioprotection of the Donor Heart for Transplantation
$638,627Paul Tang · Mayo Clinic Rochester · R01 · FY2024 · HL
ELECTRO-BOOST: Electroencephalography for cerebral trauma recovery and oxygenation
$638,579Emily Gilmore · Yale University · R01 · FY2021 · NS
Single-molecule imaging with super-resolution
$638,493Alice Y Ting · Massachusetts Institute Of Technology · R01 · FY2010 · GM
High-performance SPECT for dynamic brain imaging
$638,481Hamid Sabet · Massachusetts General Hospital · R01 · FY2023 · EB
Molecular Interplay of Endocytic Proteins
$638,385Jihong Bai · Fred Hutchinson Cancer Center · R01 · FY2025 · NS
I/UCRC Phase I: iPerform - I/UCRC for Assistive Technologies to Enhance Human Performance
$638,290Fillia S Makedon · University Of Texas At Arlington · · FY2014 · CSE
Guiding epilepsy surgery using network models and Stereo EEG
$638,159Brian Litt · University Of Pennsylvania · R01 · FY2023 · NS
Neuronal excitability and copy number variation disorders
$638,048Peter Penzes · Northwestern University At Chicago · R01 · FY2021 · NS
A flexible, low power, multi-channel, real-time BCI for seizure monitoring and Modulation
$638,036Rajit Manohar · Yale University · R01 · FY2024 · NS
The Role of Place and Grid Cells in Human Spatial and Non Spatial Memory
$638,010Joshua Jacobs · Columbia Univ New York Morningside · R01 · FY2021 · MH
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** HUMAN AND COW'S MILK CONTAIN LARGE AMOUNTS OF NATURAL NANOPARTICLES (MILK EXOSOMES, MES), WHEREAS PLANT-BASED MILK AND INFANT FORMULA CONTAIN NO MES. PRIOR RESEARCH HAS SHOWN THAT A ME-DEFICIENT DIET IMPAIRS SPATIAL LEARNING AND MEMORY (SLM) AND INCREASES THE SEVERITY OF EPILEPSY-LIKE SEIZURES. THIS PROJECTS STUDIES WHETHER THE POSITIVE EFFECTS OF MES IN THE HOST ARE MEDIATED BY ME-DEPENDENT CHANGES IN NANOPARTICLES SECRETED BY THE GUT MICROBIOME. [GRAM-NEGATIVE BACTERIA SECRETE OUTER MEMBRANE VESICLES (OMVS), WHEREAS GRAM-POSITIVE BACTERIA SECRETE CYTOPLASMIC MEMBRANE VESICLES (CMVS).] THIS PROPOSAL TESTS THE HYPOTHESIS THAT DIETARY ME DEPLETION ALTERS THE QUANTITY (NUMBER) AND QUALITY (CONTENT OF PROTEINS AND RNA) OF OMVS AND CMVS, THEREBY IMPAIRING SLM IN THE HOST. THE RESEARCHERS WILL STUDY 1) EFFECTS OF MES ON OMV AND CMV QUANTITY AND QUALITY IN CULTURES OF GUT BACTERIA, 2) ABSORPTION AND TISSUE DISTRIBUTION OF OMVS, CMVS AND THEIR PROTEIN AND RNA CARGO IN THE HOST, 3) EFFECTS OF ME-DEPENDENT CHANGE IN OMVS AND VMVS ON GENE EXPRESSION IN THE HOST, AND 4) WHETHER ME-DEPENDENT CHANGES IN OMV AND CMV ARE RESPONSIBLE FOR THE EFFECTS OF MES ON SLM N THE HOST OBSERVED IN PRIOR RESEARCH.
$638,000Board Of Regents Of The University Of Nebraska · · FY2023 · National Institute of Food and Agriculture
SUDEP Research Alliance: Respiratory and Arousal Mechanisms, Application 5 of 7
$637,998George B Richerson · University Of Iowa · U01 · FY2016 · NS
Improved EEG Patient Interface
$637,931Steven E Wilder · Electrosonics Medical Inc. · R44 · FY2007 · NS
BrainStorm: Highly Extensible Software for Advanced Electrophysiology and MEG/EEG Imaging
$637,924Richard M Leahy · University Of Southern California · R01 · FY2019 · EB
Forward Genetic Analysis of Cortical Circuits and Structure
$637,820Rolf W Stottmann · Research Inst Nationwide Children'S Hosp · R01 · FY2025 · NS
Determining the circuits and signals of sleep dysfunction in Parkinson's disease through chronic intracranial recordings and closed-loop Deep Brain Stimulation
$637,659Simon Little · University Of California, San Francisco · R01 · FY2024 · NS
Kv7.2/7.3 Activators for the Treatment of Epilepsy Disorders
$637,634Michael Bozik · Knopp Biosciences, Llc · U44 · FY2017 · NS
CHILDHOOD EPILEPSY-- FACTORS AFFECTING ADAPTATION
$637,547Indiana Univ-Purdue Univ At Indianapolis · R37 · FY2004 · NS
Transdiagnostic Associations Across Developmental Disorders
$637,506Elena L Grigorenko · University Of Houston · R01 · FY2022 · HD
Treating hyperexcitability in Alzheimer's disease with levetiracetam to improve brain function and cognition
$637,458Mouhsin Shafi · Beth Israel Deaconess Medical Center · R01 · FY2022 · AG
Higher Speed, Field and Spatial Resolution Brain 3D 1H MRS
$637,345Oded Gonen · New York University School Of Medicine · R01 · FY2010 · EB
Physiologic And Pharmacologic Studies In Epilepsy
$637,297William H Theodore · National Institute Of Neurological Disorders And Stroke · Z01 · FY2008 · NS
Ion Channels in Epilepsy and as Targets for Antiepileptic Drugs
$637,297William Theodore · National Institute Of Neurological Disorders And Stroke · Z01 · FY2008 · NS
PREDICTIVE MODELING OF BIOELECTRIC ACTIVITY ON MAMMALIAN MULTILAYERED NEURONAL STRUCTURES IN THE PRESENCE OF SUPRAPHYSIOLOGICAL ELECTRIC FIELDS
$637,210Gianluca Lazzi · University Of Southern California · U01 · FY2021 · EB