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17,054 grants matching “genome editing”
Investigating the roles of RNA-binding proteins Nocte and PRRC2 in mRNA translation and age-related neurodegeneration using Drosophila and mouse models
$727,343Weidong Wang · National Institute On Aging · ZIA · FY2025 · AG
Elucidating the Origin of Sudden Cardiac Death in Dilated Cardiomyopathy: from Phenotype Predictors to Therapeutic Targets
$727,280Luisa Mestroni · University Of Colorado Denver · R01 · FY2023 · HL
Major histocompatibility complex gene editing to prevent hematopoietic stem cell graft rejection
$725,971Hojun Li · University Of California, San Diego · R01 · FY2025 · HL
Type 2 diabetes risk variant effects on mitochondrial (patho)physiology
$725,752Michael Lee Stitzel · Jackson Laboratory · R01 · FY2024 · DK
Providing ethical guidance for the development of individualized genomic medicine as rare as n-of-1
$725,608Timothy Wei-Wen Yu · Boston Children'S Hospital · R01 · FY2023 · HG
Collaborative Research: NSF-DBT: TRTech-PGR: Developing Robust Prime Editing Systems in Plants
$725,512Yiping Qi · University Of Maryland, College Park · · FY2024 · BIO
Collaboration on preclinical autism cellular assays, biosignatures, and network analyses (Copacabana)
$725,383Eugene Wei-Ming Yeo · University Of California, San Diego · U19 · FY2017 · MH
Variant to gene mapping for Alzheimer's Disease
$725,237Struan F A Grant · Children'S Hosp Of Philadelphia · R01 · FY2020 · AG
T cell-targeted lentiviral vectors with Cas9/RNP for the in vivo gene therapy of HIV-AIDS
$725,111Priti Kumar · Yale University · R01 · FY2020 · AI
Targeted approach to the mitigation of abdominal aortic aneurysm
$724,978Lianwang Guo · University Of Virginia · R01 · FY2024 · HL
Multiplexed Locus-Specific Hypermutation for Functional Characterization of the Coding and Noncoding Genome
$724,969Fei Chen · Broad Institute, Inc. · R01 · FY2025 · HG
Understanding Complex Gene Editing Systems and RNA Biology in Oxytricha
$724,888Laura F Landweber · Columbia University Health Sciences · R35 · FY2020 · GM
Understanding Complex Gene Editing Systems and RNA Biology in Oxytricha
$724,888Laura F Landweber · Columbia University Health Sciences · R35 · FY2021 · GM
Novel Approaches to Capture, Sorting, and Characterization of CNS-Origin Extracellular Vesicles
$724,315Kenneth W Witwer · Johns Hopkins University · R33 · FY2021 · MH
Gene Therapy in Hutchinson-Gilford Progeria Syndrome
$724,153Jonathan David Brown · Vanderbilt University Medical Center · R01 · FY2025 · HL
Gene Therapy in Hutchinson-Gilford Progeria Syndrome
$724,153Jonathan David Brown · Vanderbilt University Medical Center · R01 · FY2023 · HL
CLIMATIC STRESS IS A MAJOR LIMITING FACTOR OF PRODUCTION EFFICIENCY IN BEEF CATTLE IN TROPICAL AND SUBTROPICAL ENVIRONMENTS AND IN DAIRY CATTLE THROUGHOUT MOST OF THE WORLD. THIS STRESS IS EXPECTED TO INCREASE DUE TO CLIMATE CHANGE. MORE THAN HALF OF THE CATTLE IN THE WORLD ARE MAINTAINED IN HOT AND HUMID ENVIRONMENTS, INCLUDING ABOUT 40% OF BEEF COWS IN THE US. SUBSTANTIAL DIFFERENCES IN THERMAL TOLERANCE EXIST AMONG BREEDS AND AMONG ANIMALS WITHIN BREEDS INDICATIVE OF OPPORTUNITIES FOR SELECTIVE IMPROVEMENT. USE OF GENOMIC TOOLS TO PRODUCE AN ANIMAL WITH SUPERIOR ABILITY FOR BOTH THERMAL ADAPTATION AND FOOD PRODUCTION REPRESENTS AN ENERGY-EFFICIENT SUSTAINABLE APPROACH TO MEET THE CHALLENGE OF GLOBAL CLIMATE CHANGE.OUR LONG-TERM GOAL IS TO DEVELOP THE KNOWLEDGE AND TOOLS THE CATTLE INDUSTRY NEEDS TO INCREASE TOLERANCE TO HEAT STRESS, WHILE SIMULTANEOUSLY ALLOWING FOR INCREASED EFFICIENCY OF PRODUCTION, REPRODUCTION, AND MEAT QUALITY. THE STRATEGY WE PROPOSE IS TO REVEAL THE GENETIC ARCHITECTURE OF TRAITS DEFINING THERMAL TOLERANCE USING BOS INDICUS INFLUENCED CATTLE. A POPULATION OF BRANGUS (BRAHMAN X ANGUS) CATTLE WILL BE USED IN THIS PROJECT. THE AIMS OF THIS PROJECT ARE TO DISCOVER GENETIC VARIANTS RESPONSIBLE FOR THERMAL TOLERANCE AND USE THIS KNOWLEDGE TO DEVELOP GENOMIC TOOLS FOR MARKER-ASSISTED SELECTION (MAS) TO IMPROVE THERMAL TOLERANCE IN CATTLE POPULATIONS AT RISK OF EXPOSURE TO HEAT STRESS. IN ADDITION, THE MATURATION OF TECHNOLOGIES FOR GENE EDITING MEANS THAT THERMOTOLERANCE GENES CAN BE RAPIDLY INTRODUCED INTO BEEF AND DAIRY CATTLE BREEDS. DEVELOPMENT OF "THE COW OF THE FUTURE" WILL BE REALIZED THROUGH USE OF GENOMIC SELECTION WITHIN BREEDS AND THROUGH APPLICATION OF GENE EDITING TECHNOLOGIES THAT ALLOW GENETIC VARIANTS CONFERRING THERMAL TOLERANCE TO BE RAPIDLY INCORPORATED INTO NON-ADAPTED BREEDS. INTRODUCTION OF ALLELES FOR THERMAL TOLERANCE INTO THE ELITE GERMPLASM OF A SPECIALIZED BREED PRODUCTIVELY SUPERIOR BUT POORLY ADAPTED TO TROPICAL ENVIRONMENTS OFFERS A POWERFUL NEW APPROACH TO ADDRESS THE CHALLENGES OF CLIMATE CHANGE AND DEVELOP CLIMATE-SMART PRODUCTIVE CATTLE FOR A FUTURE HOTTER WORLD.
$724,104University Of Florida · · FY2017 · National Institute of Food and Agriculture
Referral Ctr-Animal models of human genetic disease
$723,843Margret L Casal · University Of Pennsylvania · P40 · FY2023 · OD
Referral Ctr-Animal models of human genetic disease
$723,843Charles H Vite · University Of Pennsylvania · P40 · FY2020 · OD
Referral Ctr-Animal models of human genetic disease
$723,843Charles H Vite · University Of Pennsylvania · P40 · FY2021 · OD
Referral Ctr-Animal models of human genetic disease
$723,843Charles H Vite · University Of Pennsylvania · P40 · FY2019 · OD
Referral Ctr-Animal models of human genetic disease
$723,843Charles H Vite · University Of Pennsylvania · P40 · FY2022 · OD
Clinical Diagnostic Studies and Treatment of Patients with Immune Deficiencies
$723,661Suk De Ravin · National Institute Of Allergy And Infectious Diseases · ZIA · FY2019 · AI
Developing gene therapy strategies to treat alpha thalassemia
$723,621Tippi Mackenzie · University Of California, San Francisco · R01 · FY2022 · HL
Pathogenesis and Treatment of Atopic Dermatitis
$723,562Joshua Milner · National Institute Of Allergy And Infectious Diseases · ZIA · FY2012 · AI