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8,912 grants matching “sars cov 2”
Precision targeting of T cell cytotoxicity with PET
$652,933Michael John Evans · University Of California, San Francisco · R01 · FY2022 · CA
AMPK Regulation of ACE2 in Endothelial Health and Disease
$652,773John Y-J Shyy · University Of California, San Diego · R01 · FY2024 · HL
Caspr/11-dependent immunothrombosis and neuroinflammation during SARS-CoV-2 infection
$652,551Amal O Amer · Ohio State University · P01 · FY2024 · AI
Engineering the Skin Immune System to Induce Systemic Immune Responses
$652,360Louis D Falo · University Of Pittsburgh At Pittsburgh · R01 · FY2021 · AR
VALE+TU SALUD: CORNER-BASED RANDOMIZED TRIAL TO TEST A LATINO DAY LABORER PROGRAM ADAPTED TO PREVENT COVID 19
$652,260Maria Eugenia Fernandez-Esquer · University Of Texas Hlth Sci Ctr Houston · R01 · FY2021 · MD
Early detection, containment, and management of COVID-19 in dialysis facilities using multi-modal data sources
$652,205Yuedong Wang · University Of California Santa Barbara · R01 · FY2021 · DK
Engineering the Skin Immune System to Induce Systemic Immune Responses
$651,707Louis D Falo · University Of Pittsburgh At Pittsburgh · R01 · FY2022 · AR
Influence of Social Media, Social Networks, and Misinformation on Vaccine Acceptance Among Black and Latinx Individuals
$651,586Sean Young · University Of California-Irvine · R01 · FY2025 · MD
Megakaryocyte regulation by the gut microbiome
$651,485Melody Y Zeng · Weill Medical Coll Of Cornell Univ · R01 · FY2024 · HL
Inflammation, Macrophage Differentiation, and Cancer
$651,310Zheng-Gang Liu · Division Of Basic Sciences - Nci · ZIA · FY2022 · CA
Megakaryocyte regulation by the gut microbiome
$651,165Melody Y Zeng · Weill Medical Coll Of Cornell Univ · R01 · FY2025 · HL
PROJECT 2: Determine clinically relevant host-viral dependency networks for respiratory infections including SARS-CoV-2
$651,020Melanie Maria Ott · University Of California, San Francisco · U19 · FY2025 · AI
Broad-spectrum therapeutics against SARS-CoV-2 3CL protease
$650,769Raymond F. Schinazi · Emory University · R01 · FY2022 · AI
Immune Responses to Malaria, HIV and SARS-CoV-2 Infection and Immunization - Service Core
$650,701Peter Skene · Seattle Children'S Hospital · U19 · FY2022 · AI
Tracking SARS-CoV-2 one molecule at a time: Spatiotemporal investigation of coronavirus replication dynamics and host response in single cells in vitro and in vivo
$650,415Charles M. Rice · Rockefeller University · R01 · FY2024 · AI
LARGE SCALE T CELL EPITOPE DISCOVERY - COVID Supplement
$650,336Alessandro Sette · La Jolla Institute For Immunology · N01 · FY2020 · AI
High Dimensional Imaging of Postmortem Human Covid-19 Autopsy Samples to Evaluate Pathophysiology and Immunology of SARS-CoV-2
$650,270Ronald Germain · National Institute Of Allergy And Infectious Diseases · ZIA · FY2020 · AI
Alaska Native Communities Advancing Vaccine Uptake
$650,253Julie Beans · Southcentral Foundation · R01 · FY2025 · AI
The Immunobiology of Vaccine-induced Immune Thrombotic Thrombocytopenia
$650,240Mortimer Poncz · Versiti Wisconsin, Inc. · P01 · FY2024 · HL
COVID-19 vaccine development research
$650,195Barbara Felber · Division Of Basic Sciences - Nci · ZIA · FY2021 · CA
Determining the Incidence, Risk Factors and Biological Drivers of Irritable Bowel Syndrome (IBS) as Part of the Constellation of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Outcomes
$650,178Kristen M Pogreba-Brown · University Of Arizona · R01 · FY2023 · DK
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2) HAS A BROAD HOST RANGE WITH MULTIPLE SPILLOVER EVENTS OF HUMAN-TO-ANIMAL TRANSMISSION DOCUMENTED. THESE OBSERVATIONS SUGGEST A RELATIVELY LOW SPECIES BARRIER BETWEEN HUMANS AND ANIMALS. HOWEVER, THE MECHANISMS UNDERLYING SPECIES SPECIFICITY AND SUSCEPTIBILITY TO SARS-COV-2 REMAIN POORLY UNDERSTOOD.THE OVERALL GOALS OF THE PRESENT STUDY ARE TO DETERMINE THE MECHANISMS UNDERLYING HOST SUSCEPTIBILITY OR RESTRICTION TO SARS-COV-2 INFECTION AND TO IMPROVE OUR UNDERSTANDING OF THE ANIMAL SPECIES AT RISK OF NATURAL INFECTION WITH SARS-COV-2. THE SPECIFIC OBJECTIVES OF THE PROPOSED STUDY ARE:(1) TO IDENTIFY THE MECHANISMS UNDERLYING SARS-COV-2 HOST RANGE AND ANIMAL SPECIES SPECIFICITY AT THE CELLULAR LEVEL.(2)TO CHARACTERIZE THE FACTORS AFFECTING SARS-COV-2 SUSCEPTIBILITY AT THE ORGANISM LEVEL; AND(3)TO INVESTIGATE NATURAL EXPOSURE OF ANIMALS TO VARIANT SARS-COV-2 STRAINS THROUGH SURVEILLANCE. THE PROPOSED STUDY DIRECTLY ALIGNS WITHAPHIS' AMERICAN RESCUE PLAN STRATEGIC FRAMEWORK AND ADDRESSES SEVERAL IMPORTANT RESEARCH PRIORITY AREAS IDENTIFIED IN THE APHIS-AFRI NIFA COLLABORATION ON SARS-COV-2 ANNOUNCEMENT: I. EXPAND KNOWLEDGE OF SUSCEPTIBILITY OF ANIMAL SPECIES TO SARS-COV-2; II. ADDRESS GAPS IN SURVEILLANCE AND INVESTIGATION ACTIVITIES FOR SARS-COV-2 IN ANIMALS; AND III. IDENTIFY RISKS AT THE HUMAN-ANIMAL INTERFACE THAT MAY ALLOW IMPLEMENTATION OF MEASURES TO PREVENT TRANSMISSION OR SARS-COV-2 TO ANIMALS AND REDUCE POTENTIAL IMPACTS TO THE FOOD SUPPLY. THE KNOWLEDGE GAINED WITH THESE STUDIES WILL ALLOW THE DESIGN OF STRATEGIES FOR EFFECTIVE PREVENTION AND CONTROL OF SARS-COV-2 AT THE HUMAN-ANIMAL INTERFACE.
$650,000Cornell University · · FY2023 · National Institute of Food and Agriculture
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** SARS-COV-2, THE VIRUS RESPONSIBLE FOR COVID-19, HAS BEEN FOUND IN VARIOUS ANIMAL HOSTS, INCLUDING WHITE-TAILED DEER IN THE USA. THESE FINDINGS RAISE CONCERNS ABOUT THE POTENTIAL TRANSMISSION OF THE VIRUS FROM DEER TO LIVESTOCK, PARTICULARLY CATTLE. TO ADDRESS THIS SPILLOVER RISK, IT'S CRUCIAL TO MONITOR HOW SARS-COV-2 EVOLVES IN FARMED DEER AND ITS POTENTIAL INFECTION OF CATTLE. HOWEVER, CURRENT METHODS FOR DETECTING AND SEQUENCING THE VIRUS ARE EXPENSIVE, NOT TAILORED FOR ANIMAL SAMPLES, AND UNSUITABLE FOR FIELD USE. THIS PROJECT AIMS TO DEVELOP COST-EFFECTIVE AND ADAPTABLE MOLECULAR METHODS FOR MONITORING SARS-COV-2 IN AGRICULTURAL ANIMALS.THE PROJECT WILL DEVELOP TWO METHODS: 1. REVERSE TRANSCRIPTION LOOP-MEDIATED ISOTHERMAL AMPLIFICATION (RT-LAMP) WITH SOLID-STATE NANOPORE SENSING AND 2. AN AMPLICON-BASED SEQUENCING METHOD RHAMPSEQ.THIS PROJECT BRINGS TOGETHER A DIVERSE TEAM OF EXPERTS IN VIROLOGY, MOLECULAR BIOLOGY, BIOMEDICAL ENGINEERING, CLINICAL VETERINARY MICROBIOLOGY, AND VETERINARY DIAGNOSTICS TO DEVELOP AND RIGOROUSLY VALIDATE THESE METHODS. THESE PROPOSED METHODS HOLD GREAT PROMISE FOR COST-EFFECTIVE, FLEXIBLE, AND RAPID DETECTION AND GENETIC CHARACTERIZATION OF SARS-COV-2. THIS RESEARCH ALIGNS WITH THE AMERICAN RESCUE PLAN (ARP) SURVEILLANCE PROGRAM'S GOAL OF DEVELOPING SURVEILLANCE TOOLS FOR RAPIDLY DETECTING AND CHARACTERIZING INFECTIOUS AGENTS LIKE SARS-COV-2.?
$650,000University Of Pittsburgh - Of The Commonwealth System Of Higher Education · · FY2023 · National Institute of Food and Agriculture
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** SARS-COV-2, THE VIRUS RESPONSIBLE FOR COVID-19, HAS BEEN FOUND IN VARIOUS ANIMAL HOSTS, INCLUDING WHITE-TAILED DEER IN THE USA. THESE FINDINGS RAISE CONCERNS ABOUT THE POTENTIAL TRANSMISSION OF THE VIRUS FROM DEER TO LIVESTOCK, PARTICULARLY CATTLE. TO ADDRESS THIS SPILLOVER RISK, IT'S CRUCIAL TO MONITOR HOW SARS-COV-2 EVOLVES IN FARMED DEER AND ITS POTENTIAL INFECTION OF CATTLE. HOWEVER, CURRENT METHODS FOR DETECTING AND SEQUENCING THE VIRUS ARE EXPENSIVE, NOT TAILORED FOR ANIMAL SAMPLES, AND UNSUITABLE FOR THE FIELD USE. THIS PROJECT AIMS TO DEVELOP COST-EFFECTIVE AND ADAPTABLE MOLECULAR METHODS FOR MONITORING SARS-COV-2 IN AGRICULTURAL ANIMALS.THE PROJECT WILL DEVELOP TWO METHODS: 1. REVERSE TRANSCRIPTION LOOP-MEDIATED ISOTHERMAL AMPLIFICATION (RT-LAMP) WITH SOLIDSTATENANOPORE SENSING AND 2. AN AMPLICON-BASED SEQUENCING METHOD RHAMPSEQ. THIS PROJECT BRINGS TOGETHER A DIVERSE TEAM OF EXPERTS IN VIROLOGY, MOLECULAR BIOLOGY, BIOMEDICAL ENGINEERING, CLINICAL VETERINARY MICROBIOLOGY, AND VETERINARY DIAGNOSTICS TO DEVELOP AND RIGOROUSLY VALIDATE THESE METHODS. THESE PROPOSED METHODS ARE PROMISING FOR COST-EFFECTIVE, FLEXIBLE, AND RAPID DETECTION AND GENETIC CHARACTERIZATION OF SARS-COV-2. THIS RESEARCH ALIGNS WITH THE AMERICAN RESCUE PLAN (ARP) SURVEILLANCE PROGRAM'S GOAL OF DEVELOPING SURVEILLANCE TOOLS FOR RAPIDLY DETECTING AND CHARACTERIZING INFECTIOUS AGENTS LIKE SARS-COV-2.
$650,000University Of Pittsburgh - Of The Commonwealth System Of Higher Education · · FY2024 · National Institute of Food and Agriculture
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** SINCE LATE 2019, SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2) HAS INFECTED MILLIONS OF PEOPLE. AROUND 60% OF DISEASES THAT CAN INFECT HUMANS ALSO INFECT ANIMALS,AND MILLIONS OF WHITE-TAILED DEER ('DEER') LIVE IN THE UNITED STATES, INCLUDING ON THOUSANDS OF FARMS WHERE THEY INTERACT CLOSELY WITH PEOPLE AND SUPPORT JOBS, PROVIDE FOOD, AND ENHANCE RECREATION. EARLY IN THE PANDEMIC, USDA SCIENTISTS TESTED WILD DEER FOR SARS-COV-2 AND FOUND THAT ON AVERAGE ONE IN THREE WERE POSITIVE FOR SARS-COV-2. TO LEARN MORE ABOUT WHAT VARIANTS LIKE ALPHA, DELTA, AND OMICRON THE DEER WERE INFECTED BY, SCIENTISTS USED GENE SEQUENCING TO READ THE GENETIC CODE OF THE VIRUS. SEQUENCING THE VIRUS FROM WILD DEER UNCOVERED SARS-COV-2 VERSIONS NOT FOUND IN PEOPLE, AND THESE SAME UNIQUE SEQUENCES INDICATED THAT AT LEAST ONE PERSON WAS INFECTED BY SARS-COV-2 FROM A DEER. THESE SURPRISING DISCOVERIES RAISED EVEN MORE QUESTIONS ABOUT SARS-COV-2 IN DEER SINCE THEY SUGGESTED THAT DEER ARE EASILY INFECTED WITH SARS-COV-2 AND MAY ALSO TRANSMIT THE VIRUS TO EACH OTHER. WE NEED MORE RESEARCH TO UNDERSTAND HOW SARS-COV-2 IS SPREADING IN DEER, AND WE ALSO NEED TO MEASURE THE RISK THAT THIS VIRUS WILL MUTATE IN DEER AND CREATE NEW VIRUS VARIANTS THAT CAN HARM DEER, PEOPLE OR OTHER ANIMALS. SO FAR ONLY A TINY FRACTION OF DEER IN THE US, WILD OR FARMED, HAVE BEEN TESTED FOR SARS-COV-2, AND EVEN FEWER HAVE HAD THEIR VIRUS INFECTION SEQUENCED. TO HELP US UNDERSTAND HOW THE SARS-COV-2 VIRUS IMPACTS FARMED DEER, AND HELP US SOLVE PROBLEMS THE VIRUS MIGHT CAUSE FARMERS OR THE PUBLIC, THE EXTENSIVE DEER GENOMIC SURVEILLANCE (EDGES) PROJECT WILL TEST AND SEQUENCE SARS-COV-2 IN THOUSANDS OF FARMED AND WILD DEER, AND ANIMALS THE DEER INTERACT WITH, FROM TEXAS. THE GOAL OF THIS EFFORT IS TO UNDERSTAND IF, WHEN, AND HOW BOTH FARMED AND WILD DEER ARE BECOMING INFECTED WITH SARS-COV-2 TO HELP FARMERS LIMIT THE SPREAD OF SARS-COV-2 TO OTHER DEER, ANIMALS, OR PEOPLE. WE EXPECT THAT THE RESULTS OFVIRUS TESTING WILL SHOW THAT MANY FARMED DEER ARE INFECTED WITH SARS-COV-2 VIRUS, AND THE EXPECTED SEQUENCING RESULTS WILL PROVIDE EVIDENCE ABOUT THE ORIGIN OF FARMED DEER INFECTIONS. ULTIMATELY, PROJECT EDGES WILL PROTECT BOTH FARMED DEER AND DEER FARMERS BY IMPROVING OUR ABILITY TO FIND, UNDERSTAND, AND STOP THE SARS-COV-2 VIRUS IN AGRICULTURAL ANIMALS THAT PEOPLE DEPEND ON FOR JOBS, FOOD, AND SPORT.
$649,992Ginkgo Bioworks, Inc. · · FY2023 · National Institute of Food and Agriculture