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38,696 grants matching “als”
SBIR Phase II: Focused Beam Total Reflection X-Ray Fluorescence Analysis Using Doubly-Curved Crystals
$999,696Zewu Chen · X-Ray Optical Systems, Inc. · · FY2002 · TIP
Jamboxx: Interactive Respiratory Therapy through Music and Gaming
$999,500Michael Dicesare · My Music Machines, Inc. · R42 · FY2017 · HL
SUNNY DAYS HEALTHY WAYS GRADES 6-8 SUN SAFETY CURRICULUM
$999,462Amc Cancer Research Center · R01 · FY2000 · CA
An Inhaled Microbiome-Targeted Biotherapeutic for Treatment of COPD
$999,425Teodora Nicola · Alveolus Bio, Inc. · R44 · FY2024 · HL
Protein Modifications Involved in Cell Signaling
$999,153Aleksandra Nita-Lazar · National Institute Of Allergy And Infectious Diseases · ZIA · FY2023 · AI
Contact Pathway Inhibitor to Prevent Vascular Access Failure
$998,549Christina U Lorentz · Aronora, Inc. · R44 · FY2023 · HL
A digital tool for monitoring speech decline in ALS
$998,469Jordan R Green · Modality.Ai , Inc · R42 · FY2023 · DC
Myosin XVA and Other Genes Essential for Stereocilia Morphogenesis
$998,347Thomas Friedman · National Institute On Deafness And Other Communication Disorders · ZIA · FY2017 · DC
Deciphering Biological Linkages Between PTSD and Respiratory Disease in WTC Respo
$998,324Benjamin J Luft · State University New York Stony Brook · U01 · FY2014 · OH
Mitochondrial Integrated Stress Response in Neurological Diseases
$998,006Giovanni Manfredi · Weill Medical Coll Of Cornell Univ · R35 · FY2021 · NS
Southeast Center for Agricultural Health and Injury Prevention-Renewal
$997,700Robert H. McKnight · University Of Kentucky · U54 · FY2011 · OH
Motor proteins and cytoskeletal dynamics in lymphocytes, melanocytes and neurons
$997,625John A Hammer · National Heart, Lung, And Blood Institute · ZIA · FY2018 · HL
A Pixel Array Detector System for Small Angle X-ray Scattering
$997,587Scott Classen · University Of Calif-Lawrenc Berkeley Lab · S10 · FY2014 · OD
Aging, Health, and Care: the Geography of Residential Proximity Between Parents and Adult Children
$997,190H Elizabeth Peters · Urban Institute · RF1 · FY2021 · AG
Clinical Validation Center for Early Detection of Pancreatic Cancer
$996,338Anirban Maitra · University Of Tx Md Anderson Can Ctr · U01 · FY2023 · CA
New approaches to addiction treatment
$996,120David Epstein · National Institute On Drug Abuse · ZIA · FY2023 · DA
Laboratory of Oral Connective Tissue Biology
$996,009Martha Somerman · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZIA · FY2016 · AR
Genetics Study of Nicotine Dependence in African Americans
$995,890Laura Jean Bierut · Washington University · R01 · FY2010 · DA
Development of TIMP-2 derivatives or strategies as biologic therapies for cancer
$995,769William Stetler-Stevenson · Division Of Basic Sciences - Nci · ZIA · FY2018 · CA
The Roles of Key Transcription Factors on the Pathogenesis of B. Burgdorferi, the Causative Agent of Lyme Disease
$995,567Frank Gherardini · National Institute Of Allergy And Infectious Diseases · ZIA · FY2015 · AI
Deciphering Biological Linkages Between PTSD and Respiratory Disease in WTC Respo
$995,508Benjamin J Luft · State University New York Stony Brook · U01 · FY2015 · OH
La Spada Outstanding Investigator Award
$995,408Albert R La Spada · University Of California-Irvine · R35 · FY2021 · NS
Multivalent Adjuvant Immunization to Prevent Hospital Acquired Infections
$995,098Brad J Spellberg · Exbaq Llc · R42 · FY2022 · AI
WE PROPOSE TO DEVELOP A TUNABLE MILLIMETER/SUBMILLIMETER-WAVE ANTENNA COUPLED GRAPHENE MIXER-BASED HETERODYNE SENSOR ON FUTURE MISSIONS TO ICY MOONS (TITAN ENCELADUS AND EUROPA) OF THE OUTER PLANETS OF OUR SOLAR SYSTEM. THE PROPOSED TECHNOLOGY IS FOCUSED ON THE "OCEAN WORLDS" MISSION THEME AND WILL ENABLE TO ADDRESS CHALLENGE QUESTIONS - SIGNIFICANCE OF ABIOLOGICAL SYNTHESIS OF ORGANICS I.E. HYDROCARBONS THEIR DERIVATIVES AND IONS (CARBOCATIONS AND CARBANIONS) - IN THE ORIGIN OF LIFE ON EARTH. INVESTIGATING THIS ABIOTIC CHEMISTRY IS A NECESSARY STEP IN THE QUEST TO UNDERSTAND THE ORIGIN OF LIFE AND HABITABILITY CONTEXT. THE GOAL OF PLANETARY EXPLORATION RESEARCH IS THE IDENTIFICATION OF MOLECULES OF PREBIOTIC IMPORTANCE (E.G. THE AROMATIC RINGS HETEROCYCLES NUCLEIC ACID BASES AND AMINO ACIDS) IN SPACE THROUGH ROTATIONAL SPECTROSCOPY AND THE ELUCIDATION OF THEIR CHEMICAL STRUCTURES USING THE PROPOSED HETERODYNE DETECTION TECHNIQUE. THE DETECTOR SYSTEM IS BASED ON NON-LINEAR 2 WAVE MIXING OF THE WEAK THZ RADIATION AND A THZ LOCAL OSCILLATOR IN A GRAPHENE PHOTO-THERMO-ELECTRIC DETECTOR (CAI ET AL. NATURE NANOTECHNOLOGY 9(10) 814 (2014)). THIS RESULTS IN A HETERODYNE RESPONSE FOR THE WEAK THZ SIGNAL WITH THE DIFFERENCE FREQUENCY RELATIVE TO THE LOCAL OSCILLATOR. THE NOISE TEMPERATURES OF NONCRYOGENIC GRAPHENE MIXERS ARE EXPECTED TO FALL BETWEEN RESPECTIVE VALUES OF SUPERCONDUCTING SIS HETERODYNE DETECTORS AND HOT ELECTRON BOLOMETER HEB SQUARE LAW MIXERS AND REQUIRE LESS LOCAL OSCILLATOR POWER THAN SCHOTTKY DIODE MIXERS. WE EXPECT TO BRING THIS TECHNOLOGY FROM TRL1 TO TRL4. BESIDES HYDROGEN AND WATER (AS WATER ICE) METHANE AND METHANOL CONSTITUTE AS THE MAJOR MOLECULAR MATTER IN OUR SOLAR SYSTEM. WE IDENTIFIED "OLAH'S NONCLASSICAL CARBONIUM ION CHEMISTRY" AS PREFERRED CHEMICAL PATHWAY FOR ABIOTIC SYNTHESIS OF ORGANIC COMPOUNDS ON TITAN AND THIS PATHWAY BEGINS BY THE CONVERSION OF MOST ABUNDANT METHANE TO METHONIUM ION CH5+ (ALI ET AL. P&SS 109-110 (2015) 46; PUZZARINI ET AL. ASTRONJ. 154: 82(2017 )). BECAUSE OF THE OBSERVED HIGHER REACTIVITY OF METHANOL WITH RESPECT TO METHANE A FEASIBLE NEW PATHWAY HAS RECENTLY BEEN PROPOSED FOR THE CONVERSION OF METHANOL TO VARIOUS EXTRATERRESTRIAL ABIOLOGICAL ORGANICS TOGETHER WITH A POSSIBLE CONNECTION WITH METHONIUM ION-BASED CHEMISTRY (OLAH ET AL. JACS. 138 (2016) 1717). IF METHANOL (A DERIVATIVE OF METHANE) INDEED HAS BEEN DELIVERED BY METEORITES OR COMETS TO THE ICY SURFACE OF EUROPA IN THE CHEMISTRY OF FORMATION OF OUR SOLAR SYSTEM IT IS SUGGESTED THAT THE RADIATION- CATALYZED SURFACE CHEMISTRY OF EUROPA COULD ALSO MIMIC THE OBSERVED PREBIOTIC CHEMISTRY ON TITAN BY THE CASSINI-HUYGENS MISSION. ROTATIONAL SPECTROSCOPY IN SPACE FROM FUTURE ORBITING SPACECRAFTS (TITAN AND EUROPA ORBITER) WOULD PROVIDE IMPORTANT INFORMATION OF ATMOSPHERIC AND SURFACE-ASSISTED PREBIOTIC CHEMISTRY USING THE PROPOSED HETERODYNE SENSOR. ON THE DETECTION OF ANY BIOLOGICAL PROCESS OR CHEMICAL MARKERS FOR EXTRATERRESTRIAL LIFE SPECTROSCOPY OF REPRESENTATIVE BUILDING BLOCKS OF LIFE IN THE OCEAN WORLDS OF THE OUTER SOLAR SYSTEM (E.G. SPECTRUM OF ENCELADUS PLUME COMPOSITION) IS AN IMPORTANT STEP. THE PROPOSED GRAPHENE MIXER-BASED SENSOR WILL ALSO ENABLE THE MEASUREMENTS OF WINDS WITH HIGH VELOCITY RESOLUTION FROM DOPPLER SHIFT STUDIES OF OPTICALLY THIN ROTATIONAL LINES. IN ADDITION THIS TECHNOLOGY WILL PERMIT A SENSITIVE ARRAY RECEIVER CONFIGURATION FOR THERMAL IMAGING OF SURFACES OF COLD PLANETARY BODIES IN THE OUTER SOLAR SYSTEM WITH SPECTRAL RESOLUTION. A MAJOR BREAKTHROUGH IN TECHNICAL CHALLENGES ON THE DESIGN AND DEVELOPMENT OF THE SENSOR PROPOSED WILL PUT STUDIES OF SPECTROSCOPY CHEMISTRY AND DYNAMICS OF THE ENVIRONMENTS OF ICY MOONS OF OUTER PLANETS IN OUR SOLAR SYSTEM AND WILL PROVIDE A LASTING IMPACT ON THE "RELEVANCE AND SIGNIFICANCE OF EXTRATERRESTRIAL ABIOLOGICAL HYDROCARBON CHEMISTRY" IN THE ORIGIN OF LIFE AS STATED IN THE PLANETARY SCIENCE DECADAL SURVEY (2013-2022).
$995,071University Of Maryland, College Park · · FY2020 · National Aeronautics and Space Administration
Modulating brain plasticity in rehabilitation of stroke and other brain lesions
$994,997Leonardo G. Cohen · National Institute Of Neurological Disorders And Stroke · ZIA · FY2018 · NS