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38,696 grants matching “als”
Integrative genetics of behavior with high throughput technologies
$3,169,828David Goldman · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2014 · AA
Center for Alzheimer's and Related Dementias: Detection of cryptic exons (splicing differences) in TDP-43 as biomarkers for frontotemporal dementia and Alzheimer's disease
$3,169,680Andrew Singleton · National Institute On Aging · ZIA · FY2024 · AG
Childhood Onset Schizophrenia
$3,167,728Judith L. Rapoport · National Institute Of Mental Health · ZIA · FY2015 · MH
The National Dental PBRN Administrative and Resource Center
$3,166,993Gregg H Gilbert · University Of Alabama At Birmingham · U19 · FY2022 · DE
Clinical Evaluation of PET Radiotracers
$3,163,585Robert Innis · National Institute Of Mental Health · ZIA · FY2014 · MH
Dysfunction of the Autophagy-Lysosomal Pathway as a Common Mechanism of Neurodegeneration
$3,162,400Steven M Finkbeiner · J. David Gladstone Institutes · RF1 · FY2017 · AG
THIS UNSOLICITED PROPOSAL IS SUBMITTED TO NASA FOR SUPPORT SERVICES TO BE PROVIDED TO THE NEUTRON STAR INTERIOR COMPOSITION EXPLORER (NICER) DURING THE PERFORMANCE PERIOD OF 2019 JANUARY 1 TO SEPTEMBER 30. THIS TIME INTERVAL IS REFERRED TO AS THE NICER BRIDGE PHASE AND IT OCCURS BETWEEN THE NICER PRIME MISSION AND THE MISSION EXTENSION THAT IS SUBJECT TO FUNDING APPROVAL VIA THE NASA SENIOR REVIEW PROCESS (I.E. FY 2020 ONWARD). THIS PROPOSAL WOULD ALLOW THE CONTINUED CONTRIBUTIONS OF THE NICER TEAM AT THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY (MIT) TO PERFORM SUPPORT SERVICES RELATED TO THE NICER DETECTOR SYSTEM WHICH WAS BUILT AT MIT AND TO CONTRIBUTE SCIENTIFIC ANALYSES OF NICER DATA. FUNDING SUPPORT FOR THE MIT GROUP PRIOR TO THE BRIDGE PHASE COVERING NICER MISSION PHASES B THROUGH E WAS PROVIDED BY A NASA CONTRACT TO MIT (CONTRACT REFERENCE NNG14PJ13C) WHICH IS SET TO EXPIRE ON 2018 DECEMBER 31. NICER IS AN X-RAY ASTRONOMY CAMERA SYSTEM THAT HAS BEEN OPERATING ON THE INTERNATIONAL SPACE STATION (ISS) SINCE IT WAS LAUNCHED AND DEPLOYED IN 2017 JUNE (GENDREAU ET AL. 2016 PROCS. SPIE 9905E ID. 99051 H). THE NICER X-RAY TIMING INSTRUMENT (XTI) IS COMPOSED OF 56 IDENTICAL CAMERAS EACH CONSISTING OF AN X-RAY CONCENTRATOR OPTIC AND A CUSTOMIZED SI DRIFT DETECTOR POSITIONED IN THE CONCENTRATOR S FOCAL PLANE. THE OTHER PRIMARY COMPONENTS OF NICER ARE A CELESTIAL POINTING PLATFORM AND SEVEN ELECTRONICS BOXES EACH OF WHICH EXTRACTS EVENT MEASUREMENTS FROM THE SIGNAL LINES OF EIGHT DETECTORS. THE DETECTORS ARE KNOWN AS FOCAL PLANE MODULES (FPMS) AND THE ELECTRONIC BOXES ARE REFERRED TO AS MEASUREMENT&POWER UNITS (MPUS). BOTH THE FPMS AND MPUS WERE BUILT AND DELIVERED TO NASA BY THE TEAM AT MIT. THE PROPOSED SERVICES TO NICER DURING THE BRIDGE PHASE ARE ORGANIZED INTO TWO BROAD AREAS: (1) SUPPORT OF DETECTOR PERFORMANCE AND CALIBRATION AND (2) DATA ANALYSES&LEGACY SCIENCE. FURTHER DETAILS ARE PROVIDED BELOW INCLUDING A DESCRIPTIONS OF WORK TASKS ESTIMATES OF FTE SUPPORT NEEDED TO COMPLETE THESE TASKS AND A DETAILED BUDGET. MOST OF THE REQUESTED FUNDS WOULD PROVIDE PARTIAL SALARY SUPPORT OF MIT RESEARCH STAFF MEMBERS ENGAGED IN THE PROPOSED WORK AND ALL OF THESE STAFF MEMBERS HAVE PARTICIPATED IN THE HARDWARE BUILD NICER COMMISSIONING ACTIVITIES AND THE DATA ANALYSES DURING THE PRIME MISSION. THIS PROPOSAL ALSO CONTAINS A SUBCONTRACT FROM MIT TO ESPACE FOR THE COMPLETION AND DIAGNOSTIC APPLICATIONS OF AN INSTRUMENT SIMULATOR WITH WORK TO BE PERFORMED BY NOQSI SCIENTIFIC THE NICER PARTNER RESPONSIBLE FOR THE DESIGN OF THE MPU ELECTRONICS CIRCUITRY.
$3,158,294Massachusetts Institute Of Technology · · FY2020 · National Aeronautics and Space Administration
Single molecule study of C9ORF72 repeat RNA metabolisms in ALS/FTD
$3,156,336Shuying Sun · Johns Hopkins University · RF1 · FY2020 · NS
Genetics of Early Onset Parkinson's Disease: Mitochondrial Drivers of PD Pathogenesis
$3,154,937Derek Narendra · National Institute Of Neurological Disorders And Stroke · ZIA · FY2021 · NS
B cell development
$3,152,908Rafael C Casellas · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZIA · FY2014 · AR
Functional And Multi-Omics Approaches To Elucidate The Regulation Of Proteasome Complex In Neurodegenerative Diseases
$3,145,300Natura Myeku · Columbia University Health Sciences · RF1 · FY2025 · NS
Genetic Variants, Epigenome and Retinal Disease Phenotypes
$3,145,075Anand Swaroop · National Eye Institute · ZIA · FY2015 · EY
Treatment of Infections in Immunocompromised Children with Cancer, Hematopoietic
$3,141,379Thomas J Walsh · Clinical Sciences · Z01 · FY2007 · CA
The National Dental PBRN Administrative and Resource Center
$3,134,285Gregg H Gilbert · University Of Alabama At Birmingham · U19 · FY2024 · DE
Integrating the exposome and epigenome identifies determinants of ALS risk, survival, and pathogenesis
$3,133,754Eva L Feldman · University Of Michigan At Ann Arbor · R01 · FY2025 · ES
Molecular Profiling of Clinical Specimens
$3,128,081Daniel Edelman · Division Of Basic Sciences - Nci · ZIC · FY2016 · CA
Epigenetic and Transcriptional Functions of Nuclear Receptors and Chromatin Remodeling Proteins in Stem and Cancer Cells
$3,127,475Trevor K Archer · National Institute Of Environmental Health Sciences · ZIA · FY2019 · ES
Section on Light and Circadian Rhythms
$3,122,721Samer Hattar · National Institute Of Mental Health · ZIA · FY2025 · MH
Genetic Analysis of T-cell Differentiation
$3,120,251Remy Bosselut · Division Of Basic Sciences - Nci · ZIA · FY2025 · CA
The Genetics of Uveal Coloboma
$3,119,089Brian Brooks · National Eye Institute · ZIA · FY2022 · EY
Neuropixels NXT: Integrated Silicon Probes for Large Scale Extracellular Recording in Rodents and Primates
$3,116,817Timothy D Harris · Johns Hopkins University · U01 · FY2021 · NS
Integrative genetics of behavior with high throughput technologies
$3,115,277David Goldman · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2013 · AA
Clinical Trial of Ceftriaxone in ALS
$3,113,499Merit E Cudkowicz · Massachusetts General Hospital · U01 · FY2006 · NS
Integrative genetics of behavior with high throughput technologies
$3,105,339David Goldman · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2012 · AA
Clinical Evaluation of PET Radiotracers
$3,101,412Robert Innis · National Institute Of Mental Health · ZIA · FY2013 · MH