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17,828 grants matching “crispr”
Expansion of the Human Transcription Factor Genome-wide Binding Map Resource
$682,717Richard M Myers · Hudson-Alpha Institute For Biotechnology · U24 · FY2024 · HG
Precision mapping of regulatory causal variants by expression CROPseq
$682,624Gregory C. Gibson · Georgia Institute Of Technology · R01 · FY2024 · HG
Kallikrein-PAR interactions in skin inflammation
$682,599Nicole Leanne Ward · Case Western Reserve University · R01 · FY2019 · AR
Broad-spectrum HIV gene editing strategies in peripheral and brain reservoirs
$682,558Brian Wigdahl · Drexel University · R01 · FY2024 · MH
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** GLOBAL TRADE AND CLIMATE CHANGE ACCELERATE AND COMPOUND THE EMERGENCE OF PLANT PATHOGENS AND IMPACTS ON NATURAL AND MANAGED ECOSYSTEMS. PHYTOPHTHORA PLUVIALIS IS A FOLIAR PATHOGEN OF CONIFER TREES THAT HAS REPEATEDLY EMERGED IN THE UNITED STATES (US) AND INVADED NEW ZEALAND (NZ) AND MORE RECENTLY THE UNITED KINGDOM (UK). ITS EMERGENCE HAS CAUSED SEVERE EPIDEMICS ON ECONOMICALLY IMPORTANT CONIFER TREES IN BOTH PLANTATIONS AND WILD LAND FORESTS. IN ITS MOST RECENT EMERGENCE, P. PLUVIALIS NOT ONLY JUMPED TO A NEW HOST BUT WAS ASSOCIATED WITH A DEVASTATING SHIFT IN DISEASE ETIOLOGY. STUDYING P. PLUVIALIS IS OF DIRECT RELEVANCE IN SUPPORT OF GOALS TO IMPROVE THE LONG-TERM SUSTAINABILITY AND COMPETITIVENESS OF U.S. AGRICULTURAL SYSTEMS. THE CHANGE IN DISEASE ETIOLOGY IS OF PARTICULAR CONCERN. ITS POTENTIAL EFFECTS ON THE FOREST INDUSTRY IN THE PACIFIC NORTHWEST OF THE US ARE SIGNIFICANT. WESTERN HEMLOCK AND DOUGLAS-FIR, THE TWO MAIN HOSTS OF THIS PATHOGEN, MAKE UP MOST OF THE CROP TREES PLANTED ON THE 8.1 MILLION ACRES OF PRIVATE INDUSTRIAL FOREST LAND. WE AIM TO: 1) CHARACTERIZE THE VARIATION IN SUSCPETIBILITY TO P. PLUVIALIS WITHIN AND AMONG POPULATIONS OF DOUGLAS-FIR AND WESTERN HEMLOCK; 2) USE PHYLOGENY GUIDED PHENOTYPING OF PATHOGEN POPULATIONS; AND 3) DEVELOP AND DEPLOY A MULTIPLEX CRISPR BASED SHERLOCK ASSAY TO DETECT MAJOR LINEAGES OF P. PLUVIALIS IN THE FIELD. THESE AIMS WILL ALLOW US TO EVALUATE AND ATTENUATE THE RISK OF P. PLUVIALIS TO WESTERN HEMLOCK AND DOUGLAS-FIR FORESTS IN THE USA.
$682,500Oregon State University · · FY2024 · National Institute of Food and Agriculture
Development and maintenance of chronic toxoplasmosis
$682,500Sebastian Lourido · Whitehead Institute For Biomedical Res · R01 · FY2021 · AI
The Role of Aberrant Histone Acetylation in the Pathogenesis of Parkinsonâs Disease and Related Synucleinopathies.
$682,493Frank Soldner · Albert Einstein College Of Medicine · R01 · FY2024 · NS
Elucidating Regulation of Cell Fate Specification in Human Cortical Development to Understand Etiology of Neurodevelopment Disorders
$682,470Aparna Bhaduri · University Of California Los Angeles · R01 · FY2024 · MH
IMPACT OF BCL2 PHOSPHORYLATION ON HIV DYNAMICS, RESERVOIR SIZE AND SUSCEPTIBILITY TO VENETOCLAX
$682,446Andrew D Badley · Mayo Clinic Rochester · R56 · FY2024 · AI
An RNA topoisomerase complex interacts with Fragile X syndrome protein to promote neurodevelopment and maintain normal life-span
$682,399Weidong Wang · National Institute On Aging · ZIA · FY2017 · AG
Heroin-Induced genomic regulation of Ventral Pallidum neuron subtypes
$682,338David M Dietz · State University Of New York At Buffalo · U01 · FY2020 · DA
Precision mapping of regulatory causal variants by expression CROPseq
$682,310Gregory C. Gibson · Georgia Institute Of Technology · R01 · FY2025 · HG
Comprehensive Resource for the Drosophila 4th chromosome
$682,218Stuart J Newfeld · Arizona State University-Tempe Campus · R24 · FY2023 · OD
Transcriptional mechanisms and melanoma
$682,142Leonard I Zon · Massachusetts General Hospital · P01 · FY2025 · CA
Human LincRNAs in Macrophage Biology and Related Cardiometabolic Diseases
$681,984Muredach P Reilly · Columbia University Health Sciences · R01 · FY2019 · HL
Dietary Regulation of Intestinal Inflammation and Repair
$681,939David Artis · Weill Medical Coll Of Cornell Univ · R01 · FY2025 · DK
Dietary Regulation of Intestinal Inflammation and Repair
$681,939David Artis · Weill Medical Coll Of Cornell Univ · R01 · FY2023 · DK
Dietary Regulation of Intestinal Inflammation and Repair
$681,939David Artis · Weill Medical Coll Of Cornell Univ · R01 · FY2022 · DK
EUCOMM Conditional Vector and ES Cell Clone Collection (Year 24 Supplemental)
$681,936Kc Kent Lloyd · University Of California At Davis · U42 · FY2024 · OD
A clear view of encephalitis: a single cell approach to determine the basis of flaviviral pathogenesis in the central nervous system
$681,863Charles M. Rice · Rockefeller University · R01 · FY2022 · AI
The Role of PRDM16 in Cardiac Development and Cardiomyopathy
$681,823Sihem Boudina · University Of Utah · R01 · FY2021 · HL
Host-virus interactions in hantavirus glycoprotein assembly
$681,755Kartik Chandran · Albert Einstein College Of Medicine · R56 · FY2024 · AI
The STAT3 Pathway in Uterine Leiomyoma: A Therapeutic Target
$681,337Serdar E Bulun · Northwestern University At Chicago · R01 · FY2025 · CA
Multimodal omics approach to identify health to cardiometabolic disease transitions
$681,062Paivi Pajukanta · University Of California Los Angeles · R01 · FY2024 · HL
Novel recombinant Rotavirus vaccine utilizing the probiotic microorganism Lactobacillus acidophilus
$681,022Gregg A Dean · Colorado State University · R01 · FY2021 · AI