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24,576 grants matching “microbiome”
Designing a High-Throughput Platform to Bioprospect the Human Microbiome and ManipulateIts Iinterplay with Host Environments
$817,268Tagbo Herman Roland Niepa · Carnegie-Mellon University · DP2 · FY2025 · GM
Vibrio cholerae antinitrosative stress defenses and gut microbiome interaction
$817,177Jun Zhu · University Of Pennsylvania · R01 · FY2020 · AI
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** GROWING EVIDENCE SHOWS THAT THE MICROBIOME OF PLANTS INFLUENCES THEIR PRODUCTIVITY, HEALTH, DROUGHT TOLERANCE, AND REPRODUCTIVE FITNESS. THE PROPOSED RESEARCH WILL USE A FUNCTION FOCUSED APPROACH LEVERAGING NOVEL TECHNIQUES AND FIELD EXPERIMENTS TO UNDERSTAND PLANT-MICROBE INTERACTIONS IN RESPONSE TO FERTILIZATION AND DROUGHT USING MISCANTHUS × GIGANTEUS AS A MODEL BIOENERGY CROP. MISCANTHUS X GIGANTEUS IS A PROMISING FEEDSTOCK FOR SUSTAINABLE BIOENERGY DUE TO ITS HIGH PRODUCTIVITY AND ROBUST GROWTH ON SUB OPTIMAL SOIL. IN COMPARISON TO OTHER CANDIDATE BIOENERGY CROPS SUCH AS CORN AND SWITCHGRASS, MISCANTHUS HAS HIGHER BIOMASS AND ENERGY YIELDS AND LOWER CULTIVATION GREENHOUSE GAS EMISSIONS. INDEED, MISCANTHUS CAN ENHANCE SOIL CARBON (C) STOCKS MAKING THE CROP C-NEGATIVE, THAT IS, A SYSTEM THAT CUMULATIVELY STORES MORE C THAN IT RESPIRES TO THE ATMOSPHERE. APPALACHIA, IS AN IDEAL REGION TO PERFORM RESEARCH ON MICROBIOMES OF BIOENERGY CROPS ON MARGINAL LANDS DUE TO THE REGIONALLEGACY OF COAL ENERGY PRODUCTION. THE ENVIRONMENTALLY DISRUPTIVE NATURE OF COAL MINING HAS RESULTED IN AN ABUNDANCE (~4 MILLION ACRES) OF LAND THAT IS UNSUITABLE FOR THE GROWTH OF MOST ECONOMICALLY VALUABLE CROPS (I.E. MARGINAL LAND). HOWEVER, RECENT EVIDENCE SUGGESTS THAT MARGINAL LAND IS SUITABLE FOR BIOENERGY CROP PRODUCTION, PARTICULARLY CROPS LIKE MISCANTHUS THAT GROW ROBUSTLY EVEN UNDER HARSH CONDITIONS. ESTIMATES SUGGEST THAT ~3.5 MILLION HECTARES OF LAND MARGINALIZED BY SURFACE MINING COULD BE UTILIZED FOR GROWING BIOENERGY CROPS, MOST OF WHICH IS IN APPALACHIA. AS THE ENERGY INDUSTRY SHIFTS AWAY FROM COAL AND TOWARD RENEWABLE SOURCES, APPALACHIA POSSESSES THE UNIQUE OPPORTUNITY TO UTILIZE THE AGRICULTURAL POTENTIAL OF OUR MINED LANDS TO PRODUCE BIOFUEL CROPS LIKE MISCANTHUS. EFFORTS TO UTILIZE MARGINAL LANDS FOR BIOFUEL PRODUCTION WOULD DIVERSIFY THE ECONOMY OF APPALACHIA, A REGION ECONOMICALLY DEPRESSED WITH THE DECLINING AVAILABILITY OF JOBS IN THE FOSSIL FUEL SECTOR. THE FIRST AIM TO IDENTIFY AND CHARACTERIZE THE FUNCTION OF THE MISCANTHUS CORE MICROBIOME (I.E., ORGANISMS THAT RELIABLY ASSOCIATE WITH THE HOST PLANT) ON MARGINAL APPALACHIAN SOILS. THE CORE MICROBIOME OF MISCANTHUS PROVIDES THE PLANT WITH WATER AND NUTRIENTS IN EXCHANGE FOR CARBON RICH ROOT EXUDATES. IF FERTILIZATION REDUCES ROOT COLONIZATION BY BENEFICIAL MEMBERS OF THE MICROBIOME AND CHANGES MICROBIOME FUNCTION THIS MAY REDUCE THE CROPS ABILITY TO WITHSTAND DROUGHT STRESS. TO TEST THIS HYPOTHESIS, WE WILL USE A FIELD EXPERIMENT AND CUTTING-EDGE MOLECULAR TOOLS TO CHARACTERIZE PLANT MICROBIOME INTERACTIONS. LASTLY, WE WILL ASSESS IF MICROBIOME MANIPULATION, THROUGH THE ADDITION OF BENEFICIAL MICROORGANISMS CAN ENHANCE YIELD AND DROUGHT TOLERANCE IN A FIELD TRIAL. IN SUMMARY, THE PROPOSED WILL ADVANCE OUR THEORETICAL UNDERSTANDING OF PLANT-MICROBIOMES AND PROVIDE PRACTICAL GUIDANCE FOR BIOENERGY CROP PRODUCTION. THE RESULTS OF THIS WORK WILL HELP BUILD A PREDICTIVE UNDERSTANDING OF THE MISCANTHUS MICROBIOME FUNCTION AS WELL AS PLANT-MICROBIOME RESPONSES TO FERTILIZATION AND DROUGHT STRESS.
$817,167West Virginia University Research Corporation · · FY2022 · National Institute of Food and Agriculture
Early life regulation of microbiota specific thymic T cell development
$817,057Matthew Bettini · University Of Utah · R01 · FY2024 · AI
Respiratory Pathogens Research Center (RPRC)
$816,915David Topham · University Of Rochester · N01 · FY2018 · AI
Multi-omics characterization of HIV-associated changes in the gut microbiome and host mucosal immunity
$816,908Douglas Kwon · Massachusetts General Hospital · R01 · FY2018 · DK
CAREER: Learning mechanistic models with automated experiments
$816,778Paul A Jensen · Regents Of The University Of Michigan - Ann Arbor · · FY2024 · BIO
Natural History of C. trachomatis urogenital and rectal infections
$816,577Deborah Anne Dean · University Of California, San Francisco · R01 · FY2020 · AI
Structure-based microbially targeted prodrugs
$816,384Audrey Ragan Odom John · Children'S Hosp Of Philadelphia · R01 · FY2023 · AI
Effect of infant antibiotics on the development of the early-life airway and gut microbiome and risk of childhood asthma
$816,358Christian Rosas-Salazar · Vanderbilt University Medical Center · R01 · FY2024 · HL
Glycomic Modulation of Gut Microbiome During HIV Infection
$815,931Mohamed Abdel Mohsen · Wistar Institute · R01 · FY2023 · DK
Microbiome-gut-brain dysfunction in prodromal and symptomatic Lewy body diseases
$815,866Sephira Ryman · Lovelace Biomedical Research Institute · R01 · FY2023 · NS
Mechanisms of SARS-CoV-2 pathogenesis during HIV/SIV infection
$815,811Megan A O'Connor · University Of Washington · R01 · FY2023 · HL
CAREER: MECHANISMS OF ASSEMBLY AND COEXISTENCE IN SPECIES-RICH MICROBIAL COMMUNITIES
$815,698Leonora S Bittleston · Boise State University · · FY2024 · BIO
Research training in respiratory biology
$815,403Anne I. Sperling · University Of Chicago · T32 · FY2020 · HL
Integrated genomics research in parasitic tropical diseases
$814,735Joana Carneiro Da Silva · University Of Maryland Baltimore · U19 · FY2017 · AI
A novel bioengineering approach to restoring permanent periodontal inflammatory bone loss
$814,498Hae Lin Jang · Brigham And Women'S Hospital · R01 · FY2025 · DE
Core J: Virology and Molecular Biomarkers Core
$813,884Guido Silvestri · Emory University · P30 · FY2019 · AI
Artificial Intelligence, Modeling, and Informatics for Nutrition Guidance and Systems (AIMINGS) Center
$813,678Bruce Y Lee · Graduate School Of Public Health And Health Policy · U54 · FY2024 · TR
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
$813,598Jessica Robinson-Papp · Icahn School Of Medicine At Mount Sinai · R01 · FY2024 · DK
The Development of Gut Microbiota and Behavioral Inhibition in Childhood: The Role of Early Stress and Brain Development
$813,558Cathi Barbra Propper · Univ Of North Carolina Chapel Hill · R01 · FY2020 · MH
Trinity: Transcriptome assembly for genetic and functional analysis of cancer
$813,497Eric Banks · Broad Institute, Inc. · U24 · FY2019 · CA
CAREER: How do rhizosphere associated microorganisms and plant host interact to regulate soil microbial processes?
$813,496Sonny T Lee · Kansas State University · · FY2023 · BIO
Methods for Epidemiology Studies
$813,306Paul Albert · Division Of Cancer Epidemiology And Genetics · ZIA · FY2023 · CA
High-throughput single-cell RNA sequencing of bacteria to uncover cell states involved in pathogenesis
$813,272Sahand Hormoz · Dana-Farber Cancer Inst · R01 · FY2025 · AI