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38,696 grants matching “als”
Patterns and Predictors of Smoking from Adolescence to Young Adulthood
$894,472Robin J Mermelstein · University Of Illinois At Chicago · P01 · FY2012 · CA
Neural Circuits underlying the control of Executive and Emotional Behavior
$894,359Yogita Chudasama · National Institute Of Mental Health · ZIA · FY2016 · MH
TARGETING AXONAL REGENERATION PATHWAYS AS A THERAPEUTIC APPROACH TO ALS
$894,330University Of Miami · · FY2025 · Defense Health Agency
THERAPEUTIC IDEA FOR THE TREATMENT OF ALS WITH RASRX1902
$893,605University Of Arizona · · FY2019 · Department of the Army
Magnetic Resonance Spectroscopy Core Facility
$893,277Jun Shen · National Institute Of Mental Health · ZIC · FY2017 · MH
La Jolla Interdisciplinary Neuroscience Center Cores
$893,205Stuart A Lipton · Sanford Burnham Prebys Medical Discovery Institute · P30 · FY2014 · NS
Signal and Transcription Factor Network interactions in Head and Neck Cancer
$893,066Carter Van Waes · National Institute On Deafness And Other Communication Disorders · ZIA · FY2010 · DC
Mechanisms of Mammalian Epigenome Reprogramming
$892,738Todd Scott Macfarlan · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2015 · HD
Gulf Longitudinal Follow-up (GuLF) Study
$892,530Dale P Sandler · National Institute Of Environmental Health Sciences · ZIA · FY2025 · ES
Enhancing ENCODE Through a Transcription Factor Tagging Approach to ChIP-seq
$892,438Kevin P White · University Of Chicago · RC2 · FY2011 · HG
THE BOUNDARY BETWEEN THE CIRCUMPOLAR BOREAL FOREST AND ARCTIC TUNDRA IS ONE OF THE WORLD'S MOST EXTENSIVE ECOTONES WITH A DISTANCE SPANNING 13 400 KM ACROSS THE NORTHERN HEMISPHERE. AS SUCH THE FOREST-TUNDRA ECOTONE (FTE) PLAYS A CRITICAL ROLE IN GLOBAL BIOGEOCHEMICAL CYCLING AND ENERGY BALANCE BIODIVERSITY AND ECOSYSTEM SERVICES AND SOCIOECONOMICS OF ARCTIC-BOREAL REGIONS (ABR). ONGOING WARMING HAS LED TO THE COMMON ASSUMPTION OF PROGRESSIVE NORTHWARD ADVANCE OF THE ENTIRE FTE. IMPORTANTLY HOWEVER FINDINGS OF OBSERVATIONAL STUDIES DO NOT SHOW A SPATIALLY CONSISTENT FTE RESPONSE TO CLIMATE WARMING. IN THEIR CIRCUM-ARCTIC SURVEY REES ET AL. (2020) FOUND THAT DURING THE 20TH CENTURY ONLY 52% OF STUDY SITES HAVE ADVANCED NORTHWARD WHILE 46% REMAINED STATIONARY AND 2% RETREATED. THEY ALSO FOUND THAT OVERALL SITES THAT ADVANCED NORTHWARD DID SO TWO ORDERS OF MAGNITUDE MORE SLOWLY THAN EXPECTED IF VEGETATION DISTRIBUTION REMAINED IN EQUILIBRIUM WITH CLIMATE AND THAT RATES OF ADVANCEMENT VARIED SUBSTANTIALLY BY REGION. THERE ARE SEVERAL REASONS FOR THESE DISCREPANCIES INCLUDING THE POSSIBILITY THAT CHANGES IN FTE BIOPHYSICAL STRUCTURE MAY BE TOO SUBTLE TO DETECT USING TRADITIONAL APPROACHES AND TIME-LAGS BETWEEN QUANTIFIABLE FTE RESPONSES AND THE RECENT WARMING TREND IN ABRS. FURTHER HERBIVORY IS OFTEN OVERLOOKED DESPITE THE FACT THAT TREES AND WOODY SHRUBS ARE AN IMPORTANT FOOD SOURCE FOR MANY FTE DWELLING HERBIVORES SUGGESTING THAT HERBIVORY LIKELY INHIBITS NORTHWARD ADVANCE OF PORTIONS OF THE FTE. MOREOVER DESPITE THE FACT THAT HERBIVORE PRESSURE VARIES STRONGLY AS A FUNCTION OF SNOW DEPTH SNOW-HERBIVORE INTERACTIONS HAVE YET TO BE EXPLICITLY INCLUDED IN ECOSYSTEM MODELS THAT PREDICT CHANGES IN THE POSITION OF THE FTE. WHEN COMBINED WITH OUR OWN FIELD BASED OBSERVATIONS AT THE ALASKAN FTE DURING PHASE 1 OF ABOVE THESE LINES OF EVIDENCE STRONGLY SUGGEST THAT CRITICAL INTERACTIONS AMONG LOCAL ABIOTIC AND BIOTIC FACTORS MUST BE EXPLICITLY CONSIDERED IN ANY ASSESSMENT OF HOW CLIMATE CHANGE WILL ALTER NOT ONLY THE POSITION AND EXTENT OF THE FTE - HEREAFTER REFERRED TO AS FTE BEHAVIOR - BUT ALSO THE IMPLICATIONS FOR ITS ABILITY TO STORE CARBON (C) AND PROVIDE WILDLIFE HABITAT. THIS PROJECT S OVERARCHING SCIENCE GOAL IS TO INCLUDE THE LARGELY UNCONSIDERED ROLE OF INTERACTIONS AMONG SNOW KEY HERBIVORES AND VEGETATION IN DETERMINING SPATIAL AND TEMPORAL DYNAMICS OBSERVED IN FTE BEHAVIOR AND IN TURN HOW THESE DYNAMICS IMPACT BOTH THE AMOUNT OF C STORED AND AVAILABILITY OF WILDLIFE HABITAT WITHIN THE CIRCUM-ARCTIC FTE. OUR GENERAL APPROACH IS TO SYNTHESIZE OBSERVATIONS KNOWLEDGE AND MODELS FROM MULTIPLE STUDIES MADE DURING ABOVE PHASES 1 AND 2 TO BUILD AND VALIDATE A NEW QUANTITATIVE ECOSYSTEM MODELING TOOL FTE - SNOW+VEGETATION+HERBIVORY (FTE-SVH) THAT REPRESENTS WHAT WE CURRENTLY UNDERSTAND ARE KEY INTERACTIONS CONTROLLING FTE BEHAVIOR C STORAGE AND WILDLIFE HABITAT (OBJ. 1). WE WILL USE PUBLISHED STUDIES AND BIOTIC AND ABIOTIC DATA COLLECTED FROM 1980-PRESENT TO GUIDE FTE-SVH DEVELOPMENT AND VALIDATION. THESE WILL INCLUDE A COMBINATION OF NASA ABOVE SPECIFIC AND OTHER SOURCES OF ACCUMULATED KNOWLEDGE AND UNDERSTANDING AS WELL AS PREVIOUSLY DEVELOPED REMOTELY SENSED PRODUCTS GROUND-BASED OBSERVATIONS AND NUMERICAL MODELS. THIS MODELING SYSTEM WILL BE CAPABLE OF REPRODUCING OBSERVED DYNAMICS IN FTE BEHAVIOR OVER THE LAST FOUR DECADES. WE WILL THEN DETERMINE FTE-SVH MODEL SENSITIVITIES VIA FIVE EXPERIMENTS: INCREASED AIR TEMPERATURE (EXPT. 1) AND ATMOSPHERIC CO2 (EXPT. 2) CHANGES IN SNOWSCAPE PROPERTIES (EXPT. 3) AND HERBIVORE PRESSURE DYNAMICS (EXPT. 4) AND CIRCUM-ARCTIC FTE SIMULATIONS DRIVEN WITH FUTURE SCENARIO DATA FOR CLIMATE AND HERBIVORE PRESSURE (EXPT. 5) (OBJ. 2).
$892,403The Trustees Of Columbia University In The City Of New York · · FY2022 · National Aeronautics and Space Administration
Neurodifferentiation/Stem Cell Unit
$892,381David Wang · National Institute Of Neurological Disorders And Stroke · ZIC · FY2022 · NS
Anatomical basis of memory and language
$891,887Daniel T Tranel · University Of Southern California · P50 · FY2011 · NS
Phase III Trial of Minocycline in ALS:I-Clinical Center
$891,840Paul H Gordon · Columbia University Health Sciences · R01 · FY2006 · NS
Clinical Analysis Of Disorders Of Hearing And Balance
$891,718Carmen Crowell Brewer · National Institute On Deafness And Other Communication Disorders · ZIA · FY2016 · DC
An Env apex-focused HIV-1 vaccine strategy
$891,681Michael R. Farzan · Boston Children'S Hospital · R01 · FY2024 · AI
Brief Voluntary Alcohol and Drug Intervention for Middle School Youth
$891,555Elizabeth J D'amico · Rand Corporation · R01 · FY2009 · AA
BASE TITLE: PREVENT CANCER PRECLINICAL DRUG DEVELOPMENT PROGRAM: PRECLINICAL EFFICACY AND ENDPOINT BIOMARKERS; TASK ORDER TITLE: EFGR AND KRAS VACCINE
$890,873Chinthalapally V. Rao · University Of Oklahoma Hlth Sciences Ctr · N01 · FY2020 · CA
Phase II Clinical Trial of G207 HSV To Treat Children with High Grade Gliomas
$890,765George Yancey Gillespie · Treovir, Inc · R44 · FY2023 · CA
Intrathecal Cyclosporin for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
$890,731Jenny Karlsson · Maas Biolab, Inc. · U44 · FY2010 · NS
Novel modulators of the dopamine transporter for alcohol and nicotine use disorders
$890,494John M Littleton · Naprogenix, Inc · R44 · FY2020 · AA
Early Life Air Pollution Exposures as a Risk Factor for Neurodevelopmental Disorders
$890,456Deborah A Cory-Slechta · University Of Rochester · R35 · FY2021 · ES
Molecular Genetics Of Scrapie Pathogenesis
$889,806Suzette Alise Priola · National Institute Of Allergy And Infectious Diseases · ZIA · FY2021 · AI
Collaborative Research: From Pathways to Progressions: Empowering Districts to Equip K-12 Computational Thinkers with Data Science and Machine Learning Foundations
$889,630Quinn Burke · Digital Promise Global · · FY2025 · CSE
Quantification of Myocardial Perfusion
$889,477Andrew Arai · National Heart, Lung, And Blood Institute · ZIA · FY2016 · HL