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24,576 grants matching “microbiome”
MICRONUTRIENT MALNUTRITION REMAINS A MAJOR PUBLIC HEALTH PROBLEM, AFFECTING MORE THAN 2 BILLION PEOPLE, BOTH DOMESTICALLY AND INTERNATIONALLY. IN PARTICULAR, WOMEN OF REPRODUCTIVE AGE ARE AT A HIGH RISK FOR MICRONUTRIENT DEFICIENCIES AND ANEMIA. FORTIFICATION OF FOODS WITH FOLIC ACID AND OTHER MICRONUTRIENTS IS AN EFFICACIOUS AND COST-EFFECTIVE PUBLIC HEALTH INTERVENTION TO ADDRESS MICRONUTRIENT DEFICIENCIES, AND HAS BEEN IMPLEMENTED IN OVER 85 COUNTRIES. THE IMPACT OF MICRONUTRIENT-FORTIFIED FOODS ON OTHER HEALTH OUTCOMES BEYOND MICRONUTRIENT DEFICIENCIES IS NEEDED TO FURTHER INFORM FORTIFICATION POLICIES AND GUIDELINES IN THE UNITED STATES AND GLOBALLY - AS ANY ADDITIONAL HEALTH BENEFITS FROM A PUBLIC HEALTH INTERVENTION COULD HAVE A SUBSTANTIAL IMPACT ON POPULATION HEALTH.DIETARY INTAKE OF KEY MICRONUTRIENTS PROVIDES SUBSTRATES THAT CAN BE USED BY THE GUT MICROBIOTA, COMPRISED OF BACTERIA, FUNGI, AND VIRUSES. NOT ONLY CAN THESE DIETARY SUBSTRATES MODIFY THE COMPOSITION OF MICROORGANISMS RESIDING IN THE HUMAN GUT, BUT THEY CAN ALSO INFLUENCE THEIR METABOLIC FUNCTION. PREVIOUS STUDIES HAVE EXPLORED THE IMPACT OF DIETARY INTERVENTIONS ON THE GUT MICROBIOME AMONG ADULTS IN HIGHER INCOME SETTINGS. HOWEVER, NO STUDIES TO DATE HAVE FOCUSED ON THE IMPACT OF CONSUMING MICRONUTRIENT-FORTIFIED FOODS AND NUTRITIONAL STATUS ON THE GUT MICROBIAL COMPOSITION, DIVERSITY, AND FUNCTION, AMONG WOMEN OF REPRODUCTIVE AGE.OUR RANDOMIZED CONTROLLED TRIAL AMONG 1,000 WOMEN OF REPRODUCTIVE AGE IN SOUTH INDIA, FUNDED BY THE CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC), REPRESENTS AN IDEAL OPPORTUNITY TO EVALUATE THE IMPACT OF MULTIPLE MICRONUTRIENT-FORTIFIED SALT ON THE GUT MICROBIOME (ESTIMATED DATE OF COMPLETION: MARCH 2023). THIS RANDOMIZED TRIAL WILL EXAMINE THE EFFICACY OF QUADRUPLE FORTIFIED SALT (QFS; IRON, IODINE, VITAMIN B12, FOLIC ACID, AND IODINE), COMPARED TO DOUBLE-FORTIFIED SALT (DFS; IRON, IODINE), USING A 2X2 FACTORIAL DESIGN, ON ANEMIA AND MICRONUTRIENT STATUS AMONG WOMEN OF REPRODUCTIVE AGE OVER A 12-MONTH PERIOD. WE PROPOSE TO ADD AN ASSESSMENT OF THE GUT MICROBIOME TO THE PARENT TRIAL DESIGN, WHICH IS A COST-EFFICIENT APPROACH TO ANSWER THE QUESTION: "DOES MULTIPLE MICRONUTRIENT-FORTIFIED SALT-- WITH IRON, IODINE, FOLIC ACID, AND VITAMIN B12--IMPACT THE COMPOSITION, DIVERSITY, AND FUNCTION OF THE GUT MICROBIOME OVER 12 MONTHS OF AD LIBITUM CONSUMPTION?'. WE AIM TO INCREASE OUR UNDERSTANDING OF THE LINKS BETWEEN AGRICULTURAL, NUTRITIONAL, AND DIETARY INPUTS AND THE GUT MICROBIOME IN WOMEN OF REPRODUCTIVE AGE (PRECONCEPTION) AND HELP IDENTIFY CRITICAL WINDOWS FOR INTERVENTION TO IMPROVE WOMEN'S HEALTH IN THE UNITED STATES AND GLOBALLY. WE HYPOTHESIZE THAT THE MULTIPLE MICRONUTRIENT-FORTIFIED INTERVENTION IN THIS TRIAL WILL IMPROVE THE COMPOSITION AND FUNCTION OF THE GUT MICROBIOME IN WOMEN OF REPRODUCTIVE AGE.THIS PROPOSAL, IN RESPONSE TO THE PRIORITY OF "FOOD SAFETY, NUTRITION, AND HEALTH", WILL ADDRESS THE CHALLENGES OF A GROWING DIVERSE POPULATION AND PERSISTING MICRONUTRIENT DEFICIENCIES USING FORTIFIED FOODS. THIS REPRESENTS A SUSTAINABLE SOLUTION FOR IMPROVING MICRONUTRIENT STATUS, INCLUDING HUMAN FOOD AND MICRONUTRIENT NEEDS. IN TERMS OF SUSTAINABILITY, FORTIFIED FOOD CAN BE PRODUCED BY LOCAL PRODUCERS, SUSTAINING THE ECONOMIC VIABILITY OF INDUSTRY OPERATIONS. FURTHER, FORTIFICATION IS COST-EFFECTIVE AND FORTIFIED FOODS SUCH AS SALT ARE AFFORDABLE, WIDELY CONSUMED, AND CAN BE INCORPORATED INTO EXISTING PRODUCTION AND DISTRIBUTION SYSTEMS.
$800,000Cornell University · · FY2022 · National Institute of Food and Agriculture
UKRI/BBSRC-NSF/BIO: Identifying, elucidating and reprogramming synthetic microbial communities for degradation of toxic chemicals: microfluidics enabled high-throughput approaches
$800,000Xiaoxia Lin · Regents Of The University Of Michigan - Ann Arbor · · FY2024 · BIO
Integrative Omics of HepB Vaccine Response in Co-Infection with Parasites
$800,000Elias K Haddad · Drexel University · U19 · FY2017 · AI
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** POLYPHENOL-RICH HASKAP BERRIES (HASKAP) HAVE UNTAPPED THERAPEUTIC POTENTIAL TO IMPROVE HUMANHEALTH, AND AGRICULTURAL PRODUCERS IN NORTHERN U.S. STATES ARE POISED TO INCREASE PRODUCTION IFCONSUMER DEMAND INCREASES. A CRITICAL KNOWLEDGE GAP IS THAT LITTLE IS KNOWN ABOUT THE INTERACTIONSBETWEEN GUT MICROBES AND HASKAP POLYPHENOLS TO PRODUCE BIOACTIVE METABOLITES LINKED TODOWNSTREAM HEALTH IMPACTS. ADDITIONALLY, WE NEED TO KNOW WHICH HASKAP VARIETIES AND HARVESTTIMING WILL YIELD THE GREATEST BIOACTIVE POTENTIAL. THE LONG-TERM GOAL OF THIS PROJECT IS TO FORM APARTNERSHIP LINKING THE HEALTH IMPACTS OF HASKAP VARIETIES AND MANAGEMENT PRACTICES THAT MAXIMIZEHEALTH-PROMOTING COMPOUNDS TO BENEFIT BOTH CONSUMERS AND PRODUCERS. OUR OBJECTIVES ARE TODETERMINE 1) THE IMPACT OF HASKAP ON THE GUT MICROBIOME AND METABOLOME, 2) HOW GUT MICROBIOMECOMPOSITION AND PRODUCTION OF BIOACTIVE METABOLITES FROM HASKAP IMPACTS HEALTH AND INFLAMMATIONBIOMARKERS, AND 3) WHICH HASKAP VARIETIES AND GROWING PRACTICES INCREASE PRODUCTION OF HEALTH-PROMOTING COMPOUNDS. A FOUR-ARMED, RANDOMIZED, TRIPLE-BLIND, PLACEBO CONTROLLED CLINICAL TRIAL OFHASKAP VERSUS PLACEBO FOR TWO SEPARATE GROUPS WITH DISTINCTLY LOW AND HIGH METABOLIC SYNDROMESTATUS WILL BE COMPLETED. PARTICIPANTS WILL BE ASSESSED FOR HEALTH BIOMETRICS, GUT MICROBIOMECOMPOSITION, INFLAMMATION, AND BOTH THE GUT AND SERUM METABOLOME BEFORE AND AFTER 8 WEEKS OFINTERVENTION. HASKAP FRUIT FROM TWENTY VARIETIES WILL PRIMARILY COME FROM THE RANDOMIZED BLOCKDESIGN FIELD TRIAL AND FRUIT WILL BE HARVESTED AT FOUR STAGES OF FRUIT MATURITY, THEN ANALYZED FORPOLYPHENOL CONTENT. THIS PART OF THE STUDY WILL BE REPLICATED OVER THREE GROWING SEASONS.
$800,000Montana State University · · FY2024 · National Institute of Food and Agriculture
Collaborative Research: MIM: Learning how mucus shapes and maintains microbiomes
$799,999Sujit S Datta · Princeton University · · FY2021 · BIO
Collaborative Research: MIM: Learning how mucus shapes and maintains microbiomes
$799,998Jessica L Mark Welch · Marine Biological Laboratory · · FY2021 · BIO
Nitrogen Fixing Prokaryotes in Corals: Is Nitrogen Fixation a Core Function of the Coral Microbiome?
$799,896Michael P Lesser · University Of New Hampshire · · FY2014 · GEO
Human Respiratory Tract Microbiome in Health, HIV Infection and HIV Lung Disease
$799,878Ronald G Collman · University Of Pennsylvania · U01 · FY2012 · HL
Genetic Control of Addiction by Host and Microbiome
$799,817George M Weinstock · Jackson Laboratory · U01 · FY2020 · DA
Collaborative Research: From cooperation to exploitation: context-dependent effects of nectar microbes on pollination mutualisms
$799,637Robert N Schaeffer · Utah State University · · FY2022 · BIO
Duke-UNC Prevention Epicenter Program for Prevention of Healthcare-Associated Infections
$799,513Deverick John Anderson · Duke University · U54 · FY2017 · CK
Dimensions: Collaborative Research: Processes that generate and maintain phylogenetic, genetic, and functional diversity of the freshwater mussel holobiont across multiple scales
$799,456Colin R Jackson · University Of Mississippi · · FY2018 · BIO
Is Obesity an Infectious Disease?: Gut bacterial and fungal translocation as an underappreciated driver of visceral adipose expansion.
$799,441Suzanne Devkota · Cedars-Sinai Medical Center · DP1 · FY2023 · DK
Impact of ocular microbiome, immune response and Chlamydiae on trachoma following MDA
$798,995Deborah Anne Dean · University Of California, San Francisco · R01 · FY2024 · AI
Impact of ocular microbiome, immune response and Chlamydiae on trachoma following MDA
$798,995Deborah Anne Dean · University Of California, San Francisco · R01 · FY2023 · AI
Role of mouse microbiome in cancer and inflammation
$798,983Giorgio Trinchieri · Division Of Basic Sciences - Nci · ZIA · FY2015 · CA
Structure-based microbially targeted prodrugs
$798,784Audrey Ragan Odom John · Children'S Hosp Of Philadelphia · R01 · FY2024 · AI
Influence of maternal virome and HIV status on infant gut virome, growth and immunity
$798,741Heather Beryl Jaspan · Seattle Children'S Hospital · R01 · FY2023 · HD
Dietary Etiologies of Heart Disease
$798,642Eric B Rimm · Harvard School Of Public Health · R01 · FY2018 · HL
B cell clonal selection in gut-associated germinal centers
$798,576Gabriel D Victora · Rockefeller University · R01 · FY2024 · AI
Gut Microbiome Effects on Brain and Behavior
$798,563Gene E Robinson · University Of Illinois At Urbana-Champaign · · FY2021 · BIO
Cervicovaginal microbiome, mucosal immunity, and pathogen factors that contribute to spontaneous clearance of Chlamydia trachomatis
$798,536Rebecca M. Brotman · University Of Maryland Baltimore · R01 · FY2022 · AI
Point of Care maternal milk concentration device to optimize neonatal growth with targeted nutrition support
$798,508Elizabeth Randall Nelson · Mother'S Milk Is Best, Inc. · R44 · FY2024 · HD
Trilateral FPP 2023: The role of the microbiome inproviding resilience to multi-stress environments
$798,450Eric Lam · Rutgers University New Brunswick · · FY2025 · BIO
METS-Sleep: Sleep timing, gut microbiota and cardiometabolic risk across the Epidemiologic Transition
$798,387Lara Ruth Dugas · Loyola University Chicago · R01 · FY2019 · HL