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1,049,261 grants matching “t cell”
Penn State: ABSL-3 Facility Construction
$14,830,000Mary J. Kennett · Pennsylvania State University, The · C06 · FY2010 · RR
COMMUNITY PROGRAMS FOR CLINICAL RESEARCH ON AIDS
$14,755,857Social And Scientific Systems, Inc. · U01 · FY2003 · AI
Center Driven Project
$14,731,483Stuart L Schreiber · Broad Institute, Inc. · U54 · FY2011 · HG
A multimodal brain cell atlas and community resource of Alzheimer's disease and comorbid dementias.
$14,713,224Ed Lein · Allen Institute · U19 · FY2025 · AG
WE PROPOSE THE CENTER FOR THE UTILIZATION OF BIOLOGICAL ENGINEERING IN SPACE (CUBES) TO SUPPORT BIOMANUFACTURING FOR DEEP SPACE EXPLORATION THAT REALIZES THE INHERENT MASS POWER AND VOLUME ADVANTAGES OF SPACE BIOTECHNOLOGY OVER TRADITIONAL ABIOTIC APPROACHES. CUBES WILL ADVANCE THE PRACTICALITY OF AN INTEGRATED MULTI-FUNCTION MULTI-ORGANISM BIOMANUFACTURING SYSTEM ON A MARS MISSION. HIGHLY MULTIDISCIPLINARY RESEARCH WILL CULMINATE IN A CONTINUOUS BIOMANUFACTURING DEMONSTRATION OF FUEL MATERIALS PHARMACEUTICALS AND FOOD. OUR TEAM CAN EXECUTE THIS VISION BECAUSE OF OUR DEEP EXPERIENCE IN HYBRID BIOINORGANICS FOR LIGHT-DRIVEN CARBON AND NITROGEN FIXATION ENZYMOLOGY POLYMER CHEMISTRY SYNTHETIC BIOLOGY EXTREMOPHILE ENGINEERING ADDITIVE MANUFACTURING AEROSPACE ENGINEERING PLANT/MICROBIOME FOOD AND CHEMICAL MANUFACTURE AND SPACE CROP PHYSIOLOGY. CUBES ENDEAVORS WILL INCLUDE (1) MEDIA GENERATION: ARTIFICIAL PHOTOSYNTHESIS THAT TURNS CARBON DIOXIDE INTO METHANE AND ACETATE; NITROGENASE-CATALYZED CONVERSION OF NITROGEN INTO AMMONIA AND CARBON DIOXIDE TO OTHER C1 COMPOUNDS; AMMONIA NITRIFICATION; REGOLITH DETOXIFICATION AND ENRICHMENT; RECYCLING MISSION MATERIALS; (2) FUEL PRODUCTION: THE AFOREMENTIONED METHANE; C2/C3 ALKANES; NITROUS OXIDE FROM NITRITE AND ACETATE; DIESELLIKE FUELS FROM RECYCLED INEDIBLE PLANT MASS; HYDRAZINE VIA ANAMMOX BACTERIA FROM AMMONIA; (3) BIOPOLYMER PRODUCTION USE AND RECYCLING: GENERATION FROM METHANE AND C1 SUBSTRATES; ADDITIVES PRODUCTION; TESTING IN ADDITIVE MANUFACTURING DEVICES; CHEMICAL/ BIOLOGICAL RECYCLING; (4) PROCESS ENGINEERING: OPTIMIZATION OF PLATFORM ORGANISMS FOR MAXIMAL YIELD AND TOLERANCE INCLUDING MESOPHILIC AND EXTREMOPHILE BIOPROCESSING IN NOVEL BIOREACTORS; PLATFORM CHEMICALS FOR DOWNSTREAM BIOLOGICAL PROCESSES; (5) PHARMACEUTICAL SYNTHESIS BY MICROBES AND PLANTS FOR ANALGESICS BONE REGENERATION AND ANTICANCER; (6) INCREASED FOOD PRODUCTION BY MICROBES AND PLANTS THROUGH SELECTION PLANT/MICROBE SYNERGIES IN RESTRICTED ROOT-ZONE VOLUMES GENETIC ENGINEERING PLANT-MICROBIOME ENHANCEMENT AND INNOVATIVE LIGHT DELIVERY SYSTEMS FOR PHOTOSYNTHESIS IN EFFICIENT SPACE-READY PLANT GROWTH CHAMBERS; (7) PLANT SYSTEM WASTE RECYCLING AND PLANT CELL WALL DECONSTRUCTION; AND (8) DEMONSTRATION SYSTEM INTEGRATION TESTING SEEDING AND INCORPORATION OF AUTONOMY. OUR INNOVATIONS INCLUDE: NOVEL ARTIFICIAL PHOTOSYNTHETIC SUBSTRATES COUPLED TO MICROBES AND ENZYMES TO EFFECTIVELY HARVEST LIGHT AND SPLIT WATER TO FIX BOTH CARBON DIOXIDE AND NITROGEN INTO CRITICAL FEEDSTOCKS FOR MICROBIAL AND PLANT BIOMANUFACTURING; THE DESIGN OF EFFECTIVE MICROBIAL COMMUNITIES AND BIOPROCESSING TECHNIQUES FOR A RANGE OF MICROBIALLY-PRODUCED PLASTICS WITH TUNABLE PROCESSING AND MECHANICAL PROPERTIES DERIVABLE FROM AVAILABLE FEEDSTOCKS AND RECYCLING MATERIALS; THE LEVERAGING OF A UNIQUE REPRODUCIBLE MARS ENVIRONMENT-SIMULATION CHAMBER TO EXPLORE THE BOUNDS OF OPERATION OF MESOPHILIC AND EXTREMOPHILIC MICROBES TO REDUCE COST FOR CONDITIONING IN MARS ENVIRONMENTS; CHARACTERIZING ENGINEERING AND OPTIMIZING DIVERSE NON-MODEL MICROBES THAT WILL SUPPORT BENEFICIAL PLANT PHENOTYPES; CUTTING-EDGE TECHNIQUES IN USING PLANTS AND INEDIBLE PLANT BIOMASS TO QUICKLY AND EFFICIENTLY PRODUCE IMPORTANT CLASSES OF HUMAN DRUGS THAT REQUIRE CHEMISTRIES UNAVAILABLE IN MICROBIAL CELLS; OPTIMIZED PLANTS AND PLANT GROWTH CHAMBERS THAT ADDRESS THE AVAILABILITY OF LIGHT STRESSORS AND ENERGY LIKELY TO BE ENCOUNTERED IN A DEEP SPACE CULTIVATION ENVIRONMENT; AND NOVEL COMPUTATION SYSTEMS TO CAPTURE MODEL ANALYZE TEST AND DISSEMINATE BIOLOGICAL DATA ACROSS CUBES INTEGRATED PROCESSES AND SUBSYSTEM MODULES. CUBES' INDIVIDUAL APPROACHES TO MEDIA PRODUCTION MISSION PRODUCT MANUFACTURE AND FOOD AND PHARMACEUTICAL SYNTHESIS AMPLIFIED BY A FOCUS ON INTEGRATION AND OPTIMIZATION WILL LEAD TO A STRONG DATA-DRIVEN TECHNOLOGICALLY-BACKED PLATFORM FOR SPACE BIOMANUFACTURING.
$14,703,923Regents Of The University Of California, The · · FY2017 · National Aeronautics and Space Administration
TAS::75 0872::TAS CENTER FOR TRANSLATIONAL CARDIOVASCULAR NANOMEDICINE
$14,615,641Gang Bao · Georgia Institute Of Technology · N01 · FY2010 · HL
RECOVERY ACT: DEMONSTRATING ECONOMIC & OPERATIONAL VIABILITY OF 72 - HOUR HYDROGEN PEM FUEL CELL SYS
$14,546,808Sprint Communications Co Lp · · FY2009 · Department of Energy
BRAIN CONNECTS: A Center for High-throughput Integrative Mouse Connectomics
$14,497,158Jeff W Lichtman · Harvard University · UM1 · FY2023 · NS
Human Tumor Atlas Network: Data Coordinating Center
$14,488,060Ethan Cerami · Dana-Farber Cancer Inst · U24 · FY2018 · CA
Development of immunology and immunization strategies that induce broadly pro
$14,471,516Dennis R. Burton · Scripps Research Institute, The · UM1 · FY2015 · AI
NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) FOR THE CENTRALIZED OMICS RESOURCE (CORE) - TASK AREAS 2, 3, AND 4
$14,460,421Michelle Rives · Baylor College Of Medicine · N02 · FY2023 · HL
NIH Chemical Genomics Center
$14,448,955John McKew · National Center For Advancing Translational Sciences · ZIB · FY2013 · TR
CORE SUPPORT FOR THE IMMUNE CELL NETWORK
$14,407,995Ethan Dmitrovsky · Leidos Biomedical Research, Inc. · N01 · FY2024 · CA
Laboratory Support Services
$14,403,483Sophia Siddiqui · National Institute Of Allergy And Infectious Diseases · ZID · FY2017 · AI
NYU Materials Research Science and Engineering Center
$14,400,000Marcus Weck · New York University · · FY2014 · MPS
Leadership for HIV/AIDS Clinical Trials Networks; HIV Vaccine Trials Network
$14,380,617Steven G. Self · Fred Hutchinson Cancer Research Center · U01 · FY2008 · AI
Microbicide Trials Network
$14,379,710Sharon L Hillier · Magee-Women'S Res Inst And Foundation · U01 · FY2009 · AI
Access for All in ALS (ALL ALS) East Clinical Coordinating Center
$14,357,590James Dale Berry · Massachusetts General Hospital · OT2 · FY2025 · NS
Microbicide Trials Network
$14,315,989Sharon L Hillier · Magee-Women'S Res Inst And Foundation · UM1 · FY2012 · AI
The Comprehensive Center for Chemical Probe Discovery and Optimization at Scripps
$14,274,738Hugh Rosen · Scripps Research Institute, The · U54 · FY2008 · MH
A Data Center for the Discovery of the Genetic Basis of Human Disease
$14,273,023Larry J Shapiro · Washington University · C06 · FY2010 · RR
Broad Institute Comprehensive Screening Center
$14,247,691Stuart L Schreiber · Broad Institute, Inc. · U54 · FY2010 · HG
A Comprehensive Center for Mouse Brain Cell Atlas
$14,138,795Z Josh Huang · Cold Spring Harbor Laboratory · U19 · FY2017 · MH
Center for Multiomic Human Brain Cell Atlas
$14,108,251Joseph R Ecker · Salk Institute For Biological Studies · UM1 · FY2023 · MH
IDENTIFYING PATHOGENIC BACTERIA BY PHENOTYPING INDIVIDUAL CELLS
$14,100,582President And Fellows Of Harvard College · · FY2019 · Department of the Army