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24,576 grants matching “microbiome”
Identification and Characterization of Microbial Metabolites in Immunity
$789,624Ramnik J Xavier · Broad Institute, Inc. · R01 · FY2025 · AI
Targeting microbial triggers of gammopathy for immunoprevention
$789,579Madhav V Dhodapkar · Emory University · UG3 · FY2024 · CA
MOM2CHild Study: Leveraging systems biology toward discoveries in Maternal Obesity, Milk, and Translation To Child Health
$789,533Ardythe L. Morrow · University Of Cincinnati · R01 · FY2022 · HD
MicroRNA Predictors of HIV Risk in Reproductive Age Women
$789,436Raina N Fichorova · Brigham And Women'S Hospital · R01 · FY2023 · HD
Pathogenesis of Obstruction/Emphysema and the Microbiome (POEM) in HIV
$789,423Alison Morris · University Of Pittsburgh At Pittsburgh · U01 · FY2010 · HL
Characterization of the cellular and molecular bases of inborn errors of immunity
$789,400Luigi Notarangelo · National Institute Of Allergy And Infectious Diseases · ZIA · FY2025 · AI
Complex Autonomic Neuropathic Dysfunction Leading to Gastrointestinal and Immune Effects in People with HIV (CANDLE)
$789,126Jessica Robinson-Papp · Icahn School Of Medicine At Mount Sinai · R01 · FY2025 · DK
Impact of the Intestinal Microbiome on HIV/SIV Vaccines
$789,065Herbert W Virgin · Washington University · R01 · FY2018 · OD
Identifying Influenza Virus Infection Severity and Outcome Signatures Through Artificial Intelligence-driven Analyses
$788,942Christopher L. Dupont · J. Craig Venter Institute, Inc. · R01 · FY2022 · AI
Microbiome-mediated therapies for aging and healthspan in marmosets
$788,918Corinna Nicole Ross · Texas Biomedical Research Institute · R01 · FY2020 · AG
Project 2: Informing oral nicotine pouch regulations to promote public health
$788,839Brittney L Keller-Hamilton · Ohio State University · U54 · FY2024 · CA
Impact of the Intestinal Microbiome on HIV/SIV Vaccines
$788,705Megan T Baldridge · Washington University · R01 · FY2020 · OD
Development of Engineered Native Bacteria as a Tool for Functional Manipulation of the Gut Microbiome
$788,553Amir Zarrinpar · University Of California, San Diego · R01 · FY2023 · AI
Prenatal Origins of Asthma
$788,512Carole Ober · University Of Chicago · R01 · FY2017 · HL
Prenatal Origins of Asthma
$788,512Carole Ober · University Of Chicago · R01 · FY2016 · HL
Maternal-infant Virome Transmission: the role of HIV and Antiretroviral Therapy
$788,509Dara Ann Lehman · Fred Hutchinson Cancer Research Center · R01 · FY2018 · HD
Incremental effect of smoking on HIV immune activation and cardiac health
$788,433Grace A McComsey · Case Western Reserve University · R56 · FY2014 · HL
Engineered Living Materials for the Delivery of Engineered Probiotics and Therapeutics
$788,387Taylor H Ware · Texas Engineering Experiment Station · R56 · FY2022 · EB
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** BIOFORTIFICATION IS THE PROCESS OF INCREASING THE NUTRITIONAL VALUE OF THE FOODS THAT WE EAT. VITAMIN A AND ZINC ARE ESSENTIAL MICRONUTRIENTS THAT THE WORLD HEALTH ORGANIZATION CONSIDERS TO BE SHORT-FALL NUTRIENTS. THIS PROPOSAL SEEKS TO DEVELOP AND EVALUATE THE EFFICACY OF CONVENTIONALLY BRED BIOFORTIFIED ORANGE CORN (MAIZE) WITH HIGH PROVITAMIN A CAROTENOIDS AND ZINC TO IMPROVE HUMAN NUTRITION. THE MAIN OBJECTIVES OF THIS PROPOSAL ARE TO: 1) SELECT AND EVALUATE MAIZE GERMPLASM FOR INCREASED PROVITAMIN A AND ZINC IN MEXICO AND THE US; 2) DETERMINE THE INFLUENCE OF SS-CRYPTOXANTHIN-BIOFORTIFIED MAIZE ON ZINC BIOAVAILABILITY TO HEN EGGS COMPARED WITH SS-CAROTENE-BIOFORTIFIED MAIZE AND TEST BIOEFFICACY OF THE BIOFORTIFIED MAIZE AND THE NUTRITIONALLY-ENHANCED EGGS IN MONGOLIAN GERBILS; AND 3) ULTIMATELY TEST THE SELECTED HIGH CAROTENOID/ZINC VARIETY IN A BIOEFFICACY INTERVENTION STUDY IN MEXICAN SCHOOLCHILDREN. WE WILL EVALUATE THE INFLUENCE OF THE NUTRITIONALLY ENHANCED MAIZE ON THE MICROBIOME PROFILE IN THE CHILDREN CONSUMING THE BIOFORTIFIED MAIZE VERSUS A TYPICAL MAIZE. THE TWO MODEL ANIMALS (HENS AND GERBILS) WILL DEMONSTRATE PROOF-OF-CONCEPT FOR ENHANCED HUMAN NUTRITION PRIOR TO ORCHESTRATING THE HUMAN INTERVENTION STUDY IN MEXICO. THIS PROPOSAL ALIGNS WITH THE IMPROVEMENT OF THE NUTRITIONAL PROFILE OF MAIZE AND HEN EGGS AS MORE NUTRITIOUS FOOD FOR HUMAN CONSUMPTION. THIS US-MEXICO PARTNERSHIP ENCOMPASSES A SOIL-TO- MAIZE-TO-ANIMAL-TO-HUMAN APPROACH TO MEET THE GLOBAL DEMAND FOR NUTRITIOUS FOODS, WHICH IS INCLUDED AS PART OF THE US GOVERNMENT GLOBAL FOOD SECURITY STRATEGY AND THE UNITED NATION'S SUSTAINABLE DEVELOPMENT GOALS.
$788,000University Of Wisconsin System · · FY2023 · National Institute of Food and Agriculture
PROSPECT-Global Consortium and Risk Factor Discovery
$787,947Yin Cao · Washington University · OT2 · FY2024 · CA
Determination of mucosal immune responses to, and infection of the gastrointestinal tract by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)
$787,826Saurabh Mehandru · Icahn School Of Medicine At Mount Sinai · R01 · FY2020 · DK
Developing novel inhibitors of the gut microbiome to modulate drug metabolism
$787,689Bret David Wallace · Symberix, Inc. · R44 · FY2021 · TR
Designer Probiotics for the treatment of intestinal infection and inflammation
$787,620Cammie Lesser · Massachusetts General Hospital · R01 · FY2016 · DK
Diet transformation by the microbiome and its impact on bacterial infection
$787,588Andrew L Goodman · Yale University · R01 · FY2024 · DK
Vibrio cholerae antinitrosative stress defenses and gut microbiome interaction
$787,536Jun Zhu · University Of Pennsylvania · R01 · FY2023 · AI