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17,054 grants matching “genome editing”
REGULATION OF HEMATOPOIETIC PROGENITORS BY DE NOVO DNA METHYLATION
$647,536Margaret Goodell · Baylor College Of Medicine · R01 · FY2023 · DK
Additional Tool Development or Data Generation
$647,395David M Gilbert · University Of Illinois At Urbana-Champaign · U54 · FY2018 · DK
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THIS PROJECT IS DESIGNED TO ADVANCE DEVELOPMENT OF A NOVEL BREEDING TOOL IN CATTLE PRODUCTION, REFERRED TO AS SURROGATE SIRES. THE ENVISIONED IMPACT IS PROVIDING NEW OPPORTUNITY FOR ENHANCING TRAITS RELATED TO THE GENERATION OF FOODSTUFFS FOR HUMAN CONSUMPTION. THROUGH USE OF GENOME EDITING AND STEM CELL TRANSPLANTATION, THE PROJECT WILL GENERATE BULLS THAT LACK THE ABILITY TO MAKE THEIR OWN SPERM AND OPTIMIZE METHODOLOGY TO TRANSFER SPERM PRODUCING STEM CELLS ISOLATED FROM ANOTHER MALE INTO THEIR TESTICLES. THE ENVISIONED OUTCOME IS THAT SURROGATE RECIPIENT BULLS WILL GENERATE SPERM POSSESSING THE DONOR MALE'S GENETICS AT A LEVEL THAT ENDOWS THEM WITH NATURAL FERTILITY. BECAUSE SPERM ARE THE CONDUIT FOR TRANSMISSION OF A MALE'S GENETICS AND MILLIONS ARE PRODUCED DAILY, REFINEMENT OF SURROGATE SIRES METHODOLOGY WOULD PROVIDE A TOOL FOR EFFICIENT DISSEMINATION OF SELECT GENETIC INFORMATION INTO CATTLE POPULATIONS ON A WORLDWIDE SCALE.
$647,341Washington State University · · FY2023 · National Institute of Food and Agriculture
Profiling the alcohol-naive primate cortex to understand the functional role of epigenetics in predisposing the brain to risky alcohol use
$647,330Rita P Cervera Juanes · Wake Forest University Health Sciences · R01 · FY2025 · AA
A Reduced Complexity Cross in BALB/c substrains to identify the genetic basis of oxycodone dependence phenotypes
$647,133Camron D Bryant · Boston University Medical Campus · U01 · FY2021 · DA
Probing the role of SORL1 and endosomal network genetic variation on Alzheimer's disease phenotypes in human neurons.
$647,038Jessica Elaine Young · University Of Washington · R01 · FY2020 · AG
Probing the role of SORL1 and endosomal network genetic variation on Alzheimer's disease phenotypes in human neurons.
$647,038Jessica Elaine Young · University Of Washington · R01 · FY2021 · AG
Probing the role of SORL1 and endosomal network genetic variation on Alzheimer's disease phenotypes in human neurons.
$647,038Jessica Elaine Young · University Of Washington · R01 · FY2022 · AG
Project 2: Normal Cell Evolution
$646,999Darryl K Shibata · Arizona State University-Tempe Campus · U54 · FY2019 · CA
In Vivo Base Editing for Precision Oncology Models
$646,960Lukas Edward Dow · Weill Medical Coll Of Cornell Univ · R01 · FY2019 · CA
A system approach to the analysis of Heterotaxy Candidate Genes
$646,936Mustafa K Khokha · Yale University · R01 · FY2020 · HD
Probing the role of SORL1 and endosomal network genetic variation on Alzheimer's disease phenotypes in human neurons.
$646,886Jessica Elaine Young · University Of Washington · R01 · FY2019 · AG
Project 2: Therapeutic Gene Editing for Friedreich's Ataxia
$646,641David R Liu · Jackson Laboratory · U19 · FY2023 · NS
Drug Screening with a Biofrabricated 3-D Immunocompetent Skin Model for Drug Discovery in Psoriatic Disease
$646,512Angela M Christiano · Columbia University Health Sciences · U18 · FY2020 · TR
Unraveling the molecular pathology of retinal degeneration through single cell genomics
$646,507Radha Ayyagari · University Of California, San Diego · R01 · FY2022 · EY
Transgenic marmosets for translational stem cell research
$646,429Thaddeus G Golos · University Of Wisconsin-Madison · R24 · FY2015 · OD
Site-specific Integration of Large (10-100 kb) DNA Constructs into the Mouse Genome and Human Induced Pluripotent Stem Cells Using the Cas9-Bxb1 Integrase Toolbox
$646,321Vishnu Hosur · Jackson Laboratory · R01 · FY2022 · CA
Ocular Gene Therapy
$646,258Zhijian Wu · National Eye Institute · ZIA · FY2019 · EY
Gene editing in the brain with CRISPR-PEG
$646,076Hye Young Lee · University Of Texas Hlth Science Center · R01 · FY2022 · MH
Gene therapy for glycogen storage disease type III
$646,060Baodong Sun · Duke University · R01 · FY2024 · AR
Structure-Function Analysis of Mxra8 Interaction with Alphaviruses.
$646,002Michael S. Diamond · Washington University · R01 · FY2021 · AI
A Gene-Network Discovery Approach to Structural Brain Disorders
$645,930Angeliki Louvi · Yale University · R01 · FY2025 · HD
Data Coordinating Center, Microbiome of the Lung and Respiratory Tract
$645,926Mary A Foulkes · George Washington University · U01 · FY2009 · HL
In vivo engineering of B cells for the secretion of HIV broadly neutralizing antibodies
$645,746James Even Voss · Scripps Research Institute, The · R01 · FY2022 · AI
Systematic Genetic Dissection of Human Erythropoiesis
$645,733Vijay Ganesh Sankaran · Boston Children'S Hospital · R01 · FY2025 · DK