Sort
17,054 grants matching “genome editing”
Systematic Genetic Dissection of Human Erythropoiesis
$645,733Vijay Ganesh Sankaran · Boston Children'S Hospital · R01 · FY2024 · DK
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** CITRUS IS ONE OF THE MOST IMPORTANT FRUIT CROPS IN THE U.S. AND IN THE WORLD WITH MANY CULTIVATED VARIETIES. THE PRODUCTION OF CITRUS IN THE U.S. HAS BEEN DEVASTED BY THE BACTERIAL DISEASES HUANGLONGBING (HLB), AND TO SOME EXTENT BY CITRUS CANKER. WE HAVE GENERATED MULTIPLE CITRUS GENOME-EDITED LINES TARGETING SIX SELECTED HOST PLANT SUSCEPTIBILITY (S) GENES TO ACHIEVE RESISTANCE AGAINST THESE DEVASTATING BACTERIAL DISEASES. BECAUSE COMMERCIAL CITRUS HAS TO BE CLONALLY PROPAGATED, GENE-EDITED CITRUS PLANTS WILL HAVE STABLY INCORPORATED CRISPR REAGENTS IN THEIR GENOMES THROUGH GENERATIONS. THIS INDICATES THAT THERE IS A POSSIBILITY OF CONTINUED CRISPR ACTIVITY AFFECTING BOTH GENOTYPE AND PHENOTYPE OF GENE-EDITED CITRUS LINES. THEREFORE, RISK-ASSESSMENT OF GENE-EDITING TECHNOLOGY FOR ENGINEERING CITRUS SPECIES IS IMPERATIVE TO MEET THE URGENT NEED FROM THE U.S. CITRUS INDUSTRY. WE PROPOSE TO PERFORM COMPREHENSIVE EVALUATION OF GENOME-WIDE OFF TARGET EFFECTS AND ASSOCIATED PHENOTYPES IN THESE CITRUS GENE-EDITED LINES COMPARED TO NON-MODIFIED CONTROLS IN FIELD STUDIES. FURTHER, WE WILL ALSO EVALUATE THE STABILITY OF EDITS AND PHENOTYPES OVER MULTIPLE YEARS UNDER FIELD CONDITIONS. THE RESULTS FROM THIS PROJECT WILL PROVIDE CITRUS GERMPLASM TO COMBAT BACTERIAL DISEASES AND ASSIST REGULATORY AGENCIES TO EFFECTIVELY AND COMPREHENSIVELY ASSESS THE RISKS OF GENE-EDITING IN CITRUS AT BOTH GENOTYPIC AND PHENOTYPIC LEVELS.
$645,674University Of Florida · · FY2024 · National Institute of Food and Agriculture
Genomics of bone and body composition traits in children
$645,621Babette S Zemel · Children'S Hosp Of Philadelphia · R01 · FY2024 · HD
Mechanistic Insight to Predict and Prevent Nilotinib-Induced Artery Disease
$645,460Paul W. Burridge · Northwestern University At Chicago · R01 · FY2025 · CA
Genetic Repair of Familial Hypercholesterolemia
$645,390William Raymond Lagor · Baylor College Of Medicine · R01 · FY2019 · HL
Genetic Repair of Familial Hypercholesterolemia
$645,390William Raymond Lagor · Baylor College Of Medicine · R01 · FY2021 · HL
Genetic Repair of Familial Hypercholesterolemia
$645,390William Raymond Lagor · Baylor College Of Medicine · R01 · FY2020 · HL
Mechanisms governing the differentiation and maintenance of atrial identity
$645,215Joshua Waxman · Cincinnati Childrens Hosp Med Ctr · R01 · FY2023 · HL
Probing the role of SORL1 and endosomal network genetic variation on Alzheimer's disease phenotypes in human neurons.
$645,205Jessica Elaine Young · University Of Washington · R01 · FY2018 · AG
Implementing genomic medicine in clinical care of deaf patients
$645,005Xue Z Liu · University Of Miami School Of Medicine · R01 · FY2019 · DC
Molecular Genetics on Non Syndromic Hearing Loss (NSHL)
$644,918Xue Z Liu · University Of Miami School Of Medicine · R01 · FY2024 · DC
Project 2: Therapeutic Gene Editing for Friedreich's Ataxia
$644,886David R Liu · Jackson Laboratory · U19 · FY2024 · NS
In Vivo Hematopoietic Stem Cell Gene Therapy of Beta-Thalassemia and Sickle Cell Disease
$644,784Andre Michael Lieber · University Of Washington · R01 · FY2024 · HL
Epigenetics and 3D structure of miR-10b/HoxD locus in the brain and malignant glioma.
$644,662Anna M. Krichevsky · Brigham And Women'S Hospital · R01 · FY2020 · NS
Endothelial Cell Reprogramming in Familial Intracranial Aneurysm
$644,585Murat Gunel · Yale University · R01 · FY2024 · NS
Decoding schizophrenia-From GWAS to functional regulatory variants
$644,580Gregory E Crawford · Duke University · R01 · FY2016 · MH
Epigenomic Reprogramming in Patient Derived Models of Colorectal Cancer
$644,430Xiling Shen · Duke University · U01 · FY2020 · CA
Gene-by-environment interactions that affect exposure-mediated congenital heart disease
$644,317John Andrew Whitehead · University Of California At Davis · R01 · FY2021 · ES
Lentiviral Gene Therapy and Genome Editing for Wiskott-Aldrich Syndrome
$644,283David J Rawlings · St. Jude Children'S Research Hospital · P01 · FY2018 · HL
Structure, function, and mechanobiology of a compression-sensitive cell-cell junction
$644,180Christopher S Chen · Boston University (Charles River Campus) · R01 · FY2025 · HL
Mitochondrial DNA, Nuclear DNA Methylation, and Cardiometabolic Disease Traits
$644,109Chunyu Liu · Boston University Medical Campus · R01 · FY2021 · HL
Project 2: Therapeutic Gene Editing for Friedreich's Ataxia
$644,059David R Liu · Jackson Laboratory · U19 · FY2025 · NS
The Role of Non-Vesicular Lipid Transport at ER-PM Contact Sites in Phosphoinositide Signaling in Early Dendrite Development
$644,008Maya Shelly · State University New York Stony Brook · R01 · FY2025 · NS
CORE C Technology Implementation/Development and Correlative Sciences
$644,007Friederike Herbst-Nowrouzi · University Of Pennsylvania · P01 · FY2023 · CA
Functional Genomics of LINE-1 Retrotransposition
$643,873Kenneth S Ramos · Texas A&M University Health Science Ctr · R01 · FY2022 · ES