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38,696 grants matching “als”
Optimizing the graft versus leukemia effect for pediatric ALL
$846,887Terry Fry · Division Of Basic Sciences - Nci · ZIA · FY2012 · CA
Signal Transduction Events and the Regulation of Cell Growth
$846,744Jane B Trepel · Division Of Clinical Sciences - Nci · ZIC · FY2015 · CA
Novel Neuroprotective Roles for the Alzheimer's Disease Risk Gene SORLA in Tau Pathology and Pathogenesis
$846,520Timothy Yikai Huang · Sanford Burnham Prebys Medical Discovery Institute · R01 · FY2025 · AG
WE PROPOSE TO PERFORM MAGNETOHYDRODYNAMIC (MHD) SIMULATIONS OF CORONAL MASS EJECTIONS (CMES) IN THE CORONA USING OBSERVATIONS OF THE PHOTOSPHERIC MAGNETIC FIELDS AS INPUT. THE GOAL IS TO DETERMINE THE CORONAL MAGNETIC FIELD EVOLUTION OF THE CME EVENTS FROM THE QUASI-STATIC BUILD-UP TO THE DYNAMIC ERUPTION AND TO ASCERTAIN THE PROPERTIES OF THE ERUPTION SUCH AS ACCELERATION SPEED AND DIRECTION THROUGH THE LOWER SOLAR CORONA INTO THE SOLAR WIND. THE VALIDITY OF THE SIMULATED MAGNETIC FIELD EVOLUTION WILL BE EXAMINED BY COMPARING WITH CORONAL MULTI-WAVELENGTH OBSERVATIONS OF SELECTED EVENTS OBSERVED BY SDO/AIA SOHO/LASCO STEREO AND MAUNA LOA SOLAR OBSERVATORY (MLSO). THE MAIN SCIENTIFIC QUESTIONS WE WANT TO ADDRESS ARE: (1) WHAT ARE THE OBSERVATIONAL SIGNATURES THAT ARE INDICATIVE OF THE BUILD-UP OF A MAGNETIC FLUX ROPE AND READINESS FOR ERUPTION? (2) WHAT ARE THE CONDITIONS THAT LEAD TO CONFINED VS. EJECTIVE ERUPTIONS AND WHAT ARE THE CRUCIAL FACTORS THAT DETERMINE THE ACCELERATION TERMINAL SPEED AND ORIENTATION OF THE MAGNETIC FIELD IN THE OUT-GOING CMES? (3) WHAT ARE THE CONDITIONS THAT CAN LEAD TO THE DEVELOPMENT OF HOMOLOGOUS AND CANNIBALISTIC CMES AND HOW DO THEIR INTERACTIONS AFFECT THE CME SPEED SHOCKS AND MAGNETIC FIELD STRUCTURES. WE WILL USE THE MAGNETIC FLUX ERUPTION (MFE) MHD CODE (FAN 2012 2016 2017) TO CARRY OUT THE SIMULATIONS OF CME INITIATION IN THE LARGE-SCALE CORONA DRIVEN BY AN IMPOSED FLUX TRANSPORT AT THE BASE OF THE CORONA. FOR THE IMPOSED FLUX TRANSPORT WE WILL FIRST EXPERIMENT WITH PRESCRIBING THE EMERGENCE OF IDEALIZED TWISTED MAGNETIC FLUX ROPES WHOSE PROPERTIES ARE GUIDED BY THE OBSERVED FLUX EMERGENCE PATTERNS (E.G. FAN 2016) AND THEN WE WILL USE THE ELECTRIC FIELD DIRECTLY INFERRED FROM TIME SEQUENCES OF VECTOR MAGNETOGRAMS FROM SDO/HMI (KAZACHENKO ET AL. 2014 2015). THE MFE CODE SOLVES THE SEMI-RELATIVISTIC MHD EQUATIONS IN A SPHERICAL DOMAIN WITH THE THERMODYNAMICS TAKING INTO ACCOUNT THE ESSENTIAL NON ADIABATIC EFFECTS OF THE CORONA AND TRANSITION REGION INCLUDING AN EMPIRICAL CORONAL HEATING OPTICALLY THIN RADIATIVE COOLING AND FIELD-ALIGNED THERMAL CONDUCTION (FAN 2017). WE WILL CONSTRUCT SYNTHETIC EUV AND X-RAY IMAGES AS WELL AS CORONAGRAPH WHITE LIGHT IMAGES FROM OUR SIMULATIONS OF THE CME SOURCE REGIONS AND ERUPTIONS AND COMPARE THEM WITH SDO/AIA SOHO/LASCO STEREO AND MLSO/KCOR OBSERVATIONS OF THE SIMULATED EVENTS. THE PROPOSED STUDY WILL DIRECTLY CONTRIBUTE TO THE GOALS OF THE FOCUSED SCIENCE TEAM EFFORT ON THE FOCUSED SCIENCE TOPICS OF "UNDERSTANDING THE ONSET OF MAJOR SOLAR ERUPTIONS". OUR PROJECT INTEGRATES NUMERICAL SIMULATIONS WITH OBSERVATIONAL SYNTHESIS TO INTERPRET OBSERVATIONS OF CME EVENTS FOR BOTH THE BUILD-UP PHASE AND THE DYNAMIC ERUPTION PHASE. OUR OBSERVATIONALLY GUIDED MHD SIMULATIONS TO DETERMINE THE REALISTIC CORONAL MAGNETIC FIELD EVOLUTIONS OF THE CME EVENTS WILL (1) IMPROVE OUR UNDERSTANDING OF THE CONDITIONS FOR THE READINESS FOR ERUPTION AND IDENTIFY THEIR OBSERVATIONAL SIGNATURES; (2) QUANTIFY THE BUILD-UP OF FREE MAGNETIC ENERGY AND DETERMINE THE CORONAL MAGNETIC FIELD EVOLUTION OF CME SOURCE REGIONS GIVEN PHOTOSPHERIC MAGNETIC FIELD OBSERVATIONS; (3) IMPROVE OUR ABILITY TO DETERMINE THE VELOCITY AND MAGNETIC FIELD STRUCTURE OF THE OUTGOING CMES NEEDED TO IMPROVE SPACE WEATHER FORECASTS. METRICS AND MILESTONES FOR DETERMINING THE SUCCESSFUL PROGRESS AND OUTCOME OF THE RESEARCH INCLUDE REFEREED PUBLICATIONS ON RESULTS OF SIMULATIONS THAT PROVIDE PHYSICAL UNDERSTANDING AND INTERPRETATION OF THE OBSERVED SIGNATURES OF THE CME EVENTS. THE ABILITY FOR OUR OBSERVATIONALLY GUIDED SIMULATIONS TO REPRODUCE THE OBSERVED ERUPTIVE BEHAVIOR FIRST QUALITATIVELY AND THEN QUANTITATIVELY (E.G. THE SPEED DIRECTION AND MORPHOLOGY OF THE CMES) WILL BE THE MILESTONES AND MEASURE OF SUCCESS OF OUR PROJECT.
$846,133University Corporation For Atmospheric Research · · FY2020 · National Aeronautics and Space Administration
Implementation of Medical Marijuana and its Impact on Health
$846,053Rosalie Pacula · Rand Corporation · R01 · FY2011 · DA
Diabetes and Periodontics Trial - Coordinating Center
$846,038Leslie G. Hyman · State University New York Stony Brook · U01 · FY2012 · DE
Pathogenesis of Neurological Disability in Primary Diseases of Myelin
$845,598Bruce D Trapp · Cleveland Clinic Lerner Com-Cwru · R35 · FY2024 · NS
FitMi VNS: The First Automated Home Therapy System for Exercise-Paired Vagus Nerve Stimulation After Stroke
$845,369Nizan Friedman · Flint Rehabilitation Devices · U44 · FY2022 · NS
III. Investigation of the ABC Half-Transporter ABCG2
$845,208Susan Bates · Basic Sciences · Z01 · FY2007 · CA
Host Immune Responses to Antigens of Malaria Parasites
$845,075Carole Long · National Institute Of Allergy And Infectious Diseases · ZIA · FY2017 · AI
Project 2: Maximizing Retailers' Responsiveness to FDA Regulatory Autho p209-264
$845,063Jonathan M. Samet · University Of Southern California · P50 · FY2013 · CA
Subcellular Compartmentilization of Neuronal Gene Expression
$844,318Barry Kaplan · National Institute Of Mental Health · ZIA · FY2012 · MH
Systems modeling of shared and distinct molecular mechanisms underlying comorbid Major Depressive Disorder and Alzheimer's disease
$843,557Stephen R Salton · Icahn School Of Medicine At Mount Sinai · R01 · FY2019 · AG
BASE:PREVENT PRECLINICAL DRUG DEVELOPMENT PROGRAM: PRECLINICAL EFFICACY&INTERMEDIATE BIOMARKERS TASK ORDER: TARGETING STAT3 TO PREVENT HEPATOCELLULAR
$843,496David Tweardy · University Of Tx Md Anderson Can Ctr · N01 · FY2020 · CA
Do Early Maternal Antibodies Facilitate Oral Transmission of HIV in Infants?
$843,374Ruth Margrit Ruprecht · Dana-Farber Cancer Inst · R01 · FY2012 · DE
Reducing Youth Violence and Racism/Discrimination: The Efficacy of Comprehensive Prevention Strategies (CPS)
$843,348Sara McDaniel · University Of Alabama In Tuscaloosa · R01 · FY2022 · MD
Ultra-processed Foods, Diet Quality, and Cardiometabolic Health: An Inter-disciplinary Trans-Atlantic Collaborative Project
$843,047Qi Sun · Harvard University D/B/A Harvard School Of Public Health · R01 · FY2025 · DK
Systems modeling of shared and distinct molecular mechanisms underlying comorbid Major Depressive Disorder and Alzheimer's disease
$842,983Stephen R Salton · Icahn School Of Medicine At Mount Sinai · R01 · FY2022 · AG
Systems modeling of shared and distinct molecular mechanisms underlying comorbid Major Depressive Disorder and Alzheimer's disease
$842,983Stephen R Salton · Icahn School Of Medicine At Mount Sinai · R01 · FY2020 · AG
Mechanisms of SIV suppression by CD8+ lymphocytes
$842,716Guido Silvestri · Emory University · R01 · FY2010 · AI
METAL (CU,AL)/CNT COMPOSITE WIRES FOR ENERGY EFFICIENT MOTORS
$842,497The University Of Central Florida Board Of Trustees · · FY2017 · Department of Energy
The study of stem cell and neuro-vascular development
$842,408Yosuke Mukouyama · National Heart, Lung, And Blood Institute · ZIA · FY2022 · HL
NIEHS Statistical Consulting Service
$842,252Shyamal Peddada · National Institute Of Environmental Health Sciences · ZIA · FY2011 · ES
Skin biomarkers for diagnosing and characterizing AD and ADRD
$842,164Allison L Kraus · Case Western Reserve University · R01 · FY2021 · AG
Early Life Air Pollution Exposures as a Risk Factor for Neurodevelopmental Disorders
$842,086Deborah A Cory-Slechta · University Of Rochester · R35 · FY2024 · ES