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16,300 grants matching “fatty liver disease”
PULSE CONSUMPTION, THE GUT MICROBIOME, AND HUMAN HEALTH: USING PRECLINICAL MODELS TO CONDUCT A PROOF-IN-CONCEPT INVESTIGATIONTHIS PROJECT WILL INVESTIGATE WHETHER PULSE CONSUMPTION INDUCES FUNCTIONAL DIFFERENCES IN GUT MORPHOLOGY, GUT BARRIER INTEGRITY, AND/OR METABOLIC PROCESSES (ENDOTOXEMIA AND INFLAMMATION) THAT IMPACT HEALTH RELATED OUTCOMES, SUCH AS FATTY LIVER DISEASES, OBESITY. TYPE-2 DIABETES, AND CARDIOVASCULAR DISEASE IS THE FOCUS OF THE WORK PROPOSED IN THIS APPLICATION. AIM 1. DETERMINE THE EFFECT OF PULSE CONSUMPTION ON THE DISTRIBUTION OF MICROORGANISMS WITHIN MULTIPLE INTESTINAL COMPARTMENTS, I.E., IN THE LUMEN, BIOFILM ADHERING MUCOUS LAYER, AND ENTEROCYTES, IN ILEUM COLON AND IN STOOL. THERE IS LIMITED UNDERSTANDING OF THE IMPACT OF A SPECIFIC TYPE OF FOOD ON INTERRELATIONSHIPS WITHIN THESE COMPARTMENTS ACROSS INTESTINAL SEGMENTS. AIM 2. EVALUATE THE IMPACT OF PULSE CONSUMPTION ON THE META-METABOLOME (I.E., THE METABOLITES PRODUCED BY THE MICROBIOME) AND THE HOST'S METABOLOME. EMERGING EVIDENCE SHOWS A LARGE LIBRARY OF COMPOUNDS IS PRODUCED BY THE GUT MICROBIOME. IDENTIFICATION OF THE COMPOUNDS PRODUCED BY THE PULSE-ASSOCIATED MICROBIOME AND HOW THAT CORRESPONDS WITH CHANGES IN THE HOST METABOLOME WILL BE UNDERTAKEN. AIM 3. INVESTIGATE WHETHER PULSES ALTER GUT FUNCTIONALITY: BARRIER INTEGRITY AND ENDOTOXEMIA / INFLAMMATION. A THIRD AREA OF THE FOOD-FIBER-GUT HEALTH FIELD THAT HAS RECEIVED LIMITED ATTENTION IS THE IDENTIFICATION OF HOST FUNCTIONS THAT ARE AFFECTED BY THE INTERACTION OF THE HOST WITH THE MICROBIOME AND THE PRODUCTS OF ITS METABOLISM. BARRIER INTEGRITY (TIGHT JUNCTIONS AND FITC-DEXTRAN UPTAKE) AND LOCAL AND SYSTEMIC EVIDENCE OF EFFECTS OF PULSE CONSUMPTION ON ENDOTOXEMIA AND INFLAMMATION WILL BE ASSESSED.
$498,500Colorado State University · · FY2020 · National Institute of Food and Agriculture
HIGH FAT DIET INDUCED ALTERATIONS IN GENE EXPRESSION IN THE NONHUMAN PRIMATE
$498,473Joseph E Robertson · Oregon Health & Science University · P51 · FY2009 · RR
High Fat Diet Induced Alterations in Gene Expression in the Nonhuman Primate
$498,473Joseph E Robertson · Oregon Health & Science University · P51 · FY2009 · RR
DESPITE SEVERAL ADVANCES IN NUTRITION, MANAGEMENT, GENETICS AND ANIMAL HEALTH MANAGEMENT A CONSIDERABLE NUMBER OF DAIRY COWS STILL SUFFER FROM METABOLIC INSUFFICIENCY AND METABOLIC DISEASE DURING THE TRANSITION TO LACTATION. THESE DISORDERS ARE OFTEN LINKED TO INADEQUATE LIVER FUNCTION CAUSED BY METABOLIC STRESS AND ARE MOST APPARENT AROUND THE TIME OF CALVING. THE GOAL OF THIS PROJECT IS TO DETERMINE ASPECTS OF ENERGY AND GLUCOSE METABOLISM IN LIVER OF DAIRY COWS THAT FAVOR A SUCCESSFUL TRANSITION TO LACTATION. WE HYPOTHESIZE THAT THESE PROCESSES ARE LINKED TO THE COORDINATION OF THE SYNTHESIS AND RELEASE GLUCOSE AND THE CAPACITY OF LIVER TO UTILIZE FATTY ACIDS FOR ENERGY METABOLISM. FURTHERMORE WE HYPOTHESIZE THAT METABOLIC CAPACITY IN DAIRY COWS IS DETERMINED BY THE RELATIVE ACTIVITIES OF TWO KEY ENZYMES LINKED TO THE TCA CYCLE, PYRUVATE CARBOXYLASE (PC) PHOSPHOENOLPYRUVATE CARBOXYKINASE (PCK).WE WILL EXPLORE THE EFFECTS OF MODULATING THE RELATIVE ABUNDANCE OF THESE KEY ENZYMES SPECIFICALLY AT THE LEVEL OF EXPRESSION OF THEIR GENES AND WILL DETERMINE THE EFFECT OF DELIBERATE CHANGES IN THE RATIO OF PC TO PCK ON THE ABILITY OF LIVER TO SYNTHESIZE GLUCOSE AND REGULATE ENERGY METABOLISM. WE EXPECT TO UNCOVER THE BASIC BIOLOGY FOR CONTROL OF THESE KEY GENES (PC AND PCK1) IN LIVER METABOLISM AND IDENTIFY PROPERTIES OF FATTY ACIDS AND PROPIONATE THAT REGULATE THEIR FUNCTION. THIS WORK WILL BE USED TO INFORM FUTURE DIET AND MANAGEMENT INTERVENTION STRATEGIES AND TO DEVELOP DIAGNOSTICS FOR TRANSITION COWS THAT REDUCE POOR HEALTH AND PRODUCTION OUTCOMES DURING THE TRANSITION TO LACTATION. THE KNOWLEDGE GAINED FROM THIS WORK WILL LEAD TO A GREATER UNDERSTANDING THE MOLECULAR PHYSIOLOGY OF LIVER METABOLISM AND PROCESSES THAT PRECIPITATE METABOLIC DISORDERS AND IMPAIRED PRODUCTIVITY THAT IS VITAL TO DEVELOPING STRATEGIES TO BETTER MANAGE THE HEALTH AND ECONOMIC EFFICIENCY OF DAIRY PRODUCTION.
$498,380Purdue University · · FY2019 · National Institute of Food and Agriculture
Regulation of Alcohol-induced Fatty Liver Disease by Lipid Droplet Trafficking
$498,213Carol A Casey · University Of Nebraska Medical Center · RC1 · FY2010 · AA
Insulin Signaling and Metabolic Regulation in Adipocytes
$498,085Michael P Czech · Univ Of Massachusetts Med Sch Worcester · R37 · FY2013 · DK
Remediation Process for Aflatoxin Contaminated Foods
$497,950Kyle B Uselton · Lynntech, Inc. · R44 · FY2008 · CA
Altered Lipid Droplet Trafficking: Role in Alcoholic Fatty Liver Disease
$497,860Carol A Casey · University Of Nebraska Medical Center · R01 · FY2014 · AA
TREAT-VCU
$497,828Arun J Sanyal · Virginia Commonwealth University · U01 · FY2015 · AA
Physiology of Lipid Droplets and Triglyceride Storage
$497,727Robert V Farese · Harvard School Of Public Health · R01 · FY2016 · DK
Physiology of Lipid Droplets and Triglyceride Storage
$497,727Robert V Farese · Harvard School Of Public Health · R01 · FY2017 · DK
Physiology of Lipid Droplets and Triglyceride Storage
$497,727Robert V Farese · Harvard School Of Public Health · R01 · FY2018 · DK
Postprandial Vitamin A
$497,724William S Blaner · Columbia University Health Sciences · R01 · FY2020 · DK
Mechanisms of gut epithelial DUOX-mediated intestinal homeostasis
$497,721John Y Kao · University Of Michigan At Ann Arbor · R01 · FY2019 · DK
Mechanisms of gut epithelial DUOX-mediated intestinal homeostasis
$497,721John Y Kao · University Of Michigan At Ann Arbor · R01 · FY2021 · DK
Mechanisms of gut epithelial DUOX-mediated intestinal homeostasis
$497,721John Y Kao · University Of Michigan At Ann Arbor · R01 · FY2020 · DK
Novel insulin-sensitizing NASH/diabetes drugs.
$497,526Timothy R Peterson · Bioio, Llc · R42 · FY2020 · DK
Novel insulin-sensitizing NASH/diabetes drugs.
$497,526Timothy R Peterson · Bioio, Llc · R42 · FY2022 · DK
Novel insulin-sensitizing NASH/diabetes drugs.
$497,526Timothy R Peterson · Bioio, Llc · R42 · FY2021 · DK
Small molecule inhibitors of LMPTP: an obesity drug target
$497,502Nunzio Bottini · University Of California, San Diego · R01 · FY2021 · DK
Mechanistic Target of Rapamycin Pathways in Metabolism and Energy Expenditure
$497,475David A Guertin · Univ Of Massachusetts Med Sch Worcester · R01 · FY2019 · DK
Scavenger Receptors: Ligand Binding and Pathophysiology
$497,466Monty Krieger · Massachusetts Institute Of Technology · R01 · FY2009 · HL
Ultrasound Elastography for Liver Fibrosis Staging
$497,455Shigao Chen · Mayo Clinic Rochester · R01 · FY2015 · DK
Integrative Role of Bilirubin on Obesity
$497,217David E Stec · University Of Mississippi Med Ctr · R01 · FY2022 · DK
Integrative Role of Bilirubin on Obesity
$497,217David E Stec · University Of Mississippi Med Ctr · R01 · FY2023 · DK