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24,576 grants matching “microbiome”
Clinical Risk Factors for Primary Graft Dysfunction
$777,118Jason D Christie · University Of Pennsylvania · R01 · FY2017 · HL
Dietary and synbiotic strategy to limit gut microbiome dysbiosis and protect against Clostridioides difficile infection
$777,060Catherine Lozupone · University Of Colorado Denver · U01 · FY2023 · AI
Impact of the gastrointestinal microbiome on HIV reservoirs
$777,023Angela Raquel Wahl · Univ Of North Carolina Chapel Hill · R01 · FY2021 · DK
Impact of the gastrointestinal microbiome on HIV reservoirs
$777,023Angela Raquel Wahl · Univ Of North Carolina Chapel Hill · R01 · FY2022 · DK
Administrative Core
$776,995Julie Ann Baldwin · Northern Arizona University · U54 · FY2018 · MD
Impact of early-life perturbations on pediatric microbiome maturation
$776,694Gautam Dantas · Washington University · R01 · FY2023 · AI
Regulators of Food Intake
$776,666Jonathan Krakoff · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2020 · DK
Identify risk factors for type 2 diabetes in adolescents
$776,588Robert Paul Hoffman · Research Inst Nationwide Children'S Hosp · U01 · FY2024 · DK
Dietary and synbiotic strategy to limit gut microbiome dysbiosis and protect against Clostridioides difficile infection
$776,329Catherine Lozupone · University Of Colorado Denver · U01 · FY2021 · AI
National Gnotobiotic Resource Center
$776,328Ryan Balfour Sartor · Univ Of North Carolina Chapel Hill · P40 · FY2025 · OD
National Gnotobiotic Resource Center
$776,328Ryan Balfour Sartor · Univ Of North Carolina Chapel Hill · P40 · FY2024 · OD
Dietary and synbiotic strategy to limit gut microbiome dysbiosis and protect against Clostridioides difficile infection
$776,282Catherine Lozupone · University Of Colorado Denver · U01 · FY2022 · AI
Impact of metabolic programing of T cells from the GI tract and related tissues on HIV reservoir seeding, maintenance and reactivation
$776,241Cristian Apetrei · University Of Pittsburgh At Pittsburgh · R01 · FY2022 · DK
CAREER: Parallel evolution in the microbiome: novel methods for detecting repeated, rapid adaptations in metagenomic data
$776,213Nandita Garud · University Of California-Los Angeles · · FY2023 · BIO
Developmental Funds
$776,186Robert L Ferris · University Of Pittsburgh At Pittsburgh · P30 · FY2022 · CA
Developmental Funds
$776,186Robert L Ferris · University Of Pittsburgh At Pittsburgh · P30 · FY2023 · CA
Developmental Funds
$776,186Robert L Ferris · University Of Pittsburgh At Pittsburgh · P30 · FY2024 · CA
OBESITY AFFECTS A SIGNIFICANT PROPORTION OF THE U.S. POPULATION AND IS CHARACTERIZED BY ALTERED GUT MICROBIOMES, IMPAIRED CARDIO- AND IMMUNOPROTECTIVE HDL FUNCTIONS, AND PRO-INFLAMMATORY IMMUNE PROFILES, THEREBY INCREASING CHRONIC DISEASE RISK WHILE IMPAIRING IMMUNE DEFENSES. THE GUT MICROBIOME AND ASSOCIATED METABOLOME REGULATE HDL AND IMMUNE PATHWAYS THAT DIFFER BY SEX, AND REPRESENT PROMISING TARGETS TO MITIGATE OBESITY-ASSOCIATED DISEASE. OUR PREVIOUS WORK DEMONSTRATES THAT, COMPARED TO EGG WHITES, WHOLE EGGS IMPROVE HDL, INFLAMMATORY, AND IMMUNE PROFILES TO VARYING DEGREES IN HEALTHY AND METABOLIC SYNDROME POPULATIONS; HOWEVER, IT IS UNKNOWN WHETHER GUT MICROBIOME CHANGES ARE MEDIATING THESE EFFECTS, OR WHETHER THESE EFFECTS ARE SEX-SPECIFIC. THEREFORE, THE LONG-TERM GOAL OF THIS PROJECT IS TO EVALUATE THE GUT MICROBIOME ROLE IN MEDIATING WHOLE EGG EFFECTS ON HDL AND IMMUNE PROFILES BY SEX AND METABOLIC PHENOTYPE. WE WILL CONDUCT A RANDOMIZED CROSSOVER INTERVENTION TRIAL WITH HEALTHY WEIGHT AND OBESITY GROUPS TO TEST OUR HYPOTHESIS THAT, COMPARED TO EGG WHITE INTAKE, WHOLE EGGS WILL PROVIDE GREATER GUT HEALTH-PROMOTING COMPONENTS TO IMPROVE GUT MICROBIOTA COMPOSITION, FECAL AND SERUM METABOLOMES, AND MEASURES OF GUT INFLAMMATION AND INTEGRITY (OBJECTIVE 1); HDL COMPOSITION, EFFLUX AND ANTIOXIDANT CAPACITY, AND IMMUNOMODULATORY FUNCTIONS (OBJECTIVE 2); AND CLINICAL, FUNCTIONAL, AND OMICS-BASED IMMUNE PROFILES (OBJECTIVE 3); AND THAT SEX, METABOLIC PHENOTYPE, AND GUT MICROBIOME PROFILES WILL DICTATE HDL AND IMMUNE RESPONSES TO EGG INTAKE. THIS STUDY DIRECTLY ADDRESSES USDA NIFA FOOD AND HUMAN HEALTH PRIORITIES BY INVESTIGATING THE INTERRELATIONSHIP OF EGGS (AND IMPORTANT U.S. AGRICULTURAL PRODUCT), THE GUT MICROBIOME, AND CHRONIC DISEASE PATHWAYS TO INFORM PERSONALIZED NUTRITION RECOMMENDATIONS THAT SUPPORT HUMAN HEALTH.
$775,934University Of Connecticut · · FY2025 · National Institute of Food and Agriculture
Continued Development and Maintenance of the MG-RAST Metagenomics Pipeline
$775,775Ananth Grama · Purdue University · R01 · FY2016 · AI
Impact of metabolic programing of T cells from the GI tract and related tissues on HIV reservoir seeding, maintenance and reactivation
$775,683Cristian Apetrei · University Of Pittsburgh At Pittsburgh · R01 · FY2025 · DK
Clinical Risk Factors for Primary Graft Dysfunction
$775,523Jason D Christie · University Of Pennsylvania · R01 · FY2015 · HL
Dietary and synbiotic strategy to limit gut microbiome dysbiosis and protect against Clostridioides difficile infection
$775,395Catherine Lozupone · University Of Colorado Denver · U01 · FY2024 · AI
Ingestible Pill for spatially targeted sampling of gut microbiome
$775,340Sameer R Sonkusale · Tufts University Medford · R33 · FY2024 · DK
Systems Biology of Diffusion Impairment in HIV
$775,316Alison Morris · University Of Pittsburgh At Pittsburgh · R01 · FY2018 · HL
Dietary and synbiotic strategy to limit gut microbiome dysbiosis and protect against Clostridioides difficile infection
$775,185Catherine Lozupone · University Of Colorado Denver · U01 · FY2025 · AI