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24,576 grants matching “microbiome”
Leveraging early-life microbes to prevent type 1 diabetes
$770,322Michael A Silverman · Children'S Hosp Of Philadelphia · R01 · FY2023 · DK
Understanding alpha-gal red meat allergy
$770,209Scott Palmer Commins · Univ Of North Carolina Chapel Hill · R01 · FY2024 · AI
Understanding alpha-gal red meat allergy
$770,209Scott Palmer Commins · Univ Of North Carolina Chapel Hill · R01 · FY2025 · AI
The school microbiome and asthma morbidity in inner-city children
$770,182Peggy Sue Lai · Massachusetts General Hospital · R01 · FY2020 · AI
Duration of Hormonal Contraceptive Use: Immune Responses & Vaginal Microbiota
$770,085Khalil G Ghanem · Johns Hopkins University · R01 · FY2015 · AI
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** POST-WEANING DIARRHEA (PWD) CAUSED BY THE BACTERIUM 'ENTEROTOXIGENIC ESCHERICHIA COLI' (ETEC) IS AN ECONOMICALLY IMPORTANT DISEASE IN WEANED PIGLETS. CURRENTLY, ANTIBIOTICS ARE USED IN THE SWINE INDUSTRY TO CONTROL INTESTINAL INFECTIONS, INCLUDING PWD IN PIGLETS. RECENT STUDIES HAVE CONFIRMED THAT DISRUPTION OF THE NORMAL GUT BACTERIAL COMMUNITIES (GUT MICROBIOME) INDUCED DURING WEANING TRANSITION IS A CRITICAL FACTOR INVOLVED IN THE DEVELOPMENT OF PWD. DISRUPTION OF THE NORMAL GUT MICROBIOME (GUT DYSBIOSIS) HAS BEEN FOUND TO BE INVARIABLY IMPLICATED IN BOTH INITIATION AND CLINICAL MANIFESTATION OF PWD. THEREFORE, STABILIZING THE GUT MICROBIOME DURING THE WEANING TRANSITION COULD BE AN EFFECTIVE STRATEGY FOR CONTROLLING PWD. RECENTLY, FECAL MICROBIOME TRANSPLANTATION (FMT) HAS BEEN SHOWN TO PREVENT GUT-DYSBIOSIS AND CONTROL SERIOUS INTESTINAL ILLNESSES IN HUMANS. HOWEVER, THE APPLICATION OF THESE STRATEGIES IS MINIMALLY EXPLORED IN THE SWINE INDUSTRY. THIS PROPOSAL SEEKS TO OPTIMIZE FMT IN SWINE AND TO UNDERSTAND THE MECHANISMS BY WHICH IT CONTROL GUT DYSBIOSIS AND ETEC INFECTION IN WEANING PIGLETS. IN THIS PROJECT, WE WILL TEST OUR CENTRAL HYPOTHESIS THAT GUT MICROBIOME DYSBIOSIS AND PWD IN PIGLETS COULD BE PREVENTED BY THE TRANSPLANTATION OF ADULT PIG GUT MICROBIOTA OF VARYING COMPLEXITY. IN THE LONG TERM, OUR RESULTS WILL HELP TO IMPROVE THE RATIONAL DESIGN OF DEFINED GUT BACTERIA MIX AS AN ALTERNATIVE TO ANTIBIOTICS TREATMENT IN PIGS. IN SUMMARY, THIS PROJECT SEEKS TO DEVELOP A GUT MICROBIOTA BASED INTERVENTION AS A NON-ANTIBIOTIC ALTERNATIVE TO CONTROL PWD -A SIGNIFICANT CHALLENGE IS COMMERCIAL SWINE PRODUCTION.
$770,000Auburn University · · FY2023 · National Institute of Food and Agriculture
Development of a human placental extract for the prevention of necrotizing enterocolitis in premature babies
$769,983Michael Bentley Berger · Plakous Therapeutics, Inc. · R44 · FY2021 · HD
Influence of maternal virome and HIV status on infant gut virome, growth and immunity
$769,959Heather Beryl Jaspan · Seattle Children'S Hospital · R01 · FY2022 · HD
Testing sex as a moderator of health impacts of upward mobility on indicators for AD risk in young adulthood
$769,710Bridget L Callaghan · University Of California Los Angeles · R01 · FY2024 · AG
Impact of early-life perturbations on pediatric microbiome maturation
$769,606Gautam Dantas · Washington University · R01 · FY2024 · AI
The impact of bacteriophage therapy on wound infection dynamics
$769,586Daniel J Wozniak · Ohio State University · R01 · FY2022 · AI
Deciphering the ontogeny of CD4+ resident memory T cells that globally seed the skin and protect against cutaneous leishmaniasis
$769,366Phillip A. Scott · University Of Pennsylvania · R01 · FY2025 · AI
Maternal-infant Virome Transmission: the role of HIV and Antiretroviral Therapy
$769,345Dara Ann Lehman · Fred Hutchinson Cancer Research Center · R01 · FY2020 · HD
Monitoring Social Change: Dynamics Of Aging And Cognitive Function
$769,269Barry M Popkin · Univ Of North Carolina Chapel Hill · R01 · FY2020 · AG
Identifying drivers of genital inflammation and HIV acquisition in women living in sub-Saharan Africa
$769,000Douglas Kwon · Massachusetts General Hospital · R01 · FY2025 · AI
Clinical Core
$768,945Steven Grant Deeks · University Of California, San Francisco · P30 · FY2023 · AI
The Microbiome, Virome and Host Responses Preceding Ventilator-Associated Pneumon
$768,905Peter M Mourani · University Of Colorado Denver · R01 · FY2014 · HL
Recruitment and Data Collection
$768,794Unhee Lim · University Of Hawaii At Manoa · P01 · FY2015 · CA
Integrative Omics of HepB Vaccine Response in Co-Infection with Parasites
$768,783Elias K Haddad · Drexel University · U19 · FY2019 · AI
Biological Vulnerability to Chlamydia trachomatis in Adolescents and Young Women: the Complex Intersection of Cervicovaginal Microbiome, Cervical Maturation, and Mucosal Immunity
$768,767Loris Y. Hwang · University Of California Los Angeles · R01 · FY2018 · AI
Role of the Gut Microbiota in Shaping Severity of Malaria
$768,686Nathan Schmidt · Indiana University Indianapolis · R01 · FY2024 · AI
B cell clonal selection in gut-associated germinal centers
$768,621Gabriel D Victora · Rockefeller University · R01 · FY2020 · AI
B cell clonal selection in gut-associated germinal centers
$768,621Gabriel D Victora · Rockefeller University · R01 · FY2021 · AI
The role of a bifunctional mucinase in modulating personalized gut microbiota-Vibrio cholerae interactions during infection
$768,343Jun Zhu · University Of Pennsylvania · R01 · FY2024 · AI
Biofilm Elimination and Caries Prevention using Multifunctional Nanocatalysts
$768,206Hyun Koo · University Of Pennsylvania · R01 · FY2023 · DE