Sort
17,828 grants matching “crispr”
Leveraging GWAS Findings to Map Variants and Identify Novel Effector Genes for Alcohol-Related Traits
$624,067Henry Richard Kranzler · University Of Pennsylvania · R01 · FY2024 · AA
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** SALMONELLA IS A LEADING BACTERIAL CAUSE OF FOODBORNE ILLNESS IN THE UNITED STATES AND SURFACE WATER SUCH AS CREEKS, RIVERS, AND PONDS ARE A SIGNIFICANT AND PERSISTENT RESERVOIR OF THIS PATHOGEN. SALMONELLA SEROTYPES CAN EXHIBIT DIFFERENT PHENOTYPES, INCLUDING THEIR CAPACITY TO CAUSE ILLNESS AND IN THEIR SURVIVAL IN THE ENVIRONMENT. SALMONELLA SEROTYPE POPULATIONS IN SURFACE WATER ARE EXTRAORDINARILY DIVERSE AND CLINICALLY IMPORTANT SEROTYPES ARE OFTEN OUTNUMBERED IN THESE ENVIRONMENTS. THERE IS A KNOWLEDGE GAP WITH RESPECT TO SALMONELLA SEROTYPE POPULATION DYNAMICS IN SURFACE WATER, IN PARTICULAR THE INFLUENCE OF ZOONOTIC SOURCE AND HOW THE LONG-TERM SURVIVAL AND COMPETITION BETWEEN SEROTYPES IMPACTS TRANSMISSION OF CLINICALLY IMPORTANT SEROTYPES. THE OVERALL OBJECTIVE OF THE PROPOSED WORK IS TO DEFINE PATHWAYS THAT INTRODUCE SALMONELLA INTO SURFACE WATER, AND TO IDENTIFY THE GENETICS UNDERLYING SALMONELLA SURVIVAL AND PERSISTENCE IN SURFACE WATER. OUR APPROACH WILL BE TO USE HIGH RESOLUTION SEROTYPE POPULATION ANALYSIS BY CRISPR-SEROSEQ, AND MACHINE LEARNING-BASED MODELING OF ZOONOTIC AND ENVIRONMENTAL VARIABLES TO UNDERSTAND THE INTRODUCTION, MOVEMENT, AND PERSISTENCE OF SALMONELLA IN SURFACE WATER. THE EXPECTED OUTCOME OF THE PROPOSED WORK IS THAT IT WILL LEAD TO NEW STRATEGIES TO CONTROL AND MITIGATE SALMONELLA IN SURFACE WATER THAT IS USED IN CROP IRRIGATION AND ANIMAL WATER SUPPLIES, WHICH WILL FACILITATE IMPROVED FOOD SAFETY AND SECURITY.
$623,900University Of Georgia Research Foundation, Inc. · · FY2022 · National Institute of Food and Agriculture
Research Project I: AAV-CRISPR to Treat Huntington's Disease
$623,889Krystof S Bankiewicz · University Of California Berkeley · U19 · FY2025 · NS
Resource Core III: Biological Impacts Core
$623,889Jennifer A Doudna · University Of California Berkeley · U19 · FY2025 · NS
Research Project III: RNP-CRISPR to Treat Huntington's Disease
$623,889Niren Murthy · University Of California Berkeley · U19 · FY2025 · NS
Research Project II: AAV-CRISPR to Treat Amyotrophic Lateral Sclerosis
$623,889Claire Clelland · University Of California Berkeley · U19 · FY2025 · NS
Resource Core II: In Vivo Core
$623,888Piotr Hadaczek · University Of California Berkeley · U19 · FY2025 · NS
Studies in the Pathogenesis of Systemic Capillary Leak Syndrome
$623,882Kirk Druey · National Institute Of Allergy And Infectious Diseases · ZIA · FY2017 · AI
Receptor Mediated T and B Cell Activation
$623,877Richard J. Hodes · Division Of Basic Sciences - Nci · ZIA · FY2023 · CA
Collaborative Pathways that Lead to Leukemia
$623,811Peter Aplan · Division Of Basic Sciences - Nci · ZIA · FY2024 · CA
ASPH Targeted Therapy for Chondrosarcoma
$623,782Richard M Terek · Rhode Island Hospital · R01 · FY2024 · CA
Gene-by-environment interactions that affect exposure-mediated congenital heart disease
$623,698John Andrew Whitehead · University Of California At Davis · R01 · FY2023 · ES
Genetic and epigenomic determinants of hearing loss in Hispanic populations
$623,686Regie Lyn Pastor Santos-Cortez · University Of Colorado Denver · R01 · FY2024 · DC
CRISPR-enhanced adipocyte browning to improve glucose tolerance in obesity and diabetes
$623,634Michael P Czech · Univ Of Massachusetts Med Sch Worcester · R01 · FY2024 · DK
Human lncRNA mediated control of human osteogenesis
$623,628Gary S. Stein · University Of Vermont & St Agric College · R01 · FY2025 · AR
Mechanisms of mitosis and size control in Xenopus
$623,548Rebecca W Heald · University Of California Berkeley · R35 · FY2016 · GM
Molecular Basis of Hereditary Retinal Degenerations
$623,516Radha Ayyagari · University Of California, San Diego · R01 · FY2016 · EY
Using Protein Interaction Networks and Combinatorial Screens to target KRAS driven cancer
$623,508Peter Kent Jackson · Stanford University · U01 · FY2018 · CA
Esophageal Squamous Cell Cancer Initiation and Immune Landscape Remodeling
$623,452Jae-Il Park · University Of Tx Md Anderson Can Ctr · R01 · FY2024 · CA
Development of novel approaches for gene editing therapies of cystic fibrosis
$623,412Jianming Qiu · University Of Kansas Medical Center · R01 · FY2025 · HL
The roles of p53 in embryonic stem cells
$623,372Jing Huang · Division Of Basic Sciences - Nci · ZIA · FY2018 · CA
Transcriptional and epigenetic regulation of thermogenic adipocyte program
$623,366Yu-Hua Tseng · Joslin Diabetes Center · R01 · FY2023 · DK
Advancing immune organoid technology and organoid combinations
$623,357Mark M Davis · Stanford University · U19 · FY2025 · AI
Restriction of Toxoplasma growth in human cells
$623,349Jeroen Saeij · University Of California At Davis · R01 · FY2024 · AI
Mapping heritable chromatin loop variants with allele-specific Hi-C analysis
$623,307Fulai Jin · Case Western Reserve University · R01 · FY2024 · HG