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27,075 grants matching “cholesterol”
Long-term Effects of a household Air Pollution intervention: Follow-up of a randomized controlled trial
$631,630William N Checkley · Johns Hopkins University · R01 · FY2024 · HL
Prevention and Control of Diabetes in Families
$631,613Kim Daniel Reynolds · University Of Southern California · R18 · FY2006 · DK
Occupational Exposure to PM2.5 and Cardiovascular Disease(CVD)
$631,434Mark Richard Cullen · Stanford University · R01 · FY2012 · OH
Managing Atherosclerosis by Modulating HDL Function
$631,414M. Reza Ghadiri · Scripps Research Institute, The · R01 · FY2013 · HL
Expanding the Family Check-Up in Early Childhood to Promote Cardiovascular Health of Mothers and Young Children (ENRICH)
$631,115Janet M Catov · Magee-Women'S Res Inst And Foundation · UG3 · FY2022 · HL
The effects of PD-1 on tumor-mediated âemergencyâ myelopoiesis and fate commitment of myeloid cells: Implications for anti-tumor immunity
$631,075Vassiliki A Boussiotis · Beth Israel Deaconess Medical Center · R01 · FY2021 · CA
HDL composition/function and cardiovascular risk in youths with diabetes
$631,046Tomas Vaisar · University Of Washington · R01 · FY2022 · HL
Identification of Genes Influencing Total Antioxidant Status
$631,012John Blangero · Texas Biomedical Research Institute · R01 · FY2012 · HL
PORCINE MODELS OF CORONARY ARTERY DISEASE IN DIABETES
$630,978Michael Sturek · Indiana Univ-Purdue Univ At Indianapolis · R24 · FY2006 · RR
Native Healthy Lifestyle: A Return to Balance
$630,959Elisa Lee · University Of Oklahoma Hlth Sciences Ctr · U01 · FY2007 · HL
PORCINE MODELS OF CORONARY ARTERY DISEASE IN DIABETES
$630,928Michael Sturek · Indiana Univ-Purdue Univ At Indianapolis · R24 · FY2007 · RR
PORCINE MODELS OF CORONARY ARTERY DISEASE IN DIABETES
$630,928Michael Sturek · Indiana Univ-Purdue Univ At Indianapolis · R24 · FY2007 · RR
Long-term health consequences of birth by cesarean section
$630,815Jorge Eduardo Chavarro · Harvard School Of Public Health · R01 · FY2021 · HD
Structure-Function Relationships in Presenilin/y-Secretase
$630,796Dennis J Selkoe · Brigham And Women'S Hospital · P01 · FY2008 · AG
Study of biomarkers in ovarian cancer: modulation by activity & diet intervention
$630,790Cynthia A Thomson · University Of Arizona · R01 · FY2017 · CA
Molecular mechanisms underlying the genetic association between PPP1R3B and hepatic steatosis
$630,762Daniel James Rader · University Of Pennsylvania · R01 · FY2018 · DK
Mapping Brain Structure to Function in Euthymic Subjects with Bipolar Disorder
$630,630Lori L Altshuler · University Of California Los Angeles · R01 · FY2009 · MH
Mothers in Motion Program to Prevent Weight Gain in Overweight/Obese WIC Mothers
$630,597Mei-Wei Chang · Michigan State University · R18 · FY2014 · DK
WISCONSIN EPIDEMIOLOGICAL STUDY OF CARDIOVASCULAR DISEAS
$630,502University Of Wisconsin Madison · R01 · FY2000 · HL
3-Way Approach for ED Prevention
$630,488Carol Ann Podlasek · University Of Illinois At Chicago · R01 · FY2020 · DK
STEARIC ACID (18:0) IS A SATURATED FATTY ACID FOUND IN FOODS SUCH AS COCOA BUTTER, MEAT AND DAIRY. UNLIKE OTHERDIETARY SATURATED FATS WHICH ARE CONSIDERED TO BE UNHEALTHY, STEARIC ACID HAS A NEUTRAL EFFECT ON BLOOD LDL CHOLESTEROL LEVELS AND HAS BEEN INVERSELY ASSOCIATED WITH CARDIOVASCULAR DISEASE (CVD) RISK. EXISTING STUDIES HAVE EXPLORED POSSIBLE MECHANISMS SUCH AS REDUCED INTESTINAL ABSORPTION, INCREASED EXCRETION OR OXIDATION, AND CONVERSION TO OLEIC ACID IN THE BODY, BUT THESE DO NOT FULLY ACCOUNT FOR ITS DISTINCT METABOLIC EFFECTS. PRELIMINARY DATA INDICATE THAT STEARIC ACID MAY INFLUENCE THE GUT MICROBIOME, PARTICULARLY MICROBES INVOLVED IN BILE ACID (BA) METABOLISM. CHANGES IN THESE MICROBES CAN ALTER THE PRODUCTION OF SECONDARY BILE ACIDS, WHICH ARE KNOWN TO PLAY ROLES IN LIPID METABOLISM AND INFLAMMATION. MOST PREVIOUS RESEARCH HAS RELIED ON STOOL SAMPLES TO STUDY THE GUT MICROBIOME. HOWEVER, STOOL REFLECTS MICROBIAL ACTIVITY PRIMARILY IN THE LARGE INTESTINE (COLON), NOT THE ENTIRE GASTROINTESTINAL (GI) TRACT. MICROBIAL TRANSFORMATION AND REABSORPTION OF BAS OCCUR MAINLY IN THE ILEUM, A REGION OF THE SMALL INTESTINE, WHICH IS NOT WELL-REPRESENTED IN STOOL-BASED ANALYSES. TO ADDRESS THIS LIMITATION, WE WILL CONDUCT A CLINICAL TRIAL IN OLDER ADULTS USING AN INGESTIBLE SAMPLING DEVICE (MINI-PILL) TO COLLECT REGION-SPECIFIC GASTROINTESTINAL SAMPLES AND EVALUATE THE EFFECTS OF DIETARY STEARIC ACID ON GUT MICROBIAL COMPOSITION, FUNCTION, AND BA METABOLISM. FINDINGS FROM THIS WORK WILL PROVIDE A MORE DETAILED UNDERSTANDING OF THE EFFECTS OF STEARIC ACID WITHIN THE GUT AND ITS RELATIONSHIP TO HOST METABOLIC PROCESSES RELEVANT TO CARDIOVASCULAR HEALTH. THIS WILL CONTRIBUTETO THE EVIDENCE BASE NEEDED TO MODIFY CURRENT DIETARY GUIDANCE/NUTRIENT LABELING RELATED TO SATURATED FAT, AND THE POTENTIAL USE OF STEARIC ACIDAS AN ALTERNATIVE FOR TRANS FATTY ACIDS (TFAS) IN THE FOOD SUPPLY.
$630,410Trustees Of Tufts College · · FY2025 · National Institute of Food and Agriculture
Childhood Obesity and Cardiometabolic Health among Impoverished Mexican Americans
$630,356Marisol Perez · Arizona State University-Tempe Campus · R01 · FY2023 · MD
Critical Mediators of Inflammation Resolution and Immune Memory in Atherosclerosis
$630,285Amanda C Doran · Vanderbilt University Medical Center · R01 · FY2023 · HL
Supplemental Se and Vitamin E and Pulmonary Function
$630,237Cornell University Ithaca · R01 · FY2005 · HL
CSDE1 as a Post Transcriptional Regulator of the LDLR
$630,223John S Chorba · University Of California, San Francisco · R01 · FY2023 · HL