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24,576 grants matching “microbiome”
Metabolic Currencies of the Ocean Carbon Cycle
$749,220Mary Ann Moran · University Of Georgia Research Foundation Inc · · FY2017 · BIO
Addressing Malnutrition in Transplant and Cellular Therapy Patients with Healthcare-Food Bank Partnerships
$749,218Anthony Sung · University Of Kansas Medical Center · R01 · FY2025 · NR
Metagenomics of the Microbiome in Oral Health and Disease
$749,166Scott N. Peterson · J. Craig Venter Institute, Inc. · R01 · FY2010 · DE
MUCH OF THE MICROBIOME RESEARCH IN AGRICULTURE HAS BEEN FOCUSED ON SOIL AND SOIL-BASED SYSTEMS. ONE OF THE CHALLENGES OF MICROBIOME RESEARCH IS TO DEVELOP PREDICTIONS OF CROP PRODUCTIVITY FROM MICROBIOME INFORMATION AND MANIPULATION. WE PROPOSE THAT HYDROPONIC PRODUCTION SYSTEMS OFFER A CLOSED, LOW DIVERSITY, MODEL TO TEST AND PREDICT THE ENVIRONMENTAL IMPACT ON MICROBIOME DYNAMICS. IN HYDROPONICS, PLANT ROOTS ARE SUSPENDED IN A NUTRIENT SOLUTION AND ARE HOUSED IN ENCLOSED SYSTEMS WHERE THE ENVIRONMENT OF THE ROOT AND SHOOT ZONES ARE TIGHTLY CONTROLLED. IN ADDITION, IN THIS LOW-DIVERSITY SYSTEM, WE EXPECT TO INCREASE OUR ABILITY TO USE MICROBIOMES TO PREDICT THE IMPACT ON PLANT GROWTH, PLANT HEALTH, AND PATHOGEN PERSISTENCE. WE AIM TO CHARACTERIZE THE FUNCTIONALITY OF MICROORGANISMS IN HYDROPONICALLY GROWN PLANTS, AS WELL AS ON CHANGES IN MICROBIOME FUNCTIONALITY IN RELATION TO THE HYDROPONIC SYSTEM SETUP. IN THIS PROPOSAL, WE FOCUS ON LETTUCE DUE TO ITS MARKET AND FOOD SAFETY RELEVANCE. IN ADDITION, ITS SHORT PRODUCTION CYCLE ALLOWS FOR ROBUST AND REPLICABLE MANIPULATION REQUIRED FOR THE FUNCTIONAL CHARACTERIZATION OF LETTUCE MICROBIOME INTERACTIONS. WE MANIPULATE SPECIFIC ABIOTIC AND BIOTIC VARIABLES TO OPTIMIZE PRODUCTION PRACTICES IN ORDER TO PROMOTE A MICROBIOME THAT ENHANCES PLANT GROWTH. FURTHERMORE, WE WILL TEST THE HYDROPONIC MICROBIOME CONTRIBUTIONS TO FOOD SAFETY AND PLANT DISEASES. AT THE END OF THIS PROJECT, WE WILL DEVELOP A WORKING KNOWLEDGE ON PRODUCTION PARAMETERS THAT COULD BE USED TO PREDICT THE FUNCTIONAL DIVERSITY OF HYDROPONIC LETTUCE MICROBIOMES AND THE MAJOR MICROBIOME CONTRIBUTIONS TO PLANT PRODUCTIVITY AND HUMAN SAFETY.
$748,928Ohio State University, The · · FY2020 · National Institute of Food and Agriculture
PLANTS GROW IN CLOSE ASSOCIATION WITH MICROBIAL COMMUNITIES THAT INFLUENCE PLANT TRAITS RELATED TO NUTRIENT ACQUISITION, PLANT DEFENSE, PLANT MORPHOLOGY AND ABIOTIC STRESS TOLERANCE. THE CO-EVOLUTION BETWEEN PLANTS AND THEIR ASSOCIATED MICROBIAL COMMUNITIES ENABLES PLANTS TO PRODUCE AN IMMUNE SYSTEM-LIKE RESPONSE AS WELL AS PROVIDE NUTRIENTS AND MINERALS FOR PLANT GROWTH AND HEALTH. ISOLATION OF A COLLECTION OF MICROBES FROM THE ASSOCIATED CORN MICROBIOME IN A UNIQUE OLIGOSACCHARIDE MIXTURE THAT COLLECTS ON AERIAL ROOTS PROVIDED EVIDENCE THAT NITROGEN CAN BE FIXED BY MANY MEMBERS OF THE MICROBIOME. THIS UNEXPECTED RESULT WAS REPLICATED IN 600 DIFFERENT ISOLATES USING MOLECULAR MECHANISMS THAT ARE FOUND IN OTHER BACTERIA (~30%) IN ADDITION TO NOVEL MECHANISMS THAT DO NOT USE THE SAME GENE SETS (~70%) OF THE ISOLATES. THIS PROPOSAL SEEKS TO UNDERSTAND NOVEL MECHANISMS BACTERIA USE WITHIN THE MICROBIOME TO FIX NITROGEN.
$748,879University Of California, Davis · · FY2019 · National Institute of Food and Agriculture
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** EVERY GRAM OF SOIL HARBORS BILLIONS OF VIRUSES AND THOUSANDS OF VIRAL SPECIES THAT INFECT DIVERSE MICROBIOTA, INCLUDING PLANT-BENEFICIAL AND PLANT-PATHOGENIC MICROORGANISMS. WE KNOW VERY LITTLE ABOUT THESE SOIL VIRAL COMMUNITIES OR THEIR CONTRIBUTIONS TO AGRICULTURAL MICROBIOMES, BUT EVIDENCE FROM MARINE SYSTEMS SHOWS THAT VIRUSES HAVE GLOBAL-SCALE IMPACTS ON CARBON AND NUTRIENT CYCLING, MICROBIAL MORTALITY, AND AGGREGATE FORMATION. THIS PROJECT CONSIDERS DIVERSE SOIL BIOTA ACROSS TROPHIC SCALES (VIRUSES, BACTERIA, FUNGI, PROTISTS, NEMATODES, AND PLANTS) TO BUILD A SYSTEMS-LEVEL UNDERSTANDING OF AGRICULTURAL SOIL VIRAL DIVERSITY, VIRUS-HOST DYNAMICS, AND VIRAL CONTRIBUTIONS TO SOIL CHEMISTRY AND TOMATO DISEASE. USING MULTIPLE OMICS AND AMPLICON APPROACHES, VIRUSES WILL BE PLACED IN PRACTICAL CONTEXT BY MEASURING CHANGES IN VIRAL COMMUNITY COMPOSITION AND VIRUS-HOST DYNAMICS IN RESPONSE TO COMMON MANAGEMENT PRACTICES AND INPUTS THROUGHOUT THE TOMATO GROWING SEASON. THE PRIMARY OBJECTIVES ARE TO: 1) ASSESS RESPONSES OF SOIL DNA AND RNA VIRAL COMMUNITIES TO MANAGEMENT AND INPUTS, 2) LINK SOIL VIRUSES TO THEIR DIVERSE HOSTS AND EXPLORE HOW VIRUS-HOST DYNAMICS CHANGE OVER THE TOMATO GROWING SEASON AND DIFFER BETWEEN ORGANICALLY AND CONVENTIONALLY MANAGED SOILS, AND 3) EXPLORE SOIL VIRAL IMPACTS ON CARBON, NUTRIENTS, AND TOMATO DISEASE. THOUSANDS OF NEW VIRUSES WILL BE DISCOVERED, AND THEIR CONTRIBUTIONS TO SOIL MICROBIAL ECOLOGY, NUTRIENT CYCLING, AND PLANT DISEASE SUPPRESSION WILL BE INVESTIGATED. IN LINE WITH AFRI'S GOALS, RESULTS WILL IMPROVE OUR UNDERSTANDING OF AGRICULTURAL SOIL MICROBIOMES, LEADING TO OUR LONG-TERM GOAL TO LEVERAGE SOIL MICROBES TO IMPROVE CARBON STORAGE AND NUTRIENT CYCLING AND MITIGATE PLANT DISEASE IN SUSTAINABLE AGRICULTURAL SYSTEMS.
$748,834University Of California, Davis · · FY2021 · National Institute of Food and Agriculture
Investigating the role of the microbiome and inflammation in acute and chronic pain in patients with sickle cell disease
$748,758Amanda M Brandow · Medical College Of Wisconsin · R01 · FY2020 · HL
Mechanisms and regulation of replication, the cell cycle, gene expression, and horizontal gene transfer in prokaryotes, focusing on Bacillus subtilis.
$748,723Alan D Grossman · Massachusetts Institute Of Technology · R35 · FY2024 · GM
The SyngenicDNA and μPOET Platform: Overcoming Innate Barriers to Genetic Engineering in Bacteria.
$748,718Christopher D Johnston · Fred Hutchinson Cancer Research Center · R01 · FY2019 · DE
Triple-enriched metagenomics for robust resistome analysis
$748,594Noelle Noyes · University Of Minnesota · R01 · FY2025 · AI
Toward Personalized Therapeutics: Directed Remodeling of the Gut Microbiome to Treat Atherosclerosis
$748,564M. Reza Ghadiri · Scripps Research Institute, The · R01 · FY2023 · HL
Microbiome-mediated therapies for aging and healthspan in marmosets
$748,508Corinna Nicole Ross · Texas Biomedical Research Institute · R01 · FY2022 · AG
Genetic Epidemiology
$748,488Alisa Goldstein · Division Of Cancer Epidemiology And Genetics · ZIA · FY2014 · CA
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** SOIL IS ONE OF OUR MOST VALUABLE RESOURCES, PROVIDING PHYSICAL SUPPORT TO PLANTS, REGULATING DIFFERENT BIOGEOCHEMICAL CYCLES, AND MITIGATING GLOBAL WARMING THROUGH ORGANIC CARBON STOCKS. EMPIRICAL DATA SUGGESTS THAT THE RATE AND MAGNITUDE OF NET C ACCUMULATION IS OFTEN LOWER THAN THE TOTAL AGRICULTURAL INPUT AND WE HAVE YET TO UNDERSTAND HOW ORGANIC C IS STABILIZED IN SOILS. WE PROPOSE, THROUGH A SERIES OF TRANSFORMATIVE EXPERIMENTS, TO QUANTIFY THREE KEY SOIL COMPONENTS: MICROBIOME STRUCTURE (BIOLOGY), ORGANIC MATTER STRUCTURE (CHEMISTRY) AND SOIL AGGREGATE STRUCTURE (PHYSICS), CONSIDERED THE FUNCTIONAL UNIT OF SOIL. THIS RESEARCH WILL BE GUIDED BY THE FOLLOWING SPECIFIC AIMS:T1. SEPARATING AGGREGATES INTO FOUR DIFFERENT CLASSES AND DETERMINE MICROBIAL CARBON USE EFFICIENCY (CUE) IN EACH OF THOSE AGGREGATES USING 18O ISOTOPES.T2. OBTAINING METAGENOMIC SEQUENCING OF MICROBIAL COMMUNITIES AT DIFFERENT AGGREGATE LEVELS AND ESTIMATING LIFE-HISTORY TRAITS ASSOCIATED WITH CUE.T3. CHARACTERIZE C ACCUMULATION AND SOURCES (Δ13C RATIOS) OF SOM FRACTIONS FOR AGGREGATES OF DIFFERENT SIZE CLASSES: DISSOLVED ORGANIC C, MICROBIAL BIOMASS C, MINERAL ASSOCIATED ORGANIC MATTER (OM), OCCLUDED PARTICULATE OM AND FREE PARTICULATE OM.T4. IDENTIFY SPECIFIC DIFFERENCES IN C PROCESS UTILIZATION USING A SUPERVISED MACHINE LEARNING APPROACH.T5. EXPLAIN C STABILIZATION AT THE FIELD SCALE BY INCORPORATING GENOMIC-ENABLED C PROCESSES INTO THE NEXT-GENERATION SOIL C MODEL - THE MILLENNIAL MODEL - TO SIMULATE MICROBIAL GROUP DYNAMICS AND THEIR FUNCTIONAL ROLES.THIS RESEARCH PROPOSAL ADDRESSES THE NIFA-AFRI FOUNDATIONAL PROGRAM: SOIL HEALTH. SPECIFICALLY, THE RESEARCH WILL FUNCTIONALLY CHARACTERIZE SOIL MICROBIOMES, THEIR FUNCTIONAL TRAITS RESPONSIBLE FOR C STABILIZATION AND MODEL THE OUTCOME IN AGRICULTURAL SOILS UNDER DIFFERENT MANAGEMENT PRACTICES.
$748,363University Of California, Davis · · FY2023 · National Institute of Food and Agriculture
Micro-TeACH (Microbiome Technology and Analytic Center Hub)
$748,342Jose U. Scher · New York University School Of Medicine · UC2 · FY2024 · AR
Gut barrier function in Alzheimerâs disease
$748,156Barbara Brigitta Bendlin · University Of Wisconsin-Madison · R01 · FY2022 · AG
Mechanisms and regulation of replication, the cell cycle, gene expression, and horizontal gene transfer in prokaryotes, focusing on Bacillus subtilis.
$748,149Alan D Grossman · Massachusetts Institute Of Technology · R35 · FY2025 · GM
Surveillance of SARS-CoV-2 in Alaska Year 2
$748,114Brian M Barnes · University Of Alaska Fairbanks · P20 · FY2022 · GM
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** PLANTS HOST DIVERSE ENDOPHYTIC BACTERIA THAT ARE AN IMPORTANT COMPONENT OF THE PLANT MICROBIOME. CURRENTLY, ENDOPHYTIC BACTERIA REMAIN POORLY CHARACTERIZED. ON THE OTHER HAND, BECAUSE ENDOPHYTIC BACTERIA HAVE CLOSE CONTACT WITH PLANTS AND OVERLAP WITH MANY PATHOGENS IN COLONIZING THE INTERCELLULAR SPACE, IT HAS LONG BEEN SUGGESTED THAT ENDOPHYTIC BACTERIA HAVE GREAT POTENTIAL TO CONTROL PLANT PATHOGENS. OUR LONG-TERM GOAL IS TO FUNCTIONALLY CHARACTERIZE THE ENDOPHYTIC BACTERIA OF CITRUS AND TEST THEIR APPLICATION IN DISEASE MANAGEMENT. OUR CENTRAL HYPOTHESIS IS THAT ENDOPHYTIC BACTERIA PLAY IMPORTANT ROLES IN SUPPRESSING INFECTION BY PATHOGENIC MICROBES. IN OUR PREVIOUS STUDY, WE CULTURED A LARGE NUMBER OF ENDOPHYTIC BACTERIA FROM CITRUS ROOTS AND LEAVES. WE WILL TAKE ADVANTAGE OF OUR COLLECTION OF ENDOPHYTIC BACTERIA TO INVESTIGATE THEIR BENEFICIAL TRAITS AND TEST THEIR APPLICATION IN DISEASE CONTROL. THE FOLLOWING OBJECTIVES ARE PROPOSED: INVESTIGATION OF THE BENEFICIAL TRAITS OF THE ENDOPHYTIC BACTERIA, GENOME SEQUENCING OF THE ENDOPHYTIC BACTERIA, AND ENGINEERING OF SYNTHETIC ENDOPHYTIC BACTERIAL MICROBIOMES FOR DISEASE MANAGEMENT. WE WILL USE XANTHOMONAS CITRI SUBSP. CITRI (XCC) AS A MODEL PATHOGEN TO INVESTIGATE THE CONTROL EFFECT OF THE SYNTHETIC ENDOPHYTIC BACTERIAL COMMUNITY. WE WILL INVESTIGATE THE POTENTIAL MECHANISMS RESPONSIBLE FOR THE CONTROL EFFECT AGAINST XCC. SUCCESSFUL COMPLETION OF THE PROJECT WILL GENERATE USEFUL INFORMATION REGARDING THE FUNCTION OF ENDOPHYTIC BACTERIA. ENGINEERING A SYNTHETIC ROOT ENDOPHYTIC BACTERIAL MICROBIOME AND A SYNTHETIC LEAF ENDOPHYTIC BACTERIAL MICROBIOME HAS THE POTENTIAL TO PUT THE KNOWLEDGE LEARNED INTO ACTION TO BENEFIT CROP PRODUCTION.
$748,064University Of Florida · · FY2021 · National Institute of Food and Agriculture
Dissecting the Source and Mechanisms of IL-17-Mediated Modulation of Pancreatic Tumorigenesis
$748,012Florencia McAllister · University Of Tx Md Anderson Can Ctr · R37 · FY2025 · CA
Research Project 1 - The pregnancy ImmunOME
$747,949Andrea Goldberg Edlow · Massachusetts Institute Of Technology · U19 · FY2023 · AI
Impact of virome on microbial communities in the respiratory tract
$747,815Jennifer Melinda Bomberger · University Of Pittsburgh At Pittsburgh · R33 · FY2020 · HL
Determinants of S. aureus Colonization in Atopic Dermatitis
$747,753Donald Ym Leung · National Jewish Health · U19 · FY2017 · AI
Center for Demography of Health and Aging
$747,708Jason Michael Fletcher · University Of Wisconsin-Madison · P30 · FY2021 · AG
Co-culture cassette for anaerobes and primary human intestinal epithelium
$747,640Christopher Eldridge Sims · Altis Biosystems, Inc. · R44 · FY2019 · DK