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24,576 grants matching “microbiome”
FLOWERS ARE IMPORTANT REPRODUCTIVE ORGANS OF PLANTS AND EXCELLENT HABITATS FOR MICROORGANISMS. IT IS ESTIMATED THAT THE MICROBIAL DENSITY ON FLOWERS IS AT LEAST 100 TIMES HIGHER THAN THAT ON LEAVES. YET DUE TO THE SHORT LIFE SPAN, THE MICROBIOME ON FLOWERS AS WELL AS THE FUNCTIONS IT CONFERS ARE RELATIVELY UNDERSTUDIED COMPARED TO OTHER PARTS OF THE PLANTS, SUCH AS ROOTS AND LEAVES. COMPARED TO THE MICROBIOME ON VEGETATIVE ORGANS, THE MICOBIOME ON FLOWERS IS ASSEMBLED IN A MUCH MORE STOCHASTIC MANNER DUE TO THE SUDDEN EXPOSURE OF THE NUTRIENT RICH FLOWER PARTS TO THE ENVIRONMENT DURING BLOOM. IN OUR INITIAL CHARACTERIZATION OF MICROBIOME ASSEMBLY ON APPLE FLOWERS, WE OBSERVED THAT DESPITE THE VARIATION IN EARLY STAGES, THE MICROBIOME ON FLOWERS EVENTUALY FALLS INTO ONE OF THE THREE SIGNATURE STATES AT LATER STAGES (~FOUR DAYS AFTER FLOWER OPENING): 1. PSEUDOMONADACEAE-DOMINATED, 2. ENTEROBACTERIACEAE-DOMINATED, AND 3. PSEUDOMONADACEA-ENTEROBACTERIACEAE MIXED. DESPITE THESE DIFFERENCES IN COMPOSITION, THE BIOLOGICAL CONCEQUENCES OF HAIVNG THE MICROBIOME IN ALTERNATIVE STATES ARE UNKONWN. AS INDIVIDUAL FLOWERS OF THE SAME GENETIC BACKGROUND DISPLAY PHENOTYPIC DIFFERENCES IN DISEASE SUCCEPTIBILITY, POLLINATOR ATTRACTIVENESS, AND FRUIT DEVELOPMENT, WE HYPOTHESIZE THAT SOME OF THE THESE HOST DIFFERENCES MAY BE LINKED TO THE STRUCTURE OF THE MICROBIOME. IN THIS PROJECT, WE WILL USE A COMBINED APPROACH OF METATRANSCRIPTOMICS, 16S RRNA GENE SEQUENCING, MICROBIOME MANIPULATION, AND PHENOTYPIC ASSAYS TO INVESTIGATE THE FUNCTIONS OF THE FLOWER MICROBIOME IN FRUIT DEVELOPMENT AND RESISTANCE TO PLANT DISEASE. FINDINGS FROM THIS STUDY WILL PROVIDE KNOWLEDGE BASIS FOR HARNESING BENEFICIAL MEMBERS OF THE MICROBIOME TOWARDS IMPROVING PLANT PRODUCTIVITY, SUSTAINING PLANT HEALTH, WHILE REDUCING IMPACTS TO THE ENVIRONMENT
$747,602Connecticut Agricultural Experimental Station · · FY2020 · National Institute of Food and Agriculture
Role of Gut Microbial Dysbiosis and Aging on HIV-associated neurocognitive and brain dysfunction
$747,541Shirish S Barve · University Of Louisville · R01 · FY2021 · AG
Advanced Development of Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional)
$747,229James Gregory Caporaso · Northern Arizona University · U24 · FY2023 · CA
Comprehensive Toxicological Assessments for the National Toxicology Program; Subproject 5 (Microbiome)
$747,223Sangeeta Khare · National Institute Of Environmental Health Sciences · Y01 · FY2022 · ES
Mechanisms of disparities in the natural history of oral and oropharyngeal HPV infection among persons living with HIV: the CAMPO oral cohort study
$747,144Ana Patricia Ortiz · Comprehensive Cancer Center/ Univ/Pr · R56 · FY2022 · DE
Genetic and genomic influences on human milk composition and impacts on infant health
$747,000Kelsey Elizabeth Johnson · University Of Southern California · R00 · FY2025 · HD
Effects of PrEP Drugs on Female Genital HIV Infection and Women's Reproductive Health
$747,000Ashley F George · J. David Gladstone Institutes · R00 · FY2025 · HD
The Role of Nasal Mucosal Immunity and Microbiome on the Frequent Exacerbation Phenotype of COPD
$746,929Michael Bradley Drummond · Univ Of North Carolina Chapel Hill · R01 · FY2022 · HL
Next Generation Multipurpose Prevention Technology: An Intravaginal Ring for HIV Prevention and Nonhormonal Contraception
$746,693Marc Michael Baum · Oak Crest Institute Of Science · R01 · FY2023 · HD
The Role of the Gut Microbiome and Short Chain Fatty Acids in the Regulation of Inflammation and Neuropsychological Symptoms in Patients with Head and Neck Cancer
$746,641Canhua Xiao · Emory University · R01 · FY2025 · NR
Colon O-glycosylated mucus in the homeostasis of microbiota and host
$746,456Lijun Xia · Oklahoma Medical Research Foundation · R01 · FY2023 · DK
Environmental factors in pathobiology of dementia: the role of PCB exposure, microbiome, and tissue barrier dysfunction
$746,440Hans-Joachim Lehmler · University Of Iowa · R01 · FY2023 · ES
Translational Training Program in Pulmonary Biology and Medicine
$746,336Alison Morris · University Of Pittsburgh At Pittsburgh · T32 · FY2023 · HL
High-resolution genomic interrogation of pathogen-microbiome interactions in Clostridioides difficile infection
$746,205Gautam Dantas · Washington University · R01 · FY2024 · AI
Genomics of Inflammatory Bowel Disease
$746,082Leah Claire Kottyan · Cincinnati Childrens Hosp Med Ctr · R01 · FY2023 · AI
Spatial Organization of the Oral Microbiome
$745,959Jessica Leigh Mark Welch · Ada Forsyth Institute, Inc. · R01 · FY2024 · DE
Topological Mapping of Immune, Microbiota, Metabolomic and Clinical Phenotypes to Reveal ME/CFS Disease Mechanisms - Clinical Research Project
$745,955Peter Nicholas Robinson · Jackson Laboratory · U54 · FY2019 · NS
Longitudinal Study of the Vaginal Microbiome Prior To Incident STI
$745,886Rebecca M. Brotman · University Of Maryland Baltimore · R01 · FY2015 · AI
Co-culture cassette for anaerobes and primary human intestinal epithelium
$745,742Christopher Eldridge Sims · Altis Biosystems, Inc. · R44 · FY2020 · DK
Elucidating the role of the gut reservoir and inflammation in driving cardiovascular disease among persons living with HIV
$745,702Cecile Delille Lahiri · Emory University · R01 · FY2025 · HL
Elucidating the role of the gut reservoir and inflammation in driving cardiovascular disease among persons living with HIV
$745,702Cecile Delille Lahiri · Emory University · R01 · FY2023 · HL
Emergent properties of synthetic microbial consortia
$745,616Tomas Gedeon · Montana State University · · FY2014 · MPS
Immunopathogenesis of Fungal Infections
$745,599Michail Lionakis · National Institute Of Allergy And Infectious Diseases · ZIA · FY2013 · AI
Influence of maternal virome and HIV status on infant gut virome, growth and immunity
$745,594Heather Beryl Jaspan · Seattle Children'S Hospital · R01 · FY2021 · HD
A Foundation for the Oral Microbiome and Metagenome
$745,302Floyd E Dewhirst · Ada Forsyth Institute, Inc. · U01 · FY2009 · DE