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24,576 grants matching “microbiome”
IN AN ATTEMPT TO ALLEVIATE RISKS TO ECONOMIC AND NATIONAL SECURITY, RECENT U.S. ENERGY POLICY HAS MANDATED PRODUCTION OF RENEWABLE BIOENERGY WHICH HAS SPARKED A FLURRY OF ACTIVITY AND INVESTMENT IN DEDICATED BIOENERGY CROP PRODUCTION ON AGRICULTURAL LANDS. TO REDUCE COMPETITION FOR LAND BETWEEN ENERGY AND FOOD PRODUCTION, MARGINAL LANDS, THAT IS LANDS THAT ARE NOT SUITABLE FOR FOOD PRODUCTION, ARE EMERGING AS PROMISING CANDIDATES FOR GROWING DEDICATED BIOENERGY CROPS. THE GOAL OF THIS PROPOSAL IS TO EXAMINE THE SUITABILITY OF APPALACHIAN MARGINAL LANDS FOR PRODUCTION OF THE BIOENERGY CROP MISCANTHUS × GIGANTEUS (HEREAFTER, MISCANTHUS) AND TO DETERMINE WHETHER PLANT-SOIL-MICROBIAL INTERACTIONS CAN BE LEVERAGED TO IMPROVE THE CARBON (C) AND NITROGEN (N) USE EFFICIENCY OF THE CROP AND ITS ASSOCIATED SOIL MICROBIOME. UNDERSTANDING THIS DYNAMIC IS IMPORTANT, BECAUSE THE SOIL MICROBIOME MAY BENEFIT PLANT PRODUCTIVITY THROUGH IMPROVED ACQUISITION OF NUTRIENTS AND WATER AMONG OTHER MEANS. FURTHER, BIOENERGY CROP PRODUCTION ON APPALACHIAN MARGINAL LANDS HAS THE POTENTIAL NOT ONLY TO IMPROVE ENVIRONMENTAL CONDITIONS BUT ALSO TO OFFER ECONOMIC RETURNS TO GROWERS IN RURAL AREAS WITH FEW OPTIONS FOR INCOME ON THESE LANDS. WHILE PROMISING, SEVERAL QUESTIONS REMAIN ON HOW TO GROW DEDICATED BIOENERGY CROPS SUCH AS MISCANTHUS ON MARGINAL LANDS, HOW THESE CROPS WILL PERFORM ON DIFFERENT TYPES OF MARGINAL LANDS, AND WHETHER THESE SITES CAN PRODUCE ABUNDANT BIOMASS WHILE MAINTAINING AND POTENTIALLY IMPROVING ECOSYSTEM SERVICESWE HYPOTHESIZE THAT THE MISCANTHUS MICROBIOME CAN BE LEVERAGED TO SUSTAINABLY INCREASE YIELD ON MARGINAL LANDS WHILE REDUCING THE NEED FOR AND LOSS OF NUTRIENTS TO SURROUNDING ECOSYSTEMS. TO TEST OUR OVERALL HYPOTHESIS, FIRST, WE WILL DETERMINE THE INFLUENCE OF INITIAL SOIL CHARACTERISTICS AND NUTRIENT AMENDMENT LOADS ON NUTRIENT USE EFFICIENCY AND MISCANTHUS CROP YIELDS ON MARGINAL AND SUB-MARGINAL (THAT IS, HIGHLY DISTURBED) LANDS IN WEST VIRGINIA. SECOND, WE WILL DETERMINE THE MICROBIAL TAXA AND GENOMIC FEATURES THAT ARE ASSOCIATED WITH INCREASED NUTRIENT USE EFFICIENCY AND MISCANTHUS YIELD. THIRD, WE WILL UTILIZE A CONTROLLED GREENHOUSE EXPERIMENT TO TEST WHETHER THE MISCANTHUS MICROBIOME CAN BE MANIPULATED TO IMPROVE NUTRIENT USE EFFICIENCY AND MISCANTHUS YIELD IN MARGINAL AND SUB-MARGINAL SOILS. TO MEET THESE OBJECTIVES, OUR TEAM HAS DEVELOPED CUTTING-EDGE STABLE-ISOTOPE ENABLED METHODS THAT ALLOWS US TO MEASURE MICROBIAL TRAITS AT THE INDIVIDUAL SPECIES LEVEL AS WELL AS FOR ALL MICROBES IN A GIVEN SOIL. WE WILL USE THESE TECHNIQUES IN PARALLEL WITH CLASSICAL TECHNIQUES IN SOIL AND PLANT CHEMICAL ANALYSIS TO QUANTIFY THE INFLUENCE OF MICROBIAL TRAITS AND DIVERSITY ON MISCANTHUS YIELD AND QUALITY ACROSS EXPERIMENTAL PLOTS THAT SPAN GRADIENTS IN SOIL QUALITY AND NUTRIENT AMENDMENT LOADS.THIS RESEARCH WILL ESTABLISH NEW PARTNERSHIPS AND ENHANCE EXISTING COLLABORATIONS BETWEEN EARLY CAREER AND ESTABLISHED SCIENTISTS AT WEST VIRGINIA UNIVERSITY. OUR RESEARCH TEAM COMPRISES EXPERTISE IN MICROBIAL ECOLOGY, BIOGEOCHEMISTRY, PLANT AND SOIL NUTRIENT ASSESSMENT, MARGINAL LAND RECLAMATION AND ANALYTICAL INSTRUMENTATION. THIS EXPERTISE WILL ALLOW US TO USE A MULTIDISCIPLINARY APPROACH TO ENHANCE OUR UNDERSTANDING OF HOW PROCESSES AT THE MICROSCOPIC SCALE GOVERN BIOENERGY CROP YIELD, QUALITY, AND ENVIRONMENTAL IMPACT, AN IMPORTANT COMPONENT OF THE MISSION AND PRIORITY AREAS OF THE DEPARTMENT OF AGRICULTURE'S AGRICULTURE AND FOOD RESEARCH INITIATIVE. MOREOVER, THIS CONFLUENCE OF EXPERTISE WILL ENHANCE THE CAPACITY OF THE RESEARCH TEAM TO ANSWER QUESTIONS THAT SPAN MULTIPLE LEVELS OF BIOLOGICAL ORGANIZATION AND WILL PROVIDE UNIQUE TRAINING OPPORTUNITIES FOR GRADUATE AND UNDERGRADUATE STUDENTS.
$745,284West Virginia University · · FY2019 · National Institute of Food and Agriculture
High-resolution genomic interrogation of pathogen-microbiome interactions in Clostridioides difficile infection
$745,133Gautam Dantas · Washington University · R01 · FY2025 · AI
Investigating the connectivity of microbial food webs using thermodynamic models, stable isotope probing and genomics
$745,019Joseph J Vallino · Marine Biological Laboratory · · FY2017 · BIO
Vibrio microcins. A hidden field of targeted anti-cholerae natural products.
$744,990Bryan William Davies · University Of Texas At Austin · R01 · FY2025 · AI
Decoding the clinical impact of the recent evolution of metronidazole resistance on Clostridium difficile infection.
$744,973Julian G Hurdle · Texas A&M University Health Science Ctr · R01 · FY2025 · AI
Impact of metabolic programing of T cells from the GI tract and related tissues on HIV reservoir seeding, maintenance and reactivation
$744,929Cristian Apetrei · University Of Pittsburgh At Pittsburgh · R01 · FY2024 · DK
Identifying Influenza Virus Infection Severity and Outcome Signatures Through Artificial Intelligence-driven Analyses
$744,912Christopher L. Dupont · J. Craig Venter Institute, Inc. · R01 · FY2025 · AI
The Gut Microbiome and Personalized Mediterranean Diet Interventions for Cardiometabolic Disease Prevention
$744,869Dong Wang · Brigham And Women'S Hospital · R01 · FY2024 · NR
Next Generation Multipurpose Prevention Technology: An Intravaginal Ring for HIV Prevention and Nonhormonal Contraception
$744,855Marc Michael Baum · Oak Crest Institute Of Science · R01 · FY2021 · HD
Translational Geroscience Network
$744,685Robert John Pignolo · Mayo Clinic Rochester · R33 · FY2024 · AG
Probiotics for Prevention of Acute Graft-vs-Host Disease in Children with Cancer
$744,609Elena J. Ladas · Columbia University Health Sciences · R01 · FY2019 · CA
Childhood follow-up study of obesity and neurodevelopment after perinatal exposure to adjunctive azithromycin prophylaxis for cesarean delivery
$744,336Akila Subramaniam · University Of Alabama At Birmingham · R01 · FY2020 · HD
Defining the pathways of cardiometabolic health after weight loss
$744,286Vidhu V. Thaker · Columbia University Health Sciences · R01 · FY2024 · DK
Population Genomic Analysis of Gut Microbial Colonization in Premature Infants
$744,269Jillian Banfield · University Of California Berkeley · R01 · FY2025 · AI
The Role of Nasal Mucosal Immunity and Microbiome on the Frequent Exacerbation Phenotype of COPD
$744,150Michael Bradley Drummond · Univ Of North Carolina Chapel Hill · R01 · FY2021 · HL
Designer Probiotics for the treatment of intestinal infection and inflammation
$744,110Cammie Lesser · Massachusetts General Hospital · R01 · FY2017 · DK
Lung Microbiome and Pulmonary Inflammation/Immunity in HIV Infection
$744,070Homer L Twigg · Indiana University Indianapolis · U01 · FY2011 · HL
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE COMPLEXITY OF PROBLEMS FACING THE AGRICULTURAL SYSTEMS DEMONSTRATES THE NEED FOR ENGINEERED MATERIALS THAT SIMULTANEOUSLY ADDRESS SEVERAL OF THE SUSTAINABILITY CHALLENGES IN AGRICULTURE. THE PROPOSED RESEARCH PROGRAM AIMS TO CREATE AND STUDY ENGINEERED COMPOSITE MATERIALS - BIODEGRADABLE PLASTIC MULCH CONTAINING MAJOR NUTRIENTS - WITH THE POTENTIAL TO REDUCE SOIL DEGRADATION CAUSED BY PLASTIC POLLUTION. IN THIS WORK, WE WILL SYNTHESIZE UREA CO-CRYSTAL FERTILIZERS AT A KG SCALE AND COMBINE THEM WITH SEVERAL PLASTIC POLYMERS TO EXTRUDE MULCH FILMS THAT CAN BE EFFICIENTLY DEGRADED BY THE SOIL MICROBIOME. NEXT, WE WILL ASSESS THE COMPOSITE MULCH EFFECTS ON MICROBIAL COMMUNITY HEALTH, COMPOSITE MULCH DEGRADATION AS WELL AS NUTRIENT RELEASE PROPERTIES. FINALLY, WE WILL APPLY SELECTED COMPOSITE BIODEGRADABLE PLASTIC MULCH IN PILOT FIELD EXPERIMENTS CULTIVATING HIGH-VALUE CROPS, SUCH AS TOMATOES WHILE INVESTIGATING SOIL FEATURES AND HEALTH, AS WELL AS CROP PHYSIOLOGY, YIELD AND QUALITY. IN THIS MANNER, WE WILL OBTAIN OPTIMIZED BIODEGRADABLE NUTRIENT-CONTAINING PLASTIC MULCH FORMULATIONS THAT WILL RESULT IN ENHANCED CROP YIELDS COMBINED WITH ENHANCED SOIL HEALTH.
$744,000Lehigh University · · FY2024 · National Institute of Food and Agriculture
Research training in respiratory biology
$743,863Anne I. Sperling · University Of Chicago · T32 · FY2018 · HL
HPV, HIV and Oral Microbiota Interplay in Nigerian Youth (HOMINY)
$743,801Modupe Coker · Rutgers Biomedical And Health Sciences · R01 · FY2022 · DE
Human and Bacterial Molecular Pathways in Cancer Risk: Modulation by Diet
$743,782Johanna W Lampe · Fred Hutchinson Cancer Research Center · R01 · FY2016 · CA
BIOREPOSITORY OPTIMIZATION AND USE FOR ENDOTYPING CRITICALLY ILL SARS-COV-2 INFECTED PATIENTS
$743,678Leopoldo Nicolas Segal · New York University School Of Medicine · R33 · FY2024 · GM
Project 3 Population studies of major human fungal pathogens: genomic and transcriptomic analyses of interactions with the host and microbiome and the rise of antifungal resistance
$743,533Christina A Cuomo · Broad Institute, Inc. · U19 · FY2020 · AI
Continued Development and Maintenance of the MG-RAST Metagenomics Pipeline
$743,525Ananth Grama · Purdue University · R01 · FY2017 · AI
Examining the mechanisms and optimization of malaria chemoprevention strategies to improve birth outcomes in Africa
$743,488Michelle Roh · Oregon Health & Science University · R00 · FY2025 · HD