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17,054 grants matching “genome editing”
Mechanisms of genetic and non-genetic resistance to KRAS inhibition
$607,849Lukas Edward Dow · Weill Medical Coll Of Cornell Univ · R01 · FY2025 · CA
Genomic modification with purified nuclease proteins for HIV-1 therapy
$607,832Dennis R. Burton · Scripps Research Institute, The · R01 · FY2014 · DE
Genetics and Functional Studies of Autosomal Recessive Neurological Disorders
$607,782Saima Riazuddin · University Of Maryland Baltimore · R01 · FY2018 · NS
Genetic Dissection of Cells and Organisms Training Grant
$607,699Noah K Whiteman · University Of California Berkeley · T32 · FY2023 · GM
Development of scalable methods for rapid phenotyping and functional testing of variants
$607,682Gaurav K Varshney · Oklahoma Medical Research Foundation · R24 · FY2024 · OD
The role of apolipoprotein E in Alzheimer's adaptive immunity
$607,408David Gate · Northwestern University At Chicago · R01 · FY2023 · AG
The role of apolipoprotein E in Alzheimer's adaptive immunity
$607,408David Gate · Northwestern University At Chicago · R01 · FY2024 · AG
The role of apolipoprotein E in Alzheimer's adaptive immunity
$607,408David Gate · Northwestern University At Chicago · R01 · FY2022 · AG
Development and validation of novel mouse models and expression vectors for characterizing severe alpha-thalassemia pathophysiology and evaluating gene therapy approaches.
$607,388Stefano Rivella · Children'S Hosp Of Philadelphia · R01 · FY2025 · DK
Natural Killer Cell Tolerance to Self
$607,262Wayne M. Yokoyama · Washington University · R01 · FY2022 · AI
Phase II IUCRC at University of Kentucky: Center for Arthropod Management Technologies (CAMTech)
$607,199Subba R Palli · University Of Kentucky Research Foundation · · FY2018 · ENG
Discovery of conserved molecular mechanisms underlying population-wide variation in toxin responses
$607,077Erik Christian Andersen · Northwestern University · R01 · FY2019 · ES
Robust Software Components for Model Organism Databases
$607,066Peter D Karp · Sri International · R01 · FY2007 · GM
Analysis of Inhibitory Synaptic Proteins Associated with Brain Disorders
$606,937Scott H Soderling · Duke University · R01 · FY2019 · NS
Identifying causal variants and genes underlying breast cancer risk loci
$606,904Matthew L Freedman · Dana-Farber Cancer Inst · R01 · FY2018 · CA
Role of LMO1 in Neuroblastoma Initiation and Maintenance
$606,838John M Maris · Children'S Hosp Of Philadelphia · R01 · FY2016 · CA
Role of LMO1 in Neuroblastoma Initiation and Maintenance
$606,838John M Maris · Children'S Hosp Of Philadelphia · R01 · FY2018 · CA
Role of LMO1 in Neuroblastoma Initiation and Maintenance
$606,838John M Maris · Children'S Hosp Of Philadelphia · R01 · FY2017 · CA
The olfactory basis of locating nectar sugar sources in Aedes aegypti mosquitoes
$606,835Jeffrey A Riffell · University Of Washington · R01 · FY2025 · AI
Investigation of Reactions of Physiological Importance
$606,572Paul R Schimmel · Scripps Research Institute, The · R01 · FY2008 · GM
Gene-Environment interactions in Autism
$606,543Victor G. Corces · Emory University · R01 · FY2022 · ES
Neurotology Program
$606,260Wade Chien · National Institute On Deafness And Other Communication Disorders · ZIA · FY2015 · DC
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** MANY CROPS, INCLUDING MAIZE, SORGHUM, AND MANY MILLETS, OCCUR IN A SUB-FAMILY OF GRASSES CALLED THE PANICOIDEAE. ALL PANICOIDS SHARE A FLORAL TRAIT THAT CONSTRAINS THEIR POTENTIAL PRODUCTIVITY. GRASS FLOWERS OCCUR IN STRUCTURES CALLED SPIKELETS. PANICOIDEAE SPIKELETS CONTAIN TWO FLOWERS, BUT USUALLY ONLY ONE FLOWER (THE UPPER FLOWER) IS FERTILE AND PRODUCES A GRAIN AFTER POLLINATION. THIS IS BECAUSE THE FLORAL ORGANS (CALLED CARPELS) THAT GO ON TO FORM THE GRAIN ARE SUPPRESSED IN LOWER FLOWERS, LEADING TO STERILE FLOWERS. THUS, POTENTIAL CROP PRODUCTIVITY IS CONSTRAINED BY CARPEL SUPPRESSION. IN THIS ERA OF GENOME ENGINEERING, CARPEL SUPPRESSION GENES COULD BE TRANSFORMATIVE TARGETS FOR GENOME EDITING AND YIELD IMPROVEMENT. HOWEVER, ONLY A FEW GENES ARE KNOWN TO REGULATE CARPEL SUPPRESSION IN MAIZE AND ITS RELATIVES. FURTHERMORE, HOW THESE GENES INTERACT IN PATHWAYS, AND WHETHER THESE GENES HAVE CONSERVED FUNCTIONS IN MANY GRASS SPECIES REMAINS UNKNOWN. HERE, WE WILL (1) EXPAND THE LIST OF GENES WITH KNOWN ROLES IN CARPEL SUPPRESSION, (2) DETERMINE HOW CARPEL SUPPRESSION GENES ARE ORDERED INTO GENETIC NETWORKS AND PATHWAYS IN MAIZE, AND (3) TEST THE HYPOTHESIS THAT A COMMON GENETIC MECHANISM REGULATES CARPEL SUPPRESSION IN THE PANICOIDEAE. TO ACHIEVE THESE OBJECTIVES, WE WILL USE STATE-OF-THE-ART METHODS IN GENETICS, GENOMICS, COMPUTER VISION, AND QUANTITATIVE PHENOTYPING.THIS PROJECT WILL PROVIDE FUNDAMENTAL KNOWLEDGE FOR ENSURING RESILIENT AND PROSPEROUS AGRICULTURAL SYSTEMS IN THE U.S. CARPEL SUPPRESSION GENES REPRESENT PROMISING TARGETS TO INCREASE YIELD IN MAIZE, AN IMPORTANT CROP IN THE U.S., AND IN ITS CLIMATE RESILIENT RELATIVES IN THE PANICOIDEAE. OUR RESULTS WILL REPRESENT AN IMPORTANT FIRST STEP IN DETERMINING THE GENETIC ARCHITECTURE OF CARPEL SUPPRESSION AND WILL ALLOW US TO EVALUATE THE POTENTIAL FOR THE GENES WE IDENTIFY TO AFFECT PRODUCTIVITY IN MAIZE AND THE MODEL PANICOID SETARIA VIRIDIS AT SMALL SCALES. GIVEN THE RELATIVE EASE OF GENOME EDITING IN MANY GRASSES, THE DISCOVERIES WE MAKE CAN BE TRANSLATED TO OTHER CROPS, TO BE RIGOROUSLY EVALUATED IN YIELD TRIALS. THERE IS A GROWING INTEREST WORLDWIDE IN CLIMATE- RESILIENT PANICOID CROPS, INCLUDING SORGHUM AND PROSO MILLET. HOWEVER, WHILE MANY MILLETS ARE DROUGHT, SALT AND HEAT TOLERANT, MOST ARE NOT HIGH-YIELDING, AND HAVE NOT BEEN SUBJECT TO THE INTENSIVE BREEDING THAT HAS SO DRAMATICALLY IMPROVED U.S. MAIZE YIELD IN THE 20TH CENTURY. SELECTIVE BREEDING, TOGETHER WITH TARGETED MODIFICATIONS TO KEY DEVELOPMENTAL GENES, SUCH AS CARPEL SUPPRESSION GENES, COULD DRAMATICALLY ACCELERATE YIELD IMPROVEMENTS. THUS, IDENTIFYING THE GENES THAT CONTROL PANICOID CROP PRODUCTIVITY COULD ACCELERATE THE PRODUCTION OF HIGH-YIELDING, CLIMATE-RESILIENT CROPS THAT WOULD ENHANCE THE LONG-TERM SUSTAINABILITY OF U.S. FOOD PRODUCTION SYSTEMS.
$606,031Oregon State University · · FY2025 · National Institute of Food and Agriculture
Functional Validation of Intracranial Aneurysm Risk Genes
$605,997Murat Gunel · Yale University · R01 · FY2021 · NS
HBB gene-editing for treating sickle cell disease
$605,943Gang Bao · Rice University · R01 · FY2023 · HL