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15,273 grants matching “antimicrobial resistance”
MANY LEADING GOVERNMENTAL ORGANIZATIONS INCLUDING THE USDA RECOGNIZE ANTIMICROBIAL RESISTANCE AS A POTENTIAL AND SERIOUS THREAT FOR HUMAN HEALTH. MULTI-DRUG RESISTANT PATHOGENS ARE LARGELY EMERGING BY THE SHARING OF RESISTANCE GENES BETWEEN BACTERIA IN FARM ANIMALS AND HUMAN PATHOGENS THROUGH TRANSMISSIBLE PLASMIDS, WHICH ARE MOBILE GENETIC ELEMENTS THAT CAN CONFER RESISTANCE TO ANTIBIOTICS. HOWEVER, WE STILL DON'T KNOW THE TRAJECTORIES OF THE RESISTANCE PLASMIDS FROM FARMS TO DEADLY HUMAN PATHOGENS, WHICH ENVIRONMENTS PROMOTE PLASMID TRANSFER, AND WHO ARE THE KEY PLAYERS IN THIS DISSEMINATION NETWORK. FERTILIZATION OF SOIL WITH MANURE IS THOUGHT TO SPREAD ANTIMICROBIAL RESISTANCE IN SOILS BY HORIZONTAL TRANSFER OF RESISTANCE PLASMIDS, BUT EVIDENCE IS LIMITED. OUR LONG-TERM GOAL IS TO DETERMINE IF FERTILIZATION OF AGRICULTURAL SOIL WITH MANURE PROMOTES THE ESTABLISHMENT OF RESISTANCE PLASMIDS IN THE SOIL MICROBIOME TO FORM A PERSISTENT RESISTANCE GENE RESERVOIR. HERE WE PROPOSE TOACHIEVE THE FOLLOWING OBJECTIVES, THROUGH A COMBINATION OF NOVEL MOLECULAR METHOD DEVELOPMENT, FIELD AND MICROCOSM STUDIES THAT INVOLVE MULTIDISCIPLINARY APPROACHES FROM ENVIRONMENTAL MICROBIOLOGY, PLASMID BIOLOGY, BIOTECHNOLOGY, BIOINFORMATICS AND STATISTIC MODELING: (1) DETERMINE AND IMPROVE THE LIMITS OF A NEW APPLICATION OF THE HI-C METHOD TO DETECT HORIZONTAL TRANSFER OF RESISTANCE PLASMIDS BETWEEN BACTERIA IN AGRICULTURAL SOILS; (2) DETERMINE THE EFFECT OF MANURE TREATMENT ON THE SPREAD OF A MULTI-DRUG RESISTANCE PLASMID IN THE SOIL SURROUNDING THE ROOTS OF BARLEY; AND (3) DETERMINE THE LONG-TERM EFFECT OF MANURE FERTILIZATION ON THE BACTERIAL RESERVOIRS OF ANTIBIOTIC RESISTANCE GENES AND PLASMIDS IN A REAL AGRICULTURAL FIELD. OUR FINDINGS ARE CRITICAL TO CONTINUED SUSTAINABILITY OF AGRICULTURE AS THEY WILL AID FUTURE DEVELOPMENTS OF STRATEGIES TO SLOW THE SPREAD OF ANTIMICROBIAL RESISTANCE.
$454,402Regents Of The University Of Idaho · · FY2018 · National Institute of Food and Agriculture
The LiaFSR system and antimicrobial peptide resistance in enterococci
$454,282Cesar Augusto Arias · Methodist Hospital Research Institute · R01 · FY2021 · AI
Transition Metal Homeostasis and Reactive Sulfur Species in Bacterial Pathogens
$454,275David P. Giedroc · Trustees Of Indiana University · R35 · FY2023 · GM
Novel Antimicrobial Agents Against M. tuberculosis
$454,104Marcus Aaron Horwitz · University Of California Los Angeles · R01 · FY2008 · AI
Bacteriophage diversity, dynamics, function, and exploitation
$454,027Graham F. Hatfull · University Of Pittsburgh At Pittsburgh · R35 · FY2021 · GM
Bacteriophage diversity, dynamics, function, and exploitation
$454,027Graham F. Hatfull · University Of Pittsburgh At Pittsburgh · R35 · FY2020 · GM
Bacteriophage diversity, dynamics, function, and exploitation
$454,027Graham F. Hatfull · University Of Pittsburgh At Pittsburgh · R35 · FY2023 · GM
Bacteriophage diversity, dynamics, function, and exploitation
$454,027Graham F. Hatfull · University Of Pittsburgh At Pittsburgh · R35 · FY2022 · GM
Prevention of Candida biofilms by localized delivery of aurein analogues
$453,819Sean P Palecek · University Of Wisconsin-Madison · R33 · FY2021 · AI
Targeting DXP synthase in bacterial metabolism
$453,810Caren L. Freel Meyers · Johns Hopkins University · R01 · FY2025 · AI
Pseudomonas aeruginosa Microcolony Aggregates Elicit Neutrophil Swarming
$453,750Bryan P Hurley · Massachusetts General Hospital · R21 · FY2025 · AI
Role of interleukin-36gamma in genital HSV-2 pathogenesis
$453,703Melissa Marie Herbst-Kralovetz · University Of Arizona · R15 · FY2015 · AI
Transition Metal Homeostasis and Reactive Sulfur Species in Bacterial Pathogens
$453,652David P. Giedroc · Trustees Of Indiana University · R35 · FY2024 · GM
Subproject 4 Antimicrobials and Efflux Pumps in Staphylococcus aureus Infection
$453,650David C Hooper · Massachusetts Eye And Ear Infirmary · P01 · FY2018 · AI
Nutritional regulation of pathogenesis in Staphylococcus aureus
$453,635Shaun R Brinsmade · Georgetown University · R01 · FY2020 · AI
Phage-Seq phenotyping of the Pseudomonas aeruginosa surface-ome
$453,629Barbara I Kazmierczak · Yale University · R21 · FY2025 · AI
Deciphering How Bacterial Surface Properties Influence Social Behaviors
$453,621Stephen Paul Diggle · Georgia Institute Of Technology · R56 · FY2024 · AI
Binding and regulation mechanism for S aureus
$453,541Dartmouth College · R01 · FY2004 · AI
Uncultured bacteria for the discovery of novel antimicrobials
$453,409Amy Lynn Spoering · Northeastern University · P01 · FY2020 · AI
A Trial to Explore the Benefits of Antimicrobial Self-Sanitizing Surfaces on Bio-Burden Levels and Healthcare-Acquired Infections.
$453,389Chetan Jinadatha · Central Texas Veterans Research Foundation · R01 · FY2021 · HS
Novel mechanisms of DNA repair and cell cycle regulation in bacteria
$453,306Lyle Simmons · University Of Michigan At Ann Arbor · R35 · FY2025 · GM
Evolution and consequences of multidrug resistant ribosome
$453,279M.-N. Frances Yap · Northwestern University At Chicago · R01 · FY2021 · AI
Prevention of Candida biofilms by localized delivery of aurein analogues
$453,234Sean P Palecek · University Of Wisconsin-Madison · R33 · FY2020 · AI
Application of Imaging to Development of Tuberculosis Interventions
$453,203Jeffrey D. Cirillo · Texas A&M University Health Science Ctr · R01 · FY2014 · AI
Subproject 2 C. elegans-Mediated Discovery of Antimicrobial Compounds Against MRSA and VRE
$453,158Frederick M Ausubel · Massachusetts Eye And Ear Infirmary · P01 · FY2017 · AI