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24,576 grants matching “microbiome”
Translational Studies of Age-Associated Arterial Dysfunction, Western Diet and Aerobic Exercise: Role of the Gut Microbiome
$734,456Douglas R Seals · University Of Colorado · R01 · FY2018 · HL
THE CENTRAL GRASSLANDS OF THE MIDWEST, WHICH CONTRIBUTE $10 BILLION IN AGRICULTURAL ANNUALLY TO KANSAS ALONE, ARE DOMINATED BY THE PERENNIAL GRASS ANDROPOGON GERARDII. THIS FOUNDATIONAL GRASS SPECIES COMPRISES UP TO 80% OF GRASSLAND BIOMASS AND IS HEAVILY IMPACTED BY DROUGHT. GIVEN THAT DROUGHT FREQUENCY IS EXPECTED TO INCREASE, MANAGING FOR RESILIENCY IN THIS CRITICAL ECOSYSTEM REQUIRES UNDERSTANDING HOW A. GERARDII RESPONDS TO DROUGHT. DESPITE THE IMPORTANCE OF ANDROPOGON GERARDII TO NATURAL PRAIRIES AND MANAGED RANGELANDS, WE KNOW LITTLE ABOUT THE LINKAGES BETWEEN THESE COMPONENTS AND PROCESSES. WE KNOW EVEN LESS ABOUT THE POTENTIAL FOR ESTABLISHMENT OF NEW PLANT HOST POPULATIONS AND THEIR RHIZOBIOMES UNDER ANTICIPATED SCENARIOS OF ENVIRONMENTAL CHANGE WITH IMPLICATIONS FOR GRASSLAND RESTORATION. INCREASING EVIDENCE SUGGESTS THAT THE RESPONSES OF PLANTS TO DROUGHT ARE MEDIATED BY SOIL MICROBIAL PROCESSES. THUS, DESIGNING APPROPRIATE MANAGEMENT STRATEGIES TO INCREASE RESILIENCY TO DROUGHT WILL REQUIRE UNDERSTANDING UNDERLYING ECOTYPIC VARIATION IN A. GERARDII, HOW THIS RELATES TO SOIL MICROBIAL COMMUNITIES AND SOIL PROCESSES, AND THE DEGREE OF MATCH BETWEEN HOST AND SOIL MICROBES. IT WILL ALSO REQUIRE ANTICIPATING SHIFTS IN THE PLANT-SOIL MICROBE RELATIONSHIP AS CONDITIONS CHANGE.WE AIM TO ELUCIDATE THE INTERACTION BETWEEN PLANT HOST AND ITS ASSOCIATED RHIZOBIOME BY EXAMINING THE RHIZOBIOME COMPOSITION AND FUNCTION, NUTRIENT CYCLING, PLANT GENETICS, PLANT PHENOTYPE, AND PLANT GENE EXPRESSION. TO DO THIS, WE WILL USE A SET OF COMPLEMENTARY FIELD AND GREENHOUSE EXPERIMENTS, BROAD GEOGRAPHIC SAMPLING OF NATURAL GRASSLANDS ACROSS THE GREAT PLAINS, AND SEVERAL MODELING AND APPROACHES. WE WILL INTEGRATE MULTI-OMICS DATA, PLANT PHENOTYPE AND GENOTYPE ANALYSES, AND MICROBIALLY MEDIATED PROCESSES THROUGH A MIXED MODEL. FINALLY, WE WILL EXPLOIT RHIZOBIOME FUNCTIONS, STRUCTURAL EQUATION MODELING (SEM) AND SPATIAL MODELING TO PREDICT HOW ECOTYPE VARIATION WILL AFFECT RHIZOBIOME INTERACTIONS AND MICROBIALLY MEDIATED PROCESSES ACROSS THE GREAT PLAINS. THE OUTCOME WILL BE A MORE COMPLETE UNDERSTANDING OF HOW PLANT GENETIC DIVERSITY AFFECTS RHIZOBIOME COMPOSITION AND FUNCTION, AND IN TURN MICROBIALLY MEDIATED PROCESSES. HERE WE PROPOSE TO 1) QUANTIFY THE RELATIONSHIP BETWEEN THE PLANT ECOTYPE, ASSOCIATED RHIZOBIOME, AND MICROBIALLY-MEDIATED SOIL PROCESSES; 2) TEST WHETHER MISMATCHES BETWEEN HOST ECOTYPE AND RHIZOBIOME AFFECT PLANT FITNESS AND DROUGHT; 3) DETERMINE IF THE OBSERVED PLANT GENETIC DIVERSITY IN PLANT POPULATIONS IN NATURAL PRAIRIES ACROSS THE GREAT PLAINS FEEDS BACK TO AFFECT RHIZOBIOME COMPOSITION AND SOIL PROCESSES; AND 4) PREDICT CURRENT AND FUTURE RESPONSES OF PLANT-MICROBE-SOIL PROCESSES TO DROUGHT AND TEMPERATURE.WE WILL ACCOMPLISH THIS RESEARCH BY INTEGRATING TRANSDISCIPLINARY EXPERTISE IN ECOLOGICAL GENOMICS, BIOINFORMATICS AND COMPUTATIONAL SCIENCE, MICROBIOME DIVERSITY AND FUNCTION, ECOSYSTEM PROCESSES, AND SPATIAL DISTRIBUTION MODELING. THIS RESEARCH WILL HELP CHARACTERIZE A. GERARDII ECOTYPE RESPONSES TO FUTURE CHANGING CLIMATES AND WILL IDENTIFY IF LOCAL ADAPTATION TO CLIMATE AND THE RHIZOBIOME LIMITS THIS SPECIES' ABILITY TO ADJUST TO CHANGING CLIMATE, OR IF POPULATIONS HAVE POTENTIAL TO MIGRATE (OR BE RESTORED) TO MATCH FUTURE CLIMATE CONDITIONS. ULTIMATELY, OUR RESULTS WILL INFORM CONSERVATION AND RESTORATION MANAGERS TO BETTER IDENTIFY THE OPTIMAL REGIONAL ECOTYPES AND SOIL THAT OPTIMIZES PRODUCTIVITY AND ECOSYSTEM PROCESSES UNDER DIFFERENT CLIMATE SCENARIOS.OUR WORK WILL BE CRITICAL FOR ENSURING THE ECONOMIC INTEGRITY AND ENHANCING RESILIENCY OF THIS ECONOMICALLY VITAL ECOSYSTEM.
$734,398Kansas State University · · FY2020 · National Institute of Food and Agriculture
Employing the gut microbiome to accelerate effective initiation of rheumatoid arthritis therapy
$734,366Jose U. Scher · New York University School Of Medicine · R01 · FY2019 · AR
Extent and Significance of Bacterial DNA Integrations in the Human Cancer Genome
$734,269Julie Dunning Hotopp · University Of Maryland Baltimore · R01 · FY2016 · CA
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** GLOBALLY, FORESTS PROVIDE ECOSYSTEM SERVICES VALUED AT ~$5 TRILLION ANNUALLY. SUCH SERVICES INCLUDE CARBON STORAGE, THE PROCESSING OF NUTRIENTS, AND THE REGULATION OF DOWNSTREAM WATER QUANTITY AND QUALITY. WILDFIRE IS A NATURAL COMPONENT OF HEALTHY FORESTS, BUT THE INTENSITY AND FREQUENCY OF FIRE DISTURBANCE HAS DRAMATICALLY INCREASED IN RECENT DECADES. ALTHOUGH THESE LARGE DISTURBANCES LIKELY IMPACT THE SOIL MICROBIOME AND ASSOCIATED BIOGEOCHEMICAL PROCESSES, WE LACK CRITICAL INFORMATION ON HOW WILDFIRE ALTERS MICROBIOME FUNCTION AND ASSOCIATED CARBON AND NITROGEN CYCLING.ADDRESSING A KEY PROGRAM AREA PRIORITY OF CHARACTERIZING MICROBIOMES THAT OPTIMIZE ENVIRONMENTAL PROCESSES, WE PROPOSE TO DEVELOP A MECHANISTIC UNDERSTANDING OF THE FUNCTIONAL SHIFTS WITHIN THE MICROBIAL COMMUNITY IN BURNED SOILS AND THE CORRESPONDING MOLECULAR LEVEL CHANGES IN MICROBIALLY-AVAILABLE CARBON AND NITROGEN. SHORT-TERM RESPONSES WILL BE MEASURED ACROSS BURN SEVERITY GRADIENTS AT TWO RECENTLY BURNED FORESTED CATCHMENTS IN COLORADO. FROM HERE, WE WILL LEVERAGE OUR UNIQUE ACCESS TO CONTROLLED PILE-BURNS WITHIN COLORADO FORESTS THAT PROVIDE A 60-YEAR BURN AND ECOSYSTEM RECOVERY CHRONO-SEQUENCE, ENABLING US TO ASSESS LONGER-TERM MICROBIOLOGICAL AND GEOCHEMICAL RESPONSES IN AN ESTABLISHED POST-FIRE FIELD-SCALE LABORATORY. FINALLY, WE WILL USE LABORATORY PYROCOSMS TO IDENTIFY MICROBIAL AND BIOGEOCHEMICAL CHANGES UNDER A CONTROLLED RANGE OF FIRE CONDITIONS, YIELDING COMPLEMENTARY, YET TRACTABLE, DATASETS TO SUPPORT FIELD OBSERVATIONS. ACROSS THESE SCALES WE WILL USE A MULTI-OMIC FRAMEWORK THAT INFORMS ON COMMUNITY FUNCTIONAL POTENTIAL AND ACTIVITY AND GENERATES DATA TO PARAMETERIZE METABOLIC MODELS THAT LINK CHEMICAL AND MICROBIAL DATA. TOGETHER, THESE INSIGHTS WILL SHED NEW LIGHT ON MICROBIAL CONTROLS ON SOIL HEALTH FOLLOWING WILDFIRE AND WILL AID DEVELOPMENT OF MORE ACCURATE BIOGEOCHEMICAL MODELS OF POST-FIRE WATERSHED RESPONSES.
$734,243Colorado State University · · FY2021 · National Institute of Food and Agriculture
Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases
$734,233Adriana H Tremoulet · University Of California, San Diego · U54 · FY2018 · HD
Comprehensive Toxicological Assessments for the National Toxicology Program; Subproject 5 (Microbiome)
$734,167National Institute Of Environmental Health Sciences · Y01 · FY2021 · ES
Toward Personalized Therapeutics: Directed Remodeling of the Gut Microbiome to Treat Atherosclerosis
$734,089M. Reza Ghadiri · Scripps Research Institute, The · R01 · FY2022 · HL
Toward Personalized Therapeutics: Directed Remodeling of the Gut Microbiome to Treat Atherosclerosis
$734,089M. Reza Ghadiri · Scripps Research Institute, The · R01 · FY2021 · HL
Toward Personalized Therapeutics: Directed Remodeling of the Gut Microbiome to Treat Atherosclerosis
$734,089M. Reza Ghadiri · Scripps Research Institute, The · R01 · FY2020 · HL
Physiological Responses to Activation of Human Brown Adipose Tissue
$733,759Aaron Cypess · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2025 · DK
Investigating neurobehavioral consequences of COVID-19 related stressors on maternal mental health and infant development
$733,744Natalie Hiromi Brito · New York University · R01 · FY2022 · MH
Research Experiences in Genomic Applications of Responsible Data Science (REGARDS)
$733,503Donald E Brown · University Of Virginia · R25 · FY2024 · HG
Understanding Oral Diseases in Cystic Fibrosis to Develop Tailored Preventive Dental Interventions
$733,499Donald Leslie Chi · University Of Washington · U01 · FY2022 · DE
Early life antibiotics, gut microbiome development, and risk of childhood obesity
$733,455Jeffrey Stephen Gerber · Children'S Hosp Of Philadelphia · R01 · FY2017 · AI
CMV responses in autoantibody positive subjects advocate antiviral treatments for prevention of T1D
$733,450Nora E Sarvetnick · University Of Nebraska Medical Center · R01 · FY2020 · AI
Designer Probiotics for the treatment of intestinal infection and inflammation
$733,448Cammie Lesser · Massachusetts General Hospital · R01 · FY2020 · DK
Phase 2 placebo-controlled randomized trial of LACTIN-V (Lactobacillus crispatus CTV-05) among women at high risk of HIV acquisition in Durban, South Africa
$733,316Craig R Cohen · University Of California, San Francisco · R01 · FY2021 · HD
Trinity: Transcriptome assembly for genetic and functional analysis of cancer
$733,109Aviv Regev · Broad Institute, Inc. · U24 · FY2014 · CA
Prospective evaluation of outcomes in cirrhosis of different etiologies: impact of HIV infection and simvastatin therapy
$733,101Srinivasan Dasarathy · Cleveland Clinic Lerner Com-Cwru · U01 · FY2025 · DK
Prospective evaluation of outcomes in cirrhosis of different etiologies: impact of HIV infection and simvastatin therapy
$733,101Srinivasan Dasarathy · Cleveland Clinic Lerner Com-Cwru · U01 · FY2024 · DK
AZITHROMYCIN TO PREVENT RECURRENT WHEEZING FOLLOWING SEVERE RSV BRONCHIOLITIS
$733,063Avraham Beigelman · Washington University · R01 · FY2018 · HL
Evaluation of the gut-kidney axis in kidney stone disease
$732,932Gregory Edward Tasian · Children'S Hosp Of Philadelphia · R01 · FY2020 · DK
BIOREPOSITORY OPTIMIZATION AND USE FOR ENDOTYPING CRITICALLY ILL SARS-COV-2 INFECTED PATIENTS
$732,923Leopoldo Nicolas Segal · New York University School Of Medicine · R33 · FY2025 · GM
The Sepsis ClinicAl Resource And Biorepository (SCARAB) Project
$732,903Julie Anne Bastarache · Vanderbilt University Medical Center · R33 · FY2024 · GM