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27,075 grants matching “cholesterol”
Morbidity and Mortality Relating to Gastric Bypass Surgery
$604,981Steven C. Hunt · University Of Utah · R01 · FY2012 · DK
Recurrent circadian disruption & pancreatic B-cell responsiveness in older people
$604,930Charles A Czeisler · Brigham And Women'S Hospital · P01 · FY2014 · AG
THERE IS URGENT NEED TO DIVERSIFY METHODS FOR PROTEIN PRODUCTION SO THAT OUR FUTURE FOOD SYSTEM WILL BE RESILIENT TO DISRUPTIONS DUE TO THE IMPACTS OF CLIMATE VARIABILITY, NATURAL DISASTERS, AND FUTURE EPIDEMICS. ONE POTENTIAL EMERGING APPROACH USES TISSUE CULTURE METHODS TO ENABLE CULTURED MEAT. THE VISION OF THIS PROJECT IS TO DEVELOP CULTURED MEAT WITH PROPERTIES THAT CAN BE TAILORED FOR DEFINED FLAVOR AND NUTRITIONAL PROPERTIES, FROM A LEAN, LOW-CHOLESTEROL FILET MIGNON TO A MARBLED RIB-EYE RICH IN OMEGA-3 FATTY ACIDS. CRITICAL FOR THIS VISION ARE PHYSICAL SCAFFOLDS THAT MIMIC THE NATURAL GROWTH ENVIRONMENT OF MUSCLE AND FAT CELLS. SCAFFOLDS IMPACT CELL BEHAVIORS CRITICAL FOR THE EFFICIENT PRODUCTION OF PALATABLE CULTURED MEAT: THE STIFFNESS OF SCAFFOLDS CAN REGULATE CELL GROWTH, AND ALSO THE QUALITY OF MUSCLE AND FAT TISSUE, WHICH IS IMPORTANT FOR MEAT SENSORY AND NUTRITIONAL PROPERTIES, INCLUDING TEXTURE AND MOUTHFEEL. THE ROWAT LAB HAS BEEN WORKING TO DEVELOP EDIBLE 'MICROCARRIER' SCAFFOLDS THAT SUPPORT THE GROWTH OF CULTURED MUSCLE AND FAT TISSUE IN A LARGE VESSEL OR BIOREACTOR THAT HAS POTENTIAL TO SCALE UP TISSUE CULTURE THAT IS REQUIRED FOR FOOD PRODUCTION. THE GOAL OF THIS SPECIFIC PROJECT IS TO PRODUCE A CULTURED MEAT BURGER WITH DEFINED FAT CONTENT TO MEET DIFFERENT CONSUMER NEEDS, AND TO IDENTIFY SUPPLEMENTS THAT ENABLE US TO TUNE THE LIPID COMPOSITION OF CULTURED MEAT TOWARDS ACHIEVING NUTRITIOUS AND FLAVORFUL CULTURED MEAT. THE SPECIFIC OBJECTIVES OF THE PROJECT ARE: OBJECTIVE 1) DEVELOP EDIBLE MICROCARRIER SCAFFOLDS TO SUPPORT CULTURED MUSCLE MICROTISSUE; OBJECTIVE 2) DEVELOP EDIBLE MICROCARRIER SCAFFOLDS TO SUPPORT CULTURED FAT MICROTISSUE WITH DESIRED LIPID CONTENT; OBJECTIVE 3) PRODUCE CULTURED GROUND BEEF WITH DESIRED QUALITIES USING EDIBLE MICROCARRIER SCAFFOLDS. FINDINGS WILL ESTABLISH PROOF-OF-CONCEPT CULTURED BEEF IN THE FORM OF A GROUND BEEF PATTY OR 'BURGER' THAT HAS DESIRED SENSORY AND NUTRITIONAL QUALITIES. THE RESULTS OF THIS PROJECT WILL ALSO DEVELOP AN INNOVATIVE MANUFACTURING TECHNOLOGY FOR CULTURED MEAT, SPECIFICALLY FOCUSED ON EDIBLE MICROCARRIER SCAFFOLDS NECESSARY TO ACHIEVE OPTIMAL TEXTURE AND NUTRIENT PROPERTIES FOR CULTURED BEEF WITH TUNABLE FAT CONTENT. BY USING OUR EDIBLE MICROCARRIER SCAFFOLDS THAT HAVE TUNABLE MECHANICAL PROPERTIES, THERE IS POTENTIAL TO INCREASE THE EFFICIENCY OF MUSCLE AND ADIPOSE MICROTISSUE PRODUCTION FOR CULTURED MEAT APPLICATIONS. WE WILL ALSO DEVELOP A FRAMEWORK TO CULTURE A GROUND BEEF PRODUCT THAT HAS IMPROVED TEXTURE AND NUTRITIONAL PROPERTIES BY TUNING THE COMPOSITION AND CONTENT OF LIPIDS. MORE BROADLY, OUR FINDINGS SHOULD CONTRIBUTE TO THE DEVELOPMENT OF CULTURED MEAT AS A FEASIBLE METHOD FOR PROTEIN PRODUCTION, WHICH CAN ULTIMATELY SUPPORT THE INCREASED RESILIENCY OF FUTURE FOOD SYSTEMS.
$604,907University Of California, Los Angeles · · FY2022 · National Institute of Food and Agriculture
The altered lipid and protein metabolism of pediatric patients with HIV infection
$604,778Farook Jahoor · Baylor College Of Medicine · R01 · FY2010 · HD
SPHINGOLIPID BIOLOGY OF MACROPHAGE IN CORONARY ATHEROSCLEROSIS DEVELOPMENT AND PROGRESSION
$604,734Annarita Di Lorenzo · Weill Medical Coll Of Cornell Univ · R01 · FY2023 · HL
Biological Pathways of Acute and Chronic Stress in Aged Hip Fracture Caregivers
$604,647Lisa Fredman · Boston University Medical Campus · R01 · FY2012 · AG
Evaluating Standing as a Health Behavior to Promote Cardiovascular Risk Reduction in African Americans
$604,623Keith M Diaz · Columbia University Health Sciences · R01 · FY2021 · HL
Cholesterol efflux, CHIP and inflammasome activation
$604,538Alan Richard Tall · Columbia University Health Sciences · R01 · FY2024 · HL
Cyclodextrin as a Novel HIV Microbicide
$604,484James E.k Hildreth · Meharry Medical College · R01 · FY2007 · HD
Supplemental Se and Vitamin E and Pulmonary Function
$604,383Patricia A Cassano · Cornell University · R01 · FY2006 · HL
Optogenetic approaches to study post-stroke recovery mechanisms
$604,382Gary K Steinberg · Stanford University · R01 · FY2021 · NS
Vascular Endothelial Activation in Sleep Apnea
$604,381Sanja Jelic · Columbia University Health Sciences · R01 · FY2017 · HL
A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial Hypertension
$604,283Steven M Kawut · Columbia University Health Sciences · R01 · FY2007 · HL
LINKING GENOMICS TO FUNCTION VIA METABOLIC PHENOTYPING
$604,226Massachusetts Institute Of Technology · R01 · FY2000 · DK
Case Management for Underserved Hispanic Type 2 Diabetes Populations
$603,878Garry W Welch · Baystate Medical Center, Inc. · R01 · FY2011 · DK
Role of brain lipid metabolism in Alzheimer's disease
$603,824Xin Qi · Case Western Reserve University · R01 · FY2021 · AG
Role of brain lipid metabolism in Alzheimer's disease
$603,824Xin Qi · Case Western Reserve University · R01 · FY2022 · AG
Role of brain lipid metabolism in Alzheimer's disease
$603,824Xin Qi · Case Western Reserve University · R01 · FY2024 · AG
Role of brain lipid metabolism in Alzheimer's disease
$603,824Xin Qi · Case Western Reserve University · R01 · FY2023 · AG
Vascular Endothelial Activation in Sleep Apnea
$603,734Sanja Jelic · Columbia University Health Sciences · R01 · FY2018 · HL
Defining the role of PLA2G12B on apoB-containing lipoprotein assembly, plasma levels, metabolism and cardiovascular disease risk
$603,632Steven A Farber · Johns Hopkins University · R01 · FY2025 · DK
Longitudinal Study of Lipids and APOE in the Development of AD and AD Pathology
$603,622Michelle M Mielke · Mayo Clinic Rochester · U01 · FY2012 · AG
Weight management in rural health clinics
$603,552Joseph E. Donnelly · University Of Kansas Lawrence · R01 · FY2016 · DK
Atheroregression via Enhanced Reverse Choleserol Transport
$603,540Henry J. Pownall · Baylor College Of Medicine · R01 · FY2011 · HL
Endothelial Rap1 restricts inflammation in the retina
$603,488Magdalena Chrzanowska · Versiti Wisconsin, Inc. · R01 · FY2024 · EY