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24,576 grants matching “microbiome”
The Gut Microbiome and Personalized Mediterranean Diet Interventions for Cardiometabolic Disease Prevention
$726,100Dong Wang · Brigham And Women'S Hospital · R01 · FY2022 · NR
Antimicrobial Resistance and Horizontal Gene Transfer in the Human Gut Microbiome in Response to an Antibiotic
$726,080David A Relman · Palo Alto Veterans Instit For Research · R01 · FY2021 · AI
Research Training in Digestive Diseases
$725,975Raymond T Chung · Massachusetts General Hospital · T32 · FY2025 · DK
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** PLANT HIGH DIMENSIONAL PHENOTYPES (HDPS) ARE AN INCREASINGLY VALUABLE TOOL FOR UNDERSTANDING BIOLOGICAL FUNCTION AND INFORMING PLANT BREEDING SELECTION DECISIONS. ALSO KNOWN AS OMICS DATA, HDPS ENCOMPASS A WIDE RANGE OF DATA TYPES, INCLUDING SPECTRAL, METABOLOMIC, TRANSCRIPTOMIC, PROTEOMIC, AND MICROBIOME METAGENOMIC DATA. TO FURTHER THE UTILIZATION OF HDPS IN PLANT BREEDING PROGRAMS, THESE DATA MUST BE CLEARLY LABELED, EASILY ACCESSIBLE, AND FULLY INTEGRATED WITH OTHER DATA TYPES. OUR INTERDISCIPLINARY TEAM OF PLANT SCIENTISTS AND SOFTWARE DEVELOPERS HAS EXTENSIVE EXPERIENCE BUILDING USER-FRIENDLY, OPEN-SOURCE DATA MANAGEMENT AND ANALYSIS TOOLS THAT HAVE BEEN WIDELY ADOPTED BY PLANT BREEDERS AND GENETICISTS. THIS PROJECT FOCUSES ON ADDING SUPPORT FOR HDPS TO THESE TOOLS THROUGH THE FOLLOWING OBJECTIVES:A.GENERATE APPROPRIATE DATA MODELS FOR HDPS THAT ACCURATELY REPRESENT DATA STRUCTURE AND METADATA FOR PLANT BREEDING AND GENETICS USE CASES;B.DEVELOP BREEDING APPLICATION PROGRAMMING INTERFACE (BRAPI) STANDARDS TO EFFICIENTLY HANDLE EACH HDP DATA TYPE;C.DESIGN AND IMPLEMENT HDP STORAGE STRUCTURES IN A BRAPI-ENABLED BREEDING DATABASE;D.INTEGRATE HDP BRAPI ENDPOINTS INTO WIDELY-USED PLANT BREEDING DATA COLLECTION TOOLS;E.DEVELOP HDP BRAPI-ENABLED ANALYSIS APPLICATIONS (BRAPPS) THAT INTEGRATE OMICS AND OTHER PLANT BREEDING DATA TYPES.THE TOOLS DEVELOPED FROM THIS PROJECT WILL PROVIDE THE DIGITAL ECOSYSTEM NECESSARY TO HANDLE AND INTEGRATE HDP DATA WITH OTHER PLANT BREEDING DATA TYPES, ULTIMATELY ACCELERATING THE DEVELOPMENT OF IMPROVED CROP VARIETIES FOR FOOD, FIBER, AND FUEL. THIS PROPOSED PROJECT ADDRESSES THE AFRI PROGRAM PRIORITY AREAS OF PLANT HEALTH AND PRODUCTION AND PLANT PRODUCTS AND AGRICULTURE SYSTEMS AND TECHNOLOGY.
$725,925Clemson University · · FY2024 · National Institute of Food and Agriculture
Integrating quantitative energetics determines the microbiome's contribution to energy balance
$725,895Rosa Krajmalnik-Brown · Arizona State University-Tempe Campus · R01 · FY2016 · DK
Development of a New Diamine (SQ109) for the Treatment of C. difficile Infection
$725,821Marina N Protopopova · Sequella, Inc. · R01 · FY2013 · AI
METAGENOMICS OF ENTERIC DISEASE IN SIV-INFECTED AND UNINFECTED MACAQUES
$725,744Herbert W Virgin · Washington University · R01 · FY2013 · OD
3D Bioprinted skin models for drug screening
$725,728Marc Ferrer-Alegre · National Center For Advancing Translational Sciences · ZIA · FY2020 · TR
Unraveling gut-microbiome-brain interactions in neurodevelopmental disorders
$725,587Ergun Sahin · Baylor College Of Medicine · R01 · FY2025 · MH
Unraveling gut-microbiome-brain interactions in neurodevelopmental disorders
$725,587Ergun Sahin · Baylor College Of Medicine · R01 · FY2024 · MH
Reserve against Disability in Early Multiple Sclerosis (RADIEMS) Longitudinal Cohort Study
$725,508James Francis Sumowski · Icahn School Of Medicine At Mount Sinai · R01 · FY2022 · HD
Development of a New Diamine (SQ109) for the Treatment of C. difficile Infection
$725,317Marina N Protopopova · Sequella, Inc. · R01 · FY2014 · AI
Mechanisms and regulation of replication, the cell cycle, gene expression, and horizontal gene transfer in prokaryotes, focusing on Bacillus subtilis
$725,250Alan D Grossman · Massachusetts Institute Of Technology · R35 · FY2020 · GM
Viral micro-epidemics and evolutionary dynamics in bacterial biofilms
$725,000Carey D Nadell · Dartmouth College · · FY2018 · BIO
Gamma Delta T cell and microbial modulation to target chronic SIV-associated inflammation
$724,920Namita Rout · Tulane University Of Louisiana · R01 · FY2023 · DK
Effects of aging on primary and secondary vaccine responses in a 15-year longitudinal cohort
$724,766Scott Dexter Boyd · Stanford University · R01 · FY2019 · AI
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE OBJECTIVES OF THIS PROJECT ARE TO: 1) CHARACTERIZE SOIL MICROBIOME COMMUNITY STRUCTURES, FOCUSING ON VIRUSES, BACTERIA, ARCHAEA, AND FUNGI; 2) INVESTIGATE THE TEMPORAL EFFECTS AND INTERACTION OF DIFFERENT AGRICULTURAL MANAGEMENT PRACTICES ON SOIL MICROBIOMES AND CROP PRODUCTION; 3) DETERMINE THE IMPACTS OF VIRAL PREDATION ON SOIL MICROBIOME STRUCTURE AND FUNCTION, INCLUDING CROP PRODUCTION; AND 4) DEVELOP A CONCEPTUAL MODEL FOR HOW VIRUSES IMPACT SOIL MICROBIOMES, RESPOND TO SOIL MANAGEMENT PRACTICES, AND ULTIMATELY IMPACT SYSTEM PRODUCTIVITY. THESE OBJECTIVES WILL BE MET THROUGH A COMBINATION OF FIELD STUDIES AND MANIPULATIVE EXPERIMENTS USING MICROCOSM (GREENHOUSE) APPROACHES. METAGENOMICS AND AMPLICON HIGH-THROUGHPUT SEQUENCING WILL BE APPLIED TO CHARACTERIZE SOIL MICROBIAL COMMUNITIES, QUANTIFY VIRAL IMPACTS, AND ULTIMATELY INTEGRATE VIRUSES AS PART OF AGRICULTURE SOIL MICROBIOMES. THE PROPOSED WORK WILL ADDRESS PROGRAM GOALS BY: 1) CHARACTERIZING MOLECULAR MECHANISMS INVOLVEDIN MICROBIOME ASSEMBLY AND INTERACTIONS IN VARIOUS ENVIRONMENTS AND GROWTH STAGES; AND 2) FUNCTIONALLY CHARACTERIZING MICROBIOMES, INCLUDING VIRUSES, AND THEIR ROLE IN OPTIMIZATION OF ENVIRONMENTAL PROCESSES (I.E., NITROGEN CYCLING, SOIL HEALTH, PLANT GROWTH AND PRODUCTIVITY). WE LACK MODELS THAT INCLUDE THE ROLE OF VIRUSES IN AGRICULTURAL PRODUCTION SYSTEMS, AND CHARACTERIZATION OF THE SOIL VIROME STANDS AS A MAJOR CHALLENGE OF THE 21ST CENTURY. THE PROPOSED STUDY WILL SUBSTANTIALLY IMPROVE OUR FUNDAMENTAL UNDERSTANDING OF HOW VIRUSES IMPACT MICROBIAL COMMUNITY DYNAMICS, SOIL HEALTH AND CROP PRODUCTIVITY UNDER DIFFERENT AGRICULTURAL PRACTICES. PROJECT OUTCOMES WILL HELP US BETTER DESIGN AND TARGET BEST MANAGEMENT PRACTICES THAT CAN INFORM BETTER DECISION MAKING AND SUSTAIN OUR NEXT GENERATION OF AGRICULTURE.
$724,747College Of William And Mary · · FY2023 · National Institute of Food and Agriculture
CMV responses in autoantibody positive subjects advocate antiviral treatments for prevention of T1D
$724,605Nora E Sarvetnick · University Of Nebraska Medical Center · R01 · FY2019 · AI
A Foundation for the Oral Microbiome and Metagenome
$724,353Floyd E Dewhirst · Ada Forsyth Institute, Inc. · U01 · FY2010 · DE
Resilience to obesity in carriers of monogenic obesity mutations - a study on the underlying mechanisms
$724,329Ruth Jf Loos · Icahn School Of Medicine At Mount Sinai · R01 · FY2021 · DK
Impact of L. plantarum 299v Supplementation on Endothelial Function and Systemic Inflammation
$724,304Michael E Widlansky · Medical College Of Wisconsin · R01 · FY2019 · HL
Gut barrier function in Alzheimerâs disease
$724,177Barbara Brigitta Bendlin · University Of Wisconsin-Madison · R01 · FY2025 · AG
Enteric Pathogen Force of Infection among Children using Serology
$724,079Benjamin F Arnold · University Of California, San Francisco · R01 · FY2024 · AI
Alzheimer Disease Progression, Host Gut Microbiome, and Enteric Dysfunction
$723,623Beau M Ances · Washington University · P01 · FY2025 · AG
The enteric microbiome in treated and progressive HIV infection
$723,583Douglas Kwon · Massachusetts General Hospital · R01 · FY2016 · DK