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38,696 grants matching “als”
Precision mapping of individualized executive networks in youth
$755,876Damien A Fair · University Of Minnesota · R37 · FY2025 · MH
Genetically Engineered Mouse Models to Study Melanoma Genesis and Progression
$755,852Glenn T. Merlino · Division Of Basic Sciences - Nci · ZIA · FY2018 · CA
Preclinical Mouse Models for Studying Immune Checkpoint Inhibitor Response
$755,852Glenn T. Merlino · Division Of Basic Sciences - Nci · ZIA · FY2018 · CA
Early development of small molecule neuroprotectants.
$755,830Corinne Ida Lasmezas · Scripps Florida · R01 · FY2018 · NS
Zebrafish core
$755,762Christine Kettenhofen · Division Of Basic Sciences - Nci · ZIC · FY2022 · CA
Multiplexed Quantification of the Protein Poly-ADP-Ribosylation Landscape in C9ORF72-ALS/FTD
$755,606Yonghao Yu · Columbia University Health Sciences · R01 · FY2024 · NS
Drug Repurposing Screening for Rare and Neglected Diseases
$755,501Wei Zheng · National Center For Advancing Translational Sciences · ZIA · FY2025 · TR
Skin biomarkers for diagnosing and characterizing AD and ADRD
$755,388Allison L Kraus · Case Western Reserve University · R01 · FY2022 · AG
Pre-clinical Commercialization of a Synthetically Designed, Live-attenuated RSV Vaccine
$755,377Steffen Mueller · Codagenix, Inc. · R44 · FY2017 · AI
World Trade Center Monitoring and Treatment Program
$755,002Iris G Udasin · Univ Of Med/Dent Nj-R W Johnson Med Sch · U10 · FY2007 · OH
TDP-43 acetylation, phase separation, aggregation, and clearance by antibody-mediated degradation
$754,738Don W. Cleveland · University Of California, San Diego · R01 · FY2024 · NS
Resident-to-Resident Elder Mistreatment Intervention for Dementia Care in Assisted Living
$754,725Jeanne A. Teresi · Hebrew Home For The Aged At Riverdale · R01 · FY2019 · AG
Development of therapeutic chemokine-based formulations
$754,563Arya Biragyn · National Institute On Aging · ZIA · FY2014 · AG
FERMI-LAT OBSERVATIONS FROM 2008 TO 2020 UNVEILED SPECTRAL TEMPORAL AND SPATIAL FEATURES OF GAMMA-RAYS EMISSION FROM THE DISK AND HALO OF THE SUN THAT THEORETICAL MODELS ARE UNABLE TO EXPLAIN. LINDEN ET AL. PRL 121 131103 2018 SHOWED THAT THE AVAILABLE MODEL (SECKEL ET AL. APJ 382 652 1991) BASED ON MULTI-GEV TO TEV GALACTIC COSMIC-RAY (GCR) PROTONS BOUNCING BACK FROM THE SOLAR ATMOSPHERE AND THEREIN PRODUCING OUTGOING GAMMA-RAYS UNDERPREDICTS THE ~10 GEV PHOTON FLUX BY A FACTOR ~10. THESE OBSERVATIONS INDIRECTLY PROBE MAGNETIC FIELDS AND GCR TRANSPORT IN THE INNER HELIOSPHERE AND THE SOLAR ATMOSPHERE. PARKER SOLAR PROBE (PSP) HAS ALREADY REACHED THE CLOSEST DISTANCE TO THE SUN THAN ANY OTHER SPACECRAFT EVER BEFORE. PSP UNEXPECTEDLY FOUND THAT THE SOLAR WIND (SW) OUTFLOW IS LOCALLY REVERSED IN S-SHAPED STRUCTURES CALLED SWITCHBACKS (BALE ET AL. NATURE 1 2019) THAT HAD BEEN FOUND BY THE PREVIOUS MISSION HELIOS AS CLOSE AS ~0.3 AU TO THE SUN BUT ARE NOW KNOWN TO BE MUCH MORE COMMON CLOSER TO THE SUN. SCIENCE GOALS THIS PROPOSAL WILL INVESTIGATE THE ROLE OF THE TRANSPORT OF GEV-TEV GCRS IN THE MAGNETIC TURBULENCE AND IN SWITCHBACKS BY BRIDGING PSP WITH ONE OF THE MOST SUCCESSFUL AND PRODUCTIVE NASA MISSION OF THE PAST DECADE (FERMI). THE MAGNETIC TURBULENCE OF THE SW AT SMALL HELIOCENTRIC DISTANCES PROBED BY GCRS WILL BE CONSTRAINED BY LEVERAGING ON THE STEADILY INCREASING PSP DATABASE. IN PARTICULAR WE WILL INVESTIGATE THE SWITCHBACKS AS TURBULENT OR LAMINAR TRAPPING STRUCTURES FOR MULTI-GEV PROTONS AROUND THE SUN. SECONDLY WE WILL MODEL THE TRANSPORT OF GCRS CLOSE TO THE SUN ATMOSPHERE IN A REGIME OF LOW PITCH-ANGLE SCATTERING FREQUENCY. THIRDLY WE WILL COMPARE RADIO MAPS IN QUIET SW TO INFER TRANSPORT PROPERTIES OF ENERGETIC ELECTRONS BETWEEN MEV AND GEV. METHODOLOGY WE AIM AT A COORDINATED OBSERVATIONS/MODELLING EFFORT FOCUSING ON TWO DIFFERENT DISTANCES FROM THE SUN: IN-SITU MEASUREMENTS OF PSP PARTICLES (ISOIS SWEAP) AND PSP MAGNETIC FIELD (FIELDS) MULTI-GEV FLUX OBSERVATIONS FROM FERMI-LAT. WE LEVERAGE ON A LONG-ESTABLISHED VERSATILE EXPERTISE: THE UNIV OF ARIZONA WILL PROVIDE EXPERTISE IN THEORY OF PARTICLE TRANSPORT IN MAGNETIC TURBULENCE (TEST-PARTICLE SIMULATIONS IN MAGNETOSTATIC TURBULENCE SOLUTION TO THE FOCUSED TRANSPORT EQUATION) AND RADIATION MECHANISMS (NEUTRAL PION DECAY FROM PROTONS RADIO-SYNCHROTRON OR INVERSE COMPTON FOR ELECTRONS) MODELLING OF PSP DATA OHIO STATE UNIV. WILL PROVIDE EXPERTISE ON RADIATION MECHANISMS AND ON FERMI-LAT DATA ANALYSIS. STATEMENT OF RELEVANCE THIS PROJECT DIRECTLY ADDRESSES THE OVERARCHING GOAL AS DESCRIBED IN B.1 OF THE ROSES 2020 SOLICITATION EXPLORE AND CHARACTERIZE THE PHYSICAL PROCESSES IN THE SPACE ENVIRONMENT FROM THE SUN TO THE HELIOPAUSE AND THROUGHOUT THE UNIVERSE . THE PROJECT ALSO GOES BEYOND THE GOAL OF NASA MISSIONS BY ADDRESSING THE FOURTH HIGH-LEVEL SCIENCE GOAL FROM THE 2013-2022 HELIOPHYSICS DECADAL SURVEY ``SOLAR AND SPACE PHYSICS: A SCIENCE FOR A TECHNOLOGICAL SOCIETY'': DISCOVER AND CHARACTERIZE FUNDAMENTAL PROCESSES THAT OCCUR BOTH WITHIN THE HELIOSPHERE AND THROUGHOUT THE UNIVERSE . MANAGEMENT PLAN THIS PROPOSAL ASSIGNS WELL-DEFINED TASKS TO THE TEAM MEMBERS ESSENTIAL TO THE COMPLETION OF THE PROJECT: UNIV. OF ARIZONA TEAM INCLUDES PI F. FRASCHETTI CO-IS J. GIACALONE AND J. KOTA ONE POST-DOCTORAL RESEARCHER (YET UNIDENTIFIED WILL BE HIRED ACCORDING TO THEIR INTEREST/EXPERTISE). OHIO STATE UNIV. TEAM INCLUDES CO-IS A. PETER J. BEACOM AND ONE IDENTIFIED GRADUATE STUDENT.
$754,501University Of Arizona · · FY2022 · National Aeronautics and Space Administration
Brain Imaging And Modeling
$754,483Barry Horwitz · National Institute On Deafness And Other Communication Disorders · ZIA · FY2015 · DC
Familias Unidas Stage III Study: Preventing Substance Abuse in Hispanic Youth
$754,291Guillermo Prado · University Of Miami School Of Medicine · R01 · FY2012 · DA
PET Imaging Agents for the in vivo Detection of TDP-43
$754,275Allen Bernard Reitz · Fox Chase Chemical Diversity Center, Inc · R44 · FY2018 · AG
Biodistribution and PK modeling of rat vs. human systems
$754,240Michael L Shuler · Hesperos, Llc · R44 · FY2021 · ES
Advanced neural decoders for the restoration of communication
$754,087Jaimie M Henderson · Stanford University · R01 · FY2016 · DC
Genetic Mouse Models for the Study of Serotonin Function and Behavior
$753,743Dennis L Murphy · National Institute Of Mental Health · ZIA · FY2013 · MH
The Genetics of Obsessive Compulsive Disorder and Related OCD Spectrum Disorders
$753,743Dennis L Murphy · National Institute Of Mental Health · ZIA · FY2013 · MH
Single-Cell Transcriptional and Epigenomic Dissection to Identify Therapeutic Targets for ALS and FTD
$753,520Manolis Kellis · Massachusetts Institute Of Technology · R56 · FY2020 · AG
Development & Malleability from Childhood to Adulthood
$753,516Nicholas S Ialongo · Johns Hopkins University · R37 · FY2009 · DA
Reducing neural perseveration through closed loop real time fMRI neurofeedback to alleviate depressive symptoms
$753,456Yvette I Sheline · University Of Pennsylvania · R33 · FY2025 · MH
Genetic targeting of cortical pyramidal neuron subtypes
$753,224Z Josh Huang · Cold Spring Harbor Laboratory · R01 · FY2016 · MH