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24,576 grants matching “microbiome”
The dynamics of nasal bacterial ecology and S. aureus antagonism
$714,991Lance Bradley Price · George Washington University · R01 · FY2018 · AI
CoPARC: Colorado Pulmonary Alcohol Research Collaborative
$714,928Ellen L Burnham · University Of Colorado Denver · R24 · FY2019 · AA
The Development of Gut Microbiota and Behavioral Inhibition in Childhood: The Role of Early Stress and Brain Development
$714,881Cathi Barbra Propper · Univ Of North Carolina Chapel Hill · R01 · FY2021 · MH
Methods for Epidemiology Studies
$714,877Paul Albert · Division Of Cancer Epidemiology And Genetics · ZIA · FY2022 · CA
Olfactory Receptor 558 (OLFR558) Ligands and Blood Pressure Regulation
$714,816Jennifer L Pluznick · Johns Hopkins University · R01 · FY2024 · DK
Nasal biomarkers of asthma
$714,746Supinda Bunyavanich · Icahn School Of Medicine At Mount Sinai · R01 · FY2018 · AI
Heterogeneity of Diabetes: Integrated Muli-Omics to Identify Physiologic Subphenotypes and Evaluate Targeted Prevention
$714,440Tracey McLaughlin · Stanford University · R01 · FY2025 · DK
METS-Sleep: Sleep timing, gut microbiota and cardiometabolic risk across the Epidemiologic Transition
$714,359Lara Ruth Dugas · Loyola University Chicago · R01 · FY2022 · HL
Investigating the combined role of APOE4 and ketogenic diets in Alzheimer's disease
$714,224Joel William Blanchard · Icahn School Of Medicine At Mount Sinai · R01 · FY2024 · AG
Project 2: RNA vaccination in early life to induce potent and broad HIV Env-specific antibody responses
$714,185Genevieve Giny Fouda Amou Ou · Weill Medical Coll Of Cornell Univ · P01 · FY2021 · AI
HIV/ART, low birth weight, and mortality in HIV-exposed uninfected children: a translational mechanistic study
$714,124Marcel Yotebieng · Albert Einstein College Of Medicine · R01 · FY2024 · HD
Pharmacokinetics and Pharmacodynamics of Mechanistically Aware Phage Cocktails
$714,053Nicholas Michael Smith · State University Of New York At Buffalo · R01 · FY2024 · AI
Gut microbiome, enteric infections and child growth across a rurual urban gradient
$713,998Karen Levy · University Of Washington · R01 · FY2020 · AI
7T Vascular and Molecular Imaging of SVD: Sex, Equol, and Risk of Alzheimerâs Disease
$713,933Minjie Wu · University Of Pittsburgh At Pittsburgh · R01 · FY2024 · AG
Environmental factors in pathobiology of dementia: the role of PCB exposure, microbiome, and tissue barrier dysfunction
$713,928Hans-Joachim Lehmler · University Of Iowa · R01 · FY2025 · ES
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** KEYSTONE TAXA ARE HIGHLY CONNECTED TAXA IN THE MICROBIOME THAT, THROUGH THEIR CONNECTIVITY, CAN ENHANCE MICROBIOME RESILIENCE TO ENVIRONMENTAL STRESS. HARNESSING SUCH TAXA WILL CREATE OPPORTUNITIES FOR MANIPULATING MICROBIOMES TO ENHANCE CROP RESILIENCE TO STRESS IN A RAPIDLY CHANGING CLIMATE. MOST STUDIES HAVE USED NETWORK-BASED SCORES TO IDENTIFY KEYSTONE TAXA, BUT THE EMPIRICAL VALIDATION OF SUCH TAXA HAS REMAINED ELUSIVE. THE FEW ATTEMPTS TO PERFORM VALIDATION USED THE 'ADD-IN OR EXCLUSION' APPROACH WHEREIN A PUTATIVE TAXON IS ADDED OR EXCLUDED TO ASSESS ITS IMPACT. HOWEVER, TO ASSESS THE 'TRUE' IMPACT OF A KEYSTONE, IT MUST BE ELIMINATED FROM AN ALREADY ASSEMBLED COMMUNITY TO EVALUATE THE EFFECT OF ITS REMOVAL AND THEN REINTRODUCED TO ASSESS IF IT CAN RESTORE ITS EFFECT. THE USE OF BACTERIOPHAGE IS AN INNOVATIVE WAY TO ADDRESS THIS. THE PROPOSED STUDY AIMS TO USE SALINITY AS A MODEL FOR ENVIRONMENTAL STRESS AND BACTERIOPHAGE AS A TOOL TO VALIDATE THE ROLE OF KEYSTONE TAXA IN MICROBIOME RESILIENCE TO SALINE STRESS. WE WILL ACHIEVE THIS BY 1) ASSESSING THE IMPACT OF KEYSTONE TAXA ON MICROBIOME CONNECTIVITY, 2) EMPLOYING BACTERIOPHAGE TO ELIMINATE KEYSTONE TAXA AND EVALUATE THE IMPACT OF THEIR ABSENCE, AND 3) ASCERTAINING IF KEYSTONE TAXA CAN REPRODUCE THEIR EFFECTS ON MICROBIOMES UPON RE-INTRODUCTION. OVERALL, THIS STUDY WILL ELUCIDATE HOW KEY MICROBIAL GROUPS CAN BE HARNESSED TO IMPROVE RESILIENCE TO ENVIRONMENTAL STRESS. THE STUDY ADDRESSES PRIORITIES OUTLINED IN THE AGRICULTURAL MICROBIOMES PROGRAM BY INVESTIGATING MICROBIOME ASSEMBLY AND INTERACTIONS IN VARIOUS ENVIRONMENTS OR PHYSIOLOGICAL STATES SUCH AS STRESS.
$713,709North Dakota State University · · FY2024 · National Institute of Food and Agriculture
Microbiome in Asthma Induced by Environmental Particle Exposure
$713,559Lauren Marie Oldfield · J. Craig Venter Institute, Inc. · R01 · FY2019 · ES
Trial of Human Milk Oligosaccharide-based synbiotics for HIV-exposed uninfected children
$713,526Rupak Shivakoti · Columbia University Health Sciences · R01 · FY2023 · HD
Phase 2 placebo-controlled randomized trial of LACTIN-V (Lactobacillus crispatus CTV-05) among women at high risk of HIV acquisition in Durban, South Africa
$713,430Craig R Cohen · University Of California, San Francisco · R01 · FY2020 · HD
Host and microbial risk factors of oral thrush in cancer patients receiving chemotherapy
$713,351Patricia Diaz · State University Of New York At Buffalo · R01 · FY2024 · DE
Role of inflammation, innate resistance, and immunity in carcinogenesis
$713,277Giorgio Trinchieri · Division Of Basic Sciences - Nci · ZIA · FY2023 · CA
Administrative Core
$713,238Anthony Amend · University Of Hawaii At Manoa · P20 · FY2022 · GM
Administrative Core
$713,213Helmut Zarbl · Rutgers Biomedical And Health Sciences · P30 · FY2024 · ES
The dynamics of nasal bacterial ecology and S. aureus antagonism
$713,155Lance Bradley Price · George Washington University · R01 · FY2019 · AI
Microbiomes in Human Pancreatic Cancer
$713,133Dominique S Michaud · Brown University · R01 · FY2013 · CA