Sort
24,576 grants matching “microbiome”
Collaborative Research: Tracking the interacting roles of the environment, host genotype, and a novel Rickettsiales in coral disease susceptibility
$701,218Rebecca L Vega · Oregon State University · · FY2019 · GEO
Metagenomic profiling of urinary cell-free DNA to monitor urinary tract infection after kidney transplantation
$701,043Iwijn De Vlaminck · Cornell University · R01 · FY2023 · AI
Validation of a salivary miRNA diagnostic test for autism spectrum disorder
$701,023Frank A Middleton · Quadrant Biosciences, Inc. · R42 · FY2019 · MH
Aging Microbiome, Immunosenescence, and risk of Multi-drug Resistant Organism Colonization and Infection in the Nursing Home
$700,886John Patrick Haran · Univ Of Massachusetts Med Sch Worcester · R01 · FY2024 · AG
Infant Growth and Microbiome Study 2
$700,869Babette S Zemel · Children'S Hosp Of Philadelphia · R01 · FY2018 · DK
Human Gastrointestinal Biomimetics for Enteric Viral Infections
$700,783Mary Kolb Estes · Baylor College Of Medicine · U19 · FY2023 · AI
Sinusitis in Children and the Nasopharyngeal Microbiome
$700,781Ellen R. Wald · University Of Wisconsin-Madison · R01 · FY2015 · AI
Trial of Human Milk Oligosaccharide-based synbiotics for HIV-exposed uninfected children
$700,756Rupak Shivakoti · Columbia University Health Sciences · R01 · FY2021 · HD
Mammary Epithelium Permeability, Lactation Outcomes, and Infant Health
$700,685Kathleen Frances Arcaro · University Of Massachusetts Amherst · R01 · FY2023 · HD
Mechanisms of Post-Bariatric Hypoglycemia
$700,605Darleen A Sandoval · University Of Colorado Denver · R01 · FY2022 · DK
A prospective evaluation of the gut microbiome as a mediator of lymphoma treatment outcome and systemic immunity
$700,561Catherine Sibyl Diefenbach · New York University School Of Medicine · R01 · FY2025 · CA
Longitudinal Study of Early NAFLD Progression and the Gut Microbiome in Asian Americans, Native Hawaiians and Whites
$700,437Unhee Lim · University Of Hawaii At Manoa · R01 · FY2022 · MD
Infant Growth and Microbiome Study 2
$700,189Babette S Zemel · Children'S Hosp Of Philadelphia · R01 · FY2019 · DK
"A microbiome-dependent bile acid metabolite improves type 2 diabetes."
$700,144Eric Garland Sheu · Brigham And Women'S Hospital · R01 · FY2021 · DK
Pathogenesis and Treatment of Atopic Dermatitis
$700,074Joshua Milner · National Institute Of Allergy And Infectious Diseases · ZIA · FY2018 · AI
The role of the urethral microbiome in idiopathic urethritis in men
$700,004David Emmet Nelson · Indiana University Indianapolis · R01 · FY2019 · AI
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** FUNGAL PATHOGENS CAUSE DEVASTATING DISEASE IN CROP PLANTS WORLDWIDE, THREATENING GLOBAL FOOD SECURITY. FUNGAL DISEASES CAN ALSO TARGET NATIVE PLANT AND ANIMAL SPECIES, LEADING TO IRREVERSIBLE ECOLOGICAL DAMAGE. IN HUMANS, FUNGAL DISEASES ARE OFTEN OVERLOOKED, BUT KILL 1.5 MILLION PEOPLE A YEAR. DESPITE THE DANGER FUNGAL PATHOGENS POSE, CURRENT FUNGAL DISEASE MANAGEMENT STRATEGIES ARE LIMITED TO MAINLY CHEMICAL CONTROL. FUNGICIDE APPLICATION OFTEN LEAVES HARMFUL RESIDUES IN THE ENVIRONMENT, AND RESISTANT FUNGI HAVE BEEN REPORTED FOR ALMOST ALL MAJOR CLASS OF FUNGICIDES AND ANTIFUNGAL DRUGS USED IN AGRICULTURAL AND CLINICAL SETTINGS. IN ORDER TO SAFEGUARD GLOBAL FOOD SECURITY, HUMAN HEALTH, AND ECOLOGICAL BIODIVERSITY, IT IS IMPERATIVE THAT NEW TECHNOLOGIES FOR COMBATTING FUNGAL DISEASE ARE DEVELOPED. THE PI'S LAB DISCOVERED THAT SMALL RNAS (SRNAS) CAN BE TRANSPORTED BETWEEN PLANT HOSTS AND THEIR FUNGAL PATHOGENS AND INDUCE TARGET GENE SILENCING IN THE COUNTERPART THROUGH A PHENOMENON CALLED CROSS-KINGDOM RNA INTERFERENCE (RNAI). DURING THE LAST FUNDING PERIOD, THE PI'S LAB FURTHER DEMONSTRATED THAT PLANTS SEND SRNAS INTO FUNGAL CELLS USING EXTRACELLULAR VESICLES, SECRETED MEMBRANE ENCAPSULATED STRUCTURES THAT ARE IMPORTANT FOR INTERCELLULAR COMMUNICATION. FURTHERMORE, THE PI'S LAB DISCOVERED THAT FUNGAL CELLS CAN TAKE UP RNAS FROM THE ENVIRONMENT. THIS DISCOVERY HAS PROMPTED THE DEVELOPMENT OF A NEW FUNGAL DISEASE MANAGEMENT STRATEGY, SPRAY-INDUCED GENE SILENCING (SIGS), WHERE FUNGAL GENE-TARGETING RNAS ARE SPRAYED ONTO PLANTS AND TAKEN UP BY FUNGAL CELLS AND SILENCE FUNGAL VIRULENCE-RELATED GENES TO CONFER DISEASE PROTECTION. SIGS HAS BEEN SUCCESSFULLY UTILIZED TO INHIBIT MULTIPLE FUNGAL DISEASES ON BOTH PRE- AND POST-HARVESTING PLANTS. UNLIKE TRADITIONAL FUNGICIDES, RNAS ARE SAFE TO INGEST, AND DO NOT LEAVE TOXIC RESIDUES IN THE SOIL. THIS PROJECT AIMS TO IDENTIFY KEY FUNGAL VIRULENCE-RELATED GENES AND DESIGN SPECIFIC AND SAFE SIGS RNAS TO EFFECTIVELY INHIBIT FUNGAL DISEASES ON PRE- AND POST-HARVESTING PLANTS. PLANT AGGRESSIVE FUNGAL PATHOGENS BOTRYTISSCLEROTINIA SCLEROTIORUM, ASPERGILLUS NIGER AND VERTICILLIUM DAHLIAE, THE ECONOMICALLY IMPORTANT PATHOGENS THAT HAVE BROAD PLANT HOST RANGE AND CAUSE SERIOUS CROP LOSSES WORLDWIDE, WERE CHOSEN FOR THIS STUDY. THIS PROJECT WILL ADDRESS THE MAJOR CHALLENGES OF SIGS APPROACHES TO ENHANCE THE SIGS RNA STABILITY AND FUNGAL UPTAKE EFFICIENCY BY DEVELOPING ORGANIC AND INORGANIC RNA DELIVERY VEHICLES, AND TO DEVELOP COST-EFFECTIVE METHODS FOR SIGS RNA PRODUCTION. ALTHOUGH OUR PRELIMINARY DATA SUGGEST THAT DOCKING SIGS RNAS TO ORGANIC OR INORGANIC CARRIER MOLECULES CAN GREATLY ENHANCE THE SPAN OF TIME THEY CONFER PROTECTION, BUT THEY ARE STILL UNSTABLE IN THE SOIL. TO DEVELOP EFFECTIVE SIGS TO CONTROL SOIL-BORNE FUNGAL PATHOGEN. WE PROPOSE TO DEPLOY BENEFICIAL BACTERIUM AND FUNGUS, B. SUBTILIS AND TRICHODERMA VIRENS, RESPECTIVELY, FOR CONTINUOUS PRODUCTION AND DELIVERY OF SIGS RNAS TO THE RHIZOSPHERE. FURTHERMORE, THIS APPROACH CAN POTENTIALLY BE ADAPTED TO MANIPULATE SOIL MICROBIOME COMPOSITION USING RNA-PRODUCING BENEFICIAL MICROBES TO PROMOTE CROP PRODUCTION.
$700,000Regents Of The University Of California At Riverside · · FY2021 · National Institute of Food and Agriculture
Intergrated Biorepository of H3Africa Uganda
$700,000Moses Lutaakome Joloba · Makerere University College Of Health Sciences · U24 · FY2020 · HG
African Collaborative Center for Microbiome and Genomics Research (ACCME)
$700,000Clement Adebayo Adebamowo · Institute Of Human Virology · U54 · FY2017 · HG
Ecological and evolutionary constraints on the design of synthetic microbiomes
$700,000Benjamin E Wolfe · Tufts University · · FY2017 · BIO
Collaborative Research: Elucidating and Manipulating Carbon Metabolic Niches in Soil Microbiomes using Synthetic Communities for Sustainable Agriculture
$700,000Gozde S Demirer · California Institute Of Technology · · FY2025 · BIO
Reference Profiles of Extracellular RNA in 4 Body Fluids of Healthy Humans
$699,999David J. Galas · Pacific Northwest Research Institute · U01 · FY2014 · HL
Personalized Dietary Management in Type 2 Diabetes
$699,733Mary A Sevick · New York University School Of Medicine · R01 · FY2022 · NR
HIV/ART, low birth weight, and mortality in HIV-exposed uninfected children: a translational mechanistic study
$699,720Marcel Yotebieng · Albert Einstein College Of Medicine · R01 · FY2025 · HD
Colon O-glycosylated mucus in the homeostasis of microbiota and host
$699,677Lijun Xia · Oklahoma Medical Research Foundation · R01 · FY2024 · DK