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24,576 grants matching “microbiome”
Environmental Influence on Infant Microbiome Development and ASD Symptoms
$699,660Irva Hertz-Picciotto · University Of California At Davis · R01 · FY2016 · ES
Fiber-rich Foods to Treat Obesity and Prevent Colon Cancer
$699,587Terryl Johnson Hartman · Emory University · R01 · FY2023 · CA
Probiotics for Prevention of Acute Graft-vs-Host Disease in Children with Cancer
$699,411Brad H. Pollock · University Of California At Davis · R01 · FY2016 · CA
Understanding the rectal mucosal effects of cross-sex hormone therapy among US and Thai transgender women
$699,393Colleen F Kelley · Emory University · R01 · FY2020 · AI
CoPARC: Colorado Pulmonary Alcohol Research Collaborative
$699,257Ellen L Burnham · University Of Colorado Denver · R24 · FY2022 · AA
Investigating the Influences of SleepâWake Patterns and Gut Microbiome Development in Infancy on Rapid Weight Gain, an Early Risk Factor for Obesity
$699,180Megan Elise Petrov · Arizona State University-Tempe Campus · R01 · FY2023 · HL
A Long Noncoding RNA Amerliorates Periodontitis via Distinct Epigenetic Pathways
$699,118Jake Jinkun Chen · Tufts University Boston · R01 · FY2022 · DE
Oral microbial signatures in perinatal HIV infection
$699,104Louise Kuhn · Columbia University Health Sciences · R01 · FY2018 · DE
Collaborative Research: Social Predators and the Parallel Evolution of Weapon Complexity: Venom Toxins and Microbial Arsenals
$698,893Carl N Keiser · University Of Florida · · FY2025 · BIO
Vibrio fischeri as a Model for Bacterial Colonization
$698,745Margaret J Mc Fall-Ngai · Carnegie Institution Of Washington, D.C. · R37 · FY2025 · AI
Tunable therapeutic modulation of the gut microbiome by engineered probiotics
$698,741Gautam Dantas · Washington University · R01 · FY2020 · AT
A Novel Peptide for the Oral Treatment and Prevention of P. Gingivalis Infection
$698,684Neil A Fanger · Virtici, Llc · R44 · FY2025 · DE
Alcohol assoCiated gut Dysbiosis and CVD in HIV (the AC/DC HIV study)
$698,356Mollie A Monnig · Brown University · R01 · FY2024 · AA
Pancreatic proteostasis connects sleep disruption to Alzheimers Disease
$697,974Nirinjini N Naidoo · University Of Pennsylvania · R56 · FY2019 · AG
Deciphering the Critical Determinants of Enteric and Tumor Niche Colonization by Microbes in Colorectal Cancer
$697,763Christopher D Johnston · University Of Tx Md Anderson Can Ctr · R01 · FY2025 · CA
AZITHROMYCIN TO PREVENT RECURRENT WHEEZING FOLLOWING SEVERE RSV BRONCHIOLITIS
$697,570Avraham Beigelman · Washington University · R01 · FY2019 · HL
METS-Sleep: Sleep timing, gut microbiota and cardiometabolic risk across the Epidemiologic Transition
$697,543Lara Ruth Dugas · Loyola University Chicago · R01 · FY2021 · HL
Model-guided design of next-generation bacterial therapeutics to treat cardiovascular disease
$697,498Ophelia Venturelli · University Of Wisconsin-Madison · R01 · FY2020 · EB
Autonomic Control of Body Weight and Feeding
$697,498Terry L. Powley · Purdue University · R01 · FY2017 · DK
SOIL MICROBES CONFER A WIDE RANGE OF BENEFITS TO THEIR PLANT HOSTS, INCLUDING ENHANCED SURVIVAL, GROWTH AND PROTECTION AGAINST ENVIRONMENTAL STRESS. YET, AGRICULTURAL SCIENTISTS HAVE STRUGGLED TO EXPLOIT THE BENEFICIAL EFFECTS OF MICROBIOMES FOR CROP PRODUCTION. THIS IS PARTLY BECAUSE EXISTING STUDIES OVERWHELMINGLY FOCUS ON SINGLE MICROBIAL STRAINS THAT CANNOT REPLICATE THE PLANT HEALTH BENEFITS ORIGINATING FROM COMMUNITY-WIDE INTERACTIONS AMONG THOUSANDS OF CO-OCCURRING TAXA IN THE RHIZOSPHERE. TARGETED SELECTION OF WHOLE MICROBIAL COMMUNITIES BASED ON DESIRED ABOVEGROUND PLANT PHENOTYPES (E.G. GROWTH, PEST & DISEASE RESISTANCE) IS A PROMISING ALTERNATIVE METHODOLOGY PREVIOUSLY APPLIED IN MODEL SYSTEMS (E.G. ARABIDOPSIS). TO OUR KNOWLEDGE, THIS INNOVATIVE APPROACH HAS NEVER BEEN APPLIED TO ENGINEERING AGRICULTURAL MICROBIOMES THAT ENHANCE CROP PROTECTION. WE PROPOSE USE OF WILD TOMATO TO SIMULTANEOUSLY SELECT ON RHIZOSPHERE MICROBIOTA PRODUCING TWO PHENOTYPIC EXTREMES--RESISTANCE AND SUSCEPTIBILITY TO FOLIAR INSECT PESTS. USING A COMBINATION OF GENOMICS, TRANSCRIPTOMICS AND TARGETED ASSAYS MEASURING CHANGES IN PLANT RESISTANCE (E.G. PHYTOHORMONES, CHEMICAL DEFENSES) WE WILL FUNCTIONALLY CHARACTERIZE INSECT-SUPPRESSIVE AND -ENHANCING RHIZOSPHERE MICROBIAL COMMUNITIES. WE WILL THEN TRANSFER INSECT-SUPPRESSIVE MICROBIOMES INTO NOVEL CROPS (COMMERCIAL TOMATO, EGGPLANT, POTATO, PEPPER) AND DIVERSE SOIL TYPES (PRAIRIE, AGRICULTURAL, STERILE) TO DETERMINE THE EXTENT TO WHICH EFFECTS ON HERBIVORY ARE REPRODUCIBLE AND WHETHER ENHANCED PEST PROTECTION IMPOSES COSTS ON PLANT GROWTH AND YIELD. WE EXPECT TO IDENTIFY RHIZOSPHERE TAXA CONTRIBUTING TO CROP PROTECTION AND VULNERABILITY TO INSECT ATTACKERS, UNDERSTAND THE FUNCTIONAL BASIS OF MICROBE-MEDIATED PEST SUPPRESSION AND IDENTIFY HOW THESE BENEFICIAL MICROBIOMES CAN BE DEPLOYED ACROSS DIVERSE CROP PLANTS AND SOIL TYPES.
$697,482Purdue University · · FY2019 · National Institute of Food and Agriculture
Optimizing IMPDH inhibitors for the treatment of cryptosporidiosis
$697,416Gregory D Cuny · University Of Houston · R56 · FY2014 · AI
Advanced analytics for uncovering virus dynamics and functional potential
$697,412Nikos C Kyrpides · University Of Calif-Lawrenc Berkeley Lab · U01 · FY2025 · DE
Administrative Core A
$697,410Alan David Levine · Case Western Reserve University · P30 · FY2021 · DA
Administrative Core A
$697,409Alan David Levine · Case Western Reserve University · P30 · FY2025 · DA
Administrative Core A
$697,409Alan David Levine · Case Western Reserve University · P30 · FY2022 · DA