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10,829 grants matching “car t”
UCSF Center for Synthetic Immunology: Tools to Reprogram the Immune System to Combat Cancer
$7,174,211Wendell A Lim · University Of California, San Francisco · U54 · FY2019 · CA
A Data Resource for Blood and Marrow Transplants and Adoptive Cellular Therapy Research
$6,714,999Bronwen Shaw · Medical College Of Wisconsin · U24 · FY2025 · CA
A Data Resource for Blood and Marrow Transplants and Adoptive Cellular Therapy Research
$6,714,997Bronwen Shaw · Medical College Of Wisconsin · U24 · FY2023 · CA
Engineering the Next Generation of T Cells
$6,668,121Carl H. June · University Of Pennsylvania · U54 · FY2019 · CA
Postnatal and Prenatal Therapeutic Base Editing for Metabolic Diseases
$6,415,703William H. Peranteau · Children'S Hosp Of Philadelphia · U19 · FY2023 · NS
A Data Resource for Blood and Marrow Transplants and Adoptive Cellular Therapy Research
$6,375,686Bronwen Shaw · Medical College Of Wisconsin · U24 · FY2024 · CA
Adaptive Platform for Personalized Engagement
$6,000,000Praduman Jain · Vignet, Inc. · U24 · FY2019 · OD
CORE SUPPORT FOR THE IMMUNE CELL NETWORK
$5,842,482Ethan Dmitrovsky · Leidos Biomedical Research, Inc. · N01 · FY2021 · CA
GEO CARS: A NATIONAL RESOURCE FOR EARTH, PLANETARY AND ENVIRONMENTAL SCIENCE RESEARCH AT THE ADVANCED PHOTON SOURCE
$5,732,155University Of Chicago · · FY2008 · Department of Energy
THE MAIN GOAL OF THIS PROJECT IS TO DEMONSTRATE THE FEASIBILITY OF A HIGH FLOW RATE (100 KG/MIN), COST-EFFECTIVE AND SAFE TRANSFER OF LIQUID HYDROGEN (LH2) INTO A RAIL TANK CAR, AND A STRATEGY FOR MITIGATING THE IMPACT OF THE RESULTING LOSSES. TO ACHIEVE THIS GOAL, THE PROJECT WILL DESIGN, CONSTRUCT AND TEST IN A RELEVANT ENVIRONMENT A HIGH FILL-RATE PROTOTYPE AT INDUSTRIAL SCALE. THE SPECIFIC OBJECTIVES OF THIS PROJECT ARE THE FOLLOWING: 1) IDENTIFY A STEP-CHANGE APPROACH IN LH2 FILLING PERFORMANCE TARGETED AT HD RAIL APPLICATIONS; 2) CONDUCT TECHNO-ECONOMIC ASSESSMENTS TO EVALUATE ENERGY, PROCESS ECONOMICS, VALUE PROPOSITION AND ENVIRONMENTAL BENEFITS; 3) ENGAGE KEY SUPPLIERS FOR DESIGN OF SPECIALTY COMPONENTS AS A PART OF HIGH FILL-RATE DESIGNS; 4) PROVIDE AN EQUIPMENT-BASED DEMONSTRATION OF A HIGH RATE HD RAIL FILLING SYSTEM ENABLING FUTURE REPLICATION; AND 5) POSITIVELY IMPACT COMMUNITIES THROUGH DEIA ACTIVITIES IN TRAINING AND WORKFORCE DEVELOPMENT, AND ENERGY EQUITY. THE TECHNICAL DEVELOPMENT, PERFORMANCE, AND DEMONSTRATION PORTION OF THE PROJECT HAS THREE MAJOR TASKS CONDUCTED OVER THREE BUDGET PERIODS (BP) (FIGURE 1) DESIGNED TO ENSURE THE SUCCESS IN ACHIEVING THE PROJECT TARGETS. PROJECT MANAGEMENT AND REPORTING ACTIVITIES AS WELL AS COMMUNITY BENEFIT ACTIVITIES ARE CONDUCTED ACROSS ALL BUDGET PERIODS. THE HIGH-LEVEL STRUCTURE OF THE PROJECT IS AS FOLLOWS: • BUDGET PERIOD 1 (12 MONTHS): TASK 1-ARCHITECTURE DESIGN & OPTIMIZATION • BUDGET PERIOD 2 (12 MONTHS): TASK 2-ENGINEERING DESIGN & FABRICATION • BUDGET PERIOD 3 (12 MONTHS): TASK 3- FILL SYSTEM INTEGRATION & TESTING EFFORTS IN TASK 1 WILL FOCUS ON THE OPTIMIZATION OF THE LH2 SYSTEM ARCHITECTURE USING TRANSIENT THERMODYNAMIC MODELING DESIGN TO ACHIEVE TARGETED HIGH FLOW RATES (MINIMUM 100 KG/MIN) WHILE MINIMIZING FLASH LOSSES, ENERGY REQUIREMENTS AND EQUIPMENT CAPITAL COST. IN TASK 2, A PROTOTYPE WILL BE DESIGNED BASED ON THE CONFIGURATION SELECTED IN TASK 1, AND THE INDUSTRIAL SITE FOR THE DEMONSTRATION TRIAL WILL BE SELECTED. THE PROTOTYPE WILL BE COMMISSIONED AND OPERATED IN TASK 3. DATA GENERATED WILL BE ANALYZED AND FILL RATE AND VAPOR LOSS RATE PERFORMANCE WILL BE CONFIRMED. THE PROPOSAL REFLECTS A JOINT EFFORT AMONG INDUSTRY (WABTEC), TECHNOLOGY PROVIDERS (LINDE), ACADEMIA (UNIVERSITY AT BUFFALO) AND DOE NATIONAL LABORATORY (SANDIA) TO DECARBONIZE THE FREIGHT RAIL SECTOR.
$5,461,173Linde Engineering North America Llc · · FY2025 · Department of Energy
Collaborative Research: Molecular Programming Architectures, Abstractions, Algorithms, and Applications
$5,128,796Erik Winfree · California Institute Of Technology · · FY2013 · CSE
Postnatal and Prenatal Therapeutic Base Editing for Metabolic Diseases
$5,059,052William H. Peranteau · Children'S Hosp Of Philadelphia · U19 · FY2025 · NS
Postnatal and Prenatal Therapeutic Base Editing for Metabolic Diseases
$5,051,652William H. Peranteau · Children'S Hosp Of Philadelphia · U19 · FY2024 · NS
Cell and Gene Therapy for HIV Cure
$5,044,836Keith R Jerome · Fred Hutchinson Cancer Research Center · UM1 · FY2019 · AI
CPS: Large: Science of Integration for Cyber-Physical Systems
$5,027,900Janos Sztipanovits · Vanderbilt University · · FY2010 · CSE
THE CENTER FOR ASTROPHYSICAL SCIENCES (CAS) AT THE JOHNS HOPKINS UNIVERSITY (JHU) PROPOSES TO CONTINUE OUR LONG-STANDING JOHNS HOPKINS UNIVERSITY (JHU) COOPERATIVE AGREEMENT WITH THE NASA GODDARD SPACE FLIGHT CENTER (GSFC). THIS AGREEMENT COVERS RESEARCH IN EXPERIMENTAL OBSERVATIONAL ANALYTIC NUMERICAL AND THEORETICAL SPACE SCIENCE AND ENGINEERING. IT IS RECOGNIZED THAT WORKING TOGETHER SCIENTISTS ENGINEERS AND RESEARCHERS FROM THE JHU AND THE GSFC CAN SHARE EXPERTISE AND RESOURCES TO MAXIMIZE THE RETURN FROM NASA MISSION INVESTMENTS. THE COOPERATIVE AGREEMENT BETWEEN THE JOHNS HOPKINS UNIVERSITY AND THE NASA GODDARD SPACE FLIGHT CENTER HAS RESULTED IN MANY FRUITFUL COLLABORATIONS AND PRODUCTIVE RESEARCH AND HAS ENABLED JHU STUDENTS AND JUNIOR RESEARCHERS TO OBTAIN TRAINING FROM WELL-ESTABLISHED RESEARCHERS IN THE FIELD THUS EXPANDING THE EXPERTISE AT JOHNS HOPKINS UNIVERSITY AND BROADENING EDUCATIONAL OPPORTUNITIES FOR OUR STUDENTS. THESE AGREEMENTS HAVE ENHANCED THE ABILITY OF GODDARD PROFESSIONALS TO COLLABORATE WITH JHU FACULTY INSTRUMENTALISTS AND ENGINEERS RESEARCH SCIENTISTS POST-DOCTORAL FELLOWS GRADUATE STUDENTS AND UNDERGRADUATE STUDENTS. FOR EXAMPLE THESE AGREEMENTS HAVE PROVIDED A MECHANISM FOR JHU-AFFILIATED SCIENTISTS TO WORK AT GSFC AND FOR GSFC SCIENTISTS TO VISIT JHU. THE VISITING PERIODS MAY RANGE FROM HOURS TO DAYS TO MONTHS TO FOSTER MUTUALLY BENEFICIAL INTERACTION AND COLLABORATION. THE PROPOSED COOPERATIVE AGREEMENT FOR RESEARCH IN SPACE SCIENCE (CARS) PLACES NO REQUIREMENTS ON NASA; ALL INTERACTIONS AND RESEARCH ACTIVITIES OCCUR ONLY WITH THE EXPRESS APPROVAL AND CONSENT OF NASA CIVIL SERVANTS. WE PROPOSE TO RENEW THE HIGHLY PRODUCTIVE COOPERATIVE AGREEMENT FOR AN ADDITIONAL FIVE YEARS IN THE FORM OF CARS PHASE IV AS DESCRIBED IN THIS PROPOSAL.
$5,011,871The Johns Hopkins University · · FY2020 · National Aeronautics and Space Administration
C: Quantum-Enhanced Inertial Measurement Unit (QEIMU)
$4,998,729Zheshen Zhang · University Of Arizona · · FY2021 · TIP
I4C 2.0: Immunotherapy for Cure
$4,904,730Dan H. Barouch · Beth Israel Deaconess Medical Center · UM1 · FY2021 · AI
Cell and Gene Therapy for HIV Cure
$4,714,991Keith R Jerome · Fred Hutchinson Cancer Research Center · UM1 · FY2018 · AI
Cell and Gene Therapy for HIV Cure
$4,714,991Keith R Jerome · Fred Hutchinson Cancer Research Center · UM1 · FY2016 · AI
Cell and Gene Therapy for HIV Cure
$4,714,991Keith R Jerome · Fred Hutchinson Cancer Research Center · UM1 · FY2017 · AI
National Institute on Aging Alzheimer's Disease Family-Based Study (NIA-AD FBS)
$4,714,038Richard Mayeux · Columbia University Health Sciences · U24 · FY2022 · AG
GD2 CAR T MANUFACTURING
$4,696,754George Mitra · Leidos Biomedical Research, Inc. · N01 · FY2019 · CA
I4C 2.0: Immunotherapy for Cure
$4,677,761Dan H. Barouch · Beth Israel Deaconess Medical Center · UM1 · FY2022 · AI
I4C 2.0: Immunotherapy for Cure
$4,669,992Dan H. Barouch · Beth Israel Deaconess Medical Center · UM1 · FY2023 · AI