Sort
21,453 grants matching “tuberculosis”
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** BOVINE TUBERCULOSIS (BTB) CAUSED BYMYCOBACTERIUM TUBERCULOSISVARIANTBOVIS(MBO) IS ONE OF THE MOST DAMAGING DISEASES IN AGRICULTURE WORLDWIDE. THE RISE IN BTB INFECTED DEER AND CATTLE HERDS IN MICHIGAN HAS LED TO A STATE OF URGENCY DUE TO ASSOCIATED ANIMAL TRADE AND MOVEMENT RESTRICTIONS. CONTROLLING THE DISEASE IN ANIMALS IS A PRIMARY APPROACH TO PREVENTING/MITIGATING SPREAD OF MBO INTO AND FROM WILDLIFE OR HUMAN POPULATIONS. THIS STUDY PROPOSES A NOVEL VACCINE DESIGN AROUND A CENTRAL PARADIGM OF MICROBIAL PATHOGENESIS THAT POSITS THAT IMMUNE RESPONSES AGAINST VIRULENCE FACTORS OFM. BOVISARE SUFFICIENT AND EFFECTIVE TO PROTECT ANIMALS AGAINST MBO INFECTION. THESE HIGHLY CONSERVED IMMUNOGENIC PEPTIDES/PROTEINS FROMM. TUBERCULOSISCOMPLEX WILL BE GENETICALLY ENGINEERED INTO THE UBIQUITOUS SOIL BACTERIUM (AND A PROBIOTIC)BACILLUS SUBTILIS TO BE EXPRESSED AND DISPLAYED ON ITS SPORES. RECOMBINANT SPORES ARE HEAT- STABLE EASILY STORED AND EASILY ADMINISTERED MUCOSAL (ORAL OR INTRANASAL) VACCINE. RECOMBINANT SPORES WILL BE TESTED IN THIS STUDY FOR THEIR ABILITY TO ELICIT ANTI-MBO CELLULAR AND HUMORAL IMMUNE RESPONSES AND IN-VIVO TESTED FOR BACTERIAL KILLING USING IN AN ORAL VACCINATION-CHALLENGE STUDY DESIGN.
$650,000University Of Missouri System · · FY2025 · National Institute of Food and Agriculture
Epidemiology, Prevention and Treatment of Influenza and Other Respiratory Infecti
$650,000William Kwabena Ampofo · Noguchi Memorial Institute / Medical Res · U01 · FY2013 · IP
TB Meningitis: Evaluating CSF Immunology to Discover Hidden Disease and Potential Immunomodulatory Therapies
$649,938David R Boulware · University Of Minnesota · R01 · FY2024 · AI
Evolutionary and Functional Significance of Novel Mutations in MDR-XDR TB
$649,789Faramarz Valafar · San Diego State University · R01 · FY2021 · AI
Predicting neurodevelopmental risk in children born to mothers living with HIV in Kenya
$649,747Megan Song McHenry · Indiana University Indianapolis · R01 · FY2025 · HD
The effect of inflammation and damage to lymph node structures on durable protective immunity following vaccination
$649,719Timothy W Schacker · University Of Minnesota · U01 · FY2023 · AI
VACCINE AND EVALUTION TREATMENT UNITS
$649,581Mark Joseph Mulligan · Emory University · N01 · FY2015 · AI
Integrating genomic and spatial approaches for targeted control of HIV-associated tuberculosis epidemics
$649,564Theodore H Cohen · Yale University · R01 · FY2023 · AI
Immune Regulation in Mycobacterial and Fungal Infections
$649,507Daniel Barber · National Institute Of Allergy And Infectious Diseases · ZIA · FY2013 · AI
Mechanism Based Inhibition of M Tuberculosis Enzymes
$649,431Yeshiva University · R01 · FY2003 · AI
Pyroptosis maintains the integrity of a granuloma
$649,323Edward A Miao · Duke University · R01 · FY2023 · AI
Community Transmission of Tuberculosis in Urban Africa
$649,251Christopher C. Whalen · University Of Georgia · R01 · FY2015 · AI
High Content Screening of Mycobacterium Tuberculosis
$649,245Tanya Parish · Seattle Children'S Hospital · R01 · FY2019 · AI
Analysis of Chemical Structures and Therapeutic Activity of Agents for HIV, TB, and HBV (CHEMDB)
$649,242Louise Sumner · Gryphon Scientific, Llc · N01 · FY2021 · AI
Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related Meningitis
$649,235David R Boulware · University Of Minnesota · R01 · FY2013 · NS
Coping With HIV/AIDS in Tanzania
$649,145Kathryn Whetten · Duke University · R01 · FY2007 · MH
Heme and hemoglobin utilization by Mycobacterium tuberculosis
$649,102Michael Niederweis · University Of Alabama At Birmingham · R01 · FY2022 · AI
Human Brain Organoid: a new CNSTB model
$649,083Matyas Sandor · University Of Wisconsin-Madison · R56 · FY2021 · AI
Clinical Studies
$649,017Megan B Murray · Harvard Medical School · U19 · FY2020 · AI
M. tuberculosis metabolites to activate human mucosal-associated invariant T cells
$648,933Shouxiong Huang · Texas Biomedical Research Institute · R01 · FY2024 · AI
Synthesis of Anti-Infective Agents
$648,931K. C. Nicolaou · Scripps Research Institute, The · R01 · FY2011 · AI
Predictors of treatment toxicity, failure, and relapse in HIV-related tuberculosis
$648,910Timothy R Sterling · Vanderbilt University Medical Center · R01 · FY2018 · AI
Diagnostics and Pharmacotherapy for Severe Forms of TB
$648,811Scott K Heysell · University Of Virginia · U01 · FY2019 · AI
Hospital and Household Studies of Respiratory Cryptosporidiosis and Transmission
$648,792Jeffrey K Griffiths · Tufts University Boston · R01 · FY2013 · AI
Cell Phone Video Directly Observed Therapy to Monitor Short Course LTBI Treatment
$648,715Richard S Garfein · University Of California, San Diego · U01 · FY2015 · AI