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24,576 grants matching “microbiome”
Precision Medicine in Sarcoidosis
$680,760Patricia W Finn · University Of Illinois At Chicago · R01 · FY2018 · HL
Microbiome-derived Metabolites Linked to Celiac Disease Onset in Infants at Risk
$680,712Alessio Fasano · Massachusetts General Hospital · R01 · FY2016 · DK
The role of host-microbial interactions in altering preterm birth risk among black women
$680,635Michal A Elovitz · Icahn School Of Medicine At Mount Sinai · R01 · FY2024 · NR
Understanding the rectal mucosal effects of cross-sex hormone therapy among US and Thai transgender women
$680,609Colleen F Kelley · Emory University · R01 · FY2022 · AI
Development of 3D Alveolar Tissue Models, CRISPR-editing and Microbiota-immune Response Assay Platforms for Deciphering Human Lung Immunity
$680,574Derya Unutmaz · Jackson Laboratory · U19 · FY2019 · AI
Biological Vulnerability to Chlamydia trachomatis in Adolescents and Young Women: the Complex Intersection of Cervicovaginal Microbiome, Cervical Maturation, and Mucosal Immunity
$680,407Loris Y. Hwang · University Of California Los Angeles · R01 · FY2020 · AI
IUCRC Phase I Mississippi State University: Center for Insect Biomanufacturing and Innovation (CIBI)
$680,342Heather R Jordan · Mississippi State University · · FY2021 · ENG
Defining the Quantitative Functional Mechanisms that Underly Gut Microbiome-Diet Interactions Contributing to Human Energy Balance
$680,299Karen Davidowitz Corbin · Adventhealth Orlando · R01 · FY2024 · DK
Pathogenesis of Obstruction/Emphysema and the Microbiome (POEM) in HIV
$680,171Alison Morris · University Of Pittsburgh At Pittsburgh · U01 · FY2013 · HL
CoPARC: Colorado Pulmonary Alcohol Research Collaborative
$680,119Ellen L Burnham · University Of Colorado Denver · R24 · FY2021 · AA
Gut microbiota and human malaria
$680,075Nathan Schmidt · Indiana University Indianapolis · R01 · FY2024 · AI
Developmental flame retardant exposure, gut microbiome, and obesity
$679,987Julia Yue Cui · University Of Washington · R01 · FY2024 · ES
Increased risk of STI and HIV among adolescent girls and young women due to COVID-19 and pandemic mitigation: Biological, behavioral, and psychosocial mediators
$679,951Supriya Dinesh Mehta · Rush University Medical Center · R01 · FY2022 · HD
Effect of Artificially Sweetened Beverages on Diabetes Control in Adults with Type 2 Diabetes
$679,928Andrew Owen Odegaard · University Of California-Irvine · R01 · FY2018 · DK
Nutritional and clinical predictors of intestinal maturation and feeding tolerance in the preterm infant
$679,741Sharon Marie Donovan · University Of Illinois At Urbana-Champaign · R01 · FY2025 · HD
Immune Privilege, CNS Autoimmunity, and Clostridium perfringens Epsilon Toxin
$679,650Timothy Vartanian · Weill Medical Coll Of Cornell Univ · R01 · FY2023 · AI
THE ONGOING AND MAGNIFYING CONSEQUENCES OF ENVIRONMENTAL CHANGE PRESENT A COMPLEX, URGENT CHALLENGE FOR PLANTS. ONE POTENTIAL MECHANISM BY WHICH PLANTS MAY PROMOTE LONG-TERM STRESS TOLERANCE IS VIA SELECTION OF BENEFICIAL MEMBERS OF THE SEED MICROBIOME. OUR GOAL IS TO UNDERSTAND THE IMPACT OF ABIOTIC STRESS ON THE INHERITED SEED MICROBIOME; THE MECHANISMS BY WHICH THE SEED MICROBIOME MEMBERS, THE PLANT, AND THE ENVIRONMENT INTERACT; AND ITS IMPLICATIONS FOR THE RESILIENCE OF SUBSEQUENT PLANT GENERATIONS. WE WILL USE COMMON BEAN (PHASEOLUS VULGARIS L.) AS A MODEL TO INVESTIGATE CHANGES IN THE SEED MICROBIOME THAT OCCUR AS A RESULT OF TWO STRESSORS: DROUGHT AND NUTRIENT EXCESS. THESE STRESSORS ARE KEY CHALLENGES FOR SUSTAINABLE AGRICULTURE IN THE FACE OF A CHANGING ENVIRONMENT. WE WILL CONDUCT CONTROLLED EXPERIMENTS TO: 1) QUANTIFY HOW THE SEED MICROBIOME CHANGES AFTER MATERNAL PLANT EXPOSURE TO STRESS; 2A) INVESTIGATE THE GENETIC MECHANISMS OF SEED MICROBIOME ASSEMBLY VIA ROOT EXUDATEDIFFERENCES IN STRESS AND ACROSS GENOTYPES; 2B) INVESTIGATE THE EPIGENETIC MECHANISMS IMPACTING SEED MICROBIOME OUTCOMES DURING STRESS; AND 3) DETERMINE THE IMPLICATIONS OF SEED MICROBIOME MODIFICATIONS FOR THE STRESS TOLERANCE OF THE NEXT PLANT GENERATION. THIS WORK WILL INCLUDE HIGH-THROUGHPUT SEQUENCING OF THE MICROBIOME, CULTIVATION OF SEED BACTERIA, PLANT AND SEED PHENOTYPING, PLANT EPIGENETICS, AND RHIZOSPHERE METABOLOMICS. WE EXPECT THAT THIS WORK WILL PROVIDE INSIGHTS INTO COMPLEX PHYTOBIOME DYNAMICS UNDERLYING PLANT RESPONSES TO ABIOTIC STRESSES OF CONSEQUENCE FOR ENVIRONMENTAL CHANGE.
$679,605Michigan State University · · FY2019 · National Institute of Food and Agriculture
Comprehensive atlas of advanced adenomas and their surrounding primed colon: A multi-omics evaluation and clinical impact assessment
$679,511William M Grady · Fred Hutchinson Cancer Center · U54 · FY2022 · CA
Pathogenesis of Dyslipidemia and Atherosclerosis in the Diabetic State
$679,451Sudha B Biddinger · Boston Children'S Hospital · R01 · FY2022 · HL
Probiotics that moderate pH and antagonize pathogens to promote oral health
$679,345Robert A Burne · University Of Florida · R01 · FY2019 · DE
Dietary influence on infant growth and the gut microbiota
$679,194Minghua Tang · University Of Colorado Denver · R01 · FY2021 · DK
Novel recombinant Rotavirus vaccine utilizing the probiotic microorganism Lactobacillus acidophilus
$679,126Gregg A Dean · Colorado State University · R01 · FY2022 · AI
Inflammatory cross-talk between skin and gut
$679,019Richard L Gallo · University Of California, San Diego · R01 · FY2022 · DK
Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-Up
$678,888James E. Gern · University Of Wisconsin-Madison · UG3 · FY2023 · OD
Trinity: Transcriptome assembly for genetic and functional analysis of cancer
$678,887Aviv Regev · Broad Institute, Inc. · U24 · FY2013 · CA