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46,585 grants matching “heart failure”
Clinical and Basic Science Studies in Long QT Syndrome Type 3
$742,812Wojciech Zareba · University Of Rochester · R01 · FY2017 · HL
IGF::OT::IGF ATHEROSCLEROSIS IN RISK COMMUNITIES - FIELD CENTER - CORE STUDY OPERATIONS
$742,658Gerardo Heiss · Univ Of North Carolina Chapel Hill · N01 · FY2017 · HL
Clinical Implications of Blood Pressure Patterns Among Older Adults
$742,637Stephen P Juraschek · Beth Israel Deaconess Medical Center · R01 · FY2023 · HL
Dexrazoxane and Prevention of Anthracycline-Related Cardiomyopathy
$742,626Eric Jessen Chow · Fred Hutchinson Cancer Research Center · R01 · FY2017 · CA
Ventricular remodeling and heart failure after myocardial infarction: a community
$742,573Veronique L Roger · Mayo Clinic Rochester · R01 · FY2014 · HL
Bioactive lipids as effectors and indicators of the deleterious effects of environmental exposure on chronic diseases
$742,563Bruce D Hammock · University Of California At Davis · R35 · FY2019 · ES
More effective exercise modalities in older CHF patients
$742,527Feinstein Institute For Medical Research · R01 · FY2005 · HL
Ventricular remodeling and heart failure after myocardial infarction: a community
$742,525Veronique L Roger · Mayo Clinic Rochester · R01 · FY2017 · HL
Ventricular remodeling and heart failure after myocardial infarction: a community
$742,525Veronique L Roger · Mayo Clinic Rochester · R01 · FY2016 · HL
Mechanisms of diuretic resistance in heart failure
$742,504Jeffrey M Testani · Yale University · R01 · FY2023 · DK
IONIZING RADIATION EXPOSURE IS KNOWN TO DRAMATICALLY INCREASE THE LEVEL OF REACTIVE OXYGEN SPECIES (ROS) IN HUMAN CELLS. ROS HAVE BEEN IMPLICATED AS KEY CONTRIBUTORS TO NUMEROUS PATHOPHYSIOLOGICAL DISORDERS INCLUDING CANCER HEART FAILURE NEURO-DEGENERATION ETC. VIA STIMULATING AUTOPHAGY DEATH DNA DAMAGE MITOCHONDRIAL DYSFUNCTION OR PROTEIN DEACTIVATION WITHIN CELLS. IN RECENT YEARS ANTIOXIDANTS SUCH AS CURCUMIN (CCM) N-ACETYL CYSTEINE (NAC) AND N-MERCAPTOPROPIONYL GLYCINE (NMPG) HAVE BEEN DISCOVERED TO NEUTRALIZE FREE RADICALS AND PROTECT CELLS FROM THE INSULT-INDUCED DAMAGE. WITH NASA S CURRENT INTERESTS IN RETURNING TO THE MOON AND MISSIONS TO MARS ASTRONAUTS WOULD BE EXPOSED TO INCREASED AMOUNTS OF IONIZING RADIATION DUE TO THE LONG DURATIONS OF FLIGHTS.THUS THIS PROJECT SEEKS TO USE NOVEL DRUG DELIVERY SYSTEMS FOR EFFICIENT UPTAKE OF CCM NAC AND N-MPG INTO CELLS: 1) FUSOGENIC LIPOSOMES CONSTRUCTED FROM THE SAME BIOMATERIALS THAT CONSTITUTE CELL MEMBRANES; 2) ALBUMIN THE MOST ABUNDANT BLOOD PROTEIN; AND 3) CHITOSAN A FDA-APPROVED POLYSACCHARIDE. THESE PARTICLE SYSTEMS WILL BE USED TO INVESTIGATE DRUG RELEASE UPTAKE IN CELLS ANDEFFECTIVENESS (SUCH AS CELL VIABILITY AND PROTEIN EXPRESSION OF DNA DAMAGE AND REPAIR). CELLS AND ANIMALS WILL BE EXPOSED TO EITHER GAMMA RADIATION OR HIGH-ENERGY IRON-ION RADIATION AT BROOKHAVEN NATIONAL LABORATORY. THE PROPOSED DRUG-DELIVERY SYSTEMS HAVE THE CAPABILITY TO PROVIDE SHORT- (MINUTES) AND LONG-TERM (HOURS - DAYS) DELIVERY. A TREMENDOUS BENEFIT TO OUR DELIVERY SYSTEM IS THEABILITY TO TAILOR DRUG THERAPY TO ACCURATELY CORRESPOND TO THE LEVEL AND DURATION OF RADIATION EXPOSURE. ALL OTHER METHODOLOGIES HAVE PURSUED A ONE-SIZE FITS ALL APPROACH WHICH MAY NOT DELIVER AN APPROPRIATE DOSE TO MITIGATE ADVERSE EVENTS. OUR DELIVERY SYSTEM WILL RESCUE IRRADIATED CELLS VIA THE INTRODUCTION OF DRUGS TO MITIGATE THE EFFECTS OF THE IONIZING RADIATION. THE DESIGN OF COUNTERMEASURESFOR MITIGATION OF OXIDATIVE STRESS DAMAGE IS CRUCIAL FOR PROTECTION OF ASTRONAUT HEALTH. RADIATION MITIGATION RESEARCH ALIGNS WITH THE HUMAN EXPLORATION AND OPERATIONS MISSION DIRECTORATE DIRECTLY ADDRESSING THE HUMAN RESEARCH PROGRAM OF INTEGRATED RESEARCH PLAN SPACE RADIATION RISK: 1.2 RISK OF ACUTE RADIATION SYNDROMES DUE TO SOLAR PARTICLE EVENTS 1.3 RISK OF DEGENERATIVE TISSUE OR OTHER HEALTH EFFECTS FROM RADIATION EXPOSURE 1.4 RISK OF RADIATION CARCINOGENESIS FROM SPACE RADIATION AND EXPLORATIONMEDICAL CAPABILITY RISK: 1.1 INABILITY TO ADEQUATELY RECOGNIZE OR TREAT AN ILL OR INJURED CREW MEMBER. THE PROPOSED STUDIES FOCUS SPECIFICALLY ON DEGENERATIVE TISSUE - GAPS DEGEN #6; ACUTE RADIATION SYNDROMES GAPS ACUTE #7; RADIATION CARCINOGENESIS GAPS CANCER #8; AND EXPLORATION MEDICAL CAPABILITY GAP EXMC #4.22. THE PROPOSED WORK ALSO ALIGNS WITH KY SCIENCE AND TECHNOLOGY STRATEGIC PLANS BY PROPOSING SPACE-RELATED RESEARCH WHILE PROVIDING OPPORTUNITIES FOR EDUCATION TO A DIVERSE GROUP IN AMULTIDISCIPLINARY SUBJECT AREA. THE PROPOSED WORK INCLUDES TRAINING OF PH.D. STUDENTS AND POSTDOCTORAL FELLOWS THUS STRENGTHENING EDUCATIONAL OPPORTUNITIES IN STEM FIELDS IN KY. THE RESEARCH TEAM CONSISTS OF 3 FEMALES AND 3 MINORITY MEMBERS STRENGTHENING THE PARTICIPATION OF UNDERREPRESENTED GROUPS. TWO OF THE POSTDOCS ARE KY NATIVES WHICH ALIGNS WITH KEEPING TALENT WITHIN KY ANDSTRENGTHENING THE COMPETITIVE AND PRODUCTIVE COMMUNITY OF ACADEMIC SCIENTISTS. IN ADDITION THE WORK IS COLLABORATION AMONG THE SCHOOL OF ENGINEERING (BIOENGINEERING) SCHOOL OF MEDICINE (DEPARTMENT OF MEDICINE) AND INDUSTRY (EDS INC.) WHICH INCREASES FACULTY-INDUSTRY PARTNERSHIPS THAT HAVE COMMERCIAL POTENTIAL WHILE STRENGTHENING KY S SCIENCE AND RESEARCH CAPACITY IN PRIORITY STEM AREAS. IN ADDITION NASA COLLABORATORS FROM JSC WILL STRENGTHEN THE LINKAGES BETWEEN KY RESEARCHERS AND NASA CENTERS R&D PROGRAMS AND MISSIONS.
$742,484University Of Kentucky Research Foundation, The · · FY2014 · National Aeronautics and Space Administration
Genomics of myocardial transcription factors in cardiac remodeling
$742,437Thomas P Cappola · University Of Pennsylvania · R01 · FY2010 · HL
Cardiovascular Health of Low-Income Working-Age Adults in the US: Health Care Access, Policy, and the Pandemic
$742,416Rishi Kumar Wadhera · Beth Israel Deaconess Medical Center · R01 · FY2024 · HL
Genomics of Post-Operative Atrial Fibrillation After Cardiac Surgery
$742,415Jochen Daniel Muehlschlegel · Brigham And Women'S Hospital · R01 · FY2022 · HL
Clinical and Basic Science Studies in Long QT Syndrome Type 3
$742,413Arthur J. Moss · University Of Rochester · R01 · FY2014 · HL
Radiomics-based risk prediction of heart failure using CT calcium score exam
$742,395Shuo Li · Case Western Reserve University · R01 · FY2025 · HL
Cardiopulmonary Exercise MRI in Heart Failure with Preserved Ejection Fraction
$742,389Reza Nezafat · Beth Israel Deaconess Medical Center · R01 · FY2022 · HL
Epidemiologic Determinant of Cardiac Structure and Function Among Hispanics
$742,389Carlos Jose Rodriguez · Wake Forest University Health Sciences · R01 · FY2014 · HL
Minimally Invasive Cardiac Sympathetic Denervation for Malignant Ventricular Arrhythmia
$742,382Howard D Levin · Coridea, Llc · R44 · FY2019 · HL
Follistatin-like protein 1 in cardiac and systemic metabolism
$742,374Fabio A Recchia · Temple Univ Of The Commonwealth · R01 · FY2017 · HL
PAREPET II_Prediction of ARrhythnic Events with Positron Emission Tomography II
$742,356John M Canty · State University Of New York At Buffalo · R01 · FY2016 · HL
Functional studies of Forkhead transcription factors in mesoderm development
$742,347Alan Michelson · National Heart, Lung, And Blood Institute · ZIA · FY2012 · HL
Hemolysis and Free Heme Signaling in Pulmonary Hypertension
$742,328Ruslan Rafikov · Indiana University Indianapolis · R01 · FY2024 · HL
Hemolysis and Free Heme Signaling in Pulmonary Hypertension
$742,328Ruslan Rafikov · Indiana University Indianapolis · R01 · FY2025 · HL
The pulmonary visceral pleura (PVP) aortic valve
$742,323Haoxiang Luo · Vanderbilt University · R01 · FY2025 · HL