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21,281 grants matching “influenza”
Transmissibility of avian influenza viruses in mammals
$611,416Yoshihiro Kawaoka · University Of Wisconsin-Madison · R01 · FY2014 · AI
Biology, Evolution and Pathogenesis of Influenza A Virus
$611,281Jack R Bennink · National Institute Of Allergy And Infectious Diseases · ZIA · FY2016 · AI
Virus Induction of Primary and Memory B- and T-Cell Responses
$611,281Jack R Bennink · National Institute Of Allergy And Infectious Diseases · ZIA · FY2016 · AI
Immunology Team Contributions to the LSB
$611,223Ronald Germain · National Institute Of Allergy And Infectious Diseases · ZIA · FY2014 · AI
Accelerating viral outbreak detection in US cities using mechanistic models, machine learning and diverse geospatial data
$611,043Alison P Galvani · Yale University · R01 · FY2020 · AI
Cognition and Achievement
$610,923Araba Nayena Blankson · Spelman College · R01 · FY2025 · MD
Lung Macrophage Memory Development and Responses in Secondary Pneumonia and Sepsis
$610,868Bibhuti Bhusan Mishra · University Of North Dakota · R01 · FY2021 · AI
K-VAC: Kentucky Vaccinating Appalachian Communities
$610,704Marc T Kiviniemi · University Of Kentucky · R01 · FY2025 · MD
Development of Universal Influenza Virus Vaccines Using Nucleoside-Modified Messenger RNA
$610,421Norbert Pardi · University Of Pennsylvania · R01 · FY2021 · AI
Neutralization Fingerprinting Analysis of Polyclonal Antibody Responses against HIV-1
$610,412Ivelin Georgiev · Vanderbilt University Medical Center · R01 · FY2021 · AI
Mechanisms of epithelial repair and remodeling in pulmonary fibrosis
$610,399Jonathan Andrew Kropski · Vanderbilt University Medical Center · R01 · FY2020 · HL
Safer mTOR inhibition for human geroprotection
$610,352Adam R Konopka · University Of Wisconsin-Madison · U01 · FY2024 · AG
Novel immunotherapeutics for the management of otitis media due to H. influenzae
$610,246Lauren O Bakaletz · Research Inst Nationwide Children'S Hosp · R01 · FY2016 · DC
Circadian Signatures in Chronic Lung Disease
$610,245Jeffrey Adam Haspel · Washington University · R01 · FY2022 · HL
Effects of wildfire smoke on respiratory antiviral defense responses
$610,235Meghan Elizabeth Rebuli · Univ Of North Carolina Chapel Hill · R01 · FY2025 · ES
Mechanisms of Pneumococcal Persistence During Carriage
$610,200Jeffrey N. Weiser · New York University School Of Medicine · R37 · FY2025 · AI
Defining molecular mechanisms of combination adjuvants: a systems immunology, transcriptomics and imaging approach
$610,134David Huw Davies · University Of California-Irvine · U01 · FY2021 · AI
Immunologic and Predictive Features of MIS-C
$610,099Dusan Bogunovic · Icahn School Of Medicine At Mount Sinai · R01 · FY2022 · HD
Structural Genomics Centers for Infectious Diseases
$610,079Karla Fullner Satchell · Northwestern University At Chicago · N01 · FY2017 · AI
Combining Ecological and Molecular Models to Understand the Evolutionary Dynamics of Influenza
$610,071Katharina Koelle · Duke University · · FY2008 · BIO
Investigating protective adaptive immune responses to influenza antigens using human tonsil organoids
$610,039Lisa Wagar · University Of California-Irvine · R01 · FY2025 · AI
Study of Influenza Incidence, Diagnosis, Treatment Efficacy, Vaccine Effectivenes
$610,000Nestor Sosa · Gorgas Memorial Institute Of Health St · U01 · FY2017 · IP
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** INFLUENZA A VIRUSES (IAV) ARE IMPORTANT RESPIRATORY PATHOGENS THAT IMPACT ANIMAL AND PUBLIC HEALTH. A DIVERSE RANGE OF IAVS CO-CIRCULATE IN SWINE GLOBALLY, WITH SUBSTANTIAL DIFFERENCES BETWEEN THEM, COMPLICATING THE DIAGNOSIS AND CONTROL OF INFLUENZA IN PIGS. ALTHOUGH INFLUENZA IN SWINE IS USUALLY MILD, IT CAN RESULT IN SUBSTANTIAL ECONOMIC BURDEN. VACCINATION REMAINS THE MOST EFFECTIVE METHOD TO PROTECT PIGS AGAINST INFLUENZA INFECTION AND/OR DISEASE AND IS ROUTINELY USED BY U.S. SWINE PRODUCERS AND VETERINARIANS. TRADITIONAL INACTIVATED VACCINES USED FOR PIGS CONFER STRONG PROTECTION AGAINST MATCHED VIRUSES BUT LITTLE PROTECTION IN CASE OF MISMATCHED VIRUSES. ALTHOUGH VACCINES HAVE AN IMPORTANT ROLE IN THE CONTROL OF INFLUENZA IN SWINE, REPEATED FAILURES AND THE NEED FOR CONSTANT UPDATES HIGHLIGHT THE NEED FOR BETTER, MORE EFFECTIVE APPROACHES. LIVE ATTENUATED INFLUENZA VIRUS (LAIV) VACCINES HAVE AN ADVANTAGE OVER TRADITIONAL INACTIVATED PRODUCTS BECAUSE THEY MIMIC A NATURAL INFECTION AND ELICIT A COMBINATION OF ANTIBODY AND CELL-MEDIATED IMMUNE RESPONSES. A RECENTLY APPROVED LAIV VACCINE FOR USE IN PIGS HAS RAISED CONCERNS ABOUT THE SAFETY OF LIVE VACCINES IN SWINE. HOWEVER, THE ADVANTAGES FOR THE USE OF LIVE VACCINES AND THE TRACK-RECORD OF SAFETY AND SUCCESSFUL ERADICATION OR CONTROL PROGRAMS IN HUMANS AND ANIMALS STILL MAKE THEM A VALUABLE ALTERNATIVE FOR EFFECTIVE CONTROL OF INFLUENZA IN PIGS. THUS, THE MAJOR GOAL OF THIS APPLICATION IS TO DEVELOP LAIV VACCINE STRATEGIES THAT ARE NOT ONLY EFFECTIVE, BUT ALSO SHOW IMPROVED SAFETY AND LOWER ABILITY TO COMBINE WITH FIELD VIRUSES. WE WILL GENERATE SEVERAL LAIV VACCINE CANDIDATES AND TEST THEIR SAFETY IN CULTURED CELLS AND IN PIGS. ADDITIONALLY, WE WILL EVALUATE THE IMMUNE RESPONSE STIMULATED BY THE DIFFERENT VACCINE CANDIDATES IN PIGS. THE VACCINE CANDIDATE THAT STIMULATES THE STRONGEST IMMUNE RESPONSE WILL THEN BE TESTED FOR PROTECTION AGAINST INFLUENZA VIRUS INFECTION IN PIGS. THROUGH THE PROPOSED RESEARCH, WEEXPECT TO GENERATE AND DEMONSTRATE THAT THE MODIFIED LAIVS ARE SAFE AND EFFECTIVE IN PROTECTING PIGS AGAINST INFLUENZA AND REPRESENT AN EFFICIENT ALTERNATIVE TO BE USED BY THE SWINE INDUSTRY.
$610,000University Of Georgia Research Foundation, Inc. · · FY2022 · National Institute of Food and Agriculture
Mechanisms of influenza transmission bottlenecks: impact on viral evolution
$609,903Thomas C. Friedrich · University Of Wisconsin-Madison · R01 · FY2017 · AI
Inflammation and Therapy for Respiratory Virus Infection
$609,885Helene Rosenberg · National Institute Of Allergy And Infectious Diseases · ZIA · FY2011 · AI