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38,696 grants matching “als”
SPEECH MOVEMENT CLASSIFICATION FOR ASSESSING AND TREATING ALS
$686,265Jordan R Green · Mgh Institute Of Health Professions · R01 · FY2018 · DC
Novel therapies for bone marrow failure and Diamond-Blackfan Anemia
$686,026Cynthia E Dunbar · National Heart, Lung, And Blood Institute · ZIA · FY2023 · HL
Epigenetic Changes associated with Neurodegenerative Diseases
$685,942Shelley L Berger · University Of Pennsylvania · R01 · FY2016 · NS
Mechanisms of Parkinson Disease and Related Disorders
$685,930David Goldstein · National Institute Of Neurological Disorders And Stroke · ZIA · FY2014 · NS
Chromatin Remodeling and Gene Activation
$685,860David J Clark · Child Health And Human Development · Z01 · FY2007 · HD
Analytical validation of a biochemical test for alpha-synuclein aggregates in biological fluids for the diagnosis of Parkinson's Disease
$685,600Karen Macleod · Amprion, Inc. · U44 · FY2020 · NS
Genetics of ALS
$685,490Northwestern University · R01 · FY2005 · NS
Autoimmunity Center of Excellence (ACE) at Stanford
$685,303Charles Garrison Fathman · Stanford University · U19 · FY2011 · AI
AS FARMERS ATTEMPT TO EVOLVE QUICKLY TO CONFRONT 21ST CENTURY CHALLENGES INCLUDING LEVERAGING INNOVATIVE TECHNOLOGY TO IMPROVE YIELD AND REDUCE DELETERIOUS IMPACTS FROM CLIMATE CHANGE, SO TOO MUST THE EDUCATION IN THEIR SURROUNDING COMMUNITIES. WHILE RURAL COMMUNITIES IN EDUCATION DESERTS AND URBAN COMMUNITIES IN FOOD DESERTS FACE DIFFERENT CHALLENGES AND ARE OFTEN JUXTAPOSED IN THE MEDIA, THEY HAVE SHARED EDUCATIONAL GOALS AND COMPLEMENTARY ENVIRONMENTS THAT HAVE YET TO BE ADEQUATELY LEVERAGED. BOTH RURAL AND URBAN SCHOOLS ARE OFTEN UNDER-RESOURCED, LEAVING GAPS IN STRUCTURED HANDS-ON EXPERIENCES THAT ARE OFTEN FILLED IN BY NON-FORMAL EDUCATION PROGRAMS. WITH PRECISION AGRICULTURE AND VERTICAL FARMING GROWING IN POPULARITY BECAUSE OF THEIR ABILITY TO INCREASE CROP YIELD IN RURAL AND URBAN AREAS, RESPECTIVELY, IT IS CLEAR THAT THE NEXT GENERATION OF PLANT GROWERS MUST UNDERSTAND AND EMBRACE THE USE OF PLANT SCIENCE AND TECHNOLOGICAL INNOVATION. OUR FOOD AND AGRICULTURAL NON-FORMAL EDUCATION PROJECT WILL DEVELOP SUMMER PROGRAM CURRICULA THAT INTRODUCES URBAN AND RURAL YOUTH TO AGRICULTURAL RESEARCH AND TECHNOLOGY, FOSTERS COLLABORATIONS BETWEEN URBAN AND RURAL YOUTH, AND ENCOURAGES STUDENTS TO DEVELOP CONNECTIONS BETWEEN THEIR COMMUNITY'S CULTURAL WEALTH AND PLANT SCIENCE.THIS PROJECT WILL USE CORN AS THE MODEL SYSTEM TO TRAIN RURAL AND URBAN YOUTH IN AGRICULTURAL TECHNOLOGY, GALVANIZE CROSS-POLLINATION OF IDEAS AND EXPERIENCES BETWEEN THE TWO SUMMER PROGRAMS, AND ITERATIVELY ADJUST THE CURRICULA BASED ON STUDENT INPUT AND IDEAS. THE CURRICULA DEVELOPED WILL BE DESIGNED AND ASSESSED USING THE COMMUNITY CULTURAL WEALTH (CCW) FRAMEWORK (YOSSO 2005). BORNE OUT OF CRITICAL RACE THEORY, CCW PROMOTES THE INTEGRATION OF A PARTICIPANT'S IDENTITY AND CULTURE INTO THEIR EDUCATION INCLUDING NON-FORMAL STEM EDUCATION PROGRAMS (KELLY ET AL. 2019). YOUTH WILL IDENTIFY THE FAMILIAL AND SOCIAL CAPITAL THEY HAVE EARLY DURING THE PROJECT, SHARING THEIR KNOWLEDGE WITH OTHERS. THE YOUTH WILL ALSO BECOME EXPERTS IN THE AGRICULTURAL TECHNOLOGY AND CROP PROBLEMS UNIQUE TO THEIR REGION, VISITING EACH OTHER'S SITE TO LEARN FROM ONE ANOTHER AND SHARE THEIR DISCOVERIES. THE MOST SUCCESSFUL AND TRANSFERABLE ASPECTS OF THE CURRICULA WILL BE USED TO DESIGN A SCALABLE PROGRAM FOR OTHER RURAL AND URBAN COMMUNITIES.
$685,200Donald Danforth Plant Science Center · · FY2022 · National Institute of Food and Agriculture
Maryland Prostate Cancer Case-Control Study
$685,102Stefan Ambs · Division Of Basic Sciences - Nci · ZIA · FY2022 · CA
LAND-USE AND LAND-COVER CHANGE ARE A SIGNIFICANT FACTOR IN REGIONAL AND GLOBAL CARBON CYCLES. FURTHER LAND COVER DYNAMICS PLAY AN IMPORTANT ROLE IN THE ECOLOGICAL AND ECONOMIC RESILIENCE OF THE LANDSCAPE TO FUTURE CONDITIONS. PREDICTING THE INFLUENCE OF LAND-USE AND LAND-COVER CHANGE ON GLOBAL CARBON CYCLING FOOD AND FIBER PRODUCTION AND CLIMATE REQUIRES GRIDDED INPUTS DEFINING THE LAND-USE AND LAND-COVER CHANGE (TAYLOR ET AL. 2009). THESE GRIDDED LAND-USE INPUTS DESCRIBE HOW THE AREA OF THE REGION IN DIFFERENT LAND-USE AND LAND-COVER CLASSES CHANGE OVER TIME (HURTT ET AL. 2006). IN GLOBAL MODELS DIFFERENT LAND-USE AND LAND-COVER CLASSES ARE OFTEN SIMULATED AS A FRACTION OF EACH MODEL GRID-CELL THUS ALLOW FOR SUB-GRID SCALE VARIATION IN LAND-USE. TWO MAJOR WEAKNESSES IN THE REGIONAL TO GLOBAL SIMULATIONS ARE 1) A LACK OF REGIONALLY SPECIFIC DRIVERS OF LAND-USE TRANSITIONS AND REGIONALLY SPECIFIC SCENARIOS OF FUTURE LANDUSE AND 2) AN EXPLICIT CONSIDERATION OF MANAGEMENT PRACTICES ON THE CARBON CYCLE AND LAND COVER DYNAMICS. RECENT WORK BY HANSEN ET AL. (2013) SHOWS A NUMBER OF REGIONS ON THE GLOBAL FORESTED LANDSCAPE THAT ARE EXPERIENCING SIGNIFICANT CHANGES (MOSTLY FOREST LOSS). THE SOUTHEASTERN UNITED STATES STANDS OUT AS A UNIQUE REGION IN TERMS OF LAND CHANGE DYNAMICS. THE REGION IS HIGHLY PRODUCTIVE AND LARGELY FORESTED BUT WITH AN ANTHROPOGENIC DOMINANCE IN THE ECOSYSTEM. IN THE SOUTHEASTERN US PRIVATE OWNERS (FROM INDIVIDUALS TO CORPORATIONS) CONTROL A VAST MAJORITY OF LANDS (ABOUT 90%) AND ECONOMIC FACTORS DOMINATE THEIR DECISIONS. EXISTING LAND USE STUDIES EXPLICITLY ADDRESS THE INFLUENCE OF RETURNS TO ALTERNATIVE USES IN DETERMINING LAND USE CHOICES (HARDIE ET AL. 2000 LUBOWSKI ET AL. 2002 WEAR 2011). WE ARGUE THAT A LIMITING FEATURE OF PREVIOUS STUDIES HAS BEEN THE TREATMENT OF SECONDARY FORESTS AS A SINGLE LAND USE IN EFFECT LUMPING PASSIVELY MANAGED OR UNMANAGED FORESTS WITH THOSE THAT ARE INTENSIVELY MANAGED. AS PLANTED AND INTENSIVELY MANAGED FORESTS HAVE EXPANDED IN THE SOUTHEASTERN US AND NOW ACCOUNT FOR A MAJORITY OF HARVESTS IT SEEMS CLEAR THAT THESE MANAGED FORESTS ARE DISTINCT LAND USES WITH VERY DIFFERENT COSTS BENEFITS AND SERVICE FLOWS WHEN COMPARED WITH NATURALLY REGENERATED AND UNMANAGED FORESTS. WE PROPOSE A SYNTHESIS PROJECT THAT INTEGRATES FOUR MAJOR PROJECTS DECADES OF RESEARCH ON LAND USE AND FOREST MANAGEMENT IN THE SOUTHEASTERN UNITED STATES AND NASA REMOTE SENSING PRODUCTS (LANDSAT) AND ALGORITHMS TO DEVELOP A REGIONALLY SPECIFIC LAND-USE TRANSITION MATRIX THAT CONSIDERS THE ECONOMIC STRUCTURE OF LAND MANAGEMENT AND LAND USE DECISIONS UNDER VARYING SCENARIOS. THIS MATRIX WILL BE INCORPORATED INTO THE GLOBAL LAND-USE MODEL (GLM) TO GENERATE NEW LAND-USE HARMONIZATION DATASETS PAVING THE WAY FOR FUTURE INTEGRATION OF REGIONALLY SPECIFIC LAND-USE DECISIONS INTO GLOBAL CLIMATE PROJECTIONS. DELIVERABLES FOR THE PROJECT INCLUDE: 1) LANDSAT-BASED CLASSIFICATION AND TRANSITIONS THAT INCLUDE MANAGED FOREST LANDS FOR THE SOUTHEAST 2) AN INTEGRATED ASSESSMENT OF SOCIO-ECONOMIC DRIVERS OF LAND-USE TRANSITIONS IN A MANAGEMENT-DRIVEN REGION 3) REGIONALLY-REFINED LAND-USE TRANSITION MATRIX DERIVED FROM AN ECONOMIC CONCEPTUAL FRAMEWORK THAT CONSIDERS MANAGEMENT AND 4) HARMONIZATION OF THE REGIONAL RESULTS WITH THE GLM. OUR OVERALL FRAMEWORK COULD BE MODIFIED AND APPLIED ELSEWHERE TO DEVELOP REGIONALLY APPROPRIATE MATRICES THAT COULD FEED INTO THE GLOBAL PRODUCTS.
$684,942Virginia Polytechnic Institute & State University · · FY2017 · National Aeronautics and Space Administration
Animal MRI/MRS Methodological Development for Drug Addiction Applications
$684,794Yihong Yang · National Institute On Drug Abuse · ZIA · FY2013 · DA
Identification and characterization of mCpH binding proteins in neurons
$684,775Heng Zhu · Johns Hopkins University · R01 · FY2022 · NS
High channel count electrophysiology and data processing for freely-moving animals
$684,421Justin P Kinney · Leaflabs, Llc · R44 · FY2018 · MH
Validating a 3rd-generation methylation measure of accelerated aging: DunedinPoAm4x
$684,340Terrie Edith Moffitt · Duke University · R01 · FY2025 · AG
Genotype -Phenotype Correlation of PKLR Variants with Pyruvate Kinase, 2,3-Diphosphglycerate and ATP Activities in Red Blood Cells of Patients with Sickle Cell Disease
$684,323Swee Lay Thein · National Heart, Lung, And Blood Institute · ZIA · FY2025 · HL
Neurobiological predictors of spoken and written language learning
$684,227Kenneth R. Pugh · Haskins Laboratories, Inc. · R01 · FY2014 · HD
Individual Differences in Learning Potential for Language and Literacy
$684,169David Braze · Haskins Laboratories, Inc. · R01 · FY2015 · HD
Family Intervention for Teen Drinking and Alcohol-related Crises in the ER
$684,047Cynthia Lyn Rowe · University Of Miami School Of Medicine · R01 · FY2011 · AA
The health status of Caucasian and African American living with kidney donors
$683,940Sandra J Taler · Mayo Clinic Rochester · U01 · FY2010 · AI
Advanced neural decoders for the restoration of communication
$683,876Jaimie M Henderson · Stanford University · R01 · FY2019 · DC
Meaningful Engagement and Quality of Life among Assisted Living Residents with Dementia
$683,835Candace Lynn Kemp · Georgia State University · R01 · FY2018 · AG
Effectiveness Trial of Methods for Engaging Parents Into Parenting Interventions
$683,810Emily B. Winslow · Arizona State University-Tempe Campus · R01 · FY2013 · DA
In vivo Analysis of Mouse in which Genetic Mutation is Targeted to CA3 Cells
$683,764Kazutoshi Nakazawa · National Institute Of Mental Health · Z01 · FY2007 · MH
Role of preexisting immunity on airborne transmission of influenza viruses
$683,741Seema S. Lakdawala · Emory University · R01 · FY2025 · AI