Sort
24,576 grants matching “microbiome”
Regulation Of Immune Responses In Humans and in Experimental Animals
$654,659Warren Strober · National Institute Of Allergy And Infectious Diseases · ZIA · FY2023 · AI
Understanding the Impact of Lower Dose Medroxyprogesterone Acetate on Female Genital Tract Microbiome and Immunology
$654,635Jennifer Caraway Deese · Family Health International · R01 · FY2018 · HD
Associations of Gut Microbiome Predictors of Body Fat Amount and Distribution
$654,632Johanna W Lampe · University Of Hawaii At Manoa · P01 · FY2015 · CA
Regulation of neonatal inflammation by myeloid-derived suppressor cells
$654,629Yulia Nefedova · Wistar Institute · R01 · FY2020 · HL
RECENTLY, WE HAVE IDENTIFIED A NOVEL AND EVOLUTIONARILY CONSERVED PATTERN OF MICROBIOME DEVELOPMENT IN THE ROOT ENDOSPHERES OF MANY AGRONOMICALLY IMPORTANT CEREAL CROPS. SPECIFICALLY, WE OBSERVE AN ENRICHMENT OF A SUBSET OF THE BACTERIAL ROOT ENDOSPHERE FOLLOWING A PLANT'S EXPOSURE TO PROLONGED PERIODS OF DROUGHT. THIS PHENOMENA APPEARS CONSERVED ACROSS BOTH A BROAD RANGE OF HOSTS AND BACTERIAL LINEAGES, WHICH SUGGESTS THAT IT IS AN ANCIENT AND EVOLUTIONARILY-SELECTED PHENOTYPE WITH POTENTIAL BENEFITS TO HOST FITNESS. THE GOAL OF THIS PROPOSAL IS TO INVESTIGATE THE MOLECULAR CAUSES OF THIS ENRICHMENT FROM THE MICROBIAL AND HOST PERSPECTIVES, AND THE PHENOTYPIC CONSEQUENCES OF THIS ENRICHMENT FOR THE HOST PLANT. OUR TEAM WILL USE A COMBINATION OF NEW GENOMIC TECHNOLOGIES AND MICROBIOME MANIPULATION STRATEGIES, IN BOTH LAB AND FIELD-BASED EXPERIMENTAL DESIGNS, USING SORGHUM BICOLOR, WHICH REPRESENTS AN EXCELLENT AGRONOMIC MODEL FOR DROUGHT RESEARCH AND AN IMPORTANT FEEDSTOCK AND BIOENERGY CROP. THIS INVESTIGATION WILL ADVANCE THE PRACTICALITY OF USING MICROBIAL-BASED STRATEGIES FOR IMPROVING CROP DROUGHT TOLERANCE BY DISCOVERING MICROBES WITH THE ABILITY TO CONFER DROUGHT TOLERANCE IN AN AGRONOMIC SETTING, AND BY IDENTIFYING SPECIFIC GENETIC AND BIOCHEMICAL PATHWAYS THAT CAN BE MANIPULATED TO IMPROVE RATES AND EXTENTS OF COLONIZATION BY BENEFICIAL MICROORGANISMS. THIS SET OF GOALS ALIGNS WELL WITH THREE PROGRAM AREA PRIORITIES, NAMELY 1) IMPROVING UNDERSTANDINGS OF MULTIPARTITE INTERACTIONS AMONG THE HOST, ENVIRONMENT AND THE MICROBIOME, 2) CHARACTERIZING THE SPECIFIC MOLECULAR MECHANISMS INVOLVED IN MICROBIOME ASSEMBLY UNDER STRESS, AND 3) FUNCTIONALLY CHARACTERIZING MICROBIOMES IN CONFERRING SPECIFIC HOST PHENOTYPES
$654,587Agricultural Research Service · · FY2019 · National Institute of Food and Agriculture
Gut Viral and Bacterial Associations with Celiac Disease in the TEDDY Cohort
$654,482Richard E Lloyd · Baylor College Of Medicine · R01 · FY2022 · DK
Functional Analysis of the Pulmonary Microbiome during COPD
$654,446Gary B. Huffnagle · University Of Michigan At Ann Arbor · R01 · FY2020 · HL
Machine Learning and Multiomics for Predictive Models and Biomarker Discovery in Preterm Infants.
$654,188Mohan Pammi · Baylor College Of Medicine · R01 · FY2025 · HD
Role of mouse microbiome in cancer and inflammation
$654,175Giorgio Trinchieri · Division Of Basic Sciences - Nci · ZIA · FY2013 · CA
Center for Mucosal Immunobiology and Rheumatic Disease Pathogenesis
$654,010V Michael Holers · University Of Colorado Denver · P30 · FY2025 · AR
Functional Microbiomics, Inflammation and Pathogenicity
$653,846Richard J Lamont · University Of Louisville · P20 · FY2023 · GM
Biogenic Gas Nanostructures As Molecular Imaging Reporters For Ultrasound
$653,845Mikhail Shapiro · California Institute Of Technology · R01 · FY2022 · EB
Intratumoral microbiota and immune predictors of response to immunotherapy in lung cancer
$653,786Yanhong Liu · Baylor College Of Medicine · R01 · FY2025 · CA
Systems Genetics Dissection of Non-alcoholic Steatohepatitis
$653,703Aldons Jake Lusis · University Of California Los Angeles · R01 · FY2025 · DK
Project #1: Do Pathogen Genotypes, Carriage, and Social Network Differences Lead to Health Disparities in MRSA/MSSA Infections?
$653,617Talima Ross Pearson · Northern Arizona University · U54 · FY2021 · MD
Risk Factors for Microscopic Colitis
$653,593Robert S Sandler · Univ Of North Carolina Chapel Hill · R01 · FY2023 · DK
THE VAGINAL MICROBIOME, MATERNAL RESPONSE, AND PRETERM BIRTH
$653,553Molly Stout · Washington University · R01 · FY2018 · HD
The relationship of fecal microbiomes and nutritional status in CF
$653,525Lucas R. Hoffman · University Of Washington · R01 · FY2016 · DK
Gut Dysbiosis and Cardiac Remodeling in IBD
$653,505Qingjie Li · University Of Texas Med Br Galveston · R01 · FY2020 · HL
Microbiome and Worsening Glycemia Among Mexican Americans in Starr County, Texas
$653,413Craig L Hanis · University Of Texas Hlth Sci Ctr Houston · R01 · FY2017 · DK
Conserved Fetal Epigenomic and Metagenomic Signatures in a Primate Model of Maternal Obesity
$653,159Kjersti Marie Aagaard-Tillery · Baylor College Of Medicine · R01 · FY2019 · DK
A multi-centric randomized trial of daily nitrofurantoin versus bladder fulguration plus daily nitrofurantoin for the long-term management of cystitis in women with recurrent urinary tract infections
$653,123Philippe E Zimmern · Ut Southwestern Medical Center · R01 · FY2025 · DK
Unraveling gut-microbiome-brain interactions in neurodevelopmental disorders
$653,029Ergun Sahin · Baylor College Of Medicine · R01 · FY2023 · MH
Molecular mechanisms of staphylococcal modulation of skin homeostasis
$653,018Julia Oh · Duke University · R01 · FY2025 · AR
Local microbiota signatures of pro-tumor immunity and checkpoint inhibition susceptibility in lung cancer
$652,880Leopoldo Nicolas Segal · New York University School Of Medicine · R37 · FY2025 · CA