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141,003 grants matching “cytokine”
Pre-clinical progressive selection of a tenofovir analog enema
$1,062,037Justin S. Hanes · Johns Hopkins University · U19 · FY2017 · AI
Role of Memory T Cell Dynamics in SIV Infection
$1,061,520Louis J. Picker · Oregon Health & Science University · R37 · FY2010 · AI
Clinical Evaluation of a Personalized Vaccine Immunotherapy in Combination with Checkpoint Inhibitors for Triple Negative Breast Cancer
$1,061,403Christopher D Pack · Metaclipse Therapeutics Corporation · R44 · FY2021 · CA
Alcohol Metabolism, Functional Consequences and Apoptosis Signaling Mechanism
$1,061,357Byoung-Joon Song · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2024 · AA
National Exposure Assessment Laboratory at Emory
$1,061,307Gary W Miller · Emory University · U2C · FY2015 · ES
Nervous System Development and Plasticity
$1,061,290Richard Douglas Fields · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2009 · HD
Epigenomics of T cells and innate immune cells in human asthma
$1,061,129Anjana Rao · La Jolla Institute For Immunology · R01 · FY2013 · HL
Inhibition of Galectin-3 for Therapy of Remodeling After Myocardial Infarction
$1,061,083Constance M John · Mandalmed, Inc. · R44 · FY2018 · AG
Studies of Non-Ionizing Radiation-Related Cancer
$1,061,019Daryl Freedman · Division Of Cancer Epidemiology And Genetics · ZIA · FY2018 · CA
Role of the innate immune defenses in viral infections
$1,060,903Barbara Rehermann · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2016 · DK
Novel Therapies for Alcoholic Hepatitis
$1,060,741Arthur J McCullough · Cleveland Clinic Lerner Com-Cwru · U01 · FY2015 · AA
Novel Therapies for Alcoholic Hepatitis
$1,060,741Arthur J McCullough · Cleveland Clinic Lerner Com-Cwru · U01 · FY2014 · AA
Reversing Tissue Fibrosis to Improve Immune Reconstitution in HIV
$1,060,377Timothy W Schacker · University Of Minnesota · U01 · FY2015 · AI
MHC-bound, SIV-derived, CTL and HTL Epitopes
$1,060,013David I Watkins · University Of Miami School Of Medicine · R24 · FY2013 · OD
A Phase I/II Clinical Trial to Investigate Fucosylated Tregs in Prevention of GVHD
$1,059,489Joann Flaim · Targazyme, Inc. · R44 · FY2015 · CA
Epidemiology of Age-related Hearing Loss
$1,059,323Karen J Cruickshanks · University Of Wisconsin-Madison · R37 · FY2009 · AG
Characterization Of Novel Chemokine Receptors In Lymphocytes
$1,059,248Joshua M Farber · National Institute Of Allergy And Infectious Diseases · Z01 · FY2008 · AI
The UIUC Neuroproteomics Center on Cell-Cell Signaling
$1,059,091University Of Illinois Urbana-Champaign · P30 · FY2004 · DA
CHALLENGES TO ASTRONAUT HEALTH CAUSED BY SPACEFLIGHT-RELEVANT STRESSORS WILL IMPACT SIGNALING PATHWAYS BETWEEN SYSTEMS ULTIMATELY LEADING TO DEGENERATIVE CHANGES AS HOMEOSTASIS IS IMPAIRED. FOR EXAMPLE CHANGES IN THE MICROBIAL ENVIRONMENT CAN RESULT IN DRAMATIC CHANGES IN VARIOUS INTERNAL AND EXTERNAL MICROBIOMES. BOTH PSYCHOLOGICAL AND PHYSIOLOGICAL STRESS ACTIVATES THE SYMPATHETIC NERVOUS SYSTEM (SNS) AND INITIATES WIDE-RANGING PHYSIOLOGIC CHANGES. THESE CHANGES HAVE SERIOUS IMPLICATIONS ON IMMUNE FUNCTION AND THE ACTIVATION OF INFLAMMATORY PATHWAYS. WE PROPOSE TO USE CENTRIFUGATION TO CHARACTERIZE THE IMPACT OF CHRONIC CHANGES IN THE GRAVITATIONAL ENVIRONMENT ON CROSS-SYSTEM COMMUNICATION. .WE HYPOTHESIZE THAT HYPER-GRAVITY INDUCED CHANGES IN GUT MICROBIOME SNS FUNCTION AND INFLAMMATORY ACTIVITY LEAD TO A BREAKDOWN IN THE COMMUNICATION BETWEEN DISTINCT PHYSIOLOGICAL SYSTEMS (AS MEASURED BY CHANGES IN CARDIOPULMONARY CONTROL); AND THAT THESE RESPONSES DEPEND ON THE GRAVITATIONAL ENVIRONMENT. FURTHERMORE WE PROPOSE THAT THESE GRAVITY-DEPENDENT DEFICITS CAN BE COUNTERED BY A COMBINATION OF PREBIOTIC NUTRITIONAL SUPPLEMENTS THAT ARE KNOWN TO PREFERENTIALLY EXPAND STRESS PROTECTIVE BACTERIAL SPECIES..SPECIFIC AIMS .SPECIFIC AIM 1. CONFIRM THAT CENTRIFUGATION RESULTS IN DETECTABLE CHANGES IN GUT MICROBIOME AS WELL AS IN SYMPATHETIC AND INFLAMMATORY ACTIVITY INDICATIVE OF INCREASED HEALTH RISK. MICE WILL BE PLACED ON THE 8 FT DIAMETER CENTRIFUGE AT AMES RESEARCH CENTER AND EXPOSED TO 1.5 OR 2 G FOR 4 WEEKS. AFTER CENTRIFUGATION ADRENAL GLANDS BLOOD LIVER SPLEEN AND INTESTINES WILL BE COLLECTED AND ASSESSED FOR CHANGES IN SYMPATHETIC AND INFLAMMATORY ACTIVITY AS WELL AS FOR CHANGES IN MICROBIOME AS COMPARED TO MATCHED 1 G CONTROLS. .SPECIFIC AIM 2. CONFIRM THAT PROLONGED EXPOSURE TO HYPER-GRAVITY LEADS TO A BREAKDOWN IN COMMUNICATION BETWEEN DISTINCT PHYSIOLOGICAL SYSTEMS CAUSING DECREMENTS IN FUNCTION. THE SAME MICE USED IN AIM 1 WILL BE USED HERE. OUR MODEL FOCUSES ON BRAINSTEM CONTROL OF CARDIOPULMONARY FUNCTION DRIVEN PRIMARILY BY SYMPATHETIC/VAGAL INNERVATION. THE BRAINSTEM SPINAL CORD HEART AND LUNGS WILL BE COLLECTED. ANALYSIS WILL FOCUS SPECIFICALLY ON THE NUCLEUS TRACTUS SOLITARII (NTS) THE FIRST-ORDER INTEGRATIVE SITE FOR VAGAL AFFERENTS PROJECTING FROM THE GUT HEART AND LUNGS TO THE CENTRAL NERVOUS SYSTEM. THE NTS COORDINATES EFFERENT OUTPUT TO TARGETS THAT ARE CRITICAL FOR THE CONTROL OF BREATHING HEART/VASCULATURE AND GUT. IN VIVO AND IN VITRO ELECTROPHYSIOLOGY WILL BE USED TO QUANTIFY CHANGES IN SYMPATHETIC TONE AND CONFIRM THAT SYNAPTIC ACTIVITY WITHIN THE NTS IS ALTERED BY CHANGES IN MICROBIOME. IMMUNOHISTOCHEMISTRY AND RNASEQ WILL BE USED TO ASSESS CHANGES IN INFLAMMATION AND STRESS-RELATED MESSAGE ALLOWING US TO DETERMINE THE ROLE CYTOKINES AND DOWNSTREAM EFFECTORS PLAY IN MODULATING NTS NEURONAL ACTIVITY CORRELATED WITH CARDIORESPIRATORY CONTROL. .SPECIFIC AIM 3. DETERMINE THAT CENTRIFUGATION-INDUCED CHANGES IN HEALTH STATUS SIGNALING ARE LINKED TO CHANGES IN MICROBIOME. BASED ON OUR PREVIOUS FINDINGS WE HYPOTHESIZE THAT INGESTION OF A PREBIOTIC SUPPLEMENT BLEND [GALACTOOLIGOSACCHARIDES (GOS) + POLYDEXTROSE (PDX) + LACTOFERRIN + MILK FAT GLOBULE MEMBRANE PROTEIN (MFGMP)] WILL BOTH PREVENT GUT MICROBIAL DYSBIOSIS PRODUCED BY CENTRIFUGATION AND INCREASE SELECTIVE STRESS PROTECTIVE GUT BACTERIA (I.E. LACTOBACILLUS AND BIFIDOBACTERIA). PREBIOTIC-ENRICHED CHOW OR CALORICALLY MATCHED CHOW WILL BE AVAILABLE AD LIBITUM THROUGHOUT THE EXPERIMENT STARTING 1 WEEK PRIOR TO CENTRIFUGATION. MICE WILL BE PLACED ON THE 8 FT DIAMETER CENTRIFUGE AT AMES RESEARCH CENTER AND EXPOSED TO 2 G FOR 4 WEEKS. PARAMETERS DESCRIBED IN AIMS 1&2 WILL BE ASSESSED AS DESCRIBED. .
$1,058,979Loma Linda University · · FY2020 · National Aeronautics and Space Administration
LJI Epitope Validation Center: Characterization of epitope-specific T cells responding to food, fungal and inner city allergens
$1,058,699Alessandro Sette · La Jolla Institute For Immunology · U19 · FY2020 · AI
The Environmental Triggers of Diabetes (TEDDY) in Sweden
$1,058,361Ake Lernmark · Lunds Universitet · U01 · FY2010 · DK
Dynamic regulatory network models of human response to influenza virus
$1,058,296Ivan Marazzi · University Of California-Irvine · U01 · FY2024 · AI
Systemic Inflammation in Microphysiological Models of Muscle and Vascular Disease
$1,058,270George A Truskey · Duke University · UG3 · FY2018 · TR
Feeding and Pancreatic Rest in Acute Pancreatitis
$1,058,114David C Whitcomb · University Of Pittsburgh At Pittsburgh · U01 · FY2010 · DK
Vaccination to generate protective tissue resident T cells
$1,057,967Thomas S. Kupper · Brigham And Women'S Hospital · R01 · FY2013 · AI