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24,576 grants matching “microbiome”
Predicting and preventing drug metabolism by the human gut microbiome
$646,398Peter James Turnbaugh · University Of California, San Francisco · R01 · FY2023 · HL
Childhood follow-up study of obesity and neurodevelopment after perinatal exposure to adjunctive azithromycin prophylaxis for cesarean delivery
$646,325Akila Subramaniam · University Of Alabama At Birmingham · R01 · FY2021 · HD
DEFINING THE HUMAN VIROME IN IMMUNOCOMPROMISED CHILDREN
$646,293Gregory A. Storch · Washington University · R01 · FY2016 · AI
The Oral Mycobiome and Risk of Pancreatic Cancer
$646,256Jiyoung Ahn · New York University School Of Medicine · U01 · FY2021 · CA
Domestication and characterization of TM7-the most elusive oral phylum
$646,240Xuesong He · Ada Forsyth Institute, Inc. · R01 · FY2020 · DE
The Subgingival Microbiome and Impaired Glucose Regulation
$646,105Ryan T. Demmer · Columbia University Health Sciences · R01 · FY2016 · DK
Source of the Placental Microbiome
$646,028Kjersti Marie Aagaard-Tillery · Baylor College Of Medicine · R01 · FY2021 · HD
Bacteriophages in dental caries: Roles and potential as a therapy
$645,988Justin Ray Kaspar · Ohio State University · R56 · FY2025 · DE
Repurposing novel selective drugs for treatment and decolonization of vancomycin resistant enterococci
$645,971Mohamed Seleem · Virginia Polytechnic Inst And St Univ · R01 · FY2021 · AI
Conserved Fetal Epigenomic and Metagenomic Signatures in a Primate Model of Maternal Obesity
$645,963Kjersti Marie Aagaard-Tillery · Baylor College Of Medicine · R01 · FY2020 · DK
Data Coordinating Center, Microbiome of the Lung and Respiratory Tract
$645,926Mary A Foulkes · George Washington University · U01 · FY2009 · HL
Inflammatory cross-talk between skin and gut
$645,827Richard L Gallo · University Of California, San Diego · R01 · FY2024 · DK
The relationship of fecal microbiomes and nutritional status in CF
$645,802Lucas R. Hoffman · University Of Washington · R01 · FY2015 · DK
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** AS AGRICULTURAL PRODUCTION SYSTEMS ARE CONFRONTED BY UNPRECEDENTED RECORD-BREAKING FLOODING EVENTS THAT THREATEN CROP GROWTH AND PRODUCTIVITY, PROFITABILITY, AND SUSTAINABILITY OF AGRICULTURAL ECOSYSTEMS AND FOOD SECURITY, THREE CRUCIAL QUESTIONS EMERGE:1.HOW DOES FLOODING ALTER THE FUNCTIONING AND STRUCTURE OF SOIL MICROBIAL COMMUNITIES THAT UNDERPIN PLANT AND SOIL HEALTH.2. HOW DOES FLOODING IMPACT CORN PLANT GROWTH AND TRAITS THAT PUTATIVELY MEDIATE PLANT AND INSECT INTERACTIONS.3. CAN POST-FLOODING NITROGEN MANAGEMENT RECOVER LOST YIELD POTENTIAL AND MAINTAIN CROP PRODUCTIVITY?THIS RESEARCH ADDRESSES TWO FOUNDATIONAL KNOWLEDGE OF AGRICULTURAL PRODUCTION SYSTEMS PRIORITIES: 1) DETERMINE HOW PRODUCTION SYSTEMS CAN ALTER PLANT AND SOIL MICROBIOMES, THE WAY ALTERATIONS AFFECT FUNCTIONS SUCH AS PLANT NUTRIENT UPTAKE, AND RESILIENCE TO INSECTS AND WEATHER EXTREMES ASSOCIATED WITH CLIMATE CHANGE AND OTHER STRESSORS; AND 2) INVESTIGATE HOW CHANGES TO CROPPING SYSTEMS AFFECT CROP PERFORMANCE, SOIL HEALTH, AND OTHER OUTCOMES BENEFICIAL TO SYSTEM RESILIENCE. THIS PROJECT WILL CHARACTERIZE THE IMPACTS OF FLOODING AND NITROGEN MANAGEMENT ON SOIL MICROBIOTA, CORN PLANT PHYSIOLOGY AND RESILIENCE, GRAIN YIELD AND NUTRITIONAL QUALITY, AND DEFENSIVE SECONDARY METABOLITES - TRAITS THAT ARE IMPORTANT MEDIATORS OF PLANT AND INSECT INTERACTIONS. NITROGEN AVAILABILITY MAY BE A STRONG DETERMINANT IN PLANT RECRUITMENT OF MICROBIAL COMMUNITIES AND HOW THEY INFLUENCE PLANT RESPONSES, SUCH AS ACC DEAMINASE PRODUCTION, TO FLOODING AND FINAL GRAIN YIELDS. RESULTS WILL PROVIDE CRUCIAL FOUNDATIONAL DATA ABOUT HOW SOILS, SOIL MICROBES, AND CORN PLANTS ARE AFFECTED BY FLOODING, WHICH GROWERS CAN USE WHEN MAKING POST-FLOOD MANAGEMENT DECISIONS, THEREBY MITIGATING THIS STRESS FOR CORN, AMERICA'S MOST ECONOMICALLY IMPORTANT CROP.
$645,784University Of Illinois · · FY2023 · National Institute of Food and Agriculture
Protection from Mucosal Pathology by Gut Microbiota during Experimental Colitis
$645,769Sarkis K Mazmanian · California Institute Of Technology · R01 · FY2017 · DK
Bacterial biosensors for the prevention of gastrointestinal cancers
$645,698Jeff M Hasty · University Of California, San Diego · R01 · FY2024 · CA
Bacterial correlates of colorectal cancer subgroups and survival
$645,693Amanda Irene Phipps · University Of Washington · R01 · FY2021 · CA
Defining bioactivities of peptides released from human milk proteins in the preterm infant intestine
$645,659Brian Scottoline · Oregon Health & Science University · R01 · FY2024 · HD
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** OBESITY AND ASSOCIATED DISEASES SUCH AS NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) HAVE REACHED EPIDEMIC LEVEL.NAFLD'S GLOBAL PREVALENCE IS 20-30% IN GENERAL POPULATION AND 80% IN OBESE PEOPLE.EPIDEMIOLOGICAL DATA SUGGEST THAT DIETS THAT EMPHASIZE FRUITS AND VEGETABLE (F&V) REDUCE RISK FOR OBESITY-ASSOCIATED DISEASES INCLUDING NAFLD. HOWEVER, ONLY A FEW STUDIES USING SINGLE F&V OR THEIR EXTRACTS HAVE TESTED THIS HYPOTHESIS. OUR PRELIMINARY STUDIES SHOW THAT FEEDING MICE A DIET SUPPLEMENTED WITH 15% (W/W) OF A MIXTURE OF F&V COMMONLY CONSUMED BY AMERICANS PROTECTS AGAINST NAFLD IN OBESE AND LEAN MICE BY 48.4% AND 28.5%. THE MECHANISM FOR F&V-INDUCED PROTECTION AGAINST NAFLD IS NOT UNDERSTOOD, YET, IS URGENTLY NEEDED TO EXPAND EVIDENCE-BASED SUPPORT FOR DIETARY GUIDELINES OF INCREASE F&V CONSUMPTION TO PREVENT CHRONIC DISEASES. WHILE DIETARY INTERVENTIONS TO PREVENT NAFLD HAVE FOCUSED ON WEIGHT LOSS, LITERATURE AND OUR PRELIMINARY DATA SUGGEST THAT OTHER FACTORS THAN MAINTAINING ENERGY BALANCE CONTRIBUTE TO NAFLD DEVELOPMENT. IDENTIFYING THESE FACTORS THROUGH INVESTIGATING THE UNDERLYING MECHANISMS OF F&V-INDUCED PREVENTION OF NAFLD WILL HELP DEVELOP MORE EFFICIENT STRATEGIES TO COMBAT NAFLD. WE HAVE IDENTIFIED NOVEL PATHWAYS (CERAMIDE AND GUT MICROBIOME) THROUGH WHICH F&V MAY EXERT THEIR BENEFICIAL EFFECTS IN PREVENTING NAFLD, HOWEVER, THEIR CAUSAL ROLE AND RELATIVE CONTRIBUTION TO THE PROTECTIVE EFFECT OF F&V ARE NOT KNOWN. THUS, IN THIS PROPOSAL WE AIM TO ADDRESS THIS GAP IN KNOWLEDGE. RESULTS FROM THE PROPOSED STUDIES WILL EXPAND THE KNOWLEDGE BASE TO SUPPORT AND IMPLEMENT THE CURRENT DIETARY GUIDELINES AND HELP DEVELOP EFFECTIVE DIETARY INTERVENTIONS TO COMBAT NAFLD.
$645,464Trustees Of Tufts College · · FY2022 · National Institute of Food and Agriculture
Innate, Transcriptomic, and Microbiomic correlates of TB infection
$645,460Michael Haggai Glickman · Weill Medical Coll Of Cornell Univ · U19 · FY2015 · AI
Gut microbiota and metabolite interactions in atherosclerosis
$645,424Aldons Jake Lusis · University Of California Los Angeles · R01 · FY2020 · HL
Epigenetic mechanisms of carcinogenesis by Parvimonas micra, an oral cavity commensal turned colon cancer pathogen
$645,347Khashayarsha Khazaie · Mayo Clinic Arizona · R01 · FY2022 · CA
Microbiome and Worsening Glycemia Among Mexican Americans in Starr County, Texas
$645,287Craig L Hanis · University Of Texas Hlth Sci Ctr Houston · R01 · FY2018 · DK
Epidemiology of diet, metabolism and non-alcoholic fatty liver disease in Hispanic/Latino adults
$645,272Robert C Kaplan · Albert Einstein College Of Medicine · R01 · FY2024 · DK
Reference Profiles of ExRNA in Biofluids from Well-Defined Human Cohorts
$645,257Muneesh Tewari · University Of Michigan At Ann Arbor · U01 · FY2017 · HL