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38,696 grants matching “als”
Prevention of Attachment Insecurity, Physiological Dysregulation, and Child Behavior Problems
$666,462Jude A Cassidy · Univ Of Maryland, College Park · R01 · FY2022 · HD
Dynamics of State-Selected Ion/Surface Reactions
$666,350Dennis C Jacobs · University Of Notre Dame · · FY2000 · MPS
Symptom Distress Mechanisms in Digestive Disorders
$666,334Wendy Henderson · National Institute Of Nursing Research · ZIA · FY2018 · NR
Early development of small molecule neuroprotectants
$666,166Corinne Ida Lasmezas · Scripps Florida · R56 · FY2017 · NS
Experimental Therapeutics of Pediatric Hematopoietic Malignancies
$666,058Alan S Wayne · Division Of Clinical Sciences - Nci · ZIC · FY2013 · CA
PHOTOSYNTHETIC MARINE PHYTOPLANKTON FORM THE BASE OF THE MARINE FOOD WEB AND DRIVE THE BIOLOGICAL PUMP (BP) I.E. THE SINKING AND SEQUESTERING OF ORGANIC CARBON TO THE DEEP OCEAN THAT LOWERS ATMOSPHERIC CO2. PHYTOPLANKTON SIZE IS A MASTER TRAIT THAT AFFECTS THE STRUCTURE AND FUNCTION OF OCEANIC ECOSYSTEMS; PHYTOPLANKTON SIZE CLASSES (PSCS) CLOSELY CORRESPOND TO PHYTOPLANKTON FUNCTIONAL TYPES (PFTS). PSCS CHANGE INTER-ANNUALLY AND ON DECADAL TIMESCALES WITH IMPLICATIONS FOR ECOSYSTEM ECOLOGY AND THE BP. RECENT ADVANCES IN OCEAN COLOR SCIENCE ALLOW MORE COMPLETE CHARACTERIZATION OF OCEAN ECOSYSTEMS E.G. KOSTADINOV ET AL. (2016A TK16) LEVERAGE THE BACKSCATTERING-BASED PARTICLE SIZE DISTRIBUTION (PSD) ALGORITHM KSM09 IN ORDER TO RETRIEVE SIZE-PARTITIONED PHYTOPLANKTON CARBON (C) CONCENTRATIONS AND CARBON-BASED PSCS. HERE WE PROPOSE A JOINT STUDY OF OCEAN COLOR SATELLITE DATA AND THE LATEST GENERATION OF EARTH SYSTEM MODELS (WHICH ARE PART OF THE 6TH COUPLED MODEL INTERCOMPARISON CMIP6) TO: (1) IMPROVE THE KSM09 ALGORITHM COMPARE IT WITH AN ABSORPTION-BASED PFT ALGORITHM AND PRODUCE A MULTI-PLATFORM MERGED DATA SET AND (2) ESTABLISH BIOLOGY-PHYSICS CONNECTIONS AND CHARACTERIZE BIOLOGICAL EL NI O-SOUTHERN OSCILLATION (ENSO) VARIABILITY IN THIS SATELLITE RECORD AND IN CLIMATE MODELS. SPECIFICALLY WE PROPOSE: TASK A. PSD ALGORITHM IMPROVEMENTS AND MULTI-PLATFORM MERGING TASK A1. MODEL BACKSCATTERING USING NON-SPHERICAL PARTICLES AND/OR COATED SPHERES: IMPROVEMENTS IN THE KSM09 PSD ALGORITHM WILL BE INTRODUCED NAMELY PARTICULATE BACKSCATTERING WILL BE MODELED USING THE NON-SPHERICAL PARTICLE SCATTERING KERNELS OF DUBOVIK ET AL. (2006). IF REASONABLE CLOSURE OF BACKSCATTERING VALUES AND SPECTRAL SHAPE CANNOT BE OBTAINED MIE CODE FOR COATED SPHERES WILL BE USED INSTEAD (ZHANG ET AL. 2017). HERE WE PROPOSE A JOINT STUDY OF OCEAN COLOR SATELLITE DATA AND THE LATEST GENERATION OF EARTH SYSTEM MODELS (WHICH ARE PART OF THE 6TH COUPLED MODEL INTERCOMPARISON CMIP6) TO: (1) IMPROVE THE KSM09 ALGORITHM COMPARE IT WITH AN ABSORPTION-BASED PFT ALGORITHM AND PRODUCE A MULTI-PLATFORM MERGED DATA SET AND (2) ESTABLISH BIOLOGY-PHYSICS CONNECTIONS AND CHARACTERIZE BIOLOGICAL EL NI O-SOUTHERN OSCILLATION (ENSO) VARIABILITY IN THIS SATELLITE RECORD AND IN CLIMATE MODELS. SPECIFICALLY WE PROPOSE: TASK A. PSD ALGORITHM IMPROVEMENTS AND MULTI-PLATFORM MERGING TASK A1. MODEL BACKSCATTERING USING NON-SPHERICAL PARTICLES AND/ OR COATED SPHERES: IMPROVEMENTS IN THE KSM09 PSD ALGORITHM WILL BE INTRODUCED NAMELY PARTICULATE BACKSCATTERING WILL BE MODELED USING THE NON-SPHERICAL PARTICLE SCATTERING KERNELS OF DUBOVIK ET AL. (2006). IF REASONABLE CLOSURE OF BACKSCATTERING VALUES AND SPECTRAL SHAPE CANNOT BE OBTAINED MIE CODE FOR COATED SPHERES WILL BE USED INSTEAD (ZHANG ET AL. 2017). TASK A2. COMPARISON WITH ABSORPTIONBASED ALGORITHM OF ROY ET AL. (2013): SATELLITE IMAGERY OF PSD/PFT GENERATED USING THE KSM/TK16 ALGORITHMS WILL BE COMPARED TO THE OUTPUT OF THE ROY ET AL. (2013) PSD/PFT ALGORITHM THAT IS DESIGNED TO RETRIEVE THE PHYTOPLANKTON-ONLY PSD. THE KSM09 ALGORITHM IS SENSITIVE TO ALL PARTICLES. THIS COMPARISON WILL YIELD INFORMATION ABOUT THE PARTICLE ASSEMBLAGE AND/OR INFORM FUTURE IMPROVEMENTS TO THE KSM09 ALGORITHM E.G. INTRODUCTION OF BETTER TREATMENTS OF THE INDEX OF REFRACTION IN KSM09.
$665,865California State University San Marcos Corp · · FY2020 · National Aeronautics and Space Administration
Function and Pathogenic Mechanism of LRRK2 in Parkinson's Disease
$665,812Huaibin Cai · National Institute On Aging · ZIA · FY2013 · AG
Neuronal cell-cycle re-entry and neurodegeneration
$665,765Shanthini Sockanathan · Johns Hopkins University · R01 · FY2020 · AG
Multi-Targeting Oligonucleotide Therapeutics for Familial and Sporadic Amyotrophic Lateral Sclerosis
$665,737Jonathan K Watts · Univ Of Massachusetts Med Sch Worcester · R01 · FY2025 · NS
Multi-Targeting Oligonucleotide Therapeutics for Familial and Sporadic Amyotrophic Lateral Sclerosis
$665,737Jonathan K Watts · Univ Of Massachusetts Med Sch Worcester · R01 · FY2024 · NS
Characterization of Neural Stem Cells in Adult Brain
$665,609Arturo Alvarez-Buylla · University Of California, San Francisco · R01 · FY2014 · NS
Profiles of Working Memory for Educational Research
$665,498Shelley I Gray · Arizona State University-Tempe Campus · R01 · FY2019 · DC
Hexanucleotide repeat translation in ALS and Frontotemporal Dementia
$665,420Peter K Todd · University Of Michigan At Ann Arbor · R01 · FY2023 · NS
Kentucky TRIALS Research Center
$665,244Carl G Leukefeld · University Of Kentucky · U01 · FY2016 · DA
1/2 Development of a Screening Interview for Research Studies of ASD
$665,065Christopher Stephen Monk · University Of Michigan At Ann Arbor · R01 · FY2010 · MH
Inflammation and Therapy for Respiratory Virus Infection
$665,051Helene Rosenberg · National Institute Of Allergy And Infectious Diseases · ZIA · FY2012 · AI
Brain Bank Core
$665,048Ann Carolyn McKee · Boston University Medical Campus · U54 · FY2022 · NS
Role of G protein-coupled receptors in regulating glucose and energy homeostasis
$665,035Jurgen Wess · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2010 · DK
Myosin Movement in Vitro-Molecular Characterization
$665,027James A Spudich · Stanford University · R01 · FY2013 · GM
INTEGRATED FIRST PRINCIPLES CALCULATIONS AND COMPUTATIONAL MODELING OF PHASE STABILITY AND THERMAL EXPANSION OF NI-AL-PT BASED ALLOYS
$665,000The Pennsylvania State University · · FY2008 · Department of the Navy
Protein Structure
$664,957Byungkook Lee · Division Of Basic Sciences - Nci · Z01 · FY2008 · CA
Diagnostic and Natural History Markers in ALS
$664,947Columbia University Health Sciences · R01 · FY2002 · NS
EXAMINING THE EFFICACY OF 'PARENTS WHO CARE'
$664,801University Of Washington · R01 · FY2004 · DA
Microvascular mechanisms of growth restriction after environmental toxicant exposure
$664,796Phoebe Stapleton · Rutgers, The State Univ Of N.J. · R01 · FY2022 · ES
Expanding the chemical diversity of therapeutic oligonucleotides to treat neurodegenerative disorders
$664,751Anastasia Khvorova · Univ Of Massachusetts Med Sch Worcester · R01 · FY2018 · NS