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24,576 grants matching “microbiome”
Methods to Test the Role of Age-related Lifestyle and Vaginal Microenvironment Changes and the Prevention, Treatment, and Progression of Genitourinary Syndrome of Menopause
$640,205Michelle Denise Shardell · University Of Maryland Baltimore · R01 · FY2022 · AG
Pathogenic Heterogeneity in Mucosal Stem Cells in Pediatric Crohn's Disease
$640,193Wa Xian · University Of Houston · R01 · FY2021 · DK
Project 1 - Determining the contributions of the gut microbiota to the physiologi
$640,091Jeffrey Ivan Gordon · Washington University · P01 · FY2016 · DK
Defining Dysbiosis and Mechanisms of Periodontitis Progression and Stability
$640,090Flavia Rocha Teles · University Of Pennsylvania · R01 · FY2024 · DE
The Microbiome and Bone Strength
$640,042Christopher John Hernandez · University Of California, San Francisco · R01 · FY2023 · AG
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** EARLY LIFE CHALLENGES IN PIGS INCLUDE INTESTINAL DIARRHEAL DISEASE AND WEANING STRESS. THESE CHALLENGES RESULT IN INJURY TO THE LINING OF THE INTESTINAL TRACT, WHICH WE HAVE SHOWN IS SLOW TO REPAIR IN THE SUCKLING PIG. WE HAVE LINKED THE FAILURE TO REPAIR THE INTESTINE TO AN IMMATURE GUT NERVOUS SYSTEM, WHICH IS RESPONSIVE DURING EARLY LIFE TO A DEVELOPING POPULATION OF MICROBES CALLED THE MICROBIOME. WE PROPOSE THAT FEEDING SOLUBLE FIBER WILL ENRICH THE MICROBIOME, RESULTING IN SIGNALING TO THE INTESTINAL NERVOUS SYSTEM, FOLLOWED BY A MORE MATURE RESPONSE TO INTESTINAL DISEASE AND TO OFFSET THE EFFECT OF WEANING ON THE INTESTINAL TRACT. THIS IN TURN SHOULD LEAD TO INCREASED GROWTH PERFORMANCE IN YOUNG SWINE.
$640,000North Carolina State University · · FY2022 · National Institute of Food and Agriculture
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** BESIDES BEING A POTENT GLOBAL WARMING GAS, ENTERIC METHANE FROM RUMINANTS REPRESENTS ARELEVANT SOURCE OF FEED INEFFICIENCY BY SEQUESTERING 3-12% OF THE ENERGY INTAKE. HOWEVER, DIRECTINHIBITION OF RUMEN METHANOGENESIS HAS NOT CONSISTENTLY INCREASED ENERGY CAPTURE FROM THE DIET.NEVERTHELESS, TO TRANSLATE METHANE INHIBITION TO FEED EFFICIENCY IMPROVEMENTS, THE CONSERVEDENERGY NEEDS TO BE REROUTED TOWARDS THE SYNTHESIS OF NUTRITIONALLY RELEVANT METABOLITES FOR THEANIMAL LIKE RUMINAL PROPIONATE. THE INCONSISTENT IMPROVEMENTS IN PRODUCTION PARAMETERS AS ARESULT OF DIRECT INHIBITION OF METHANOGENESIS, SUGGESTS THAT SPARED ENERGY IS BEING ALTERNATIVELYREDIRECTED TOWARDS OTHER PATHWAYS.WE DEMONSTRATED THAT FEEDING CATTLE NOVEL PROBIOTICS COMPOSED OF COMPETITIVE KEYSTONERUMEN-NATIVE SUCCINOGENIC BACTERIA ISOLATED FROM THE RUMEN OF FEEDLOT STEERS, IMPROVED GROWTHPERFORMANCE PARAMETERS, DECREASED METHANE EMISSIONS YIELD, AND MODIFIED THE COMPOSITION OFTHE RUMEN MICROBIOME. THESE KEYSTONE PROBIOTICS, WHICH ALREADY SUCCESSFULLY COMPETED WITHMETHANOGENS IN VIVO, HOLD GREAT POTENTIAL TO THRIVE AND DIVERT THE CONSERVED ENERGY TOWARDSPROPIONATE PRODUCTION IN A METHANOGENESIS-INHIBITED RUMEN ENVIRONMENT. THEREFORE, WEHYPOTHESIZE THAT THE USE OF RUMEN-DERIVED SUCCINATE-PRODUCING BACTERIA, TOGETHER WITH A POTENTMETHANE INHIBITOR, CAN CONSTITUTE AN INNOVATIVE APPROACH TO REDUCE METHANE EMISSIONS WHILE ALSOFURTHER IMPROVING FEED EFFICIENCY IN BEEF CATTLE. THE OBJECTIVE OF OUR RESEARCH PROJECT IS TO TESTTHE ABOVE HYPOTHESIS USING A COMBINATION OF THE NEW PROBIOTICS (RUMEN-NATIVE SUCCINOGENICBACTERIA) AND RED ALGAE (ASPARAGOPSIS TAXIFORMIS). THE OUTCOMES OF THIS RESEARCH WILL NOT ONLYMITIGATE METHANE EMISSIONS AND SUPPORT A MORE SUSTAINABLE BEEF PRODUCTION, BUT WILL ALSO BENEFITPRODUCERS ECONOMICALLY DUE TO GROWTH PERFORMANCE IMPROVEMENTS.
$640,000Ohio State University, The · · FY2024 · National Institute of Food and Agriculture
A life course perspective on gut microbiome aging and health in a non-human primate model
$639,997Elizabeth Archie · University Of Notre Dame · R01 · FY2024 · AG
Microbial triggers and molecular mechanisms of Th17 mediated airway inflammation-Resubmission-1
$639,905Sergei Borisovich Koralov · New York University School Of Medicine · R01 · FY2016 · HL
Defining the Human Microbiome
$639,871Bruce W. Birren · Broad Institute, Inc. · U54 · FY2012 · HG
Ambystoma Genetic Stock Center
$639,842Stephen Randal Voss · University Of Kentucky · P40 · FY2025 · OD
Project #1: Do Pathogen Genotypes, Carriage, and Social Network Differences Lead to Health Disparities in MRSA/MSSA Infections?
$639,692Talima Ross Pearson · Northern Arizona University · U54 · FY2018 · MD
Cutaneous biomarkers of pediatric non-alcoholic fatty liver disease
$639,629Marialena Mouzaki · Cincinnati Childrens Hosp Med Ctr · R01 · FY2025 · DK
Impact of the Environment and Host Microbiome on Asthma Development: Mechanistic Studies
$639,549Donata Vercelli · University Of Arizona · P01 · FY2021 · AI
Lung Microbiome and Pulmonary Inflammation/Immunity in HIV Infection
$639,466Homer L Twigg · Indiana University Indianapolis · U01 · FY2013 · HL
Data Coordinating Center, Microbiome of the Lung and Respiratory Tract
$639,423Mary A Foulkes · George Washington University · U01 · FY2011 · HL
Pathogenic Heterogeneity in Mucosal Stem Cells in Pediatric Crohn's Disease
$639,357Wa Xian · University Of Texas Hlth Sci Ctr Houston · R01 · FY2018 · DK
Data Coordinating Center, Microbiome of the Lung and Respiratory Tract
$639,293Mary A Foulkes · George Washington University · U01 · FY2010 · HL
Mammary Epithelium Permeability, Lactation Outcomes, and Infant Health
$639,253Kathleen Frances Arcaro · University Of Massachusetts Amherst · R01 · FY2024 · HD
NOVEL METABOLITE AND MICROBIOTA PATHWAYS FOR HYPERURICEMIA AND GOUT
$639,196Hyon K Choi · Massachusetts General Hospital · R01 · FY2025 · AR
Project 2: Molecular signatures for ME/CFS sub-types
$639,146John Greally · Columbia University Health Sciences · U54 · FY2019 · AI
Circulating microbiome and premature mortality in hemodialysis patients
$639,117Keiichi Sumida · University Of Tennessee Health Sci Ctr · R01 · FY2021 · DK
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** HEAVY METALS ARE SIGNIFICANT THREATS TO HUMAN AND ANIMAL HEALTH. MEAT PRODUCTION ANIMALS, LIKE CATTLE, CAN BE EXPOSED TO HEAVY METALS BY INGESTING CONTAMINATED FEED AND WATER. IF EXPOSURES ARE HIGH ENOUGH, ANIMALS FAIL TO THRIVE, FAIL TO GAIN WEIGHT, AND ARE MORE SUSCEPTIBLE TO DISEASE. ALSO, METALS MIGHT ENTER THE FOOD CHAIN IN RETAIL MEAT PRODUCTS AND IMPACT HUMAN HEALTH. CURRENTLY, THERE IS LITTLE INFORMATION REGARDING SAFE EXPOSURE LEVELS FOR AG ANIMALS. THIS PROJECT WILL GENERATE THIS IMPORTANT INFORMATION USING CONTROLLED, EXPERIMENTAL EXPOSURES IN GROUPS OF BEEF CATTLE (STEERS). GROUPS OF STEERS WILL BE EXPOSED TO INCREASING DOSES OF HEAVY METALS AND THE LOWEST DOSE AT WHICH THEIR LIVER AND IMMUNE SYSTEMS ARE AFFECTED WILL BE IDENTIFIED. DURING THESE EXPERIMENTS, WE WILL ALSO DETERMINE WHETHER MEAT AND OTHER RETAILS PRODUCTS FROM THESE ANIMALS ACCUMULATE METALS FOLLOWING EXPOSURE.MICROORGANISMS LIVING IN THE GUT OF CATTLE, CALLED THE MICROBIOME, HELP PROTECT THESE ANIMALS FROM TOXIC EFFECTS OF HEAVY METALS AND OTHER CONTAMINANTS. BISON AND CATTLE HAVE SIMILAR GUT MICROBIOMES AND WE KNOW THAT BISON LIVING IN YELLOWSTONE NATIONAL PARK ARE NATURALLY EXPOSED TO VERY HIGH LEVELS OF METALS IN SURFACE WATERS ORIGINATING FROM HOT SPRINGS AND GEYSERS. WE THINK THAT BISON DRINKING WATER WITH HIGH LEVELS OF METALS MIGHT HOST GUT MICROORGANISMS WITH SPECIAL ABILITIES TO DETOXIFY TOXIC METALS. IF SO, THESE MICROORGANISMS MIGHT HELP PRODUCERS MINIMIZE THE METAL EXPOSURE IN THEIR HERDS AND ULTIMATELY MINIMIZE METALS IN THE FOOD CHAIN AND HUMAN EXPOSURE. WE WILL COLLECTED SAMPLES (STOOL AND URINE) FROM EXPOSED AND UNEXPOSED BISON HERDS AND IDENTIFY MICROORGANISMS IMPORTANT FOR DETOXIFYING HEAVY METALS.
$638,935Montana State University · · FY2024 · National Institute of Food and Agriculture
An autoimmune center of excellence for the study of IgG4-related disease
$638,905Shiv Subramaniam Pillai · Massachusetts General Hospital · U19 · FY2023 · AI
Establishment of the New York University Vaccine and Treatment Evaluation Unit (NYU VTEU)
$638,651Mark Joseph Mulligan · New York University School Of Medicine · UM1 · FY2022 · AI