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24,576 grants matching “microbiome”
Vaginal microbiome seeding and health outcomes in Cesarean-delivered neonates: a randomized controlled trial
$638,646Suchitra Hourigan · National Institute Of Allergy And Infectious Diseases · ZIA · FY2025 · AI
The role of the microbiome in childhood disease
$638,646Suchitra Hourigan · National Institute Of Allergy And Infectious Diseases · ZIA · FY2025 · AI
Barrier integrity, microbiome and HIV target cell interactions in the human male genital tract pre and post circumcision
$638,625Thomas Hope · Northwestern University At Chicago · R01 · FY2017 · DK
Gut Microbiome and Cancer Immunotherapy Outcomes in Advanced Renal Cell Carcinoma
$638,550Veronika Fedirko · University Of Tx Md Anderson Can Ctr · R01 · FY2022 · CA
A Phase II randomized controlled trial to evaluate the role of BB-12 in antibiotic-associated diarrhea and its effects on the gut microbiome
$638,532Daniel J Merenstein · Georgetown University · R01 · FY2017 · HD
Detecting and locating cancer for patients with CT-detected lung nodules
$638,167Xianghong Jasmine Zhou · University Of California Los Angeles · R01 · FY2023 · CA
The role of tuft cells in norovirus pathogenesis
$638,139Craig Brian Wilen · Yale University · R01 · FY2023 · AI
The role of tuft cells in norovirus pathogenesis
$638,139Craig Brian Wilen · Yale University · R01 · FY2024 · AI
The role of tuft cells in norovirus pathogenesis
$638,139Craig Brian Wilen · Yale University · R01 · FY2022 · AI
Structure, function, and inhibition of the SARS-CoV-2 replication-transcription complex
$638,072Seth A Darst · Rockefeller University · R01 · FY2021 · AI
1/2 Alcohol Associated Comorbidities and Microbiome Evaluation in HIV (ACME HIV)
$638,020Matthew S Freiberg · Vanderbilt University Medical Center · U01 · FY2018 · AA
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** HUMAN AND COW'S MILK CONTAIN LARGE AMOUNTS OF NATURAL NANOPARTICLES (MILK EXOSOMES, MES), WHEREAS PLANT-BASED MILK AND INFANT FORMULA CONTAIN NO MES. PRIOR RESEARCH HAS SHOWN THAT A ME-DEFICIENT DIET IMPAIRS SPATIAL LEARNING AND MEMORY (SLM) AND INCREASES THE SEVERITY OF EPILEPSY-LIKE SEIZURES. THIS PROJECTS STUDIES WHETHER THE POSITIVE EFFECTS OF MES IN THE HOST ARE MEDIATED BY ME-DEPENDENT CHANGES IN NANOPARTICLES SECRETED BY THE GUT MICROBIOME. [GRAM-NEGATIVE BACTERIA SECRETE OUTER MEMBRANE VESICLES (OMVS), WHEREAS GRAM-POSITIVE BACTERIA SECRETE CYTOPLASMIC MEMBRANE VESICLES (CMVS).] THIS PROPOSAL TESTS THE HYPOTHESIS THAT DIETARY ME DEPLETION ALTERS THE QUANTITY (NUMBER) AND QUALITY (CONTENT OF PROTEINS AND RNA) OF OMVS AND CMVS, THEREBY IMPAIRING SLM IN THE HOST. THE RESEARCHERS WILL STUDY 1) EFFECTS OF MES ON OMV AND CMV QUANTITY AND QUALITY IN CULTURES OF GUT BACTERIA, 2) ABSORPTION AND TISSUE DISTRIBUTION OF OMVS, CMVS AND THEIR PROTEIN AND RNA CARGO IN THE HOST, 3) EFFECTS OF ME-DEPENDENT CHANGE IN OMVS AND VMVS ON GENE EXPRESSION IN THE HOST, AND 4) WHETHER ME-DEPENDENT CHANGES IN OMV AND CMV ARE RESPONSIBLE FOR THE EFFECTS OF MES ON SLM N THE HOST OBSERVED IN PRIOR RESEARCH.
$638,000Board Of Regents Of The University Of Nebraska · · FY2023 · National Institute of Food and Agriculture
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** INFLAMMATORY BOWEL DISEASES (IBD) ARE AN INCREASINGLY IMPORTANT GLOBAL HEALTH PROBLEM; OVER 850,000 PEOPLE IN THE UNITED STATES ARE EFFECTED ANNUALLY, AND THE WORLDWIDE INCIDENCE OF IBD HAS INCREASED SINCE 1990. IBD ARE CHARACTERIZED BY CHRONIC INFLAMMATION AND ULCERATION OF THE COLON, ABDOMINAL PAIN, WEIGHT LOSS, BLOODY DIARRHEA, AND AN INCREASED RISK OF A NUMBER OF OTHER DISEASES, INCLUDING COLORECTAL CANCER AND TYPE 2 DIABETES. WHILE DIETARY, DRUG, AND BIOLOGICAL THERAPIES HAVE BEEN USEFUL IN THE MANAGEMENT OF IBD, THE ONLY 'CURATIVE' TREATMENT CURRENTLY AVAILABLE IS SURGICAL RESECTIONING OF THE COLON. IN ADDITION TO NOT BEING TRULY CURATIVE, SURGICAL OPTIONS HAVE SIGNIFICANT SIDE-EFFECTS, INCLUDING INCREASED RISK OF INFECTION. CHRONIC INFLAMMATION HAS BEEN SHOWN TO UNDERLIE IBD, AS WELL AS OTHER CHRONIC DISEASES, INCLUDING LIVER DISEASE AND DIABETES. AND THE ARYL HYDROCARBON RECEPTOR (AHR) IS A CRUCIAL REGULATOR IN THE GASTROINTESTINAL TRACT, PROMOTING BALANCE IN THE GUT WHILE LOWERING INFLAMMATION AND PROTECTING AGAINST NUMEROUS DISEASES.BOTANICALS CONTAIN HUNDREDS OF DIFFERENT PHYTOCHEMICALS, AND HAVE BEEN SHOWN TO HAVE BENEFICIAL HEALTH EFFECTS. AND CONSUMPTION OF THESE FOODS (FRUITS, VEGETABLES, NUTS, FUNGI, ETC.) HAS BEEN LINKED TO IMPROVED GASTROINTESTINAL HEALTH AND LOWER INFLAMMATION. A DIVERSE ARRAY OF FOODS, INCLUDING BROCCOLI, CORN, MUSHROOMS, CARROTS, BERRIES, ETC., HAVE DEMONSTRATED ACTIVITY IN ACTIVATING THE AHR IN PRELIMINARY STUDIES. HOWEVER, THE CHEMICAL AGENTS OF THESE FOODS THAT ARE RESPONSIBLE FOR THIS ACTIVITY REMAIN UNKNOWN. USING OUR INNOVATIVE CHEMICAL PROFILING AND DATA MODELING APPROACHES, WE WILL BE ABLE TO TEASE APART THE DIFFERING CHEMICAL SIGNATURES AND IDENTIFY WHICH MOLECULES ARE ABLE TO ACTIVATE THE AHR. WE WILL BE INVESTIGATING INTERACTIONS AT THE INTERFACE OF FOOD, NUTRITION, THE GUT MICROBIOME, AND THEIR DOWNSTREAM EFFECTS ON CHRONIC HUMAN DISEASE. USING BOTH CELLULAR AND MOUSE MODELS, WE WILL BE ABLE TO ASCERTAIN THEIR EFFECTS ON THE AHR AS WELL AS SUBSEQUENT EFFECTS ON THE GASTROINTESTINAL SYSTEM, INCLUDING THEIR ABILITY TO MITIGATE INFLAMMATORY BOWEL DISEASES.THIS PROJECT WILL PROVIDE A GREATER UNDERSTANDING OF THE MECHANISMS THAT UNDERLIE DIETARY PROTECTION AGAINST INFLAMMATORY GASTROINTESTINAL DISEASES. IT WILL LEAD TO A GREATER UNDERSTANDING OF THE BOTANICAL PHYTOCHEMICALS AND THEIR AHR ACTIVITY, AND THE DATA CAN BE USED TO GUIDE DIETARY RECOMMENDATIONS THAT MODULATE AHR ACTIVITY TO IMPROVE HUMAN GASTROINTESTINAL HEALTH AND COMBAT CHRONIC GI DISEASES. MOREOVER, THESE ENDEAVORS WILL ALLOW US TO PROVIDE PREDICTIVE MODELS AND TO ENHANCE THE ABILITY TO DISCRIMINATE BETWEEN SPECIES OR CULTIVARS AND EVEN PREDICT THE CULTIVAR AND BIOACTIVITY OF UNKNOWN BOTANICAL PRODUCT. THESE DATA WILL ALSO BENEFIT BOTANICAL USERS (SUPPLEMENT MANUFACTURERS AND CONSUMERS) BY PROVIDING A MORE NUANCED UNDERSTANDING OF THE RELATIONSHIP BETWEEN PHYTOCHEMISTRY AND BIOACTIVITY OF VEGETABLE CROPS AND BOTANICALS. WHILE THE P,RESENT STUDY IS FOCUSED ON A LIMITED SELECTION OF MODEL CROPS, THE INNOVATIVE APPROACHES ARE APPLICABLE TO ANY NUTRITIONAL OR MEDICINAL PLANT.
$638,000The Pennsylvania State University · · FY2023 · National Institute of Food and Agriculture
Prebiotics and Metformin Influences Gut and Hormones in Type 2 Diabetes Youth (MIGHTY-Fiber)
$637,949Stephanie Therese Chung · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2023 · DK
Mechanisms by which intestinal bacteria contribute to maintenance of tolerance in food allergy
$637,755Cathryn R Nagler · University Of Chicago · R01 · FY2021 · AI
Diabetes Progression with Metabolomic Profiling in Starr County Mexican Americans
$637,736Goo Jun · University Of Texas Hlth Sci Ctr Houston · R01 · FY2020 · DK
Conserved Fetal Epigenomic and Metagenomic Signatures in a Primate Model of Maternal Obesity
$637,564Kjersti Marie Aagaard-Tillery · Baylor College Of Medicine · R01 · FY2021 · DK
A life course perspective on gut microbiome aging and health in a non-human primate model
$637,563Elizabeth Archie · University Of Notre Dame · R01 · FY2021 · AG
Data Coordinating Center, Microbiome of the Lung and Respiratory Tract
$637,531Mary A Foulkes · George Washington University · U01 · FY2012 · HL
Fiber-rich Foods to Treat Obesity and Prevent Colon Cancer
$637,531Terryl Johnson Hartman · Emory University · R01 · FY2021 · CA
The Microbiome and Bone Strength
$637,475Christopher John Hernandez · Cornell University · R01 · FY2022 · AG
Immunology of aging and immunotherapy of aging-associated diseases
$637,389Arya Biragyn · National Institute On Aging · ZIA · FY2019 · AG
Liver-Gut-Microbiome Axis and Fatty acid absorption in Preterm Infants
$637,366Amy Boriskie Hair · Baylor College Of Medicine · R01 · FY2025 · DK
Autophagy genes and the microbiome in Crohn's Disease
$637,341Ramnik J Xavier · Broad Institute, Inc. · R01 · FY2014 · DK
Clinical safety and pharmacokinetic studies of intravaginal rings releasing multiple antiretrovirals
$637,265Thomas J. Smith · Auritec Pharmaceuticals, Inc. · R44 · FY2016 · HD