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24,576 grants matching “microbiome”
Periodontitis as a comorbidity in SIV infection and Antiretroviral Therapy
$636,068Prasun K Datta · Tulane University Of Louisiana · R01 · FY2023 · DE
Mechanisms underlying recurrent bacterial vaginosis and HIV risk A Multidisciplinary approach
$635,997Maria Luisa Alcaide · University Of Miami School Of Medicine · R01 · FY2023 · AI
Population genomic analysis of gut microbial colonization in premature infants.
$635,973Jillian Banfield · University Of California Berkeley · R01 · FY2020 · AI
Staphylococcal protease-mediated epithelial barrier perturbation and allergen sensitization
$635,901Jin Mo Park · Massachusetts General Hospital · R01 · FY2025 · AI
Dietary and Microbial Reprogramming of Intestinal Microbiota-Produced Metabolites
$635,777Justin Sonnenburg · Stanford University · R01 · FY2022 · DK
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** IRONIS AN ESSENTIAL NUTRIENT IN THE DIET. DIETARY IRON IS CONSUMED EITHER FROM ANIMAL PRODUCTS (AS HEME AND NON-HEME IRON) OR FROM PLANT SOURCES (AS NON-HEME IRON). HUMANS CANNOT REGULATE THE EXCRETION OF IRON SO IT IS VERY IMPORTANT TO TIGHTLY CONTROL THE AMOUNT OF IRON THAT IS ABSORBED FROMDIETARY SOURCES. THE ABSORPTION OF NON-HEME IRON CAN BE TIGHTLY CONTROLLED IN RELATION TO BODY IRON STORES. AS IRON STORES ACCUMULATE, THE AMOUNT OFNON-HEME IRON ABSORBED FROM THE DIET DECREASES TO PREVENT IRON OVERLOAD. SIMILARLY WHEN IRON STORES ARE DEPLETED, ABSORPTION OF NON-HEME IRON WILL INCREASE TO HELP RESTORE IRON BALANCE. IN CONTRAST TO NON-HEME IRON, ABSORPTION OFHEME IRON DOES NOT CHANGE MUCH IN RELATION TO BODY IRON STORES OR IN RELATION TO IRONREGULATORY HORMONES. LIKE HUMANS, THE BACTERIA IN OUR INTESTINES (CALLED THE GUT MICROBIOTA) CAN SENSE THE AMOUNT OF IRON PRESENT IN THE INTESTINAL TRACT AND THEY CAN ABSORB THIS IRON FROM THE INTESTINAL CONTENTS. THIS RESULTS IN A COMPETITION FOR IRON BETWEEN THE HUMAN AND THEIR GUT MICROBIOTA. AS GROWING NUMBERS OF AMERICANS ADOPT PLANT-BASED DIETS, HEME FE INTAKES ARE MARKEDLY REDUCED. THIS MAY SHIFT THE GUT MICROBIOME AS SOME GUT MICROBIOTA CANNOT INDEPENDENTLY MAKE HEME AND REQUIRE DIETARY HEME SOURCES TO SUPPORT THEIR HEME-DEPENDENT FUNCTIONS. ANIMAL DATA HAVE RECENTLY DISCOVERED THAT OTHER GUT MICROBIOTA RESPOND TO A LOW NON-HEME IRON DIET BY PRODUCING METABOLITES THAT INCREASE ABSORPTION OF NON-HEME IRON. TO DATE, SIGNIFICANT KNOWLEDGE GAPS EXIST ON THE INTERRELATIONSHIPSBETWEEN DIETARY HEME AND NON-HEME IRONSOURCES, THE GUT MICROBES, AND IRON ABSORPTION IN HUMANS. THE PROPOSED PROJECT WILLUNIQUELY COMBINEDEEP SHOTGUN METAGENOMICS AND STABLE IRON ISOTOPE TECHNOLOGYTO EVALUATE GUT MICROBIOME FEATURES AND THEIR INTERRELATIONSHIPS WITH DIETARY IRON ABSORPTION IN HEALTHY ADULTS WHO ARE HABITUALLY INGESTING EITHER A PLANT-BASED OR A NON-PLANT-BASED DIET. GROWING NUMBERS OF AMERICANS ARE INGESTING A PLANT BASED DIET. DATA GENERATED FROM THIS PROJECT WILL PROVIDE NOVEL INFORMATION ON HOW IRON COMPOSITION OF THE DIET INFLUENCES OUR GUT MICROBIOTA AND OUR ABILITY TO UTILIZE IRON FROM THE FOODS WE EAT.
$635,769Cornell University · · FY2023 · National Institute of Food and Agriculture
Harnessing iron acquisition to hinder enterobacterial pathogenesis
$635,769Manuela Raffatellu · University Of California, San Diego · R01 · FY2025 · AI
The Microbiome, Virome and Host Responses Preceding Ventilator-Associated Pneumon
$635,764Peter M Mourani · University Of Colorado Denver · R01 · FY2017 · HL
The Microbiome, Virome and Host Responses Preceding Ventilator-Associated Pneumon
$635,764Peter M Mourani · University Of Colorado Denver · R01 · FY2016 · HL
Development of standardized resources for characterization of the resident ocular surface microbiome.
$635,758Laura Ensign · Johns Hopkins University · U24 · FY2023 · EY
Commensal modulation of Peri-implant Microbiome Dysbiosis via Veillonella parvula
$635,522Georgios Kotsakis · Rutgers Biomedical And Health Sciences · R01 · FY2025 · DE
Training in Pediatric Gastroenterology and Nutrition
$635,520Scott B Snapper · Boston Children'S Hospital · T32 · FY2022 · DK
The Pacific Ocean Native Observational (PONO) Health Legacy Study
$635,390Marjorie K Mau · University Of Hawaii At Manoa · UH3 · FY2025 · HL
Building the Microbiome into the Hibernator Metabolic Phenotype
$635,307Hannah V Carey · University Of Wisconsin-Madison · · FY2016 · BIO
Clinical Interventional Studies of HIV Reservoirs
$635,273Frank Maldarelli · Division Of Basic Sciences - Nci · ZIA · FY2022 · CA
Prevention Center U01: Early Targets for Antigen-Specific Tolerance Induction in Preclinical Rheumatoid Arthritis
$635,263V Michael Holers · University Of Colorado Denver · U01 · FY2019 · AI
Global Omics and Viromics Initiative on Pregnancy
$635,208Gregory A Buck · Virginia Commonwealth University · R01 · FY2021 · HD
Time restricted feeding versus daily calorie restriction: Effect on body weight, metabolic risk, and the gut microbiome
$635,081Krista Amy Varady · University Of Illinois At Chicago · R01 · FY2024 · DK
Symptom Distress Mechanisms in Digestive Disorders
$634,998Wendy Henderson · National Institute Of Nursing Research · ZIA · FY2019 · NR
Gut microbial fermentation products of muscle-derived lactate as mediators of exercise and metabolism
$634,993Aleksandar David Kostic · Joslin Diabetes Center · R01 · FY2023 · DK
Clinical Interventional Studies of HIV Reservoirs
$634,967Frank Maldarelli · Division Of Basic Sciences - Nci · ZIA · FY2021 · CA
Regulation of neonatal inflammation by myeloid-derived suppressor cells
$634,964Yulia Nefedova · Wistar Institute · R01 · FY2023 · HL
Gut Dysbiosis and Cardiac Remodeling in IBD
$634,956Qingjie Li · University Of Texas Med Br Galveston · R01 · FY2023 · HL
Role of the Gut Microbiota in Abdominal Aortic Aneurysm
$634,924Albert Phillip Owens III · University Of Cincinnati · R01 · FY2023 · HL
Role of the Gut Microbiota in Abdominal Aortic Aneurysm
$634,924Albert Phillip Owens III · University Of Cincinnati · R01 · FY2022 · HL